INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2014
·
IF 3.096
Xin Hu,Lingling Lu,Chen Xu,Xinsong Li
In this report, biological macromolecular full IPN hydrogel fibers composed of gelatin and alginate with an interpenetrating network (IPN) structure were prepared by wet spinning using a combination of enzymatic and calcium ions crosslinking. In the full IPN hydrogel fibers, mTG catalyzed the formation of one network of gelatin while calcium ions crosslinked another network of alginate intertwining with the former. The mechanical strength of the full IPN hydrogel fibers was measured by an electronic single fiber strength tester. The results showed that gelatin–alginate full IPN hydrogel fibers had a significant improvement of mechanical strength over gelatin–alginate semi-IPN gel fibers crosslinked only by calcium ions. The full IPN fiber has the highest tension of 62 cN and elongation of 739%, which are much higher than those of alginate hydrogel. Furthermore, biological evaluation indicated that gelatin–alginate full IPN hydrogel fibers enhance cell adhesion and proliferation significantly, illustrating the cyto-compatibility. A preliminary trial of hand weaving showed the knittablity of the mechanically tough full IPN hydrogel fibers. Because of their both excellent biocompatibility and mechanical strength, the biological macromolecular hydrogel fibers with full IPN structure may be desirable candidates for engineering tissue scaffolds.
研究领域:
生物材料学
·
组织工程学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2018
·
IF 3.909
Yuanfeng Pan,Jingchun Wang,Pingxiong Cai,Huining Xiao
In this work, the stepwise synthesis of interpenetrating polymer network (IPN) strategy was developed in an attempt to fabricate novel hydrogels consisting of sugarcane bagasse cellulose (SBC), carboxymethylcellulose (CMC) and poly (N-isopropylacrylamide) (PNIPAm) as a dual-responsive drug carrier. The pretreated and dissolved SBC was pre-crosslinked using epichlorohydrin in the presence of CMC, followed by in-situ free-radical polymerization of NIPAm in the presence of N,N′-Methylene-bis(acrylamide) as a crosslinking agent. The carboxyl groups in CMC and PNIPAm chains rendered the resulting hydrogel pH and thermal responsive. The results from scanning electron microscopy, infrared spectroscopy , thermogravimetric analysis and mechanical property testing demonstrated the successful formation of the IPN with proper structure and mechanical strength . The swelling experiments at different temperatures and pH showed the dual–sensibility of the hydrogels. Moreover, bovine serum albumin (BSA) was used as a model drug and loaded in the hydrogel; and the drug release behavior was revealed in phosphate buffer solution (PBS) and simulated gastric fluid (SGF). The results indicated that the dual-responsive IPN hydrogel is of great potential for the controlled release of drug.
研究领域:
高分子材料
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药物递送
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生物医学工程
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智能响应材料
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药剂学
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DOI
高影响因子
COMPOSITES SCIENCE AND TECHNOLOGY
·
2017
·
IF 4.873
Shuyan Yang,Wenjian Wu,Yuanqi Jiao,Zhuodi Cai,Hongbo Fan
Sustainable self-reinforcement organic filler, which does not contribute to environmental pollution , has been realized in the rubber industry as an alternative to modifying inorganic fillers with coupling agents or preparing rubber fillers, such as carbon black, with petrochemical products that cause environmental problems. In this work, tannic acid (TA), the world's third largest class of plant components that are easily available, is used as a self-reinforcing organic filler to prepare nitrile–butadiene rubber/TA (NBR/T) composites. Results show that TA can melt partially under vulcanization to assemble a weak interpenetrating polymer network (IPN) structure by hydrogen bonds under cooling, which is responsible for the dramatic increase in the mechanical and flexible properties of NBR/T composites even at low TA dosage. This finding provides a new perspective in preparing high-performance and sustainable rubber composites without sacrificing fossil fuels or non-renewable environmental resources .
研究领域:
高分子材料科学
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复合材料
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可持续化学
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橡胶工业
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2020
·Vol. 45
·期 2
·861-871
·
IF 3.288
Xiaoxu Liang,Hongyao Ding,Qiao Wang,Miaomiao Wang,Bibo Yin,Guoxing Sun
Tough hydrogels with high mechanical properties and multi-responsiveness have attracted increasing attention in recent decades. Herein, we report a series of tough semi-interpenetrating hydrogels (poly(N-acryloyl-2-glycine)/polyvinyl alcohol hydrogels, PACG/PVA hydrogels, i.e., PAP hydrogels) comprised of natural amino acid-derived polymers PACG within physical crosslinked PVA. The PAP hydrogels demonstrated tunable mechanical properties, with tensile breaking stress (σb), breaking strain (εb), Young's modulus (E) and toughness (Wb) of 0.14–1.38 MPa, 420–530%, 15–106 kPa and 21–308 kJ m−3, respectively. Based on the ionizable side chains containing amino and carboxyl groups of PACG, the PAP hydrogels exhibited a significant response to salt and pH as well as self-healing, self-rolling, and reconstruction ability. Thus, the obtained hydrogels can act as promising candidates in soft actuators, flexible sensors, etc.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Materials Advances
·
2023
·Vol. 4
·期 7
·1671-1677
·
IF 5
Yi Xu,Xinyue Sun,Keqi Zhu,Shumin Xu,Changhui Liu,Shenghua Xiong,Chao Li
Oily wastewater and oil spills pose a threat to the environment and human health, and absorbing these harmful organics through porous aerogel materials is an efficient method for oil/water separation. Herein, we design degradable, hydrophobic, and mechanical 4,4′-methylenedianiline polybenzoxazine/silicone-based polyhexahydrotriazine aerogels (BOZ/Si-PHT) for efficient oil/water separation. The BOZ/Si-PHT interpenetrating network (IPN) aerogels were successfully prepared by sequential polymerization, followed by atmospheric drying without any additional post-processing. The as-prepared BOZ/Si-PHT aerogels exhibit prosperous hydrophobicity (a water contact angle of 121.5°) and good mechanical properties (a compressive strength of 449.6 kPa). Meanwhile, the BOZ/Si-PHT aerogels possess good absorption capacity of oils or organic solvents ranging from 4.6 to 16.3 times their own weights. More importantly, the BOZ/Si-PHT aerogels show rapid degradation after use. This work provides simple, environmentally friendly and sustainable materials for oil/water separation and the rationally designed hydrophobic BOZ/Si-PHT aerogels display enormous potential for practical applications dealing with oily wastewater and oil spills.
研究领域:
材料科学
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环境科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Dong Guo,Ziyue Zhang,Jichao Sun,Wanguo Hou,Na Du
Hypothesis Simple single-chain amphiphiles (sodium monododecyl phosphate, SDP) and organic small molecules (isopentenol, IPN), both of primitive relevance, are proved to have been the building blocks of protocells on the early Earth. How do SDP-based membrane and coexisting IPN come together in specific ways to produce more complex chemical entities? What kind of cell-like behavior can be endowed with this protocell model? These are important questions in the pre-life chemical origin scenario that have not been answered to date. Experiments The phase behavior and formation mechanism of the aggregates for SDP/IPN/H 2 O ternary system were characterized and studied by different electron microscopy, fluorescent probe technology, DLS, IR, ESI-MS, SAXS, etc. The stability (freeze–thaw and wet-dry treatments) and cell-like behavior (chemical signaling communication) were tested via simulating particular scenarios. Findings Vesicles, microtubules and asters phases resembling the morphology and structure of modern cells/organelles were obtained. The intermolecular hydrogen bonding is the main driving force for the emergence of the aggregates. The protocell models not only display remarkable stabilities by simulating the primordial Earth’s diurnal temperature differences and ocean tides but also are able to exhibit cell-like behavior of chemical signaling transition.
研究领域:
前生物化学
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生命起源
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软物质物理
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生物物理学
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产品关联
DOI
PubMed
高影响因子
PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2025
·
IF 2.9
Yue Wang,Guineng Li,Yeying Li,Mutiao Yao,Qiaobo Wang,Liang Peng,Hua Gu
Hydrogels with excellent mechanical properties and high drug-delivery capacity are highly advantageous for wound healing applications. However, reconciling mechani-cal properties with drug-delivery performance remains challenging. Herein, a semi-interpenetrating polymer network (semi-IPN) hydrogel composed of poly(vinyl alcohol) (PVA) and sodium alginate (SA) was fabricated via freeze-thaw cycling. Through component optimization, this hydrogel achieved a unique combination of de-sirable properties, including softness (Young’s modulus of 32.5 kPa), high stretchability (fracture strain of 283.9%), and high water-content (96.46%). Linagliptin (LIN), a DPP-4 inhibitor crucial for diabetic wound repair, was loaded into the system with an effective loading efficiency of 89.25%. The hydrogel system demonstrated tempera-ture-responsive release kinetics: minimal release occurred at low temperatures, while rapid, sustained release at physiological temperature was achieved, reaching a cumu-lative release efficiency of up to 85.17%, which was highly beneficial for the storage and application of drug-loaded hydrogels. This study presents a hydrogel platform with effectively integrates material robustness, temperature-triggered drug delivery and high-efficiency loading and releasing LIN, which showcases significant potential as a novel therapeutic material for diabetic wound healing.
研究领域:
生物材料
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药物递送
·
组织工程
·
高分子科学
·
伤口愈合
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产品关联
DOI
PubMed
高影响因子
WATER SCIENCE AND TECHNOLOGY
·
2018
·Vol. 2017
·期 1
·16-26
·
IF 1.247
Liu Zejun,Zhou Shaoqi
In this study, we provide the first documented removal of humic acid (HA) from aqueous solution using polyacrylamide/chitosan (PAAm/CS) semi-IPN hydrogel. The prepared semi-IPN hydrogel was characterized by scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR). The factors effecting HA adsorption performance were individually tested, including initial pH, ionic strength, contact time, initial HA concentration, and temperature. The results indicated that semi-IPN hydrogel was successfully fabricated and can be applied in a wide pH range, from 3 to 9. Low ionic strength effectively enhanced the adsorption capacity. As the ionic strength increased, this enhancement was less obvious but still positive. The adsorption kinetics were fitted to a pseudo-first-order kinetic model, and the adsorption isotherm was described using the Sips isotherm model. The HA adsorption capacity increased with increasing temperature. The maximum adsorption capacity has the potential to attain 166.30 mg g −1 , based on the Sips isotherm at 25 °C. Experiments demonstrated that the HA adsorption process can be primarily attributed to electrostatic interactions, and hydrogen bonding was also involved. Facile synthesis and good adsorptive performance indicate that semi-IPN hydrogel can be used for removing HA from water.
研究领域:
环境科学
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高分子化学
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水净化
·
吸附技术
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DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Xinyu Hu,Yongmei Wang,Liangliang Zhang,Man Xu,Wei Dong,Jianfa Zhang
Salecan is a novel water-soluble extracellular β-glucan and has excellent physicochemical and biological properties. A series of hydrogels were fabricated from Salecan and poly(2-acrylamido-2-methylpropanesulfonic acid- co - N -hydroxymethyl acrylamide) (poly(AMPS- co -HMAA), PAH) by semi-IPN technique. The introduction of Salecan into the PAH network endows the system with enhanced cell adhesion properties. These semi-IPN hydrogels with open interconnected pores had pH and salt-sensitive swelling behavior. The increase in the content of hydrophilic Salecan could enhance the water uptake of the hydrogels. Rheological results indicated that the incorporation of PAH into hydrogels increased the storage modulus. The degradation property of the hydrogels can be tuned by modulating the content of Salecan and BAAm. Cytotoxicity results revealed that the hydrogels were non-toxic to COS-7 cells. All these results suggested that Salecan/PAH semi-IPN hydrogels exhibited great potential for applications in soft tissue engineering.
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 7
·51650
·
IF 3.125
Zirong Xu,Kelin Wu,Huayong Luo,Qin Wang,Tian C. Zhang,Xiaobing Chen,Hongwei Rong,Qian Fang
An electro-responsive hydrogel with semi-interpenetrating polymer networks (semi-IPN) composed of crosslinked poly(2-acrylamido-2-methyl-l-propanesulfonic acid- co -acrylamide) (P(AMPS-AM)) and linear polyelectrolyte polyacrylic acid (PAA) was explored. The semi-IPN hydrogel was characterized with different methods and then used as advanced draw agent toward high water recovery for forward osmosis (FO) desalination. The swelling kinetics of the semi-IPN hydrogel was investigated, and the electro-responsive nature of the hydrogel under electric stimulus (in direct contact with electrodes) was determined. Results indicated that in comparison with pure P(AMPS-AM) hydrogel, the semi-IPN hydrogel exhibited a loose network structure with more pores. In addition, a higher equilibrium swelling capacity and more pronounced deswelling under electric stimulus can be observed for the semi-IPN hydrogel. Furthermore, the semi-IPN hydrogel displayed a similar initial water flux of 2.20 L m −2 h −1 (LMH) from 2 g/L NaCl solution of a lab-scale FO process. Importantly, the semi-IPN hydrogel had a 25% increase in water recovery efficiency under the electric stimulus of 15 V, and showed better recyclability during three cycles of regeneration compared with pure P(AMPS-AM). The mechanism of enhanced dewatering nature for the semi-IPN hydrogel under electric stimulus was elucidated. These results indicate this new hydrogel's potential as a promising candidate for improving FO performance.
研究领域:
材料科学
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环境工程
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2014
·Vol. 131
·期 22
·
IF 1.64
Bing Qu,Jun-rong Li,Hui-ning Xiao,Bei-hai He,Li-ying Qian
Sodium carboxymethylcellulose/poly(methyl acrylate) (NaCMC/PMA) interpenetrating polymer networks (IPNs) were prepared by fractional step in 40 wt % ethanol solution with N,N′-methylenebisacrylamide as a crosslinker. Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), and differential scanning calorimeter were used to characterize the NaCMC/PMA IPN hydrogels and confirm the IPN structure as well. Simultaneously, adsorption of the obtained IPN hydrogels to methylene blue (MB) was also investigated. It was observed that the adsorption of MB onto the hydrogels was mainly dependent on the initial concentration of MB and the pH of the solution. Adsorption rate of MB was much higher in the first 9 h than that in the following period and saturated adsorption amount of MB was 2370 mg/g at the initial MB concentration of 100 mg/L. Moreover, the adsorption capacity of the IPN hydrogels at the neutral pH condition is much higher than those at acid or alkaline pH conditions. © 2014 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2014 , 131 , 41101.
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DOI
高影响因子
Journal of Coatings Technology and Research
·
2021
·Vol. 18
·期 4
·1027-1035
·
IF 2.382
Ding Wenfei,Zhao Zheng,Jiang Lingmei,Jian Xigao,Song Yuan,Wang Jinyan
Guidewires have crucial roles in intravascular, critical care, and urological applications. In recent years, the demand for guidewires with lower friction surfaces has arisen for medical applications. Among various surface lubrication strategies for guidewires, the most promising is the use of a hydrophilic coating. However, obtaining a hydrophilic coating on guidewires with strong adhesion remains difficult owing to the surface energy difference between the substrate and hydrophilic coating. Herein, we present a UV-curing semi-interpenetrating polymer network coating for medical thermoplastic polyurethane (TPU)-sheathed nitinol guidewires. A polyurethane acrylate (PUA) was synthesized and cured as a transition layer on the TPU substrate to provide strong adhesion. Then, polyvinyl pyrrolidone (PVP) and polyethylene glycol diacrylate (PEGDA) permeated into the PUA layer and cured to form the composite coating. The PUA–PEGDA–PVP coating exhibited excellent lubricity and satisfactory adhesion force. The surface coefficient of friction decreased to approximately 0.02 after modification with the coating, and the coating was stable during long-term soaking in water and repeated friction. In vitro toxicity tests revealed that the coating had good biocompatibility. Thus, our PUA–PEGDA–PVP coating has the potential for application as super-lubricity guidewires and other medical devices.
研究领域:
材料科学
·
医学工程
·
生物医学材料
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）