ELECTROANALYSIS
·
2020
·Vol. 32
·期 6
·1155-1159
·
IF 2.544
Shuang Han,Yuan Gao,Lin Li,Beibei Lu,Yongxing Zou,Ling Zhang,Jiaheng Zhang
In this study, we found that glucose enhance electrochemiluminescence (ECL) intensity of both Au nanoclusters (Au NCs) and carbon quantum dots (CQDs) with K 2 S 2 O 8 as the co-reactants. The enhancing effects by Au NCs and CQDs were overlapped, enabling the detection of glucose. The increased ECL intensity of glucose was linear with the logarithm of concentrations of glucose in the range of 50 μM–3.0 mM, and the limit of detection is 20 μM. Anti-interruption ability was achieved, and ascorbic acid, urea, and uric acid had little influence to glucose detection. This method realized the direct detection of glucose by enhancing ECL of Au NCs and CQDs, which was fast and economic, possessing potential applications for glucose detection in human serum.
研究领域:
纳米技术
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分析化学
·
生物医学工程
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DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2022
·
IF 5.304
Xiaojiao Du,Jun Sun,Yan Li,Wenhan Du,Ding Jiang
A highly sensitive electrochemiluminescence (ECL) aptasensor for lincomycin (Lin) detection was designed based on a novel self-accelerated ECL luminophore of Ag 3 PO 4 -Ti 3 C 2 nanohybrids. The Ag 3 PO 4 -Ti 3 C 2 nanohybrids demonstrated prominent ECL performances with K 2 S 2 O 8 as co-reactant, and the Ti 3 C 2 as co-reaction accelerator, which catalyzes K 2 S 2 O 8 into more active radicals and inducing a tremendous amount of excited-state luminophores. Besides, it can be used for loading aptamer molecules owing to its large surface area. Given these attributes, a self-accelerated ECL aptasensor for Lin detection was constructed based on the effect of target induced aptamer dissociating. Under optimized conditions, the ECL aptasensor exhibited wide linear relationship of 1.0 × 10 −4 nmol/L to 1.0 × 10 2 nmol/L, low detection limit of 6.17 × 10 −5 nmol/L (S/N = 3) and good stability and reproducibility for Lin detection. The aptasensor was successfully applied for the Lin detection in milk and water samples, implying immense potential in real applications.
研究领域:
分析化学
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生物传感器
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纳米技术
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药物分析
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DOI
高影响因子
ENVIRONMENTAL TECHNOLOGY
·
2025
·
IF 2
Lei Chen,Yun Wang,Haiyang Shao,Chengkai Mao,Minghong Wu,Gang Xu
The increasing presence of benzothiazole (BTH) in industrial wastewater poses significant environmental and health risks due to its persistence and toxicity. This study compares UV/persulfate (UV/K₂S₂O₈) and UV/H₂O₂ systems for benzothiazole (BTH) degradation, revealing that UV/K₂S₂O₈ achieves complete BTH removal (100%, 0.189 min−1) versus 85% (0.092 min−1) for UV/H₂O₂ under identical conditions. Radical scavenging experiments and LC-MS analysis demonstrate sulfate radicals outperform hydroxyl radicals in oxidizing BTH heterocyclic structure, reducing intermediates by 63% (quantified via peak area ratios). pH-dependent kinetics show UV/K₂S₂O₈ maintains efficacy (90–100% removal) across pH 3–9, while UV/H₂O₂ efficiency drops to 58% at pH > 7. Practical validation in river water confirms UV/K₂S₂O₈ robustness (98% BTH degradation), positioning it as a scalable, energy-efficient solution for refractory pollutant treatment. The results showed that the oxidant concentration and pH affected the degradation rate of BTH by changing the free radical concentration, and the UV/ K2S2O8 was demonstrated to be able to achieve efficient removal of pollutants in complex environmental matrices. Free radical scavenging experiments and liquid chromatography-mass spectrometry analysis confirm that sulfate radicals are more effective than hydroxyl radicals in oxidizing and degrading BTH, enabling rapid, efficient, and environmentally friendly degradation of pollutants. This is mainly due to the higher redox potential of sulfate radicals (2.8–3.1V) compared to hydroxyl radicals (2.01V), resulting in the generation of fewer intermediates. Compared to UV/H2O2, UV/K2S2O8 is a more effective, cleaner, and energy-saving method for pollutant removal in various complex environmental matrices.
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PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 36
·23437-23446
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IF 4.036
Lina Wang,Qi Wu,Ru Yu,Hongge Zhang,Fei Nie,Wenyan Zhang
A silver nanoparticle-doped Zn(II) metal–organic framework composite (AgNPs@ZnMOF) was investigated as an electrochemiluminescence (ECL) signal enhancer for potassium persulfate. First, ZnMOF was prepared by a one-step hydrothermal method, and then AgNPs@ZnMOF composite was obtained by depositing AgNPs on the surface and interior of ZnMOF. After the AgNPs@ZnMOF composite was modified on the glass carbon electrode (GCE), the cathode luminescence of potassium persulfate on bare GCE was enhanced by 8 times. A dual amplification mechanism provided by Zn(II) and Ag nanoparticles in the AgNPs@ZnMOF composite has been validated by ECL spectra, fluorescence spectra, and electrochemical methods. The interaction between the sulfhydryl groups in L-cysteine (L-Cys) and AgNPs significantly affects the catalytic luminescence of the AgNPs@ZnMOF composite. Thus, a sensitive ECL method for the determination of L-Cys was developed based on the inhibition effect of L-Cys on the ECL signal within the linear range from 5.0 nM to 1.0 μM and the limit of detection was found to be 2 nM (S/N = 3). The established method has been successfully applied to the determination of L-Cys in human urine.
研究领域:
分析化学
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纳米技术
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生物化学
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DOI
PubMed
高影响因子
ChemistrySelect
·
2024
·Vol. 9
·期 23
·e202401018
·
IF 1.9
Hai Shuai,Hanfeng Cui,Jie Zhang,Huiting Hu,Qian Long,Xiaocui Yin,Fusheng Liao,Hao Fan,Zhiqiang Liu,Bo Wu
Graphical In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples. In this study, we present the novel combination of AE-TPEA with RuMOF to construct an electrochemiluminescence (ECL) sensor using a TPEA-RuMOF composite material specifically for copper ions (Cu 2+ ) detection. Using K 2 S 2 O 8 as a co-reactant, we explored the ECL behavior of the TPEA-RuMOF modified electrode, enabling the quantitative detection of Cu 2+ . Remarkably, this sensor exhibited a wide linear range from 1×10 −5 to 1×10 −9 M (R 2 =0.998) and boasted a detection limit as low as 0.41 nM, which is considerably below the EPA (Environmental Protection Agency) permissible copper ion concentration in drinking water of <1.3 mg/L. our synthesized probe offers enhanced stability and selectivity in copper ion detection. This indicates its considerable potential for high-performance copper ion detectors. We further validated the analytical applicability of this sensor using river water samples.
研究领域:
分析化学
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环境科学
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材料科学
·
传感器
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2018
·
IF 8.173
Xianzhen Song,Xiaojian Li,Dong Wei,Rui Feng,Tao Yan,Yaoguang Wang,Xiang Ren,Bin Du,Hongmin Ma,Qin Wei
In this work, 3,4,9,10-perylenetetracar-boxylic acid (PTCA) as luminophor was grafted on the surface of graphene oxide (PTCA-GO) directly. GO exhibited large specific surface area and excellent electrical conductivity which can immobilize large amounts of PTCA to improve the electrochemiluminescence (ECL) efficiency. Moreover, gold nanoparticles (Au NPs) were anchored on the surface of PTCA-GO to immobilize primary antibodies (Ab 1 ) via Au-NH 2 bond and enhance the electron transport of PTCA-GO. CuS was used as a novel co-reaction accelerator in PTCA-K 2 S 2 O 8 system to label secondary antibodies (Ab 2 ), which can react with the coreactant (K 2 S 2 O 8 ) to produce more SO 4 •- . SiO 2 nanospheres with large specific surface area were used to load a mass of CuS and Au NPs, which can directly combine with Ab 2 and accelerate the ECL emission remarkably. Therefore, a novel sandwich-type ECL immunosensor was fabricated successfully for amyloid-β protein (Aβ) detection. Under the optimal condition, a wide detection range from 50 fg/mL to 25 ng/mL and a low detection limit of 18 fg/mL (S/N = 3) were obtained. Featuring favorable specificity, stability and reproducibility, the strategy can be a powerful analytical tool in sensitive trace detection of biomolecules in clinical analysis.
研究领域:
生物分析化学
·
医学检测
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DOI
PubMed
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2021
·
IF 4.464
Zhimin Liu,Jie Wang,Yilei Lu,Chen Cui,Limei Zheng,Leqian Hu
In this work, an effective signal amplification strategy was used for the fabrication of the ultrasensitive sandwich-typed electrochemiluminescence (ECL) immunosensing platform. The combining of K 2 S 2 O 8 -H 2 O 2 dual coreactants with the localized surface plasmon resonance of silver nanoparticles (AgNPs) resulted in the remarkable increase of ECL response. Noticeably, because of the perfect overlap between the plasmon spectra of AgNPs and the ECL emission spectra of graphitic carbon nitride quantum dots (g-CNQDs), a plasmon-enhanced ECL phenomenon was proved in g-CNQDs/AgNPs system result from high efficient energy transfer. Besides, the ECL signal of the ECL immunosensor was greatly improved in the presence of K 2 S 2 O 8 -H 2 O 2 dual coreactants. Consequently, this synergistic amplified ECL sensing platform was applied for the specific prostate specific antigen (PSA) analysis. Under the optimum conditions, the immunoassay strategy demonstrated excellent sensing performance with a wide linear concentration of PSA from 1.0 × 10 − 5 ng mL −1 to 500 ng mL −1 and a detection limit of 0.0046 pg mL −1 (S/N = 3). Considering the favorable analytical feedback in actual serum samples assay, the developed strategy indicated an enormous potential for biomarkers analysis.
研究领域:
生物医学工程
·
分析化学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2020
·
IF 10.257
Yao Lu,Hong Ke,Yang Wang,Yao Zhang,Huan Li,Chusen Huang,Nengqin Jia
A ratiometric electrochemiluminescence resonance energy transfer (ECL-RET) platform depended on novel dye BODIPY derivatives was proposed for rapid detection of lactoferrin . This ECL-RET platform is composed of aptamer decorated BODIPY composites and C 60 @BSA, in which BODIPY derivative is the ECL probe and can generate significant resonance energy transfer with K 2 S 2 O 8 . BODIPY derivative and K 2 S 2 O 8 are used as built-in reference signal and calibration signal respectively to eliminate background signal and abnormal change signal by double signal self-calibration process. At the same time, C 60 , as the accelerator of K 2 S 2 O 8 , can effectively increase the ECL signal and further transfer as much energy as possible to BODIPY derivative. Under optimal conditions, the constructed ECL-RET platform exhibited sensitive detection of lactoferrin in the wide linear range of 10 -4 - 850 ng/mL with a LOD of 42 fg/mL. Meanwhile, the proposed ECL-RET aptasensor demonstrated superior stability, specificity and reproducibility, displaying favorable application value in practical diagnosis of this method.
研究领域:
分析化学
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生物化学
·
生物技术
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DOI
PubMed
高影响因子
ANALYTICAL CHEMISTRY
·
2020
·
IF 6.785
Dexin Du,Jiangnan Shu,Mingquan Guo,Mohammad A. Haghighatbin,Di Yang,Zhiping Bian,Hua Cui
Recently, nanoluminophores with the potential-resolved multicolor electrochemiluminescence (PRMCECL) property have emerged and shown promising applications in sensitive, selective, and accurate bioassays, bioimaging, and multicolor emitting devices. However, only limited PRMCECL nanoluminophores and their applications in ratiometric biosensors eliminating proportional errors have been reported. Herein, a novel PRMCECL nanoluminophore was synthesized by encapsulating CdS quantum dots (CdSQDs) into MOF-5 (CdSQDs@MOF-5). Using K2S2O8 as a coreactant, two electrochemiluminescence (ECL) peaks, ECL-1 centered at 685 nm and ECL-2 centered at 475 nm, were observed at −1.4 and −1.8 V, respectively. Related ECL mechanisms have been proposed. Based on the potential-resolved ECL signals, a label-free differential ECL immunosensor for the determination of cardiac troponin I (cTnI) was established by assembly of poly(diallyldimethylammonium chloride), CdSQDs@MOF-5, and cTnI antibody-functionalized silver nanoparticles on the surface of the fluorine-doped tin oxide electrode subsequently. In the presence of cTnI, cTnI was captured by the sensing interface, leading to an increase in ECL-1 and ECL-2 intensity. cTnI could be determined in the range of 0.01–1000 pg/mL with a detection limit of 5.01 fg/mL using the intensity difference between ECL-1 and ECL-2. This work provides a new family member of PRMCECL nanoluminophores. The proposed label-free differential ECL immunosensor provides a new strategy based on potential-resolved ECL signals, which could effectively eliminate the additive error and show better sensitivity, selectivity, and accuracy for the detection of cTnI than the single-signal strategy and ratiometric strategy.
研究领域:
电化学
·
纳米技术
·
生物传感器
·
心脏病学
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
·
2019
·
IF 6.393
Yang Li,Yanxin Chu,Yuanfang Li,Cheng Ma,Lingling Li
The detection of specific DNA sequences provides a powerful tool for early diagnosis and prevention of disease. Herein, an enzyme-free electrochemiluminescence (ECL) DNA biosensor was developed by coupling inorganic-organic nanocomposite as the luminophore and ZnCo 2 O 4 as the efficient accelerator. ZnCo 2 O 4 nanoparticles (ZCO NPs), derived from Co and Zn based bimetallic zeolite imidazole framework, was used as the ECL substrate due to their large surface area and excellent catalytic effect. AgInS 2 -ZnS quantum dots (ZAIS) were covalently linked with meso -tetra(4-carboxyphenyl)-porphine (TCPP) to form ZAIS/TCPP inorganic-organic nanocomposites, which were used for the first time as the cathodic ECL luminophore with the coreactant of K 2 S 2 O 8 . Detection of target DNA (tDNA) about chronic myeloid leukemia (CML) was achieved based on dual-signal amplification via cascade toehold-mediated strand displacement reaction (TMSDR). On the basis of experimental results, a limit of detection (LOD) of 200 aM was achieved in the range of 0.5 fM to 1 nM, which showed the excellent performance of this biosensor. This work not only indicates that inorganic-organic nanocomposites as the ECL luminophore is a feasible strategy for efficient emission, but also expands the application of nanomaterials derived from metal organic frameworks.
研究领域:
生物化学
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纳米技术
·
分析化学
·
分子生物学
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高影响因子
Analytical Methods
·
2014
·Vol. 7
·期 4
·1395-1400
·
IF 1.938
Li Wang,Di Luo,Dongdong Qin,Duoliang Shan,Xiaoquan Lu
This paper reports the electrochemiluminescence (ECL) behavior of CdSe/ZnS with K2S2O8 as the coreactant. The effects of pH, K2S2O8 concentration, the duration of the reaction of 4-ATP with GCE and the duration of the reaction of 4-ATP/GCE with QDs on ECL intensity were studied in detail. A possible ECL reaction mechanism was then proposed. In addition, it was observed that the ECL intensity was efficiently quenched by trace amounts of heavy metal ion. Based on the quenching effect of Pb2+ upon the ECL of CdSe/ZnS QDs, a QDs-ECL sensor was constructed to detect Pb2+ in preserved duck egg. The sensor showed good reproducibility and stability.
研究领域:
分析化学
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电化学
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环境科学
·
材料科学
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DOI
高影响因子
JOURNAL OF ELECTROANALYTICAL CHEMISTRY
·
2019
·
IF 3.218
Peijin Wang,Qian Wu,Caixia Wang,Xue Yang,Min Wei,Yuxin Pu,Mao Zhou,Mingxiao Zhang
In this work, Prussian blue nanocubes functionalized partial reduced graphene oxide (PBs-PrGO) was first employed as a new electrochemiluminescence (ECL) signal amplification strategy of perylenetetracarboxylic acid (PTCA), and the ECL signal of PBs-PrGO-PTCA composite presented 3-fold enhancement compared with PTCA. The Fe III and Fe II active site of Prussian blue nanocubes (PBs) could promote the reduction of K 2 S 2 O 8 to generate more sulfate radical anion (SO 4 − ), which enhanced the ECL signal of PTCA. The partial reduced graphene oxide (PrGO) not only used as the substrate for in-situ growing PBs, but also could assemble PTCA through π–π stacking. Besides, folic acid (FA) could effectively quench the ECL signal of PTCA. Based upon above, a rapid and effectual FA sensor was constructed. Under the optimum conditions, the ECL sensor exhibited an excellent linear relationship for FA determination with the limit of detection low as 0.719 nM. The constructed sensor applied in the determination of FA in tablets and human urine with satisfactory results, which could realize rapid and accurate FA analysis.
研究领域:
分析化学
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纳米材料
·
生物传感器
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）