Foods
·
2025
·Vol. 14
·期 20
·3481
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IF 5.1
Xinxin Zhang,Changfeng Zhang,Menglian Gong,Pao Li,Hui Tang,Liwen Jiang,Yang Liu
To elucidate the mechanisms underlying the formation of the bacterial community predominantly composed of lactic acid bacteria (LAB) in sour bamboo shoots, the dynamics of the bacterial community structure and the influence of organic acids on the growth of dominant species were investigated. The results showed that the dominant bacteria in sour bamboo shoots changed fromEnterobacteriaceaeat first to LAB after fermentation. Correlation analysis revealed that organic acids, especially lactic acid and acetic acid, had great effects on bacteria. Even low concentrations of organic acids had negative effects on the growth ofEnterobacter asburiae, while LAB exhibited remarkable tolerance to 8 g/L of organic acids. Notably,Levilactobacillus spicheridisplayed a normal growth rate during incubation in medium containing 4 g/L of malic acid for 48 h. This study clarified the regulation of organic acids on bacterial community formation and provided a new understanding for bacterial control in traditional fermented foods.
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
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2026
·
IF 4.9
Aiju Chen,Qiulu Wang,Xiangtai Wang,Lixia Yuan,Hui Yan,Lingfeng Gao,Min Liu
Baicalein (Bai), a flavonoid with multiple pharmacological effects, suffers from poor solubility and low stability, limiting its therapeutic application. To overcome these limitations, biocompatible solvents with high solvation capacity present a simple and efficient strategy. In this work, three natural deep eutectic solvents (NADES) were prepared from choline chloride (ChCl) and structurally comparable organic acids: levulinic acid (LevA), lactic acid (LacA), and malic acid (MalA). These NADES exhibited good biocompatibility and were mixed with water to improve the solubility and stability of Bai. The solubility enhancement of Bai in these solvents followed the order: ChCl-LevA > ChCl-LacA > ChCl-MalA > water. Thermodynamic analysis revealed an entropy-driven dissolution process. To delve deeper into the dissolution mechanism, density measurements, FTIR spectroscopy, and molecular dynamics simulations were conducted to elucidate solvent-solvent and solute-solvent interactions. Additionally, the storage stability, photostability, and pH stability of Bai in NADES were also investigated. The results indicated that the differences in intermolecular interactions caused by different NADES exerted varying effects on the stability of Bai. The DPPH free radical scavenging assay was used to investigate the synergistic or antagonistic antioxidant effects between Bai and NADES, with the data analyzed by response surface methodology. These results are expected to provide a theoretical basis for the development of NADES-based solubilizers or drug carriers in pharmaceutical and food science.
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POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2026
·
IF 6.8
Jiahui Jiang,Qianlong Shi,Dan Li,Qingmin Chen,Cong Han,Jing Wei,Maorun Fu,Huaimei Cao,Xiaofei Xin
Vacuum-packed lotus roots slices are prone to swelling and quality deterioration when stored above 15 °C. Our study aimed to investigate the effect of combined treatment of 0.7 % lactic acid (LA), 0.7 g L −1 ε-poly- L -lysine (ε-PL), and 0.3 % sodium isoascorbate (SI) solution on the swelling, microbial growth, antioxidant and quality characteristics of vacuum-packed lotus root slices stored at 20 °C for 6 d. Results showed that, the primary bacterial genera responsible for bag swelling were identified as Tolumonas , Aeromonas , and Enterobacter, utilizing 16S rDNA amplicon sequencing. Compared with the control, the LA + ε-PL + SI treatment exhibited inhibitory effect on these genera, reduced the relative abundance of Tolumonas , Aeromonas , and Enterobacter from 65.97 %, 13.20 %, and 3.85–1.07 %, 0.20 %, and 0.44 %, respectively, yielding suppression rates of 98.4 %, 98.5 %, and 88.6 %, thus, effectively preventing swelling. Moreover, lotus root treated with LA + ε-PL + SI showed the better color, quality attributes. These findings indicated that the LA + ε-PL + SI treatment successfully prevented swelling, inhibited microbial growth, prolonged the shelf life, and preserved the better quality of vacuum-packed fresh cut lotus root.
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Journal of Analysis and Testing
·
2026
·
IF 7
Lu Heng,Chen Jingru,Zhang Maosheng,Guo Liangqia
Microplastics (MPs) are emerging pollutants, considered one of the most serious threats to the ecosystem and human health. Nile Red (NR) is the most widely used dye for visualizing MPs. However, NR staining is affected by natural organic materials and shows weak fluorescence for certain types of MPs, such as polyamide (PA) and polyvinyl chloride (PVC), as well as MPs with fiber morphology. Herein, a rapid, universal staining method for visualizing MPs was proposed, using CsPbBr 3 perovskite nanocrystals (NCs) as a fluorescent dye synthesized by natural deep eutectic solvents (NADESs) as solvents and surface ligands (CsPbBr 3 @NADESs NCs). The staining method proved to be highly effective for common MPs, including PA and PVC MPs. Moreover, natural organic substances, such as cellulose, lignin, mussel shell, chitin, clam shell, shrimp shell, humic acid, and sand grains, could not be stained by CsPbBr 3 @NADESs NCs, which allowed MPs to stand out for visual detection even that the environmental samples were incompletely pre-treated. This study demonstrated CsPbBr 3 @NADESs NCs as a promising fluorescent dye for visual detection of MPs in environmental samples.
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Cell Reports
·
2026
·Vol. 45
·期 1
·
IF 6.9
Hanli Guo,Minghui Sun,Mengdie Tao,Juanjuan Zhu,Yulu Song,Saihua Chen,Zhaoxi Guo,Xiang Zhang,Fajian Hou,Chunmeng Sun,Xiaonan Ma,Haiyang Hu,Ze Hong,Chen Wang
Osteoarthritis (OA) is a prevalent age-related joint disorder with limited treatment options. Chronic activation of the innate immune response in chondrocytes plays a key role in OA progression. However, the underlying mechanisms remain incompletely understood. Here, we report that mitochondrial antiviral signaling protein (MAVS) exacerbates cartilage extracellular matrix (ECM) degradation in OA. MAVS activation is observed in chondrocytes from both OA patients and the destabilization of the medial meniscus (DMM) mouse model. Both constitutive and chondrocyte-specific MAVS knockout alleviate cartilage degradation, osteophyte formation, subchondral bone remodeling, and synovitis in DMM mice. Conversely, MAVS overexpression aggravates these OA phenotypes. Mechanistically, cytosolic accumulation of mitochondrial double-stranded RNA in chondrocytes triggers MAVS activation, leading to MAVS-nuclear factor κB-dependent ECM degradation by inducing matrix metalloproteinase 3 (MMP3) and MMP13. Pharmacologically blocking MAVS using L-lactate significantly attenuates ECM degradation and OA progression. These findings suggest that MAVS signaling is critical in OA pathogenesis and may be a potential therapeutic target for OA treatment.
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BIOMATERIALS
·
2026
·
IF 13.6
Jin Li,Mengyi Yang,Rui Xing,Jingmei Pan,Xing Guo,Shaobing Zhou
Ischemic stroke therapy remains challenging due to a detrimental post-reperfusion inflammatory cascade that exacerbates neuronal damage, a process critically mediated by neutrophils and microglia. Neutrophils infiltrate the brain to release pro-inflammatory factors and neutrophil extracellular traps (NETs), while microglia become activated and amplify neuroinflammation. However, both cell types possess phenotypic plasticity that allows for immunomodulation toward repair. To address this, we developed a biomimetic nanoparticle strategy designed to reprogram these immune cells. Specifically, we encapsulated rosiglitazone into mPEG-PLA nanoparticles and further coated them with platelet membranes, obtaining a targeted nanoplatform termed pmPELA@R. In a mouse model of middle cerebral artery occlusion (MCAO), the platelet membrane coating markedly enhanced neutrophil targeting and improved brain accumulation of pmPELA@R. The released rosiglitazone activated PPAR-γ to polarize neutrophils toward the N2 phenotype and suppressed NETosis. Concurrently, the lactate generated from PLA degradation promoted microglial M2 polarization via enhanced histone lactylation. This dual modulation synergistically shifted the inflammatory microenvironment toward a reparative state, leading to enhanced neural tissue recovery. Our findings present a novel nanotherapeutic approach for precise immunomodulation in ischemic stroke.
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INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Meng He,Xian Yang,Mengfan Xu,Chao Liu,Binghua Yan
The valorisation of agricultural byproducts into functional biomaterials presents a crucial pathway towards a circular economy and precision agriculture. Herein, we report a closed-loop strategy to synthesise high value-added seed tape by integrating nanolignin from Camellia oleifera shells with chitosan matrices. Lignin is extracted from Camellia oleifera shells using a choline chloride–lactic acid deep eutectic solvent. Subsequently, size-controlled lignin nanoparticles (LNPs) are synthesised via an antisolvent method. These LNPs are incorporated into a chitosan (CS) matrix to prepare a film for agricultural seed tape. The lignin extraction demonstrated a high yield of 93.3% with almost-complete cellulose depletion, affording a guaiacyl–syringyl– p -hydroxyphenyl (G–S–H) type. The incorporation of LNPs in CS markedly enhanced the properties of the CS films. Specifically, the tensile strength of the CS/LNPs5 composite film (14 wt% LNPs) increased by 71.85% and its ultraviolet shielding capability reached 99.90%. A germination rate of 85% was achieved with the CS/LNPs4 (11 wt% LNPs) when the seed tape was tested for radish. Compared with treatments without LNPs, the CS/LNPs composites promote root and stem elongation. This study establishes a closed-loop biorefinery framework that converts lignocellulosic agricultural residues into biomass-derived functional materials.
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ANALYTICAL CHEMISTRY
·
2025
·
IF 6.7
Xing Yang,Yongqi Liu,Mei Yuan,Ke Chu
The surface charge state has a significant effect on the process of chiral recognition. Charged surfaces can selectively adsorb specific chiral molecules through electrostatic interactions. Herein, the surface charge state of coordination polymer particles (CPPs) was transformed from negative to positive by changing the dosage of acetic acid. By combination of the chiral properties of zirconium-based metal–organic frameworks (L-PCN-224) with the surface advantages of oppositely charged CPP-1 and CPP-5 (CPP-1@L-PCN-224 and CPP-5@L-PCN-224), a chiral composite material with oppositely charged surfaces has been constructed. Systematic studies indicate that the polarity of surface charges under varying pH conditions significantly influences the selective adsorption of tryptophan (Trp) enantiomers. Our findings reveal a clear structure–property relationship between the charge polarity and chiral recognition performance in chiral metal–organic frameworks (CMOFs), offering an alternative approach to traditional chiral site-dependent materials. This study reveals the correlation between the altered charge polarity of CMOFs and their chiral recognition properties, offering an alternative to conventional materials. This study focuses on the transformation patterns of supramolecular interactions driven by charge alterations in materials under specific pH conditions. While grounded in conventional paradigms, it elucidates the role of charge polarity in determining dominant interaction types, offering novel insights into traditional chiral recognition.
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ACS Biomaterials Science & Engineering
·
2023
·
IF 5.8
Jinni Luo,Huanxia Wang,Jinfei Wang,Yuan Chen,Chenglong Li,Kejun Zhong,Jie Xiang,Pengxiang Jia
Conductive hydrogels have been in huge demand in biomedical and wearable electronics. However, the application of traditional conductive hydrogels is largely limited due to their poor mechanical properties. Here, a conductive hydrogel with excellent mechanical strength and swelling resistance properties is prepared by ion cross-linking, directional freeze-drying, and rehydration. First, the acrylamide and acrylic acid are polymerized in the κ-carrageenan solution to form the hydrogel. Then, the obtained hydrogel is cross-linked with Fe3+ by soaking in ferric chloride solution. Finally, the ionic cross-linked hydrogels are reinforced by directional freeze-drying and rehydration. The resulting hydrogel has excellent tensile strength (5.67 MPa) and high toughness (7.63 MJ/m3). It is worth noting that the hydrogel also had excellent anti-swelling properties. Its mechanical strength and volume almost show no changes after soaking in deionized water for 40 days. In addition, the hydrogel exhibits good ionic conductivity (0.091 S/m), high sensitivity, and excellent stability when applied as a strain sensor. This work proposes a simple method to fabricate a conductive hydrogel with great mechanical properties and swelling resistance, which displays huge potential in varied fields.
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Materials Science and Engineering B-Advanced Functional Solid-State Materials
·
2022
·
IF 3.407
Shuhui Yang,Kunqiang Wang,He Yu,Ying Huang,Peiyuan Guo,Chenxi Ye,He Wen,Gaotian Zhang,Dongxiang Luo,Feng Jiang,Liang Zhang
The research of waste recycling and clean energy are the key to sustainable development. To simultaneously accomplish the waste recycling and clean energy generation, carbon fibers (Fiber) prepared from the spent cigarette filters are utilized to promote the photocatalytic hydrogen evolution efficiency of a heterojunction photocatalyst. The spiral ladder morphology of Fiber supplies abundant loading sites for the ZnIn 2 S 4 /g-C3N 4 photocatalysts, allowing efficient charge separation. Detailed chemical and optical features of the samples are subsequently demonstrated by a combination of scanning electron microscopy, X-ray diffraction, Fourier transform infrared tests. X-ray photoelectron spectrum results reveal that a strong internal electric field was formed between Fiber and ZnIn 2 S 4 /g-C 3 N 4 , allowing sufficient driving force to extract the photo-generated electrons from the heterojunction photocatalyst. Gas chromatography monitors a ca . 37 % enhancement for H 2 evolution (322.41 μmol·g −1 ·h −1 ) compared with control group. This work suggests an attempt to exploit general wastes for promoting photocatalytic hydrogen evolution.
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Foods
·
2023
·Vol. 12
·期 3
·586
·
IF 5.2
Tao Sun,Junxia Bian,Yangyang Wang,Jian Hu,Xueyan Yun,Eerdunbayaer Chen,Tungalag Dong
Proper packaging can extend the shelf life and maintain the quality of mushrooms during storage. The purpose of this study is to investigate the preservation ofAgaricus bisporususing copolymer-modified poly (L-lactide-co-butylene fumarate) and poly (L-lactide-co-glycolic acid) (PLBF and PLGA) packaging. Shelf life and quality were evaluated over 15 days of storage ofAgaricus bisporusat 4 ± 1 °C and 90% relative humidity, including weight loss, browning index (BI), total phenolics (TP), ascorbic acid (AA), malondialdehyde content (MDA), electrolyte leakage rate (EC), and superoxide dismutase (SOD) and catalase (CAT). The results showed that mushrooms packaged in PLBF films exhibited better retention in BI, TP, and AA than those with PLLA, PLGA, or polyethylene (PE) films. They can reduce the rate of weight loss, EC, and MDA, which in turn increases the activity of SOD and CAT. PLBF and PLGA have substantially improved flexibility in comparison with PLLA. They also significantly reduced oxygen (O2) and carbon dioxide (CO2) permeability and changed the gas permeability ratio. These positive effects resulted in the effective restriction of O2and CO2in these packages, extending the post-harvest storage period of white mushrooms.Keywords:Agaricus bisporus;one-step synthesis;poly (L-lactic acid);soft packaging film;O2/CO2atmosphere;food shelf life
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iScience
·
2023
·
IF 5.8
Yuanyuan Zhang,Jie Zheng,Shiraku Margaret Linyerera,Richard Odongo Magwanga,Yuqing Hou,Yuhong Wang,Yanchao Xu,Aziz Khan,Shuxun Yu,Zhongli Zhou,Fang Liu,Xiaoyan Cai
Summary The 5′-deoxyadenosine deaminase (DADD), a member of the amidohydrolase family regulates biological purine metabolism. In this study, bioinformatic analysis, overexpression and knockdown of GhdadD gene were detected to identify its potential role in drought and salt stress tolerance. The results revealed that GhdadD was induced by ABA, Auxin, MBS and light responsive elements. In transgenic Arabidopsis, seed germination rate and root length were increased under drought or salt stress. GhdadD overexpressed seedlings resulted in higher plant height, less leaf damage and lower ion permeability. The expression of osmotic stress and ABA-responsive genes were up regulated. While in GhdadD -silenced cotton seedlings, CAT, SOD activity and soluble sugar content were reduced, MDA content was increased, and the stoma opening was depressed under drought or salt stress. Some osmics stress marker genes were also up regulated. These data indicating that GhdadD enhanced plant resistance to drought and salt stress through ABA pathways.
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