INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Lijun Wang,Weilong Peng,Ji Cheng,Yaning Shi,Jingui Li,Shifeng Pan
COSMO-RS identified Bet-LA as the optimal green solvent for antioxidant recovery. • ANN-GA accurately optimized the non-linear ultrasound-assisted extraction process. • Bet-LA combined with ultrasound increased polyphenol yield by 1.86-fold vs ethanol. • MD simulations and SEM revealed the micro-level synergistic extraction mechanisms. • The green polyphenol extracts exhibited robust in vitro antioxidant capacities. The industrial extraction of bioactive compounds from plant matrices is increasingly shifting towards sustainable and green technologies for pharmaceutical, cosmetic, and functional food applications. In this study, a green and highly efficient strategy combining natural deep eutectic solvents (NADES) with ultrasound-assisted extraction (UAE) was developed to recover antioxidant polyphenols from Celastrus orbiculatus Thunb. To avoid empirical trial-and-error, the conductor-like screening model for realistic solvents (COSMO-RS) was first employed to predict the thermodynamic solubility of representative polyphenols, identifying the betaine-lactic acid (Bet-LA) system as the optimal solvent. Subsequently, an artificial neural network-genetic algorithm (ANN-GA) model was utilized to map and optimize the non-linear extraction parameters. Under optimal conditions (liquid-solid ratio of 33 mL/g, ultrasonic time of 36 min, and power of 520 W), the polyphenol yield reached 22.89 ± 0.41 mg GAE/g DW, representing a 1.86-fold increase over conventional 70% ethanol extraction. UPLC-Q Exactive/MS analysis revealed a significant enrichment of bioactive phenolics, predominantly epicatechin. Furthermore, scanning electron microscopy (SEM) and molecular dynamics (MD) simulations elucidated the extraction mechanisms: ultrasound-induced cavitation aggressively disrupted the plant cell walls, while the dense hydrogen-bonding network of Bet-LA provided superior solvation energy and affinity for the target polyphenols. Crucially, the green Bet-LA extracts exhibited robust in vitro antioxidant capacities (DPPH, ABTS, and FRAP). Overall, this study provides a theoretical and practical framework for the sustainable extraction of plant-derived polyphenols, highlighting their promising potential as natural antioxidants in various bio-based industries. Download: Download high-res image (221KB) Download: Download full-size image
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高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
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2026
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IF 7.1
Guohua Teng,Min Zhou,Initizar Anwar,Yang Liu,Fuyi Li,Yanxu Chang,Yidan Wang,Yuefei Wang,Fei Tian
Flavonoids in Scutellaria Radix ( SR ) exhibit significant pharmacological activities, yet conventional extraction methods often suffer from low efficiency and poor selectivity. Here, a green and effective strategy was developed using deep eutectic solvent (DES)-functionalized magnetic nanoparticles for selective flavonoid enrichment. Forty-eight DESs were screened, and levulinic acid/L-proline (2:1) was identified as the optimal system. The selected DES was employed to synthesize Fe 3 O 4 @SiO 2 @DES, which demonstrated high specificity and adsorption performance in magnetic solid-phase extraction. Under optimized conditions, adsorption efficiencies for four representative flavonoids ranged from 0.770 ± 0.01 to 0.983 ± 0.002, with desorption recoveries of 0.551 ± 0.003 to 0.919 ± 0.019. The method showed excellent linearity (R 2 ≥ 0.9998) and low limits of detection and quantification (0.01-0.35 μg mL −1 and 0.03-0.98 μg mL −1 , respectively). Moreover, the adsorbent retained high adsorption efficiency after six reuse cycles, demonstrating stability and reusability. This work provides a sustainable and selective approach for flavonoid enrichment from SR and highlights the potential of DES-functionalized magnetic nanomaterials as an eco-friendly alternative to conventional organic solvent-based extraction.
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ACS Food Science & Technology
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2026
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IF 3
Jiayi Chen,Dandan Zhang,Lu Liu,Xiaoli Wu,Meihan Guo,Hong Yan Zou,Xi Yang
Herein, a cost-effective, naked-eye-readable platform for on-site biogenic amines (BAs) detection and shrimp freshness monitoring was developed based on a ratiometric fluorescent CDs–RhB hybrid nanosystem that was constructed by integrating carbon dots (CDs) with rhodamine B (RhB). Biogenic amines induced a significant enhancement in the green fluorescence emission of CDs, while the red fluorescence emission of RhB remained unchanged, enabling an instant self-calibration during detection. Loaded on filter paper to form disposable test strips, the nanosystem enabled a visible color transition from orange to green with increasing BAs concentration. Readable via a smartphone RGB app, the paper-based assay showed a linear response of 5.0–250 μM with a limit of detection (LOD) of 3.56 μM using histamine as the model analyte. Validated through on-site shrimp quality evaluation, the paper-based sensor established a reliable “nanoprobe–paper–phone” strategy, facilitating on-site and quantitative freshness assessment in real-world demand scenarios.
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COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Zhifeng Cai,Lingjie Hou,Qun Cai,Yaxuan Feng,Yiran Zhang,Yuqi Zhang
Mangiferin is beneficial to human health. However, excessive use can cause side effects. Herein, we fabricated a hydrothermal strategy for the development of blue-emissive fluorescence carbon quantum dots (BCQDs) for the measurement of mangiferin. An excellent fluorescence emission signal around 468.7 nm was observed at the excitation wavelength of 363.4 nm. Some amazing features for BCQDs could be observed, such as exceptional stability, radiation resistance, salt resistance, and water solubility. The BCQDs displayed a specific response for mangiferin, leading to fluorescence weakening in a linear range of 0.5–100 μM. And the detection limit was 0.061 μM. The fluorescence quenching mechanism was assigned to the inner filter effect. Furthermore, two different real samples were sensitively determined to mangiferin using this as-prepared BCQDs-based nanosensor, generating satisfactory results with recoveries of 94.8–104.8 %. Notably, the apparent color variation from blue to green in the presence of mangiferin suggested smartphone-based visual inspection, indicating emphatic potential for on-site sensing. Moreover, the BCQDs-based sensing system had exceptional greenness and blueness.
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POLYMER
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2026
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IF 5.1
Yongchao He,Hanzhao Kuang,Xiaoqing Liu,Hai Zheng,Yinhang Zhang,Xuan Wang,Yinghua Huang,Jinjing Tang,Feng Wang,Xudong Cui,Mingbo Yang,Hang Chen,Yanhao Huang
Coumarin oxime esters (COXEs) have received extensive attention for their outstanding photoinitiation performance, but their rational and efficient design is challenged by the vast combinatorial space of possible electron donor/acceptor substituents on the coumarin core. In this work, a two-dimensional quantitative structure-activity relationship (2D-QSAR) analysis of reported COXE structures was performed to examine the relationship between structural descriptors and photo-reactivity. It was revealed that the acceptor and donor of hydrogen bond (HA, DH), total energy ( E ), as well as energy gap ( E g ) strongly influence the absorption wavelength ( λ max ). In particular, the phenyl ring with electron-withdrawing substituents enhances the charge asymmetry of the adjacent N–O bond and induces a red shift in the absorption wavelength. As a result, a novel COXE, namely C-5, was rationally designed and synthesized with a pentafluorophenyl substituent. The λ max of C-5 was predicted by DFT and confirmed by the UV-vis spectrum to be 424 nm in acetonitrile. Meanwhile, C-5 exhibits strong absorption ( ε ) of about 8.66 × 10 3 M −1 cm −1 at 405 nm and shows rapid photobleaching under 405 nm irradiation. In addition, the GelNB system photocured by the C-5 photoinitiator enabled a polymerization conversion of about 25.8%, with an elastic modulus of 2878 MPa. This modulus is significantly higher than that of the samples cured by the LAP and Irgacure 2959. These results demonstrate that the 2D-QSAR-DFT collaborative design can identify and optimize novel COXE photoinitiators, thereby advancing the highly efficient, rational preparation of visible-light-active photoinitiators for visible-light photopolymerization.
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MOLECULAR CELL
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2026
·Vol. 86
·期 4
·722-739
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IF 16
Jie Du,Chaoqun Li,Li Chai,Fabao Zhao,Lin Lv,Zongcheng Yang,Zhiyuan Zhao,Rong Gong,Liu Yang,Meng Wu,Meng Nie,Jihui Jia,Dongwei Kang,Chengjiang Gao,Wei Zhao,Mutian Jia
Competition between the host and invading viruses for cellular nutrients determines the outcomes of infectious diseases. Nutrients are increasingly being recognized as regulators that interact with immunological signals, but how immune cells sense specific nutrients to regulate antiviral innate immune responses remains elusive. Here, we establish asparagine (Asn) as an intercellular nutritional checkpoint that is sensed by TANK-binding kinase 1 (TBK1) to drive innate immune responses in human and murine cells. Mechanistically, Asn directly binds to TBK1, which robustly induces TBK1 phase separation and forms liquid-like droplets, promoting TBK1 transautophosphorylation and activation. Moreover, viral infection reduces asparagine synthetase (ASNS) expression to establish an Asn-restricted microenvironment, thereby evading TBK1-triggered host immune defenses. Overall, our results suggest that TBK1 is a natural Asn sensor that links host nutritional homeostasis to antiviral immune responses and reveal that targeting Asn availability is a promising therapeutic strategy for diseases involving dysregulated TBK1 activation.
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PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
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2026
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IF 6.4
Penghua Shu,Wenhao Zou,Yu Meng,Jiaqi He,Tingting Guo,Xinfeng Fan,Di Hu,Hao Yin,Shuxian Fan,Na Wang,Simin Liu,Lu Lv,Si Chen,Xialan Wei,Jihong Huang
Astragali complanati Semen (ACS) is frequently used as Chinese medicines and functional foods. Complanatoside A (CA), a key bioactive phytochemical isolated from ACS, exhibits broad-spectrum pharmacological properties. This investigation systematically formulated sixteen natural deep eutectic solvent (NADES) systems by combining three hydrogen-bond acceptors with eleven hydrogen-bond donors at varying molar ratios. These NADES formulations were subsequently employed in tandem with ultrasonic-assisted extraction to isolate CA. Optimization studies identified the following parameters as most effective for extraction using the L -proline/levulinic acid-based NADES (molar ratio 1:2): 60℃, 30 min, 40 % water content, liquid-solid ratio 25 mL/g, achieving an extraction yield of 1.57 %. The adsorption and desorption conditions were optimized employing a macroporous resin for the recovery of CA, while the reusability of the NADES solvent was thoroughly evaluated throughout the extraction process. The CA extract exhibited significant tyrosinase and α-glucosidase inhibitory activity. These findings establish ultrasound-assisted NADES extraction as a sustainable methodology for efficient extraction of CA from ACS, providing valuable insights for eco-friendly extraction and pharmacological exploitation of plant-derived bioactives.
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MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Fenfen Zeng,Fuhui Luo,Yangting Ou,Wanting Liang,Xu Ren,Fengxiang Zhang,Hanqing Pang,Wei Shi
The simultaneous extraction of bioactive compounds with differing polarities from plant matrices remains a significant challenge. This study was conducted to overcome the drawbacks of traditional extraction methods for the precious medicinal herb Hedyotis diffusa (HD), such as their low extraction efficiency, incapacity to completely utilize HD, and instability of active ingredients. To this end, a biphasic DES with ultrasound assistance was developed for the simultaneous extraction of high-value iridoids and triterpenes from HD. Following a thorough screening process that encompassed 56 two-phase combinations, the choline chloride-acetic acid (ChCl-Aa)/L-menthol-n-octanoic acid (Men-Oa) system was identified as the optimal formulation. Through the implementation of polarity regulation and response surface methodology, this optimal biphasic DES attained extraction yields of 15.65 ± 0.19 mg/g for five target compounds under mild conditions (41.65 °C, 30.71 min, liquid-solid ratio 15.73 mL/g, hydrophilic-to-hydrophobic phase volume ratio 0.77), which is a 2–3-fold improvement over traditional extraction methods. Characterization results indicated that the DES facilitated target release primarily by forming hydrogen-bond networks, which not only enhanced solubilization but also contributed to the disruption of cell wall. This disruptive effect was further augmented by the biphasic interface generated under ultrasonication, leading to significantly improved extraction efficiency. This strategy establishes a green and efficient approach for the valorization of plant resources.
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Foods
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2026
·Vol. 15
·期 7
·1159
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IF 6
Shengyu Yang,Qingqing Xiao,Kaige Chen,Haojie Zhang,Jun Cai,Zexin Zhao
Development of green and efficient technologies for valorizing crayfish shell waste is crucial for enhancing industrial value. This study presents an integrated strategy for the extraction and structural engineering of chitin using a novel alkaline deep eutectic solvent (DES) system composed of lysine and monoethanolamine (LysMEA), which enables the simultaneous deproteinization and architectural modification of chitin. Following mild demineralization, the optimized process yielded chitin with 97.1% purity and a high molecular weight of 209.3 kDa. DES demonstrated considerable reusability and decolorization capability. Structural characterization revealed that the LysMEA system effectively engineered the chitin architecture, resulting in lower crystallinity and a larger surface area compared to conventional methods. This engineered structure rendered the chitin highly accessible to enzymes. Consequently, the chitin extracted by LysMEA exhibited superior reactivity, achieving a deacetylation degree of 63.7% when catalyzed byBacillus aryabhattaichitin deacetylase, significantly outperforming chitin obtained via acid-alkali or acidic DES methods. Molecular dynamics simulations elucidated the mechanism, showing that lysine and monoethanolamine molecules penetrated the chitin fiber bundles at high temperatures, weakening interchain hydrogen bonds and partially separating the chains. This work provides a green route for producing enzymatically reactive chitin, demonstrating the potential of solvent-based structural engineering in biocatalytic valorization.
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Advanced Optical Materials
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2026
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IF 7.2
Xuetao Yan,Lifei Chen,Yuze Ren,Kaixuan Cui,Tianliang Li,Lixing Lin,Zeyu Li,Haicheng Song,Yingying Chen,Zhenzhen Li,Lingyan Feng
Circularly polarized luminescence (CPL) materials are highly sought after for their unique chiroptical properties, but their rational design remains challenging. To address this, a machine learning (ML) platform that intelligently screens deep eutectic solvents (DES) for crafting G-quartet-based gels with tailored CPL is established. An ML classifier trained on experimental data predicts CPL activity with 0.916 accuracy. SHapley Additive exPlanations (SHAP) analysis identifies key DES molecular descriptors, guiding the discovery of novel materials that exhibit a record-high luminescence dissymmetry factor (g lum ) of 0.222 for nucleotide-based systems and achieve chirality inversion via DES modulation. The Sure Independence Screening and Sparsifying Operator (SISSO) algorithm further yields interpretable design formulas. Leveraging the distinct polarization of these gels, we demonstrate a fourth-level anti-counterfeiting strategy, decrypting concealed information via Morse and ASCII codes to enhance information security. This ML-driven methodology accelerates the discovery of high-performance CPL materials and opens new design avenues.
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高影响因子
MICROCHEMICAL JOURNAL
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2026
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IF 5.2
Yuying Han,Xingyu Hou,Rui Hu,Xiaopeng Yang,Lin Hou,Xue Sun,Yuguang Lv,Lixin Ding,Ze Li
A straightforward yet sensitive dual-signal strategy was developed for the detection of melatonin (MT), based on the fluorescence properties and peroxidase-like activity of zinc‑nitrogen co-doped carbon dots (Zn,N-CDs). Through hydrogen bonding, electron transfer, as well as coordination interactions with MT, Zn,N-CDs undergo fluorescence quenching driven by the synergistic effects of static and dynamic mechanisms. Meanwhile, the generated singlet oxygen oxidizes 3,3′,5,5′-tetramethylbenzidine (TMB) into the blue-colored oxidized product (oxTMB), thus producing a ‘triggered’ dual-signal response. This platform enables simultaneous fluorescence and colorimetric analyses, offering wide linear ranges (fluorescence: 2–600 μM; colorimetry: 5–500 μM) and remarkably low detection limits (0.020 μM and 0.999 μM, respectively). Furthermore, the method exhibits excellent selectivity and has been successfully applied to pharmaceutical sample analysis, highlighting its promise for visual quality monitoring of relevant products.
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TALANTA
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2026
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IF 6.7
Haoran Li,Shijun Xiong,Beibei Chen,Zhekuan Wu,Zhen Zhou,Yong Liang,Man He,Bin Hu
Amadori and Heyns compounds are key Maillard reaction intermediates, resulting from the reaction of a certain amino acid with glucose (Glu) or fructose (Fru), respectively. They play a dual role in augmenting cigarette aroma and attenuating sensory irritation, and their quantification in tobacco is vital for tobacco quality evaluation and Maillard reaction mechanism study. Currently, simultaneous quantification of Amadori and Heyns compounds derived from the same amino acid, which present as isomers, is encumbered by poor chromatographic separation, and reliance on unavailable specific fragment ions. Herein, a method based on high performance liquid chromatography combined with tandem mass spectrometry (HPLC-MS/MS) detection was developed for the simultaneous quantification of Amadori and Heyns compounds derived from the same three amino acid (alanine, proline, phenylalanine, abbreviated as Ala, Pro, and Phe, respectively) with an ion ratio strategy. Under the optimized conditions, the limits of detection ranging from 2.22 to 6.94 ng/mL were obtained for six target analytes (Fru-Phe/Glu-Phe, Fru-Pro/Glu-Pro, Fru-Ala/Glu-Ala). When the method was applied to tobacco leaf powder extracts, target Amadori and Heyns compounds were found in the range of 0.65-56.4 μg/g, with Heyns compounds consistently less abundant than Amadori counterparts. In the recovery test, target analytes showed recoveries of 76.8-111%. Compared with reported methods, the proposed method features universal applicability without requiring characteristic fragment ions or chromatographic separation. It provides a reliable tool for analyzing hard-to-separate sugar-derived Maillard intermediates in tobacco.
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