EUROPEAN POLYMER JOURNAL
·
2024
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IF 5.8
Kun Liu,Yawen Fu,Qiqi Dai,Haoyun Tan,Zhuowei Gu,Qiaoqiao Xiong,Shuai Yang,Mingming Zhang,Jianxiang Feng,Wenjun Yi,Lijun Li
Pure multi-block copolymers and deformed multi-block copolymers have unique applications in the field of high-performance thermoplastic elastomers, resins and rubber materials. For styrene ( S ) and conjugated 1,3-dienes ( e.g. 1,3-pentadiene, P ) monomers, living anionic polymerization ( LAP ) has significant advantages in precise control of molecular weight and its distribution and precise control of microstructure and the sequence distribution. Subsequently, the post-polymerization modification strategy including epoxidation can further expand the application field of such polymer materials. Herein, a series of novel symmetrical triblock copolymers of different compositions with homo-polystyrene as end-blocks and strictly alternating sequence as mid-block, poly( S )- b -poly( S - alt - P )- b -poly( S ) ( SSPS ), were synthesized in cyclohexane by the classical three-step sequential feeding method using n -BuLi as initiator. The effect of the block ratio of SSPS triblock copolymer on impact strength, flexural strength and yield strength of transparent resin products was studied in detail. In addition, quantitative epoxidation post-polymerization functional modification was performed to obtain the novel triblock copolymer product which had a high-polarity and high-transparent thermoplastic resin with well-defined structure and quantitative degree of epoxidation ( ED ). All these novel copolymers before and after modification were characterized by 1 H NMR, 13 C NMR, FTIR, DSC and GPC.
研究领域:
材料科学
·
高分子化学
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DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-22
·
IF 17.694
Zhou Tian,Li Yuxin,Li Xiaoyu,Zeng Fanzhuo,Rao Yanxia,He Yang,Wang Yafei,Liu Meizhen,Li Dali,Xu Zhen,Zhou Xin,Du Siling,Niu Fugui,Peng Jiyun,Mei Xifan,Ji Sheng-Jian,Shu Yousheng,Lu Wei,Guo Feifan,Wu Tianzhun,Yuan Ti-Fei,Mao Ying,Peng Bo
Microglia are important immune cells in the central nervous system (CNS) that undergo turnover throughout the lifespan. If microglial debris is not removed in a timely manner, accumulated debris may influence CNS function. Clearance of microglial debris is crucial for CNS homeostasis. However, underlying mechanisms remain obscure. We here investigate how dead microglia are removed. We find that although microglia can phagocytose microglial debris in vitro, the territory-dependent competition hinders the microglia-to-microglial debris engulfment in vivo. In contrast, microglial debris is mainly phagocytosed by astrocytes in the brain, facilitated by C4b opsonization. The engulfed microglial fragments are then degraded in astrocytes via RUBICON-dependent LC3-associated phagocytosis (LAP), a form of noncanonical autophagy. Interference with C4b-mediated engulfment and subsequent LAP disrupt the removal and degradation of microglial debris, respectively. Together, we elucidate the cellular and molecular mechanisms of microglial debris removal in mice, extending the knowledge on the maintenance of CNS homeostasis.
研究领域:
神经科学
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免疫学
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细胞生物学
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DOI
PubMed
高影响因子
COMPOSITES PART B-ENGINEERING
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2022
·
IF 11.322
Weijuan Zou,Longchen Wang,Junnian Hao,Lixian Jiang,Wenxian Du,Tao Ying,Xiaojun Cai,Haitao Ran,Jianrong Wu,Yuanyi Zheng
Insufficient concentrations of intracellular substrates such as hypoxia and H 2 O 2 considerably reduce the effectiveness of reactive oxygen species (ROS)-associated cancer therapy. Modulating the tumor microenvironment (TME) for augmenting efficacy has become a promising strategy. Herein, a phase-change cascaded nanomedicine (Lap-IrO x @PCM) was constructed via co-encapsulation of iridium oxide nanozyme (IrO x ) and β-lapachone (Lap) by using thermal-responsive phase-change materials (PCMs). After photothermal activation, the protective PCM layer was melted, causing the rapid release of IrO x and Lap. Simultaneously, the peroxidase-like nanozyme IrO x reacted with endogenous H 2 O 2 to liberate highly toxic hydroxyl radicals (•OH) for inducing tumor cell death. Meanwhile, IrO x as another glutathione peroxidase nanozyme also consumed glutathione (GSH) to protect ROS from scavenging. Importantly, the released Lap efficiently generated H 2 O 2 for facilitating the catalytic efficacy of IrO x and provoke the cleavage of heat shock protein 90 (Hsp90) for overcoming tumor heat tolerance in photothermal therapy (PTT). As systematically demonstrated both in vitro and in vivo , this well-defined system achieved a superior antitumor effect via mild photothermal-enhanced nanocatalytic therapy. Our findings have provided the proof of concept of the phase change-mediated, in vivo catalytic activity of nanozymes that can be customized for intensive, TME-mediated, self-enhanced nanocatalytic cancer therapy.
研究领域:
纳米技术
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癌症治疗
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生物医学工程
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药学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Minghao Sun,Weiwei Liu,Yuanyuan Ma,Pengfei Ni,Wenjing Yao,Yingjie Xu,Rui Bao,Jue Wang,Fei Xiong,Xihe Kuang,Teng Zhang,Xiaochen Zhang,Xikuang Yao,Shenghong Ju,Wenpei Fan
Chemodynamic therapy (CDT) efficacy in the tumor microenvironment (TME) remains compromised. Inspired by the potential of fever-like heat to activate a redox-favorable microenvironment, mild photothermal therapy (mPTT) is expected to sensitize tumors to CDT, turning “redox-cold” tumors into “redox-hot” ones. Herein, an injectable gel engine (LMFT@SG-R) is meticulously constructed based on the co-encapsulation of R848 and β-lapachone (LAP)-loaded metal–organic framework-199 (MOF-199) within a lipidic gel reservoir with the unique ability of thermally reversible sol–gel phase transformation. With mPTT reprogramming TME, the custom-designed LMFT@SG-R can realize systemic redox homeostasis remodeling through mPTT-activated chemodynamic immunotherapy (MPCIT). Once reaching the TME, LMFT@SG-R quickly hydrates into solid gel and subsequently undergoes gel-to-sol transformation under mild NIR laser irradiation, resulting in on-demand release of LMFT and R848 for controllable CDT and immunostimulation. LMFT undergoes stepwise degradation for sequential release of Fe 3+ , Cu 2+ and LAP, which can promote ROS cascade amplification owing to the upregulation of HSP70/NQO1 axis upon mild hyperthermia, resulting in robust ICD effects and T lymphocytes infiltrations together with R848. Notably, the controllable immunostimulation can facilitate robust abscopal effects and prominent suppression of distal tumors. The well-designed LMFT@SG-R may represent an updated CDT catalyst with the highly-integrated gel engine for chained-cooperative MPCIT.
研究领域:
癌症治疗
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生物医学工程
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免疫疗法
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化学生物学
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材料科学
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产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xinyang Peng,Hui Li,Jie Xu,Changming Lan,Junqiu Liu,Baiheng Wu
Hydrogels with reprogrammable shape morphing have been widely embraced by the fields of smart robots, sensors, wearable devices and biomedicines. Programming shape morphing without the application of external stress remains a significant challenge. In this study, we introduce photochromic cadmium sulfide quantum dots (CdS QDs) to develope hybrid hydrogels capable of undergoing reversible color change, serving as a differentiated photothermal antenna for reprogramming of complex deformation. Our strategy leverages the synergetic photochromic and photothermal effects, which are individually controlled by patterned UV irradiation and global vis-IR irradiation. This method demonstrates non-contact photo-responsive characteristics, real-time reconfigurability and on-demand reprogrammability, enabling shape morphing hydrogel to perform functions such as 3D/4D information encryption, object manipulation, and logic circuit control.
研究领域:
智能材料
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生物医学工程
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纳米技术
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2024
·
IF 5.4
Yang Xiang,Yuanhui Gao,Qiuhua Cheng,Zhongwen Lei,Xiaoyu Zhang,Yijun Yang,Jianquan Zhang
Bile duct injury presents a significant clinical challenge following hepatobiliary surgery, necessitating advancements in the repair of damaged bile ducts is a persistent issue in biliary surgery. 3D printed tubular scaffolds have emerged as a promising approach for the repair of ductal tissues, yet the development of scaffolds that balance exceptional mechanical properties with biocompatibility remains an ongoing challenge. This study introduces a novel, bio-fabricated bilayer bile duct scaffold using a 3D printing technique. The scaffold comprises an inner layer of polyethylene glycol diacrylate (PEGDA) to provide high mechanical strength, and an outer layer of biocompatible, methacryloylated recombinant collagen type III (rColMA) loaded with basic fibroblast growth factor (bFGF)-encapsulated liposomes (bFGF@Lip). This design enables the controlled release of bFGF, creating an optimal environment for the growth and differentiation of bone marrow mesenchymal stem cells (BMSCs) into cholangiocyte-like cells. These cells are instrumental in the regeneration of bile duct tissues, evidenced by the pronounced expression of cholangiocyte differentiation markers CK19 and CFTR. The PEGDA//rColMA/bFGF@Lip bilayer bile duct scaffold can well simulate the bile duct structure, and the outer rColMA/bFGF@Lip hydrogel can well promote the growth and differentiation of BMSCs into bile duct epithelial cells. In vivo experiments showed that the scaffold did not cause cholestasis in the body. This new in vitro pre-differentiated active 3D printed scaffold provides new ideas for the study of bile duct tissue replacement.
研究领域:
组织工程
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生物医学工程
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再生医学
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外科研究
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产品关联
DOI
PubMed
高影响因子
Applied Materials Today
·
2024
·
IF 7.2
Jingyue Wang,Yilei Ding,Jianan Liu,Yian Chen,Yuanfeng Wang,Ansha Zhao
While revascularization is acknowledged as a critical process in wound healing, the scenario becomes more complex when considering diabetic wounds. In such cases, oxidative stress introduces two primary challenges that impede the healing process: ensuring the directional movement of functional cells to the wound site and combating the heightened risk of infection. These challenges underscore the need for innovative therapeutic strategies that can effectively address these restrictions in the context of diabetic wound healing. Hydrogen sulfide (H 2 S) acts as a signaling gas and shows significant therapeutic potential in biomedical research. In this study, we encapsulate Allicin, a natural H 2 S donor, in selenium micelles that specifically respond to oxidative stress. To create the GMA (Allicin@Micelle-GelMA) Composite hydrogel system, we utilize Methacrylic anhydride gelatin (GelMA) hydrogel as a matrix and form it through in-situ light curing. This composite system effectively addresses the problem of healing deep, narrow, and lengthy wounds that pose a challenge, as well as preventing nonspecific sudden release of H 2 S. Additionally, the composite hydrogel system promotes angiogenesis, anti-inflammatory, antibacterial, and antioxidant properties. It also facilitates the directional movement of stem cells and macrophages, as demonstrated through the chicken embryo chorioallantoic membrane vascular test and the establishment of a diabetes wound model that is difficult to heal. Consequently, we conclude that the GMA composite hydrogel has the potential to serve as a versatile skin wound dressing that can effectively respond to oxidative stress.
研究领域:
生物医学工程
·
伤口愈合
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材料科学
·
药学
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产品关联
DOI
高影响因子
Polymers
·
2024
·Vol. 16
·期 6
·840
·
IF 4.7
Li Tang,Xuemei Wu,Yue Xu,Youwei Li,Shaoji Wu,Liang Gong,Jianxin Tang
Bilayer hydrogel actuators, consisting of an actuating layer and a functional layer, show broad applications in areas such as soft robotics, artificial muscles, drug delivery and tissue engineering due to their inherent flexibility and responses to stimuli. However, to achieve the compatibility of good stimulus responses and high mechanical properties of bilayer hydrogel actuators is still a challenge. Herein, based on the double-network strategy and using the synchronous ultraviolet (UV) polymerization method, an upper critical solution temperature (UCST)-type bilayer hydrogel actuator was prepared, which consisted of a poly(acrylamide-co-acrylic acid)[MC] actuating layer and an agar/poly(N-hydroxyethyl acrylamide-co-methacrylic acid)[AHA] functional layer. The results showed that the tensile stress/strain of the bilayer hydrogel actuator was 1161.21 KPa/222.07%. In addition, the UCST of bilayer hydrogels was ~35 °C, allowing the bilayer hydrogel actuator to be curled into an “◎” shape, which could be unfolded when the temperature was 65 °C, but not at a temperature of 5 °C. Furthermore, hydrogel actuators of three different shapes were designed, namely “butterfly”, “cross” and “circle”, all of which demonstrated good actuating performances, showing the programmable potential of bilayer hydrogels. Overall, the bilayer hydrogels prepared using double-network and synchronous UV polymerization strategies realized the combination of high mechanical properties with an efficient temperature actuation, which provides a new method for the development of bilayer hydrogel actuators.
研究领域:
软体机器人
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材料科学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xing Zhang,Ye Hu,Haofei Li,Junlin Chen,Chuhan Lv,Xiaobao Yang,Fanna Liu,Xin Chen,Hua Dong
Chronic kidney disease (CKD) is a major public health disease that threatens human life. To address the urgent need for high-risk populations and patients to monitor CKD in a non-invasive and real-time manner, a novel wearable porous eutectogel with high-performance NH 3 enrichment and sensing is developed for the first time to rapidly and precisely detect the NH 3 concentration in the breath. Herein an eutectogel (EG) containing N-acryloyl glycinamide (NAGA), glycerol (Gly), choline chloride (ChCl) and bromocresol green (BCG) is constructed via digital light processing (DLP) 3D printing. The abundant internal hydrogen bond network in EG/BCG material shows a strong affinity towards NH 3 , leading to remarkable NH 3 capture and enrichment when exposing to the exhaled breath. On the other hand, its porous structure increases significantly the residence time and absorption rate of NH 3 . As a consequence, this new NH 3 sensing material displays fast NH 3 response time (3 s), low detection limit (0.5 ppm), wide NH 3 sensing range (0–10 ppm), high specificity and high temperature/humidity stability, leading to obvious color change within the range of NH 3 concentration in the exhaled breath of healthy individuals and CKD patients. Simply by introducing EG/BCG into a regular medical mask, wearing it for 10 min and monitoring its color change, early screening and continuous monitoring of CKD become feasible by correlating NH 3 concentration with blood urea nitrogen (BUN) levels. With the aid of artificial intelligence (deep learning) algorithms, the detection accuracy of 96.5 % has been achieved in practical clinic test.
研究领域:
医学
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材料科学
·
人工智能
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产品关联
DOI
高影响因子
Science Advances
·
2025
·Vol. 11
·期 3
·
IF 12.5
Lang Li,Hao Tian,Liulin Wu,Na Chen,Qiao Zhang,Lin Chen,Kai Zhu,Lin Lin,Xi Chen,Lang He,Min Liu,Wenyan Zhao,Yang Su,Juan Yan,Xingli Zhao,Xin Zhou,Zhenhua Zhou,Wen Zeng
The body weight–based thrombolytic medication strategy in clinical trials shows critical defects in recanalization rate and post-thrombolysis hemorrhage. Methods for perceiving thrombi heterogeneity of thrombolysis resistance is urgently needed for precise thrombolysis. Here, we revealed the relationship between the thrombin heterogeneity and the thrombolysis resistance in thrombi and created an artificial biomarker-based nano-patrol system with robotic functional logic to perceive and report the thrombolysis resistance of thrombi. The nano-patrols are contrallable and are able to accomplish thrombolysis resistance-matched personalized and precise therapy according to the feedback signal from artificial biomarkers. This nano-patrol system depicted more enhanced thrombolytic efficiency (elevated by 25%) than alteplase for mini pig model and clinical thrombi and achieved recanalization in thrombotic model where alteplase encountered failure. Moreover, the nano-patrol remarkably reduced the infarct volume and the hemorrhagic transformation risk (0.12-fold of alteplase) of cerebral thrombosis. Therefore, we developed a unique tool for diagnosing thrombolysis resistance and achieving personalized and precise thrombolysis.
研究领域:
医学
·
药理学
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生物医学工程
·
纳米技术
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产品关联
DOI
PubMed
高影响因子
ACS Nano
·
2025
·
IF 16
Bingfang Wang,Ailin Lv,Haofan Wu,Bihan Guo,Yuhan Lu,Zhiqiang Chang,Yuqing Wu,Xiang Li,Qiuyu Yang,Jianfang Nie,Jing Wei,Qinjuan Ren,Daizong Ji,Ya Zhang,Menahem Y. Rotenberg,Yin Fang
Cardiovascular disease (CAD) is a major global public health issue, with mortality rates being significantly impacted by cold temperatures. Stable and reliable electrocardiogram (ECG) monitoring in cold environments is crucial for early detection and treatment of CAD. However, existing skin sensor struggle to balance freeze resistance, breathability, flexibility, conductivity and adhesion at cold temperatures. Here, we introduce a solvent cross-linking strategy and an in situ transfer method to prepare ultrathin bioionic gels, featuring a freezing point below −80 °C and a thickness of only 12.6 μm. The strong and abundant interactions between the ionic liquid solvent and the zwitterionic polymer effectively suppress low-temperature crystallization, forming a toughened and highly adhesive network structure. This network enables the in situ formation of an ultrathin morphology, which can be seamlessly transferred onto various substrates. Furthermore, the solvent-cross-linked network maintains a large interpolymer chain spacing, facilitating rapid ion transport pathways. Even at subzero temperatures, the gel maintains its multifunctionality, demonstrating tissue-like softness (34.6 kPa), high ionic conductivity (10.06 mS cm–1), excellent stretchability (360%), high transparency, robust adhesive strength (175.3 kPa) and interfacial toughness (1146 J m–2). Integrated into a flexible wearable device, the ultrathin gel ensures excellent skin conformity, user comfort, and high signal-to-noise ECG signal acquisition. Leveraging an artificial neural network, the system analyzes bradycardia ECG signals and achieves 96.88% accuracy in arrhythmia detection under cold conditions. This bioionic gel-based system presents a promising solution for early CAD diagnosis and prediction in extreme environments.
研究领域:
生物医学工程
·
心血管疾病诊断
·
材料科学
·
人工智能辅助医疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Yan Zhang,Jianlin Yang,Yali Zhao,Zhecun Wang,Gwo Sung Lai
Membrane separation has been acknowledged as an advanced technology to handle the oil spills. However, most of the superhydrophilic/underwater superhydrophobic membranes currently applied for oil/water separation would lose their superwettability when exposed to salty marine environments, leading to serious membrane plugging and separation performance deterioration. Herein, inspired by seawater fish and mussels, a simple, green, and versatile one-step co-deposition strategy is proposed for fabricating a ternary zwitterionic coating with strong surface hydration on diverse membranes, showing excellent anti-fouling properties in high salinity environments, even in the saturated NaCl solution. Moreover, the modified membrane performs well in the long term when separating surfactant-stabilized oil-in-seawater emulsion and with impressive recyclability. The ternary zwitterionic coating membrane exhibits great potential in treating oily wastewater in marine.
研究领域:
材料科学
·
环境科学
·
海洋生物学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）