ACS Applied Materials & Interfaces
·
2014
·
IF 5.9
Jie Deng,Xinyue Liu,Lang Ma,Chong Cheng,Wenbin Shi,Chuanxiong Nie,Changsheng Zhao
In this study, multifunctional and heparin-mimicking star-shaped supramolecules-deposited 3D porous multilayer films with improved biocompatibility were fabricated via a layer-by-layer (LbL) self-assembly method on polymeric membrane substrates. Star-shaped heparin-mimicking polyanions (including poly(styrenesulfonate-co-sodium acrylate; Star-PSS-AANa) and poly(styrenesulfonate-co-poly(ethylene glycol)methyl ether methacrylate; Star-PSS-EGMA)) and polycations (poly(methyl chloride-quaternized 2-(dimethylamino)ethyl methacrylate; Star-PMeDMA) were first synthesized by atom transfer radical polymerization (ATRP) from β-cyclodextrin (β-CD) based cores. Then assembly of 3D porous multilayers onto polymeric membrane surfaces was carried out by alternating deposition of the polyanions and polycations via electrostatic interaction. The surface morphology and composition, water contact angle, blood activation, and thrombotic potential as well as cell viability for the coated heparin-mimicking films were systematically investigated. The results of surface ATR-FTIR spectra and XPS spectra verified successful deposition of the star-shaped supramolecules onto the biomedical membrane surfaces; scanning electron microscopy (SEM) and atomic force microscopy (AFM) observations revealed that the modified substrate had 3D porous surface morphology, which might have a great biological influence on the biointerface. Furthermore, systematic in vitro investigation of protein adsorption, platelet adhesion, human platelet factor 4 (PF4, indicates platelet activation), activate partial thromboplastin time (APTT), thrombin time (TT), coagulation activation (thrombin-antithrombin III complex (TAT, indicates blood coagulant)), and blood-related complement activation (C3a and C5a, indicates inflammation potential) confirmed that the heparin-mimicking multilayer coated membranes exhibited ultralow blood component activations and excellent hemocompatibility. Meanwhile, after surface coating, endothelial cell viability was also promoted, which indicated that the heparin-mimicking multilayer coating might extend the application fields of polymeric membranes in biomedical fields.
研究领域:
材料科学
·
生物医学工程
·
表面化学
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产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
·
2022
·
IF 0.847
Rui Zhai,Yindi Zhu,Limei Chang,Zhigang Gu,Jian Zhang
Metal-organic frameworks with chiral feature (chirMOFs) are attracting great attention on circularly polarized luminescence (CPL). However, developing new efficient strategy to achieve or improve CPL properties is an urgent task. Herein, new chiral MOF thin films prepared by liquid-phase epitaxial layer by layer (lbl) growth method (SUR-chirMOF) are composed of D- or L-camphorate (D/Lcam) and aminopyrazine (Pr-NH 2 ) by using liquid phase epitaxial layer by layer (lbl) method. The resulted Zn 2 (D/Lcam) 2 Pr-NH 2 SURchirMOF shows strong chirality and luminescence but weak CPL emission at 390 nm. After lbl modifying a dye molecule FluoresceinIsothiocyanate (FITC), the chiroptical Zn 2 (D/Lcam) 2 Pr-NH-FITC SURchirMOFs with ~7 times CPL signal improvement and ~3 times g lum value amplification are obtained. This work provides a new strategy to develop chiral MOF thin films for CPL improvement using lbl grafting approach.
研究领域:
材料科学
·
光学
·
化学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2017
·
IF 6.035
Guanhua Liu,Zhongyi Jiang,Cheng Chen,Lipeng Hou,Boxin Gao,Hao Yang,Hong Wu,Fusheng Pan,Peng Zhang,Xingzhong Cao
Fabricating ultrathin membranes with high separation performance and stability remains a great challenge. Tannic acid (TA) is a bio-based polyphenol and can form multifunctional coatings through catechol chemistry. In this study, polyethyleneimine (PEI) and TA were alternatively deposited on hydrolyzed polyacrylonitrile (HPAN) porous membrane via layer-by-layer (LbL) assembly driven by covalent interaction between the amine groups of PEI and polyphenols of TA. The LbL assembly process was verified by the step-wise change of water contact angles. The formation of covalent bond was confirmed by X-ray photoelectron spectroscopy (XPS). The free volume property of the membranes was revealed by the Doppler broadening energy spectra. The resultant membranes possessed ultrathin active layers with thicknesses ranging from 118 to 220 nm. When utilized for pervaporation dehydration of 90 wt% ethanol aqueous solution, the membrane exhibited high separation performance with permeation flux of 1343 g/m 2 h and separation factor of 1012 with 5.5 bilayers and pH 8 at 349 K, arising from the increased hydrophilicity and favorable free volume property. Moreover, the membrane showed favorable long-term stability due to the strong interfacial interactions.
研究领域:
材料科学
·
分离技术
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DOI
高影响因子
Journal of Functional Biomaterials
·
2023
·Vol. 14
·期 1
·43
·
IF 4.8
Xiaoyu Wang,Yuyang Zhou,Melissa Johnson,Cameron Milne,Sigen A,Yening Li,Wenxin Wang,Nan Zhang,Qian Xu
To explore the potential applicability of chitosan (CTS), we prepared aldehyde chitosan (CTS-CHO) with chitosan and sodium periodate via oxidation reaction and then a chitosan-based hydrophilic and antibacterial coating on the surface of poly (lactic acid) (PLA) film was developed and characterized. The oxidation degree was determined by Elemental analyser to be 12.53%, and a Fourier transform infrared spectroscopy was used to characterize the structure of CTS-CHO. It was evident that CTS-CHO is a biocompatible coating biomaterial with more than 80% cell viability obtained through the Live/Dead staining assay and the alamarBlue assay. The hydrophilic and antibacterial CTS-CHO coating on the PLA surface was prepared by ultrasonic atomization assisted LbL assembly technique due to Schiff’s base reaction within and between layers. The CTS-CHO coating had better hydrophilicity and transparency, a more definite industrialization potential, and higher antibacterial activity at experimental concentrations than the CTS coating. All of the results demonstrated that the ultrasonic atomization-assisted LbL assembly CTS-CHO coating is a promising alternative for improving hydrophilicity and antibacterial activity on the PLA surface. The functional groups of CTS-CHO could react with active components with amino groups via dynamic Schiff’s base reaction and provide the opportunity to create a drug releasing surface for biomedical applications.Keywords:chitosan;PLA;hydrophilic;antibacterial;coating
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DOI
PubMed
高影响因子
RSC Advances
·
2015
·Vol. 5
·期 34
·26965-26971
·
IF 3.84
Bin Zhou,Xing Jin,Hongshan Liang,Jing Li,Shilin Liu,Yan Li,Yijie Chen,Bin Li
Electrospinning nanofibrous mats are extensively studied as efficient two-dimensional nanomaterials and applied in the fields of filtration, catalysis, and biosensors due to their flexibility and porosity. In this article, gold nanoparticle (AuNPs) loaded composite nanofibers were fabricated by a simple method, which consisted of the preparation of the nanofibers by electrospinning, the deposition of tannic acid (TA) on the surface of the nanofibers via layer-by-layer assembly and the reduction of the AuNPs on the nanofibrous mats. The as-prepared nanofibers were characterized by scanning electron microscopy (SEM), energy dispersive spectroscopy (EDS), transmission electron microscopy (TEM), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), and X-ray photoelectron spectroscopy (XPS), respectively. The results revealed that AuNPs were successfully generated on the nanofibers without aggregation. In addition, by adjusting the number of the bilayers in the assembly process, the content of gold supported on the nanofibrous mats could be easily controlled. The catalytic performance of the hybrid nanofibrous mats on the reduction of 4-nitrophenol (4-NP) with sodium borohydride was monitored by UV-visible spectroscopy (UV-vis). Notably, the hybrid composite nanofibrous mats could be easily separated from the reaction mixture.
研究领域:
材料科学
·
催化化学
·
纳米技术
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产品关联
DOI
高影响因子
Biomedical Materials
·
2022
·Vol. 17
·期 3
·035006
·
IF 4.103
Haibo Wang,Ao Dong,Kun Hu,Weiwei Sun,Jundong Wang,Lu Han,Lixin Mo,Luhai Li,Wei Zhang,Yan Guo,Li Zhu,Fuzhai Cui,Yen Wei
Poly L-lactic acid (PLLA) is a non-toxic, biocompatible degradable polymer material with excellent mechanical properties after moulding. However, it faces challenges in the use of biomedical materials because of its intolerance to bacteria. Here, we use an easy-to-operate method to prepare a composite multilayer membrane: PLLA membrane was used as substrates to assemble positively charged chitosan and negatively charged Ag@MXene on the surface using the layer-by-layer (LBL) method. The assembly process was detected by fluorescein isothiocyanate-labelled chitosan and the thickness of the coating multilayer was also detected as 210.0 ± 12.1 nm for P-M membrane and 460.5 ± 26.5 nm for P-Ag@M membrane. The surface self-assembled multilayers exhibited 91.27% and 96.11% growth inhibition ratio against Escherichia coli and Staphylococcus aureus strains under 808 nm near-infrared laser radiation with a synergistic photothermal antibacterial effect. Furthermore, best biocompatibility of P-M and P-Ag@M membranes compare to PLLA membrane motivated us to further explore its application in biomedical materials.
研究领域:
材料科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2023
·
IF 8.6
Ning Yang,Renqiang Yuan,Weikun Li,Xin Tan,Zonghao Liu,Qianli Zhang,Chunyang Li,Liqin Ge
Spills of marine oily pollutants and illegal discharges of industrial organic solvents have severely undermined the natural resources and ecological sustainability. Herein, a versatile and durable modified melamine sponge (MS) was fabricated by integrating with multilayered microcapsules (MCs) and chemical vapor deposition of 1H,1H,2H,2H-perfluorodecyltriethoxysilane (PFDTES), namely PFDTES@MCs@MS. The combination of giant microcapsules on the sponge structure imparts the rough surface micro-construction, accompanied by the hydrophobic modification, which enabled PFDTES@MCs@MS to exhibit superhydrophobic/super-oleophilic and self-cleaning capabilities. PFDTES@MCs@MS displayed outstanding oil–water mixtures or emulsions separation capabilities with the separation efficiencies more than 99%. Impressively, PFDTES@MCs@MS preserved mechanical and chemical durability in 100 recycle tests or chronic processes under harsh conditions. In addition, PFDTES@MCs@MS exhibited the remarkable uptake capacity of organic solvents or oils, and the adsorption amount of light or heavy oil was barely impacted with squeezing after the 50 times of circulation. Furthermore, the PFDTES@MCs@MS displayed antibacterial performance. Significantly, the PFDTES@MCs@MS showed superior photothermal conversion capability, the temperature of it increased dramatically to approximately 80 °C within 180 s under simulated sunlight from room temperature (about 25 ℃), and the flux of separating high-viscosity oils was significantly increased. This study presents a novel oil sorption and separation materials with excellent durability and repeatability, which establishes the foundation for the judicious design of innovative weapons to combat the challenging oil spills.
研究领域:
材料科学
·
环境科学
·
化学工程
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产品关联
DOI
高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2018
·
IF 3.112
Jiawei Yan,Zisheng Luo,Zhaojun Ban,Hongyan Lu,Dong Li,Dongmei Yang,Morteza Soleimani Aghdam,Li Li
Postharvest strawberries ( Fragaria × ananassa Duch.) were coated either by the layer-by-layer (LBL) electrostatic deposition, based on chitosan and carboxymethyl cellulose (CMC), or coated by 1% chitosan. Results suggested that LBL edible coating was significantly effective at inhibiting the loss of fruit firmness and aroma volatiles of strawberry, with little effect on the total soluble solids and total acidity contents. Through an untargeted metabolomic analysis, we found that the LBL application significantly reduced the primary metabolite contents involved in carbohydrate, fatty acids and amino acids metabolism, as well as the secondary metabolite contents involved in terpenoid, carotenoid, phenylpropanoid and flavonoid metabolism after storage. Our results indicated that the LBL edible coating could be potential to maintain strawberry quality with lower metabolites contents after eight days of storage.
研究领域:
食品科学
·
采后生理学
·
代谢组学
·
可食用涂层
·
园艺科学
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Liangbin Xia,Youmei Long,Dan Li,Li Huang,Yanqing Wang,Fangfang Dai,Fenghua Tao,Yanxiang Cheng,Hongbing Deng
Pelvic floor dysfunction diseases (PFD) become more prevalent with the increase of elderly population, and complications of pelvic floor reconstructive surgery (e.g. infection and exposure of mesh) have been troubling to patients and gynecologists. In this study, the nanofibrous mats were prepared by alternately depositing chitosan (CS) and silk fibroin (SF) on Nylon6 (N6) nanofibrous mats via layer-by-layer (LBL) technique. The as-prepared mats were characterized. The results showed that CS and SF molecules were successfully assembled on the nanofibers. Additionally, after LBL modification, the hydrophilicity of the nanofibrous mats was reduced and the mechanical properties were improved. Furthermore, the antibacterial activity of the LBL-structured mats reached >95% inhibiting Escherichia coli ( E. coli) and Staphylococcus aureus ( S. aureus) . The in vitro cell co-culture experiments indicated that LBL-structured mats had smaller toxic effects and more excellent biocompatibility to L929 fibroblasts, especially the mats with 15 bilayers coated films. Hence, the LBL-structured mats are promising materials for pelvic floor reconstruction to reduce postoperative pelvic complication rates.
研究领域:
医学材料学
·
妇科学
·
生物医学工程
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产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 25
·4205-4215
·
IF 4.776
Pengzhong Shi,Shan Luo,Brigitte Voit,Dietmar Appelhans,Xingjie Zan
Basic proteins play important roles in biological activities and disease treatment, but their high sensitivity to the body environment and short life time have limited their applications. Encapsulating the proteins into carriers has been demonstrated to be an effective way to prolong the protein half life time and to control the release temporally and spatially. However, fabricating protein carriers with high protein loading efficacy under mild conditions is still a big challenge. The capsules generated by the combination of the layer by layer (LBL) technique and sacrificial templates have been extensively investigated for the encapsulation of proteins. Porous CaCO3 is an effective sacrificial template with the ability to load various drugs efficiently under mild conditions, but it shows very poor ability in loading basic proteins. Here, we developed a highly efficient but very simple method to encapsulate lysozyme into porous CaCO3. An efficiency of 99.5% and capacity of 91.6 mg g−1 under very gentle conditions were obtained by doping heparin into porous CaCO3. Most importantly, the activity of the encapsulated lysozyme was almost 100% retained. Furthermore, we evaluated the encapsulation efficiency of the loaded lysozyme during the LBL wrapping process and demonstrated that the loss of the loaded lysozyme was controllable by choosing suitable polyelectrolyte pairs. Considering the multi-interaction mode of heparin with various proteins and the ability to retain the function of the loaded protein demonstrated in our study, we believe that the developed approach has great potential for encapsulating various functional proteins with a wide range of applications in catalysis, disease treatment, and tissue engineering.
研究领域:
生物技术
·
药学
·
材料科学
·
蛋白质工程
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产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2015
·Vol. 25
·期 48
·7470-7477
·
IF 11.805
Xia-Chao Chen,Ke-Feng Ren,Jia-Hui Zhang,Dan-Dan Li,Emily Zhao,Zhong Jonathon Zhao,Zhi-Kang Xu,Jian Ji
Layer-by-layer (LbL) self-assemblies have inherent potential as dynamic coatings because of the sensitivity of their building blocks to external stimuli. Here, humidity serves as a feasible trigger to activate the self-healing of a microporous polyethylenimine/poly(acrylic acid) multilayer film. Microporous structures within the polyelectrolyte multilayer (PEM) film are created by acid treatment, followed by freeze-drying to remove water. The self-healing of these micropores can be triggered at 100% relative humidity, under which condition the mobility of the polyelectrolytes is activated. Based on this, a facile and versatile method is suggested for directly integrating hydrophobic drugs into PEM films for surface-mediated drug delivery. The high porosity of microporous film enables the highest loading (≈303.5 μg cm −2 for a 15-bilayered film) of triclosan to be a one-shot process via wicking action and subsequent solvent removal, thus dramatically streamlining the processes and reducing complexities compared to the existing LbL strategies. The self-healing of a drug-loaded microporous PEM film significantly reduces the diffusion coefficient of triclosan, which is favorable for the long-term sustained release of the drug. The dynamic properties of this polymeric coating provide great potential for its use as a delivery platform for hydrophobic drugs in a wide variety of biomedical applications.
研究领域:
材料科学
·
聚合物化学
·
药物递送系统
·
生物医学工程
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产品关联
DOI
高影响因子
FUEL
·
2024
·
IF 6.7
Guoyan Yang,Yuxin Zhang,Zuozhu Yin,Yuanting Deng,Zihao Li,Yu Xie,Yuhua Chen,Chenggang Yang,Haitao Yang,Yidan Luo,Zhen Hong,Mingshan Xue
Superhydrophobic materials possessing efficient and rapid oil–water separation capabilities, as well as robustness, have emerged as the epicenter of global attention. Conventional three-dimensional adsorbent materials often succumb to impaired performance under extreme environmental conditions, rendering it arduous to ensure the efficacy of oil–water separation, and confining the application scenarios. In this study, polyurethane sponges (PUs) co-modified with stearic acid (SA), polydimethylsiloxane (PDMS), and multi-walled carbon nanotubes (MWCNTs), designated as SA-PDMS/MWCNTs@PU (SPMPU), were successfully synthesized via layer-by-layer (LBL) self-assembly and liquid-phase deposition. The SPMPU sponge exhibits an overall separation efficiency of not less than 90 %. It boasts a stable adsorption capacity, formidable mechanical properties, and commendable reusability. SPMPU sponges maintain unparalleled stability in extreme environments, such as strong acids and alkalis, and in the photothermal effect experiment, the SPMPU sponge can attain a temperature of 101.5 °C within 2 min, with rapid reaction kinetics, high efficiency, and unwavering stability. Through the photothermal effect-assisted oil–water separation, a reliable solution is furnished for the current oil–water separation endeavors. The SPMPU sponge preparation is uncomplicated, economical, and yields stable performance, holding significant potential for application in marine oil spills and industrial oil–water separation scenarios.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）