SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2023
·
IF 4.4
Huimin Zhou,Anni Zhu,Caiyin Wang,Xiaoyu Guo,Ye Ying,Yiping Wu,Xinling Liu,Feng Wang,Ying Wen,Haifeng Yang
5-Hydroxyindole-3-acetic acid (5-HIAA) is regarded as a biomarker for diagnosis of carcinoid tumors, and it is of great significance to developing a precision assay for monitoring 5-HIAA levels. In this work, gold nanoparticles loading on the surface of MOF-199 (Au NPs/MOF-199) is prepared to propose a surface enhanced Raman scattering (SERS) assay for 5-HIAA. When 4-mercaptopyridine (4-MPy) is used as a SERS probe, on Au NPs/MOF-199, limit of detection (LOD) at 10 −9 mol/L can be achieved. In addition, Au NPs/MOF-199 substrate with good preparation reproducibility shows long-term storage stability at 4 °C. Under optimal condition, the Au NPs/MOF-199-based SERS method is applied to determine 5-HIAA in serum. The concentration linear range is from 10 −9 to 10 −5 mol/L and LOD is of 6.40 × 10 −11 mol/L. Much importantly, Au NPs/MOF-199 substrate exhibits specific response toward 5-HIAA against other metabolites in the serum due to the capturing selectivity from porous MOF-199. The recoveries obtained on spiked human serum samples locate in the span from 94.30% to 106.00% with RSD of 4.01–7.43%. Au NPs/MOF-199-based SERS sensing strategy is a promising avenue for on-field monitoring biomedical species for clinic diagnosis purpose.
研究领域:
生物医学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2023
·
IF 3.9
Pingtao Ming,Yuanyuan Niu,Yongxin Liu,Jinhao Wang,Haohong Lai,Qing Zhou,Haiyun Zhai
In this study, the synthesis of Cu-MOF-199@multiwalled carbon nanotubes (Cu-MOF-199@MWCNTs) composites was achieved and utilized to create an advanced electrochemical sensor for creatinine (Cre) detection. The composites were modified on a glassy carbon electrode surface through direct drip coating, followed by the deposition of copper nanoparticles (CuNPs) via constant potential deposition. Characterized by various techniques and electrochemical analyses, the Cu-MOF-199@MWCNTs composite increased the CuNPs load, improving the detection sensitivity for Cre. Under optimal conditions, the modified electrode exhibited good linearity across a broad range of Cre concentrations (0.05–40.0 μM) with a low detection limit of 11.3 nM. The developed sensor demonstrated remarkable stability, reproducibility, and selectivity, showing promise in sensitive and accurate Cre detection in serum samples.
研究领域:
生物医学工程
·
分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2025
·
IF 2.5
Zhaoxiang Zeng,Lihua Huang,Caiyan Xu,Siqi Rao,Yin Chen,Wenjin Xu,Hao Hong
Metal-organic frameworks (MOFs) are a unique type of coordination polymer characterized by their high porosity and enormous specific surface area, which enable their use as carriers. We have constructed a novel MOFs-based nanodelivery system designed for multimodal combination therapy to enhance the delivery efficiency and efficacy of chemotherapeutic drugs. The synthesis of MOF-199, which inherently possesses a drug-release response function, was used as a nanodrug carrier. Doxorubicin (DOX) was encapsulated through physical adsorption, and the carrier surface was modified with a biomimetic material, polydopamine (PDA). Both PDA and hyaluronic acid (HA) molecules contain carboxyl groups, which can be connected through Fe3+-mediated coordination interactions. Transmission electron microscopy (TEM) and dynamic light scattering (DLS) were used to test the size, dispersity, and structural characteristics of the synthesized products, confirming their appropriate size and dispersity. BET(BET surface area) and TGA test results indicated that the nanocarrier exhibits good stability, a large specific surface area, and high porosity, making it suitable for use as a drug carrier. Ultraviolet spectrophotometry confirmed that the nanocarrier MOF-199-PDA-HA has the ability to consume GSH, with the drug loading rate and encapsulation efficiency of DOX in the system were measured as 39.58% and 73.26%, respectively. In cellular experiments, the DOX@MOF-199-PDA-HA group produced toxic hydroxyl radicals following H2O2 addition. After near-infrared light irradiation, both cellular toxicity and reactive oxygen species fluorescence intensity increased, indicating further enhanced anticancer efficacy. Using free HA as a control, it was confirmed that HA enhances tumor-specific accumulation of DOX@MOF-199-PDA-HA by binding to CD44 receptors on cancer cell surfaces.DOX@MOF-199-PDA-HA is a pH/GSH/NIR-responsive nanodelivery system with targeting functionality. This system ensures that drugs are released with higher efficiency in the tumor microenvironment through pH and glutathione (GSH) responsive drug-release mechanisms, thereby reducing toxicity to healthy tissues
研究领域:
药剂学
·
纳米医学
·
肿瘤学
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产品关联
DOI
高影响因子
FUEL
·
2022
·
IF 8.035
Yeshuang Wang,Chao Yang,Chaonan Zhang,Mingxian Duan,Hui Wang,Huiling Fan,Yuankai Li,Ju Shangguan,Jianying Lin
Hierarchical porous MOF-199 with small crystal sizes was synthesized via PVP (Polyvinylpyrrolidone) regulation in an aqueous system, in which PVP acted as nucleating, coordination and template agent. The ambient desulfurization performance of the obtained MOF-199 regulated with different PVP amounts toward CH 3 SCH 3 and H 2 S and their structure-performance relationship were systematically studied. It is found that CH 3 SCH 3 was first chemisorbed on the surface of the adsorbent in a monolayer by weak coordination and then physisorbed in multilayers. This whole process was reversible and the structure of MOF kept stable. The hierarchical pores plus the small crystal size of MOF-199-P 1 , especially to the latter, endowed the uptake for CH 3 SCH 3 reaching 88.1 mg S/g, 42% higher than that of pristine MOF-199. However, the adsorption of H 2 S by MOF-199 is chemical and the collapse of the MOF structure was observed. The hierarchical porous structure helped H 2 S access as many active sites as possible before the blockage of pores caused by the structural damage. As a result, MOF-199-P 2 achieved the optimum breakthrough capacity of 74.3 mg S/g towards H 2 S, 34 % higher than the bare MOF-199. This study provides new strategies and insights for the adsorption process between sulfide and adsorbents in different reaction modes.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2019
·Vol. 19
·期 2
·627-633
·
IF 1.093
Wang Xiaobing,Zhu Huijuan,Shi Xiuyi,Qiu Xiuzhen,Lu Wenguan,Guo Huishi
A hybrid nanocomposite containing a moisture-resistant surface based on MOF-199 and carbon nanotubes (CNTs) was synthesized. Characterization was undertaken using powder X-ray diffraction (PXRD), scanning electron microscopy (SEM) and Fourier transform infrared spectroscopy (FT-IR).
The adsorption behavior of the MOF-199/CNTs composite to ibuprofen was then investigated at room temperature. Experimentation revealed that the hybrid absorbent had excellent adsorption capacity for the nonsteroidal anti-inflammatory drug (NSAID), ibuprofen, with maximum adsorption up to 40.8
mg/g. The adsorbent was able to be recycled several times without deactivation. Finally, the MOF-199/CNTs composite was used as the extraction sorbents for selective extraction of ibuprofen, ketoprofen and naproxen in human urine. The results showed successful application of the nanocomposite
to NSAID analysis in spiked human urine samples. Recoveries at three concentrations were 89.7–96.8%, 79.3–85.5% and 95.6–97.5% for ibuprofen, ketoprofen and naproxen, respectively. The relative standard deviations (RSDs) were within the range of 2.9–5.3%. The results
demonstrated that the MOF-199/CNTs composite is an excellent adsorbent for determination of NSAIDs in spiked urine samples.
研究领域:
分析化学
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药物分析
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材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
FUEL
·
2016
·
IF 3.611
Si-Wen Li,Rui-Min Gao,Rong-Lan Zhang,Jian-she Zhao
A catalyst system designed by a kind of hybrid material POM@MOF-199@MCM-41 (PMM) was found by a one pot and POM template self-construction of MOF-199 in the pore of MCM-41. This catalyst was exploited to act as a stable heteropolyacid-based one in the direct oxidative desulfurization process with a feedstock of model oil under O 2 as oxidant. Based on optimal conditions, the DBT conversion reached up to 98.5% and the PMM could be recycled ten times with a slight decrease, which was compared with heteropolyacid only based on MOF-199 and MCM-41, respectively. Additionally, the structure of ordered nano-sized pores of MOF-199 with POM encapsulated in was clear under crystal analysis, which offered strong evidences for the further movement into the MCM-41.
研究领域:
化学
·
催化材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHROMATOGRAPHIA
·
2022
·Vol. 85
·期 9
·851-863
·
IF 2.213
Jiang Xiao-Xue,Sun Yue-Na,Zhang Chen,Yang Zhao,Yu Li-Qing,Lv Yun-Kai
In this paper, SiO 2 @MOF-199 composite with core–shell structure was prepared by in-situ growth of MOF-199 on the surface of SiO 2 microspheres, and SiO 2 @MOF-199 coated fiber was prepared for headspace solid phase microextraction (HS-SPME) of phthalate esters (PAEs) in plastic bottled milk. The prepared SiO 2 @MOF-199 has both mesoporous structure of SiO 2 and microporous structure of MOF-199. The hierarchical porous structure not only gives the analyte higher adsorption performance, but also improves the diffusion rate of the analyte in SiO 2 @MOF-199. The coated fibers have good thermal stability and are relatively uniform in size and structure. The extraction conditions of the prepared fibers for PAEs were optimized by single factor optimization and response surface Box-Behnken design. Under optimized conditions, the fiber displays wide linear ranges of PAEs (dimethyl phthalate, diethyl phthalate and diallyl phthalate are 5–800 ng L −1 , di-n-butyl phthalate, butyl benzyl phthalate and di-n-octyl phthalate are 50–1000 ng L −1 ), low limits of detection (0.3–19.8 ng L −1 ), and high enrichment factors (325–2089). The intra-day and inter-day relative standard deviations (RSD) for PAEs extractions using a single fiber were (4.7–8.5%) and (5.7–9.1%), respectively. The fiber-to-fiber reproducibility for three fibers prepared in parallel was 7.2–11.3% (RSD). The method was successfully applied to the extraction of PAEs from plastic bottled milk and to the quantitation by a gas chromatograph with a flame ionization detector. The average recoveries were 84.0% to 105%.
研究领域:
分析化学
·
材料科学
✓ 已验证
DOI
高影响因子
Molecular Catalysis
·
2025
·
IF 4.9
Yibo Zhang,Yang Liu,Wei Wang,Chunlai Liu,Hongyu Zhou,Na Wang,Jianglei Hu,Fengwei Shi
Metal-organic framework (MOF)-based composites have received significant attention for catalytic applications and are believed excellent heterogeneous catalysts. In this article, we prepared a new type of material, HPW@MOF-199/SBA-15C (PMS-15C). For this material, the MOF-199 encapsulating Keggin-type phosphotungstic acid (HPW) was grown inside the pores of the SBA-15 functionalized by carboxylic acids. The N 2 adsorption-desorption isotherms and pore size distributions, X-ray powder diffraction, transmission electron microscopy, and scanning electron microscopy analyses showed that the PMS-15C composites had an ordered two-dimensional hexagonal mesoporous structure, in which HPW encapsulating by MOF-199 loaded into the SBA-15C. Fourier-transform infrared spectroscopy and X-ray photoelectron spectroscopy indicated that HPW was successfully loaded, and the Keggin structure of HPW in PMS-15C remained unchanged. With the reaction of acetic acid and ethanol, the catalytic performance of PMS-15C was studied. Under the optimal conditions, ethyl acetate yield reached 81.4 %. The forward reaction rate was 0.432 mL mol −1 min −1 , and the activation energy was 38.35 kJ mol −1 . And the data were found to be consistent with the second-order reversible reaction kinetic model. The catalytic activity of the PMS-15C-0.2 composites remained stable after five catalytic cycles. In addition, the esterification of n-octanol/acetic acid and ethanol/oleic acid were studied using PMS-15C-0.2 as the catalyst. The results suggested that the catalytic activity of PMS-15C-0.2 was weakened upon increasing the substrates’ alkyl chain length.
研究领域:
材料科学
·
催化化学
✓ 已验证
产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2023
·
IF 4.8
Ben Niu,Zhenyu Zhai,Shuyan Yu,Tong Li,Jiaona Wang,Yan Zhou,Congju Li
A copper-based metal–organic framework (MOF-199) demonstrates excellent performance and considerable potential in the gas detection of volatile organic compounds (VOCs). However, the powder of MOF-199 seriously limits its application in the fabrication of flexible devices. Herein, we introduce a simple method of blending electrospinning, combining MOF-199 with polyacrylonitrile (PAN) nanofiber to form a MOF-199/PAN nanofiber membrane with the flexibility of PAN nanofiber and the functionality of MOF-199. The capacitive sensor comprising MOF-199/PAN nanofiber membrane and carbon nanotubes exhibits good flexibility, high porosity, and sufficient adsorption active sites. The sensor has the highest response to methanol among seven target VOCs. It exhibits outstanding sensitivity, long-term stability, good linear response, and repeatability toward methanol (250–1250 ppm). Owing to the flexibility of the MOF-199/PAN nanofiber membrane, the sensor maintains a stable sensing response after repeated bending at 180˚–0˚ 50 times and exhibits a certain degree of response in the 180˚ bending state. The results show that the sensor has flexibility potential. These provides some ideas and reference for the development of VOCs sensors.
研究领域:
材料科学
·
化学传感
·
环境监测
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF HYDROGEN ENERGY
·
2023
·
IF 7.2
Chenwei Xu,Zheng Wang,Chi Chen,Fengfeng Kuang
Porous octahedral copper-based metal organic framework MOF-199 anchored with Ru, RuMo, RuP, and RuMoP nanoparticles (NPs) was fabricated by a simple liquid impregnation method and applied as a high-performance catalyst for the hydrolysis of ammonia borane (AB) at room temperature . Comparison of the catalytic activities of Ru@MOF-199, RuMo@MOF-199, RuP@MOF-199, and commercial Ru/C shows that RuMoP@MOF-199 owns a very high turnover frequency of 735.6 mol H 2 min −1 (mol Ru) −1 and a low activation energy of 46.9 kJ/mol. Loading RuMoP NPs onto MOF-199 owing to synergistic effects , functional, size, and support effects kinetically facilitates the oxidative cleavage of attacked H- OH and elevate the catalytic performance. Moreover, this catalyst shows satisfied durability after five cycles for the hydrolytic dehydrogenation of AB. The novel structural features and efficient performance would provide an essential reference for the utilization of high-performance catalyst development.
研究领域:
催化
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2024
·
IF 5.7
Xiao-Qin Yang,Li-Qing Yu,Lan-Fen Li,Yun-Kai Lv
Background The practical application of moisture sensitive metal organic frameworks (MOFs) in extraction technology faces challenges related to competitive adsorption and water stability. The target analytes cannot be effectively extracted under humid conditions due to the competitive moisture adsorption and/or framework structure collapse of MOFs. In this study, the microporous organic networks (MONs) were synthesized through Sonogashira coupling reaction to use for hydrophobic modification on the surface of MOF-199. Results The MOF-199@MON as coating was deposited on stainless steel wires for solid-phase microextraction (SPME) of benzene series (BTEX) in aqueous environments. Under the optimal extraction conditions, the MOF-199@MON coated fiber for SPME coupled with GC-MS for the determination of BTEX gave the linear range of 0.5–500 μg L −1 , the limit of detections (LODs, S/N = 3) of 0.01–0.04 μg L −1 , the limit of quantifications (LOQs, S/N = 10) of 0.04–0.12 μg L −1 , the enhancement factors of 3567–4878, and the intra-day, inter-day and fiber-to-fiber precisions (relative standard deviations, RSDs) of 1.0–9.8, 1.9–7.9 and 4.5–9.5 %, respectively. The developed method was successfully applied to the analysis of BTEX in water samples with the recoveries of 71.0 %–113 %. Significance This work reveals the home-made SPME fibers have a long service life (the extraction efficiency of fiber decreased by only 7.26 %−13.14 % after 100 cycles). The potential of MON functionalized MOFs as effective adsorbents for the SPME of pollutants in the water environment.
研究领域:
分析化学
·
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF THE CHINESE CHEMICAL SOCIETY
·
2020
·Vol. 67
·期 10
·1807-1817
·
IF 1.554
Hai-Tao Wang,De Ao,Mei-Chan Lu,Na Chang
MOF-199@PVDF composite membranes are prepared by blending with different amounts of ultrasonic synthesized MOF-199 nanomaterials for improving the pure water flux (PWF) and achieving better antifouling and antibacterial performance. The membrane morphology, elemental composition, and surface properties are analyzed by various means of characterizations, including scanning electron microscopy, energy-dispersive X-ray spectroscopy, and water contact angle measurements. The performance of the modified membranes is also determined from the perspective of the PWF, bovine serum albumin rejection, as well as antifouling and antibacterial properties. Due to the variation in the viscosity of dope solution, the composite membranes possess remarkably different morphology, and the M5 membrane, which exhibited a sponge-like structure, the largest surface pore size, and the highest porosity, shows the highest PWF, reaching up to 185.05 L/m 2 h. Moreover, with the incorporation of MOF-199 nanocrystals, the antifouling property, together with the antibacterial property, toward both gram-negative bacteria and gram-positive bacteria, based on M5 and M7 membranes, increases dramatically compared with the pristine polyvinylidene fluoride membrane. In addition, the long-term permeation performance and copper leakage of the membrane are investigated. As a result, the composite membrane, M5, shows great potential in real water treatment.
研究领域:
材料科学
·
环境工程
·
膜技术
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）