COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2026
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IF 5.4
Haoxiang Wang,Peilun Shen,Dianwen Liu,Rong Peng,Hang Zhu,Xianren Dai,Jinpeng Cai
EDA/2-MP turns inert Cu–O–Si domains into KBX-responsive Cu-organic sites. • EDA unlocks Cu(II) sites for 2-MP anchoring via Cu–N/Cu–S bonding. • A continuous ~30 nm N/S/Cu-rich activation film is visualized on chrysocolla. • Interface reconstruction enables 95% chrysocolla recovery and selective separation. Chrysocolla is one of the most difficult oxide copper minerals to recover by flotation because of its strong hydrophilicity, low reactivity, and poor adaptability to conventional activation methods. In this study, an EDA/2-MP synergistic activation system was developed using KBX as the collector. At pH 10, single-mineral flotation tests were conducted with 38–74 μm chrysocolla at a pulp solid concentration of 10 g/L and a flotation time of 8 min, with three independent tests performed for each condition; an artificial chrysocolla–dolomite mixture at a mass ratio of 1:1 was also used to evaluate separation performance. At EDA, 2-MP, and KBX concentrations of 40, 280, and 60 mg/L, respectively, chrysocolla recovery reached 95.34%. In the mixed-mineral system, concentrate Cu recovery remained above 95%, with a Cu grade of approximately 34%. FIB-TEM revealed a continuous low-crystallinity film approximately 31.2–33.9 nm thick after EDA/2-MP treatment. Raman, XPS, and ToF-SIMS showed that EDA/2-MP altered the chemical environments of surface Cu, N, and S species and promoted the enrichment of KBX-related components at the activated interface. Accordingly, EDA/2-MP pretreatment followed by KBX addition increased the chrysocolla contact angle from 24.52° to 82.65°, confirming surface hydrophobization. This study provides a new selective interfacial activation strategy for efficient flotation recovery of refractory silicate-type oxide copper minerals. Download: Download high-res image (203KB) Download: Download full-size image
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高影响因子
FOOD SCIENCE AND TECHNOLOGY INTERNATIONAL
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2023
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IF 2.3
Mingru Wang,Lei Ma,Peng Xie,Cuiping Li,Xiaoxi Yang,Yumiao Lang
The characterization and antioxidant ability of Res-loaded MP-CS stabilized Pickering emulsion, and its effects of fat reduction (25%, 50%, 75%, and 100%) in meat patties on pH, color, texture, cooking yield and antioxidant activity were investigated. Fat substitute using emulsion had no significant effect on pH and cooking yield. The addition of emulsion increased L* value and reduced a* value. a* value of meat patties with resveratrol added were higher than those without resveratrol group. Hardness and chewiness of meat patties with 25% and 100% fat replacement was lower than 50% and 75% fat replacement. The addition of emulsion could improve the network structure of meat patties and enhance oxidative stability. Oxidative stability of meat patties was improved by Res-loaded MP-CS stabilized Pickering emulsion. The results showed that MP-CS stabilized Pickering emulsion had great potential to be used as fat substitute for developing low-fat meat products, and the addition of resveratrol can improve the antioxidant ability of substitute fat meat products.
研究领域:
食品科学
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生物化学
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DOI
PubMed
高影响因子
International Journal of Electrochemical Science
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2023
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IF 1.5
Mengli Xu,Yuan Shen,Linyu Wang,Coucong Gong,Shouhui Chen
In this work, a novel H 2 O 2 biosensor was developed based on the composites of microperoxidase-11 (MP-11) encapsulated in graphene oxide (GO)-PCN-333 (Al) (PCN stands for porous coordination network, one of the metal-organic frameworks). The PCN-333(Al) firmly and uniformly grew on the surface of GO sheet with large specific surface and excellent electrical conductivity, which provided a lots of pores for the encapsulation of MP-11 in the composites and selectively accumulated analytes into its mesopores to improve the selectivity of enzymatic reaction. The MP-11 molecules might freely move through mesopores of PCN-333 (Al) to maintain bioactivity, which remarkably enhanced the mass transfer rate and quickened the electron transfer for electrochemical biosensors. Scanning electron microscopy was used to characterize the GO and PCN-333(Al)-GO composites. Cyclic voltammetry and differential pulse voltammetry were used to characterize the electrochemical behaviors and performance of the H 2 O 2 biosensor. The target electrode showed excellent performance with a wide linear range from 10 μ M to 800 μ M, a low detection limit of 3 μ M, good stability and high selectivity, which was superior to some other H 2 O 2 biosensors.
研究领域:
生物化学
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材料科学
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分析化学
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高影响因子
BIOMATERIALS
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2019
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IF 10.273
Yuejun Yao,Jie Ding,Zhaoyi Wang,Haolan Zhang,Jieqi Xie,Yingchao Wang,Liangjie Hong,Zhengwei Mao,Jianqing Gao,Changyou Gao
Reactive oxygen species (ROS) play an important role in the pathogenesis of numerous diseases including atherosclerosis, diabetes, inflammation and myocardial infarction (MI). In this study, a ROS-responsive biodegradable elastomeric polyurethane containing thioketal (PUTK) linkages was synthesized from polycaprolactone diol (PCL-diol ), 1,6-hexamethylene diisocyanate (HDI), and ROS-cleavable chain extender . The PUTK was electrospun into fibrous patches with the option to load glucocorticoid methylprednisolone (MP), which were then used to treat MI of rats in vivo . The fibrous patches exhibited suitable mechanical properties and high elasticity. The molecular weight of PUTK was decreased significantly after incubation in 1 mM H 2 O 2 solution for 2 weeks due to the degradation of thioketal bonds on the polymer backbone . Both the PUTK and PUTK/MP fibrous patches showed good antioxidant property in an oxidative environment in vitro . Implantation of the ROS-responsive polyurethane patches in MI of rats in vivo could better protect cardiomyocytes from death in the earlier stage (24 h) than the non ROS-responsive ones. Implantation of the PUTK/MP fibrous patches for 28 days could effectively improve the reconstruction of cardiac functions including increased ejection fraction , decreased infarction size, and enhanced revascularization of the infarct myocardium.
研究领域:
生物材料
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心脏病学
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药理学
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PubMed
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2018
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IF 5.667
Dandan Fang,Xiangqin Zheng,Huan Yi,Hong Dai,Zhensheng Hong,Yiru Peng,Yanyu Lin
A highly sensitive electrochemiluminescence (ECL) immunosensor was fabricated for the quantitative analysis of deoxynivalenol (DON) based on an effective all-in-one bioprobe that composed of TiO 2 -B with Fluoro-coumarin silicon phthalocyanine (F-couSiPc) and luminol. Herein, TiO 2 -B with large specific area was served as a favorable carrier, greatly increased the loading of enhancer F-couSiPc and luminophore luminol, resulting in the tremendous enhancement of ECL signal. Specifically, F-couSiPc as coreaction accelerator could facilitate the decomposition of dissolved O 2 to generate substantial reactive oxygen species (ROS) to participate in the ECL reaction of luminol. Additionally, the prepared PEDOT/HA@mp MnO 2 was employed as the sensing platform of biosensor, which can not only capture substantial antibody to improve the sensitivity, but also could expedite the electronic transmission rate to make the ECL intensity further amplified. Ultimately, the proposed immunosensor presented favorable performance for the determination of DON, such as high sensitivity, good stability, wide liner range (from 1.0*10 −6 ng/mL to 10 ng/mL) and a low detection limit of 3.3*10 -7 ng/mL.
研究领域:
分析化学
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食品安全检测
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DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2023
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IF 13.6
Zhihao Yan,Hanyang Qian,Juanjuan Yao,Meng Guo,Xiong Zhao,Naiyun Gao,Zhi Zhang
Microplastics (MPs) in drinking water are predominantly < 10 µm. The leaching of MPs derived dissolved organic matters (MP-DOM) from 5 µm polypropylene MPs (PP-MPs) and polystyrene MPs (PS-MPs) and the formation of MP-DOM derived disinfection byproducts during chlorination disinfection were first investigated. Comparably, PS-MPs are more vulnerable to chlorination and the primary attacks are on para C in aromatic side-chains via electrophilic Cl-substitution and oxidation by two-electron transfer. The O/C and Cl/C ratio of polystyrene MPs was linear and exponential versus initial available Cl 2 concentrations, respectively. The significant PS-DOM leaching was observed with initial available Cl 2 of 4.0 mg/L (USEPA recommended upper dose). As the initial available Cl 2 concentration increased to 8.0 mg/L, the adsorption of chloro-phenolic-components of 200 Daltons in PS-DOM by 5 µm PS-MPs was observed for the first time. Trichloromethane (TCM) was identified as the dominant disinfection byproduct with a formation potential of 60.3 ± 7.8 and 73.7 ± 9.8 μg/mg for PS-DOM and PP-DOM, respectively. The derived TCM could adsorb onto PS-MPs followed the pseudo-second-order kinetic and Langmuir isotherm models. Extreme chlorination could reduce the maximal adsorption capacity of TCM on 5 µm PS-MPs from 196.68 ± 48.66 to 146.02 ± 32.98 μg/g. Thus, PS-MPs act as precursors and carriers of TCM in chlorination.
研究领域:
环境科学
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化学工程
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PubMed
高影响因子
MOLECULAR PHARMACEUTICS
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2025
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IF 4.5
Hao Zhang,Dan Xie,Meng Chen,Qiangqiang Yin,Guangyue Shi,Jialong He,Xiaoyang Yu,Qian Lu,Zhengji Wang,Jing Dong,Liguo Hao
Chemotherapy is a widely used cancer treatment modality, while the complex tumor microenvironment (TME) significantly impedes drug delivery and deep tissue penetration. An MR molecular imaging drug-loaded nanomotor has been developed to achieve deep tumor tissue penetration and imaging-guided drug delivery, enabling combined photothermal and chemotherapeutic treatment of pancreatic cancer. A Janus-type nanomotor (Au@H-MP NMs) was fabricated via magnetron sputtering for application in photothermal therapy. Doxorubicin (DOX) was loaded onto one hemisphere of the nanomotor, achieving combined photothermal and chemotherapeutic treatment. Additionally, the nanomotor exhibits dual responsiveness to pH and glutathione (GSH), facilitating the controlled release of DOX within deep tumor tissues. Studies confirmed the nanomotors excellent biosafety, strong photothermal conversion capability, and effective induction of apoptosis. Tumor tissue penetration was validated through in vitro migration and infiltration assays, while in vivo experiments demonstrated significant tumor suppression and enhanced drug accumulation. Moreover, MR imaging technology enables real-time monitoring of nanomotor dynamics. These findings suggest that the synthesized Janus-type MR molecular imaging nanomotor offers a promising strategy for multimodal treatment of pancreatic cancer with significant clinical potential.
研究领域:
肿瘤学
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生物医学工程
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药理学
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影像医学
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PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
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2020
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IF 9.038
Can Cheng,Jianjun Li,Jinyan Cao,Jiaxiu Guo,Wanglai Cen
The absorption properties of N-(2-hydroxyethyl) morpholine (HEM), morpholine (MP) and N-(2-aminoethyl) morpholine (AEM) for SO 2 were studied using sulfolane (SUL) as solvent in this work. Among these solvent combinations, HEM/SUL shows the best cyclic absorption performance, and the capacity of HEM-SUL-40 (40 wt% of HEM and 60 wt% of SUL) to absorb 8580 mg/m 3 SO 2 (the remainder is N 2 ) is 192.18 mg/g at 293.15 K. The absorption capacity of the second cycle is 97.5% of the first absorption cycle, which is higher than 70% of the Cansolv amine solution in a commercial application with similar experimental conditions. However, MP/SUL is difficult to desorb at high temperature, and the absorption capacity of AEM/SUL is much lower than HEM/SUL and MP/SUL. According to the FTIR , 1 H NMR and 13 C NMR, all three cyclic amines have charge transfer effects with SO 2 . The structure of HEM/SUL can be recovered after heating, but MP cannot be recovered. Δ r G m ° in the reaction against HEM with SO 2 increases significantly with increasing temperature. The Δ r G m ° of HEM-SO 2 and MP-SO 2 at 353.15 K is −12.56 kJ/mol and −16.29 kJ/mol, respectively, which further explains the easy desorption of HEM-SO 2 and the difficult desorption of MP-SO 2 at high temperature.
研究领域:
化学工程
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环境科学
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物理化学
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2019
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IF 4.784
Jixu Wu,Huarong Shao,Jinhua Zhang,Yong Ying,Yanling Cheng,Dan Zhao,Xixi Dou,Huimin Lv,Shuaiguang Li,Fei Liu,Peixue Ling
We isolated and characterized a Mussel polysaccharide, α -D-glucan (MP-A), from Mytilus coruscus earlier. In this work, the pharmacological activity and mechanisms of MP-A as an oral supplement for non-alcoholic fatty liver disease (NAFLD) were explored. High fat diet (HFD) was utilized to induce NAFLD in Sprague Dawley male rats and MP-A (0.6 g/kg) was supplemented for 4 weeks. The results showed that MP-A supplementation reduced blood lipid levels, intrahepatic lipid accumulation and NAFLD activity score in HFD-fed rats. Additionally, the analysis of 16S rDNA sequencing on gut microbiota samples revealed that HFD could induce microbial dysbiosis. However, MP-A supplementation could remodel gut microbiota structure, inhibit LPS-TLR4-NF- κ B pathway activation, and restrain subsequent inflammation factors secretion. Furthermore, MP-A regulated the lipid metabolism by promoting the production of short chain fatty acids and suppressing PPAR γ and SREBP-1c expression. Our results support that MP-A can prevent against NAFLD and act as an oral supplementation for hepatoprotection via modulating gut microbiota and related gut-liver axis signaling pathways.
研究领域:
药理学
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胃肠病学
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微生物学
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代谢学
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DOI
PubMed
高影响因子
PROGRESS IN ORGANIC COATINGS
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2024
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IF 6.5
Yuhan Zhang,Nan Xiao,Yanjing Gao,Fang Sun
This study introduces a novel p -diethylene glycol monomethyl ether cinnamyl formamide-based disulfide monomer , N,N′ -(disulfanediylbis(2,1-phenylene)) bis(4-(4-(2-(2-methoxyethoxy)ethoxy) phenyl)-2-oxobut-3-enamide) (Mp-BSCF), designed to reduce the volume shrinkage of photosensitive resins and initiate monomer polymerization under 455 nm LED light irradiation. The photochemical properties and photoinitiation efficiency of Mp-BSCF are systematically investigated using UV–vis absorption spectroscopy , electron paramagnetic resonance (EPR) and real-time infrared spectroscopy . Although its weak absorption around 455 nm, Mp-BSCF can generate arylthiyl radicals under 455 nm LED irradiation, and then effectively initiate the polymerization of triethylene glycol dimethacrylate (TEGDMA)/A glycerolate dimethacrylate (Bis-GMA) system. Increasing Mp-BSCF addition enhances the final double bond conversion and maximum polymerization rate of the TEGDMA/Bis-GMA system, reaching up to 82.0 % and 2.02 % s −1 , respectively. Notably, Mp-BSCF significantly reduces the volume shrinkage of the photopolymerization system, with the addition of 10 % Mp-BSCF resulting in a 50 % reduction compared to the control system. This reduction is attributed to the dynamic reversible nature of the S S bond “breaking-recovery” and the intermolecular hydrogen bond interaction. Additionally, Mp-BSCF improves the thermal stability, friction resistance, and hardness of the TEGDMA/Bis-GMA photopolymerization system.
研究领域:
材料科学
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高分子化学
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光化学
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DOI
高影响因子
危险品化学品经营许可证（带存储）