查找使用阿拉丁产品的科研文献

Targeting cAMP in D1-MSNs in the nucleus accumbens, a new rapid antidepressant strategy

Yue Zhang,Jingwen Gao,Na Li,Peng Xu,Shimeng Qu,Jinqian Cheng,Mingrui Wang,Xueru Li,Yaheng Song,Fan Xiao,Xinyu Yang,Jihong Liu,Hao Hong,Ronghao Mu,Xiaotian Li,Youmei Wang,Hui Xu,Yuan Xie,Tianming Gao,Guangji Wang,Jiye Aa

Studies have suggested that the nucleus accumbens (NAc) is implicated in the pathophysiology of major depression; however, the regulatory strategy that targets the NAc to achieve an exclusive and outstanding anti-depression benefit has not been elucidated. Here, we identified a specific reduction of cyclic adenosine monophosphate (cAMP) in the subset of dopamine D1 receptor medium spiny neurons (D1-MSNs) in the NAc that promoted stress susceptibility, while the stimulation of cAMP production in NAc D1-MSNs efficiently rescued depression-like behaviors. Ketamine treatment enhanced cAMP both in D1-MSNs and dopamine D2 receptor medium spiny neurons (D2-MSNs) of depressed mice, however, the rapid antidepressant effect of ketamine solely depended on elevating cAMP in NAc D1-MSNs. We discovered that a higher dose of crocin markedly increased cAMP in the NAc and consistently relieved depression 24 h after oral administration, but not a lower dose. The fast onset property of crocin was verified through multicenter studies. Moreover, crocin specifically targeted at D1-MSN cAMP signaling in the NAc to relieve depression and had no effect on D2-MSN. These findings characterize a new strategy to achieve an exclusive and outstanding anti-depression benefit by elevating cAMP in D1-MSNs in the NAc, and provide a potential rapid antidepressant drug candidate, crocin.

Regulation of IFP in solid tumours through acoustic pressure to enhance infiltration of nanoparticles of various sizes

Yangcheng He,Yuyi Feng,Danxai Qiu,MinHua Lin,Hai Jin,Zhiwen Hu,Xue Huang,Suihong Ma,Yan He,Meiqi Lai,Wenhui Jin,Jianhua Liu

Numerous nanomedicines have been developed recently that can accumulate selectively in tumours due to the enhanced permeability and retention (EPR) effect. However, the high interstitial fluid pressure (IFP) in solid tumours limits the targeted delivery of nanomedicines. We were previously able to relieve intra-tumoural IFP by low-frequency non-focused ultrasound (LFNFU) through ultrasonic targeted microbubble destruction (UTMD), improving the targeted delivery of FITC-dextran. However, the accumulation of nanoparticles of different sizes and the optimal acoustic pressure were not evaluated. In this study, we synthesised Cy5.5-conjugated mesoporous silica nanoparticles (Cy5.5-MSNs) of different sizes using a one-pot method. The Cy5.5-MSNs exhibited excellent stability and biosafety regardless of size. MCF7 tumour-bearing mice were subjected to UTMD over a range of acoustic pressures (0.5, 0.8, 1.5 and 2.0 MPa), and injected intravenously with Cy5.5-MSNs. Blood perfusion, tumour IFP and intra-tumoural accumulation of Cy5.5-MSNs were analysed. Blood perfusion and IFP initially rose, and then declined, as acoustic pressure intensified. Furthermore, UTMD significantly enhanced the accumulation of differentially sized Cy5.5-MSNs in tumour tissues compared to that of the control group, and the increase was sevenfold higher at an acoustic pressure of 1.5 MPa. Taken together, UTMD enhanced the infiltration and accumulation of Cy5.5-MSNs of different sizes in solid tumours by reducing intra-tumour IFP.

A novel superhydrophobic composite coating based on DTMS modified MSNs containers for active protection of aluminum alloys

Xue-Fen Zhang,Wen-Ju Ji,Xiang Li,Chen-Xiang Wang

Superhydrophobic coatings hold great promise for protecting aluminum alloys from corrosion. However, most existing coatings offer only short-term passive protection, with limited attention to their long-term efficacy. In this study, dodecyltrimethoxysilane (DTMS)-modified mesoporous silica nanoparticles (SH-MSNs) were selected for the first time as the containers of benzotriazole (BTA). The resulting SH-MSNs@BTA was then incorporated into epoxy resin to create a functional primer, which was then combined with a superhydrophobic silica (SH-SiO 2 ) topcoat to develop a superhydrophobic composite coating system (ESMSS@BTA) that provides both active and passive protection to aluminum alloys. Due to the synergistic effect of excellent water repellency, dense primer structure, and self-healing of BTA, the ESMSS@BTA coating exhibits higher anti-corrosion performance than the coating without BTA loading after immersion in 3.5 wt% NaCl solution for up to 30 days. Additionally, the mechanical stability of the ESMSS@BTA coating, along with the tolerance to either alkaline or acid media, was evaluated to assess its durability. This research is expected to provide new ideas for designing superhydrophobic coatings for long-lasting protection of metals.

Enhanced corrosion protection of superhydrophobic SiO2/epoxy composite coatings for aluminum alloys with 8-HQ incorporated MSNs containers

Chen-Xiang Wang,Hao Yang,Li-Wei Liu,Ji-Peng Han,Xue-Fen Zhang

Background Superhydrophobic coatings have shown great promise in providing temporary corrosion protection for aluminum alloys. However, their long-term effectiveness is often compromised by poor mechanical durability and the lack of active protection. Methods In this study, we developed a novel protection coating by integrating a functional epoxy primer containing 8-hydroxyquinoline-loaded mesoporous SiO 2 nanocontainers (8-HQ@MSNs) and a superhydrophobic SiO 2 topcoat. Significant findings After chemical and structural characterization of 8-HQ@MSNs, its optimized content is determined to be 0.5 %. The resulting coating provides long-term protection for aluminum alloys in 3.5 wt. % NaCl solution over 30 days. Notably, the low-frequency impedance modulus of the scratched coating, even after immersion in NaCl solution for 12 h, is one order of magnitude higher than that of the coating lacking 8-HQ with a shorter corrosion duration (6 h). Furthermore, this coating exhibits a strong interfacial bond with aluminum alloys (Grade 0) and can withstand an abrasion distance of 1360 cm on 600 grit sandpaper under a 100 g load, as well as 140 min of continuous high-pressure water impact (25 kPa) without losing its superhydrophobic properties. This study is expected to contribute new insights into developing durable superhydrophobic coatings with active protection for aluminum alloys.

A dual-mode T1 MRI/CT contrast agent of Gd2O3/Au@MSNs for tumor imaging with high performance

Jianfeng Yang,Qingling Zhao,Zehao Zang,Shuquan Zhang,Ziwu Wang,Lanlan Li,Xiaofei Yu,Xiaojing Yang,Zunming Lu,Xinghua Zhang

Magnetic resonance imaging (MRI) contrast agents with high relaxivity is of great importance for clinical diagnosis. Here we propose an effective method to enhance the relaxivity of MRI contrast agents. Ultra-small gadolinium oxide nanoparticles (Gd 2 O 3 NPs) with different surface ligands were prepared by coprecipitation method, and the polyacrylic acid (PAA) modulated Gd 2 O 3 NPs (PAA-Gd 2 O 3 ) have the high r 1 relaxivity of 53.34 mM –1 s –1 , which is mainly induced by the strong affinity between PAA and water molecules. In addition, PAA modulated Gd 2 O 3 NPs were successfully loaded on Au@MSNs (Au nanorod coated with mesoporous silica , Gd 2 O 3 /Au@MSNs) with enhanced affinity between Gd 3+ and water molecules, as well as increased motional time of Gd 3+ . Therefore, the r 1 relaxivity of Gd 2 O 3 /Au@MSNs can be up to 64.53 mM –1 s –1 , which is 17 times of the commercial agent Gd-DTPA. The Gd 2 O 3 /Au@MSNs NPs also have a low r 2 /r 1 of 1.04 and good computed tomography (CT) imaging performance, as well as good biocomatibility, which have great potential applications in multimodal bioimaging.

MMP-responsive theranostic nanoplatform based on mesoporous silica nanoparticles for tumor imaging and targeted drug delivery

Jing-Jing Hu,Li-Han Liu,Ze-Yong Li,Ren-Xi Zhuo,Xian-Zheng Zhang

In this paper, we report on an intelligent mesoporous silica-based multifunctional theranostic nanoplatform (designated as MMTNP) for tumor imaging as well as controlled drug release. This theranostic nanoplatform consists of MCM-41 typical mesoporous silica nanoparticles (MSNs) as a hydrophobic drug carrier, matrix metalloprotease-2 (MMP-2) activated fluorescence imaging peptides on the surface of MSNs served as diagnostic probes as well as enzyme-responsive nanovalves blocking the pores, and cRGD peptides further functionalized on the surface of MSNs for tumor targeting. In the absence of MMP-2 conditions, the proximity between the fluorescent dye 5(6)-carboxytetramethylrhodamine hydrochloride (TAMRA) and the quencher 4,4-dimethylamino-azobenzene-4′-carboxylic acid (Dabcyl) on the surface of MSNs resulted in no fluorescence. When the drug loaded nanoplatform arrived at tumor tissue with overexpressed MMP-2, the fluorescence of TAMRA became recovered efficiently due to the hydrolysis of the MMP-2 sensitive peptide substrate, realizing tumor imaging and triggering drug release. In addition, the further introduced cRGD peptide significantly enhanced the targeting efficiency through receptor-mediated endocytosis in tumor cells.

Folic acid-mediated MSNs@Ag@Geb multifunctional nanocomposite heterogeneous platform for combined therapy of non-small cell lung cancer

Jianbo Lin,Rujie Zheng,Liping Huang,Yuanrong Tu,Xu Li,Jianfeng Chen

Molecularly targeted drugs are flourishing in the clinical treatment of non-small cell lung cancer (NSCLC). However, the treatment of a single drug (such as Gefitinib (Geb)) had defects such as poor pharmacokinetics , insufficient drug delivery, and considerable toxic side effects, which greatly affect its therapeutic efficacy against NSCLC. To solve these issues, this study developed a new nanocomposite heterogeneous platform (MSNs@Ag@Geb-FA) that combined photothermal therapy and molecular targeted therapy. The high specific surface area empowered mesoporous silicon dioxide (SiO 2 ) heterostructure the ability to efficiently load Ag photothermal agents and anti-tumor drug Geb. Meanwhile, a favorable pH response (degradation of residual MnO 2 ) achieved the controlled release of Ag and Geb. Besides, the targeting and endocytosis properties of nano drugs were greatly improved through the modification of folic acid (FA). Both in vivo and in vitro experiments authenticated that this nanocomposite heterogeneous platform could effectively integrate the multiple tumor suppressor properties of Ag nanoparticles and cooperate with Geb to hasten A549 cell apoptosis, thereby achieving a favorable anti-tumor effect. This heterogeneous structure of the nanocomposite heterogeneous platform could provide an effective strategy for the treatment of NSCLC.

Cascade-Targeting of Charge-Reversal and Disulfide Bonds Shielding for Efficient DOX Delivery of Multistage Sensitive MSNs-COS-SS-CMC

Lan Cui,Wentao Liu,Hao Liu,Qian Qin,Shuangxia Wu,Suqin He,Zhenya Zhang,Xinchang Pang,Chengshen Zhu

Simultaneous removal of Pb(II) and 2,4,6-trichlorophenol by a hierarchical porous PU@PDA@MSNs sponge with reversible “shape memory” effect

Shucheng Liu,Jianming Pan,Jun Cao,Xiaohui Dai,Minjia Meng,Runrun Wu,Juntong Yao,Yongsheng Yan

A hierarchical porous PU@PDA@MSNs sponge with reversible “shape memory” effect was employed in this investigation for the simultaneous adsorption of Pb(II) and 2,4,6-trichlorophenol (TCP). Our strategy was based on facile conjugation of carboxyl groups modified mesoporous silica nanoparticles (MSNs) to poly(dopamine) (PDA) coated polyurethane (PU) sponge (PU@PDA), and the as-prepared PU@PDA@MSNs sponge possessed the advantages of less operation time, convenient adsorbent collection and regeneration owing to its reversible “shape memory” effect. In single system, Pb(II) and TCP adsorption were implemented at pH   =   6.0, and their max monolayer adsorption amount at 298   k were 104.2   mg   g −1 and 184.2   mg   g −1 , respectively. However, the binary system exhibited that the coexistence of Pb(II) and TCP could obviously accelerate jointly adsorption at low concentrations, due to partial complexation between Pb(II) and TCP during the 10–30   mg   L −1 of Pb(II) and TCP. While at higher concentrations, TCP adsorption was inhibited in relation to the competition from Pb(II), but Pb(II) adsorption was scarcely affected due to its smaller size and strong complexation with amino groups from PU@PDA@MSNs sponge. The PU@PDA sponge could be simply recycled and maintained stability after seven adsorption/desorption cycles in the regeneration steps.

Mesoporous silica nanoparticles (MSNs)-based organic/inorganic hybrid nanocarriers loading 5-Fluorouracil for the treatment of colon cancer with improved anticancer efficacy

Gang Pan,Ting-ting Jia,Qian-xia Huang,Yan-yan Qiu,Jie Xu,Pei-hao Yin,Tao Liu

Novel methods to improve the anticancer performance of 5-fluorouracil (5-FU) is quite necessary for clinical medicines. In the present work, we fabricated a novel type of mesoporous silica nanoparticles (MSNs)-based inorganic/organic hybrid nanoparticles covalently attached with poly(oligo(ethylene glycol) monomethyl ether methacrylate) (POEGMA) for improved stabilization and targeting peptide (RGD) for targeted delivery with the aim of improving the anticancer performance of 5-FU. Atom transfer radical polymerization (ATRP) initiator functionalized MSN (MSN-Br) was synthesized at first, which was followed by surface-initiated ATRP of water soluble OEGMA and carboxyl-containing monomer (2-succinyloxyethyl methacrylate, SEMA). Functionalization of RGD onto the hydrophilic P(OEGMA- co -SEMA) chains afforded the final hybrid nanoparticle, MSN-P(OEGMA- co -RGD). 5-FU can be effectively loaded into the meso -pores of MSN-P(OEGMA-c o -RGD) ( [email protected] ) with drug content ∼7.5   wt%. And the dynamic diameter ( D h ) and zeta potential (ζ) of [email protected] were determined to be 199.3   ±   5.4   nm and −8.7   ±   0.5   mV, respectively. It was demonstrated that MSN-P(OEGMA-c o -RGD) exhibited improved internalization into colon cancer cells and enhanced accumulation in tumor tissues. In addition, compared with free 5-FU, [email protected] showed enhanced anticancer efficacy both in vitro and in vivo, implying promising clinical applications.

Ni-metal-organic-framework (Ni-MOF) membranes from multiply stacked nanosheets (MSNs) for efficient molecular sieve separation in aqueous and organic solvent

Guiliang Li,Yanmin Qi,Haibo Lin,Na Lu,Jiaping Chen,Jianqiang Wang,Qiu Han,Fu Liu

Lamellar membranes are attracting extensive attention for high throughput and precise molecules/ions sieve separation. However, the energy-consuming exfoliation and low yield of single-layer nanosheets restrict the massive production of membranes. Herein, we facilely fabricated 2D Ni-mediated metal-organic framework (Ni-MOF) membranes directly from multiply stacked nanosheets (MSNs) for both aqueous and organic molecular sieve separation. Multiply layered nanosheets were obtained from a high concentration dispersion via simple ultrasonic treatment. The morphology and chemistry of synthesized Ni-MOF nanosheets were characterized via scanning electron microscopy (SEM), N 2 adsorption-desorption, Fourier transform infrared spectra (FTIR), and X-ray photoelectron spectra (XPS). The thickness of Ni-MOF membranes could be well regulated by the volume of dispersion. The membrane exhibited high molecular rejection to 8GX (97.29%), EB (96.28%), CR (99.69%), and CBB (93.31%) in water, respectively and a stable perm-selectivity in continuous 24 h filtration. The lamellar membrane showed excellent pressure and pH (2–10) resistance. The membrane achieved rational permeance of various organic solvents mainly depending on viscosity and good rejection to MB (91.37%), BY (92.01%), and EB (96.90%) in isopropanol.

Nanocellulose composites with enhanced mechanical and flame-retardant properties based on grafting of inorganic organic/multilayer core-shell matter — MSNs-TMSB/DA/TOCNF

Qingshuo Wang,Lanfeng Hui,Yiyi Zhang,Wenwen Guo,Chengfeng Zhu,Mingyue Zhao,Qian Yang,Yu Qu,Zitong Zhang

Flame retardant materials are essential for safety, yet their development is often hindered by trade-offs between efficiency, aging resistance, and mechanical properties. Traditional organic flame retardants are inefficient and degrade over time, while inorganic alternatives, despite their effectiveness, are difficult to integrate into composites. Here we showed the synthesis of a novel inorganic silica-based flame retardant, PDA@MSNs-TMSB, which chemically modified nanocellulose fibrils, enhancing flame retardancy, aging resistance, and toughness without compromising integrity. The results showed that, compared to pure TOCNF, the modified nanocellulose materials (TOCNF-PDA@MSNs-TMSB) exhibited a higher limiting oxygen index (46.5 %), reaching the UL-94 V-0 level (GB) rating with self-extinguishing behavior and no flame propagation. In contrast, pure TOCNF had a limiting oxygen index of only 22 % and burned rapidly upon ignition which did not achieve the UL-94 V-0 level rating. The toughness of the modified TOCNF-PDA@MSNs-TMSB was superior to that of pure TOCNF, representing a 37.5 % increase. Combining powerful tenacity, high flame retardancy, and better aging resistance, the flame retardant nanocellulose material from renewable resource shows great potential for flame retardant applications and emits no toxic byproducts post-combustion.