E-POLYMERS
·
2022
·Vol. 22
·期 1
·223-233
·
IF 3.074
Shaofeng Liang,Yuxuan Qin,Wei Gao,Muqun Wang
In this study, we have produced a lightweight foam composite material by a simple freeze-drying method, which is composed of carboxylated multi-walled carbon nanotubes (MWCNTs), mesoporous carbon hollow microspheres (MCHMs), water-based polyurethane (WPU), and polyvinyl alcohol (PVA). MCHMs were prepared by a novel and facile method. We found that the electromagnetic shielding performance of foam composites can be adjusted by adjusting the density of foam composites, and the electromagnetic shielding performance of composites can be enhanced through the synergistic effect of hollow mesoporous carbon and MWCNTs. The composite material with a density of 232.8042 mg·cm −3 and 40 wt% MWCNT has a δ of 30.2 S·m −1 and SE of 23 dB. After adding 10 wt% MCHMs to the composite material, δ reaches 33.2 S·m −1 , and SE reaches 28 dB. Both absorption losses accounted for 70%. The increase in the content of MWCNT, the increase in density, and the introduction of MCHMs all have a positive effect on the δ and SE of the composite material.
研究领域:
材料科学
·
电磁学
✓ 已验证
DOI
高影响因子
JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
·
2016
·Vol. 16
·期 1
·1060-1066
·
IF 1.338
Lv Xiangying,Wang Yonghao,Wang Yongjing,Lin Zhang
The self-supported ZnS microsphere composed of interwoven nanosheets was synthesized by hydrothermal method. The as-prepared ZnS powders were characterized by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The photocatalytic activity of the fabricated ZnS powders was
evaluated by the degradation of 2,4-dichlorophenol (DCP) under UV light. Effects of DCP initial concentration, ZnS dosage, solution pH, light source, and dissolved oxygen on DCP photocatalytic degradation efficiency were investigated and optimized systematically. Results demonstrated that
53% of DCP could be effectively degraded under the optimal experimental conditions. Finally, highperformance liquid chromatography (HPLC) and gas chromatography-mass spectrometry (GC-MS) were used to analyze the degradation products. Based on the experimental results obtained, a probable degradation
pathway was proposed.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
INTERNATIONAL JOURNAL OF PHARMACEUTICS
·
2025
·
IF 5.2
Bingwen Zhang,Haofan Liu,Yixuan Li,Tong Cao,Jinkuo Cao,Liandong Hu
This paper proposes a novel and efficient centrifugal microfluidic technology to prepare risperidone-loaded poly(lactic-co-glycolic acid) (PLGA) microspheres (RIS-MS). The effects of key parameters, including PLGA concentration and type, microchannel inner diameter and centrifugal speed on particle size, morphology and drug release were evaluated and optimized. The in vivo pharmacokinetic study of RIS-MS was conducted in rabbits. The results demonstrated that RIS-MS could be produced from microchannels with inner diameters of 170–210 μm at a centrifugal speed of 400 revolutions per minute (rpm) when the PLGA content is 15 % or higher. The mean plasma concentration of RIS-MS was more stable and C max of RIS-MS was significantly lower than that of the suspension group, and the RIS-MS could maintain the release of RIS in rabbits for up to 42 days. This study provided pioneering ideas for developing microspheres using centrifugal microfluidic technology. The optimized RIS-MS can make excellent sustained release and have the potential for the long-acting therapy of schizophrenia.
研究领域:
制药工程
·
生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Penghui Wang,Yingying Yang,Yudong Yin,Hua Zhang,Tianqi Shi,Wenjie Zhang,Huiyun Liao,Shuang Li,Xiaoyan Tan,Zheng Yao,Bo Chi
Hydrogel microspheres have attracted extensive attention as the key carriers for drug delivery and cell culture. The traditional microspheres are limited in their application in the regenerative medicine fields due to their closed surface structure and biological inertness. To this end, this study used polylactic acid and selenocysteine modified hyaluronic acid through microfluidic technology and a microsphere surface modification strategy to prepare a hydrogel porous microsphere with reactive oxygen species (ROS) responsive properties and achieved effective removal of ROS through Se–Se rupture. It was then incorporated into a glycopeptide hydrogel, cross-linked by polyglutamic acid and hyaluronic acid, incorporating poloxamer. The glycopeptide hydrogels/microspheres with temperature response characteristics were prepared to reconstruct the dynamic microenvironment required for the repair and regeneration of damaged tissues. The interaction between dynamic and static bonds in the hydrogel system gives the microsphere composite hydrogel excellent injectability, mechanical strength, structural stability, organizational adaptability, and biocompatibility. It can be used as a tissue implant material in the field of tissue regeneration and cell microenvironment reconstruction with a broad application potential.
研究领域:
生物材料学
·
再生医学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Polymer Materials
·
2025
·
IF 4.7
Yehui Liang,Xiaoying Li,Guanxiang Zhong,Ruoyu Chen,Wenyang Kou,Kai Wang,Hetao Chu
Polyimide films have been widely used in the fields of microelectronics and aerospace due to their exceptional overall performance. However, achieving simultaneous improvements in the dielectric, toughness, and mechanical properties of PI films has been a critical and challenging problem. Herein, pyromellitic dianhydride and 4,4′-oxydianiline were used as reactive monomers to prepare polyamic acid porous microspheres (PM) (PAA–PM) and polyimide PM (PI–PM) using a multiple emulsion method. The results show that PAA–PM has high transverse relaxation times (T2) in the precursor solution, which enables high additive capacity, and its homogeneous dispersion in the precursor solution benefits from the hydrogen bond interactions between the carboxyl groups of PAA–PM and the molecular chains of the precursor. Due to the formation of a microcross-linking bridged structure between PAA–PM and the precursor after thermal imidization, the toughness of the final composite film was increased by 332.6% compared to pure PI film, while the tensile strength and elongation at break were improved by 24.5% and 71.1%, respectively. In addition, the dielectric constant decreased by 23.1% (from 3.63 to 2.79 at 1 MHz) and the incorporation of microspheres has almost no effect on thermal stability of the film (T5% of 559.46 °C). The PM effectively mitigated the deterioration of dielectric properties caused by the reduction of the free volume fraction during the thermal stretching of the films.
研究领域:
材料科学
·
微电子学
·
航空航天工程
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2024
·
IF 2.7
Chunbao Du,Zichun Feng,Changji Yin,Xingang Jia,Yameng Zhao,Yuan Cheng
Topical fluid foam has a considerable application value in the field of topical medicine due to benefits such as simple uniform distribution on the skin’s surface, ease of use, and good patient compliance. The longevity of topical fluid foam is crucial in assessing its therapeutic success, particularly in complicated heat and salt settings. Nanoparticles could improve the stability of topical fluid foam, but their density, size, homogeneity, and surface characteristics are difficult to be taken into consideration simultaneously, resulting in the unclear underlying molecular mechanism. In this work, the raspberry-like microspheres (RM) with a high cross-linked structure were synthesized using a simple one-step dispersion polymerization. The stabilizing foam function of RM in fluid foam was connected to their size, surface chemical characteristics, and foaming temperature. The effect of gravity on foam stability induced by liquid flow acceleration of RM competed fiercely with their size and surface chemical characteristics, and this competitive connection was highly influenced by temperature. The unique surface properties of RM1 (polymerization time of 1h) allowed for their irreversible adsorption at the gas-liquid interface following sodium dodecyl sulfate (SDS) adsorption. RM1 could counteract the harmful effect of gravity on foam stability at a high temperature of 60 oC, enhancing the surface elasticity of the liquid film and improving foam stability. This work is a fantastic starting point for the development of novel nanomaterials to improve the stability of topical fluid foam for pharmaceutical and medical applications.
研究领域:
药学
·
材料科学
·
胶体与表面化学
✓ 已验证
产品关联
DOI
高影响因子
Science Bulletin
·
2025
·
IF 21.1
Fangke Zhang,Jiancheng Zheng,Fei Wang,Yaping Zhuang,Yunkai Tang,Juan Wang,Yawei Du,Wei-Li Zhao,Min Lu,Weiguo Hu,Wenguo Cui
Mutations in cytoplasmic DNA-degrading enzymes can lead to the accumulation of cytoplasmic DNA (cytoDNA), which excessively activates DNA-sensing pathways and exacerbates inflammatory aging. Reducing cytoDNA levels to suppress DNA-sensing mechanisms is therefore critical for treating elderly-onset rheumatoid arthritis (EORA). In this study, we constructed Trex1 mRNA loaded lipid nanoparticles (LNPs) via microfluidics and prepared DNase I loaded polydopamine (PDA) nanoparticles through oxidative polymerization. These two components were co-encapsulated into methacrylated hyaluronic acid (HAMA) microspheres using microfluidic photopolymerization. The LNPs incorporate cationic lipids to facilitate mRNA loading and promote endosomal escape, enabling efficient translation of TREX1 and subsequent recognition and degradation of cytoDNA. Meanwhile, cationic mesoporous polydopamine electrostatically adsorbs and degrades extracellular DNA. The microspheres function as a reservoir for sustained nanoparticle release, enabling synergistic inhibition of DNA sensing pathways. This microsphere based vaccine upregulates TREX1 expression in antigen-presenting cells (APCs) and reduces cytoDNA levels, thereby suppressing overactivation of the cGAS-STING signaling axis and promoting immune tolerance. It also attenuates the differentiation of CD4+ T cells into Th1, Th2, Th17, and Treg subsets. In an aged rat model of rheumatoid arthritis, the vaccine alleviated soft tissue swelling, synovitis, and cartilage and bone damage. By clearing excess cytoDNA and restraining DNA-sensing hyperactivation, this vaccine induces cellular immune tolerance and represents a promising therapeutic strategy for rheumatoid arthritis in the elderly.
研究领域:
免疫学
·
纳米医学
·
分子生物学
·
疫苗学
·
风湿病学
·
衰老研究
·
基因治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Acta Biomaterialia
·
2025
·
IF 9.6
Qilong wang,Zeyu Xu,Xuedi Weng,Min Ni,Michael Adu-Frimpong,Xiaoli Li,Yize Lv,Li Jinghan,Hongran Huang,Yue Sun,Ziyun Wu,Xia Cao
Repair of skin injuries is often hindered by the challenge of neovascularization, particularly in severely damaged wounds that struggle to self-heal, potentially leading to organ dysfunction or even death. Thus, promoting vascularization is crucial for effective skin repair. This study employed electrostatic spraying to fabricate methacrylated hyaluronic acid (HAMA) hydrogel microspheres for encapsulation of ectodermal mesenchymal stem cells (EMSCs), and optimization of the process parameters to assess their biocompatibility. Under in vitro conditions, EMSCs microspheres were successfully induced to differentiate into structures with vascular networks. Additionally, the optimal modification ratio of dopamine-modified hyaluronic acid (HADA) was determined to enhance the adhesive and mechanical properties of the dressing. Based on these findings, a dressing incorporating cell microspheres and adhesive hydrogels was developed. This dressing demonstrated formation of microvascular structures in vitro . Upon in vivo transplantation, it integrated tightly with surrounding tissues, modulated the inflammatory response, and accelerated wound healing in mouse model. This composite dressing, integrating cell-laden microspheres within a hydrogel’s framework, offers a simple and effective approach to promote skin microvascular. Statement of Significance : This study describes a hydrogel dressing that uses electrostatically sprayed methacrylated hyaluronic acid (HAMA) microspheres to encapsulate ectodermal mesenchymal stem cells (EMSCs). The hydrogel composition was optimized using dopamine-modified hyaluronic acid (HADA), which improved adhesion, while methacrylated polyvinyl alcohol (PVAMA) enhanced mechanical strength. This highly effective, low-risk hydrogel dressing promoted angiogenesis and accelerated wound healing. The results of this study highlight the potential of hydrogel dressing for clinical applications in tissue engineering and regenerative medicine, thus providing a promising strategy for the treatment of severe skin injuries.
研究领域:
生物医学工程
·
组织工程
·
再生医学
·
生物材料
·
干细胞治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
OPTICAL MATERIALS
·
2022
·
IF 3.754
Jian Lin,Yulian Tao,Jialiang Liu,Chan Zheng,Xiaoyi Song,Pingqiang Dai,Qianting Wang,Wei Li,Wenzhe Chen
Photocatalytic micromotors hold considerable promise for use in water remediation owing to the synergistic effect of a combination of photocatalytic activity and self-propulsive behavior. We designed a symmetric TiO 2 @carbon microsphere (CMS) core–shell micromotor with photocatalytic TiO 2 for enhanced degradation of organic contaminants. TiO 2 @CMS micromotors were obtained via a facile sol–gel method and subsequent heat treatment to obtain an anatase TiO 2 shell. The self-propulsion of TiO 2 @CMS micromotors is governed by asymmetric decomposition of H2O2 via asymmetric illumination of the spherical particles. The photocatalytic propulsion can be switched on and off by modulating the incident light. The speed of the photocatalytic TiO 2 @CMS core–shell micromotors can be increased by increasing either the light intensity or concentration of the chemical fuel, i.e., H 2 O 2 . In the degradation of rhodamine B, the photocatalytic performance of the micromotors was higher than those achieved with control group photocatalysts . The degradation efficiency reached ∼100% in approximately 60 min when all necessary conditions, i.e., use of micromotors, UV irradiation, and H 2 O, were applied. TiO 2 @CMS core–shell micromotors have the advantages of facile preparation, a simple structure, self-propulsion, and a high degradation efficiency and photocatalytic performance. They will therefore be important in the development of methods for water purification and wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2025
·
IF 12.5
Guancheng Liu,Zhe Zhang,Xin Long,Kai Zhang,Yunfeng Li,Bai Yang
The pore structure of cellulose microspheres is vital for their adsorption performance, however it is still challenge to control pore size and their distribution by a simple and cost-effective method. Here, through adjusting volume ratios of ethylene glycol diacetate to n-octanol in the cellulose solution, we prepare cellulose microspheres with adjustable pore size ranging from the micron- to nanometer scale in a straightforward and scalable method. We show that the average diameter of pores in cellulose microspheres is controlled from 4.58 μm to 108.43 nm with the median of pore diameter being from 1.63 μm to 7.69 nm. Cellulose microspheres exhibited good performance in both static and dynamic adsorption of methylene blue dye with a maximum capacity of 20.6 mg/g. A monolayer adsorption mechanism is revealed through fitting the Langmuir isotherm model. Interestingly, cellulose microspheres exhibit compressive strength comparable to that of adsorption resins, with maximum compressive stress ranging from 5.25 to 52.1 MPa, enabling them to pack in adsorption columns. Notably, a removal efficiency of 94.1 % was achieved by using column adsorption. Cellulose microspheres show adjustable pore size, good mechanical properties, and good adsorption performance, which will accelerate their practical applications in the environmental remediation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
MACROMOLECULES
·
2012
·
IF 5.167
Chuanzhuang Zhao,Guangcui Yuan,Charles C. Han
Poly(N-isopropylacrylamide) (PNIPAM) microgels are adsorbable to the surface of polystyrene (PS) microspheres in the experimental temperature range (25–40 °C) and can induce aggregation of microspheres through the bridging mechanism. The bridging mechanism proceeds in two elementary steps: the first is an adsorption (negligible desorption relatively) of free microgel to one microsphere surface, and the next is a reversible connection of the adsorbed microgel to another microsphere surface. The surface coverage is found as an important factor in triggering the stabilization, aggregation, and gelation of the mixtures. And most importantly, the nonnegligible dynamic disconnection of a bridge is the essential prerequisite for structure or state transition. For mixtures with the same concentration of microsphere, depending on the concentration of microgel, various transitions can be induced by changing temperature, including the transition from a weaker gel to a stronger gel, from a fluid to a bridging gel and from a depletion gel to a bridging gel.
研究领域:
材料科学
·
胶体化学
✓ 已验证
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2026
·
IF 12.5
Danlong Yang,Qing Liu,Qianqian Pan,Xude Yu,Yangeng Lan,Jianhong Xu,Tao Wang
Silica aerogel microspheres (SAMs) have attracted considerable interest for applications in catalysis and aerospace, yet the lack of systematic, quantitative design rules remains a major barrier to their scalable synthesis. Herein, we present a mechanism-based, multiscale modeling framework that quantitatively integrates predictive descriptions of each critical step in the synthesis of hydrophobic SAMs. First, droplet formation in microchannels was resolved using CFD-based Volume of Fluid (VOF) simulation, permitting accurate prediction and control of microsphere size via channel geometry and flow conditions (deviations <10%). The subsequent sol–gel transition and surface modification are described by a diffusion-controlled shrinking-core model, establishing explicit relationships between microsphere diameter and reaction time. Finally, classical nucleation theory (CNT) combined with molecular dynamics simulation identifies a critical temperature for cavitation-dominated solvent removal under ambient pressure, enabling the production of shrinkage-free aerogel microspheres. Compared with previous studies, this multiscale, mechanism-driven framework converts an optimized synthesis route into a predictable, engineerable process with clear advantages for scale-up and manufacturing.
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）