NEW JOURNAL OF CHEMISTRY
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2019
·Vol. 43
·期 24
·9466-9471
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IF 3.069
Ke Xing,Jia Ge,Wei-Xia Wang,Xin Geng,Xue-Ping Shen,Jin-Lu Tang,Ling-Bo Qu,Yuan-Qiang Sun,Zhao-Hui Li
Ascorbic acid plays a crucial role in biochemical processes as a scavenger for preventing oxidative damage. Herein, a sensitive and selective fluorescent biosensor for the detection of ascorbic acid was proposed based on green-emission fluorescent silicon nanoparticles (SiNPs) and bovine serum albumin (BSA) templated-MnO2 nanosheets. Green-emission fluorescent SiNPs have been synthesized by a facile one-pot reduction reaction at room temperature by using DAMO and 3-hydroxytyramine hydrochloride as the silicon source and the reactants, respectively. The fluorescence of the SiNPs could be effectively quenched by MnO2 nanosheets. When ascorbic acid is introduced, the MnO2 nanosheets are reduced to Mn2+ ions by ascorbic acid, resulting in the fluorescence recovery of SiNPs. This sensing system exhibits a good linear range for ascorbic acid detection from 1 to 400 μM with a detection limit of 0.102 μM. Meanwhile, the detection system also exhibits high selectivity against other possible co-existing species. The present sensor was successfully applied for the detection of ascorbic acid in a commercially available vitamin C supplement, suggesting this sensing system holds great potential in food safety and disease diagnosis.
研究领域:
生物化学
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纳米技术
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分析化学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
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2021
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IF 4.098
Fuming Sang,Menglin Li,Suyao Yin,Huahua Shi,Yan Zhao,Zhizhou Zhang
Glutathione (GSH) plays a critical role in biological defense system and is associated with numerous human pathologies. However, it still remains a challenge for fluorescent detection of GSH over cysteine (Cys) and homocysteine (Hcy) because of their similar structures. In this work, MnO 2 nanosheets can efficiently quench the fluorescence of gold nanoclusters (Met-AuNCs) prepared by blending methionine and HAuCl 4 owing to their superior absorption capability. However, GSH can reduce MnO 2 nanosheets into Mn 2+ which leads to the fluorescence recovery of Met-AuNCs. More intriguingly, GSH can dramatically and selectively enhance the fluorescence intensity of Met-AuNCs. Hence, a low background, ultrasensitive fluorescent detection of GSH was obtained with a detection limit of 68 nM. Moreover, the assay has been successfully used for GSH detection in human serum samples and cellular imaging with high selectivity over Cys and Hcy.
研究领域:
生物化学
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分析化学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Materials Today Communications
·
2018
·
IF 0
Jing Liu,Hongbo Cui,Siyu Yan,Xunan Jing,Daquan Wang,Lingjie Meng
We report a facile fabrication approach for sensitive theranostic nanoprobe - gold [email protected] 2 nanosheets, by which gold nanostars were grown on the surface of MnO 2 nanosheets. Owing to the ability of gold nanostars to absorb light at near infrared (NIR) wavelength, the nanoprobe showed excellent photothermal conversion effect, while exhibited tumor microenvironment-responsive magnetic resonance imaging property due to the redox property of MnO 2 nanosheets. Amazingly, photothermal irradiation experiment showed that the nanoprobe sensitively triggered lung cancer cell death, while produced negligible effect on normal lung epithelial cells. Therefore, these demonstrate that the nanoprobe may have potential application in magnetic resonance imaging-guided photothermal therapy of lung cancer.
研究领域:
纳米技术
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生物医学工程
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癌症研究
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DOI
Analytical Methods
·
2016
·Vol. 8
·期 19
·3935-3940
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IF 1.915
Shichao Lin,Hanjun Cheng,Qiran Ouyang,Hui Wei
Two-dimensional (2D) nanomaterials (such as 2D MnO2 nanosheets) have received increasing attention due to their unique photophysical properties, rich redox chemistry, excellent colloidal stability, good biocompatibility, etc. Recently, numerous sensing platforms have been reported by exploring the 2D MnO2 nanosheet mediated fluorescence quenching towards fluorophores and/or redox reactions between MnO2 and reductive targets. Though various fluorophores have been used in 2D MnO2 nanosheet based turn-on sensing systems, ultrasmall metal nanoclusters have not been exploited yet. Furthermore, the quenching mechanisms of MnO2 nanosheets towards various fluorophores have remained elusive. To address these issues, we studied the quenching of Au nanocluster fluorescence by 2D MnO2 nanosheets. First, we demonstrated that 2D MnO2 nanosheets were effective quenchers towards the fluorescence of metal nanoclusters (e.g., AuNC@BSA, the bovine serum albumin stabilized Au nanocluster). We further revealed that both dynamic and static quenching effects played critical roles in the quenching process while fluorescence resonance energy transfer (FRET) and inner filter effect (IFE) only played very minor roles in the quenching process. Finally, we developed a turn-on sensing strategy for detection of glutathione (GSH), an important antioxidant with good sensitivity and selectivity. This work provides useful insights in understanding the mechanisms of nanomaterial-induced fluorescence quenching. It also paves a way to design turn-on fluorescent sensors for important reductive targets.
研究领域:
材料科学
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分析化学
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生物医学工程
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产品关联
DOI
高影响因子
TALANTA
·
2020
·
IF 5.339
Yun Shu,Jinlong Gao,Jingyuan Chen,Jing Yan,Jiawei Sun,Dangqin Jin,Qin Xu,Xiaoya Hu
Near−infrared (NIR) emitting Ag 2 S quantum dots (QDs) are excellent fluorescent nanoprobes for bioassays with low toxicity. A novel fluorescent sensing platform which employing NIR fluorescent Ag 2 S QDs and MnO 2 2D nanosheets as NIR emitters and quenchers is designed for rapid and selective determination of glutathione (GSH). A facile and efficient approach was demonstrated for the synthesis of NIR fluorescent Ag 2 S QDs with the emission of 845 nm. Then the NIR fluorescent nanoprobe of Ag 2 S QDs−MnO 2 nanosheets is obtained by adsorbing Ag 2 S QDs onto the surface of MnO 2 nanosheets which have atomically thick two−dimensional structure and high specific surface area. And the NIR fluorescence of Ag 2 S QDs is quenched by the MnO 2 nanosheets. The presence of GSH could reduce MnO 2 to Mn 2+ that results in the restoration of NIR fluorescence for Ag 2 S QDs. The NIR fluorescent nanoprobe could be used for highly selective detection of GSH. Also a low detection limit of 60 μmol/L was obtained. Because NIR fluorescence of the Ag 2 S QDs can efficiently reduce the interferences from background scattering and autofluorescence. The NIR fluorescent nanoprobe was directly applied to monitor the GSH level in human serum sample with high accuracy and precision.
研究领域:
生物传感
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纳米医学
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Nano
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2021
·
IF 15.881
Xiaodong Zhu,Ziyi Cao,Wenjie Wang,Haijing Li,Juncai Dong,Shangpeng Gao,Dongxiao Xu,Lei Li,Jianfeng Shen,Mingxin Ye
Mn-based aqueous zinc-ion batteries (ZIBs) are promising candidate for large-scale rechargeable energy storage because of easy fabrication, low cost, and high safety. Nevertheless, the commercial application of Mn-based cathode is hindered by the challenging issues of low rate capability and poor cyclability. Herein, a manganese–vanadium hybrid, K–V2C@MnO2 cathode, featured with MnO2 nanosheets uniformly formed on a V2CTX MXene surface, is elaborately designed and synthesized by metal–cation intercalation and following in situ growth strategy. Benefiting from the hybrid structure with high conductivity, abundant active sites, and the synergistic reaction of Mn2+ electrodeposition and inhibited structural damage of MnO2, K–V2C@MnO2 shows excellent electrochemical performance for aqueous ZIBs. Specifically, it presents the high specific capacity of 408.1 mAh g–1 at 0.3 A g–1 and maintains the specific capacity of 119.2 mAh g–1 at a high current density of 10 A g–1 in a long-term cycle of up to 10000 cycles. It is superior to almost all reported Mn-based cathodes for ZIBs in the aqueous electrolyte. The superior electrochemical performance suggests that the Mn-based cathode materials designed in this work can be a rational approach to be applied for high-performance ZIBs cathodes.
研究领域:
材料科学
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电化学
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产品关联
DOI
PubMed
高影响因子
SENSORS
·
2018
·Vol. 18
·期 8
·2525
·
IF 2.475
Zhengjun Huang,Linlin Zheng,Feng Feng,Yuyuan Chen,Zhenzhen Wang,Zhen Lin,Xinhua Lin,Shaohuang Weng
Simple and effective methods for the detection of the level of blood glucose are closely linked to the monitoring of people’s health. In the study, MnO2nanosheets with absorption range of 300 nm~500 nm and obvious yellow color were easily prepared and applied to detect glucose through their absorbance and color. The proposed method is based on the fact that a specific concentration of glucose can be quantitatively transformed into hydrogen peroxide (H2O2) under the catalytic effect of glucose oxidase. Based on the redox reaction of MnO2with H2O2, yellow MnO2can be converted into colorless Mn2+to monitor the concentration of glucose. Under optimal conditions, a simple and effective visual assay for the sensitive and reliable detection of glucose was developed. The linear range was estimated to the range from 0 μM to 100 μM, with a detection limit of 12.8 μM. Furthermore, the proposed colorimetric assay based on MnO2nanosheets can effectively detect blood glucose of clinical serum samples with accuracy and convenience.Keywords:glucose;colorimetric assay;MnO2nanosheets;UV-vis;quantitative determination
研究领域:
生物化学
·
医学检测
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产品关联
DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2017
·Vol. 184
·期 9
·3399-3404
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IF 4.58
Song Hu,Wang Yunhan,Wang Guanquan,Wei Hongyuan,Luo Shunzhong
The authors report on a chromogenic system based MnO 2 nanosheet and the chomgenic substrate 3,3′,5,5′-tetramethylbenzidine (TMB). The MnO 2 nanosheet can oxidize TMB in acidic environment to form a yellow solution with an absorption peak at 450 nm. The process does not require the presence of an enzyme or H 2 O 2 . However, on addition of ferrous ion to the chromogenic system, the MnO 2 nanosheet is decomposed via the redox reaction that occurs between Fe(II) and MnO 2 . As a result, the intensity of the absorption at 450 nm is reduced. This finding is exploited in a photometric method for determination of Fe(II) that shows high selectivity and a 0.3 μM detection limit (based on the 3σ/slope criterion). Fe(II) can also be detected visually in concentrations down to 100 μM. The method was applied to the determination of Fe(II) in spiked water samples and gave satisfactory recoveries.
Schematic illustration of the chromogenic system composed of MnO 2 nanosheets and 3,3′,5,5′-tetramethylbenzidine (TMB) for highly sensitive colorimetric detection of ferrous ion (Fe 2+ )
研究领域:
分析化学
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材料科学
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产品关联
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Bicheng Liu,Zoujun Peng,Sihao Wu,Tianshuang He,Ping Qiu
In this paper, a novel fluorescence assay has been constructed for the determination of parathion-methyl (PM) by using 4-amino-3-hydroxy-1-naphthalenesulfonic acid (AHNSA) as probe. MnO 2 nanosheets (MnO 2 NS) could quench the fluorescence of AHNSA, while Mn 2+ , the reduction product of MnO 2 NS, has no influence on it, resulting in fluorescence recovery. This is because that MnO 2 NS have oxidized characteristic, and they can react with choline (TCh), which is the product of acetylthiocholine (ATCh) catalyzed by acetylcholinesterase (AChE). In the presence of OPs, the activity of AChE was inhibited, accompanied by the restraint of the redox reaction of MnO 2 NS, therefore the fluorescence of AHNSA was quenched. Under the optimized experimental conditions, a linear range of PM was determined to be 0.4–40 ng/mL (R 2 = 0.997) by the proposed method with the limit of detection for 0.18 ng/mL (S/N = 3). The assay was successfully applied to the determination of PM in lake water, which average recoveries were between 86.5% and 114.4%.
研究领域:
分析化学
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环境科学
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毒理学
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DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Tiantian Yao,Anran Liu,Yong Liu,Min Wei,Wei Wei,Songqin Liu
The detection of organophosphorus pesticides (OPs) has received considerable attention for their great harm to human beings. Herein, a novel ratiometric fluorescence biosensor was constructed for the determination of OPs by using Scopoletin (SC) and Amplex Red (AR) as probe pairs that have opposite responses to MnO 2 nanosheets (MnO 2 NS). MnO 2 NS possess peroxidase-like catalytic activity , which could quench the fluorescence of SC as well as enhance the fluorescence of the non-fluorescent substance AR by oxidation . In the absence of OPs, acetylcholinesterase (AChE) hydrolyzed acetylcholine chloride (ATCh) into choline (TCh) and acetate. TCh led the decomposition of MnO 2 NS to manganese ions (Mn 2+ ), increasing signal of SC and decreasing signal of AR. In the presence of OPs, the activity of AChE was inhibited and the decomposition of MnO 2 NS was hindered, therefore the fluorescence intensity of SC was weak and the fluorescence intensity of AR had an obvious increase. Moreover, under the optimal conditions, the ratio of fluorescence intensity response recorded on the AR/SC increases with increasing the concentration of DDVP. The method has wider linear range of 5.0 pg/mL ∼500 ng/mL with a detection limit of 1.6 pg/mL, which is superior to previously reported methods. This strategy has also been applied to a visual observation based on the color change of the solution under UV light.
研究领域:
分析化学
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环境科学
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生物传感技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2021
·
IF 4.098
Yingfeng Qin,Gaojie Ye,Hao Liang,Ming Li,Jingjin Zhao
It is highly desirable to develop a simple, efficient and sensitive strategy for organophosphorus pesticides (OPs) in both environment pollution and human health. Herein, a novel amplified fluorescence polarization (FP) biosensor was established for highly sensitive detection of OPs using MnO 2 nanosheets as the signal enhancer. In this system, OPs can suppress the activity of acetylcholinesterase (AChE) efficiently, blocking the hydrolysis reaction of acetylthiocholine (ATCh) to generate thiocholine (TCh) by AChE. TCh can lead the decomposition of MnO 2 nanosheets to manganese ions. So, without the influence of TCh, MnO 2 nanosheets can maintain its original shape and form a stable complex with FAM-DNA, which greatly enhanced the FP signal. This method can tremendously improve the sensitivity of FP with a detection limit of 0.01 ng/mL for diazinon. In addition, it was also applicable to determine other four OPs and investigate the level of diazinon in real water samples. Consequently, the proposed approach provides a new promising platform for detection of OPs and is expected to be used in application of environmental monitoring.
研究领域:
环境科学
·
分析化学
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生物传感
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产品关联
DOI
PubMed
高影响因子
ANALYTICAL AND BIOANALYTICAL CHEMISTRY
·
2015
·Vol. 408
·期 4
·1231-1236
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IF 3.436
He Yi,Wang Zeru,Long Dengying
The increasing application of nanomaterials will inevitably lead to their release into the environment, which may pose a threat to the environment and human health. As such, there is an urgent need to detect various nanomaterials. In the present work, we present a novel, rapid, and simple visual detection of MnO 2 nanosheets in buffer solution and environmental water sample. In this assay, a redox reaction between MnO 2 nanosheets and 3,3′,5,5′-tetramethylbenzidine (TMB) occurred, leading to the oxidation of TMB to TMB diimine. This redox reaction generated different colors dependent on the concentration of MnO 2 nanosheets, including colorless, blue, green, and yellow, which allowed semiquantitative detection of MnO 2 nanosheets with the naked eye. The detection range of the visual assay was 2–15 μg/mL, and the minimum concentration of MnO 2 nanosheets can be visually detected at concentrations down to 2.0 μg/mL. Moreover, the developed visual assay showed a high selectivity to MnO 2 nanosheets over Mn 2+ ions, tetramethylammonium hydroxide, hydrogen peroxide, graphene oxide, and graphitic carbon nitride nanosheets.
Visual detection of MnO 2 nanosheets
研究领域:
环境科学
·
纳米技术
·
分析化学
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产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）