International Journal of Nanomedicine
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2025
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IF 6.5
Jinlu Shang,Yongjun Chen,Fangliang Wang,Jing Yang,Yi Li,Liuxuan Yang,Xiuqiong Liu,Zhirong Zhong,Chaochi Yue,Meiling Zhou
Background Melanoma is an aggressive form of skin cancer, and single-modality treatments often fail to prevent tumor recurrence and metastasis. Combination therapy has emerged as an effective approach to improve treatment outcomes.Methods In this study, we developed a multifunctional nanoplatform, MIL@DOX@ICG, utilizing MIL-101-NH2(Fe) as a carrier to co-deliver the chemotherapeutic agent doxorubicin (DOX) and the photosensitizer indocyanine green (ICG). MIL-101-NH2(Fe) was synthesized via a hydrothermal method. Drug release was evaluated under different pH conditions, and the photothermal effect was tested under near-infrared (NIR) laser irradiation. Hydroxyl radical and reactive oxygen species generation capacities were quantified. Cellular studies using B16F10 cells assessed cytotoxicity, cellular uptake, migration inhibition, and colony formation suppression. In vivo experiments in melanoma-bearing mice evaluated antitumor efficacy and systemic safety through tumor growth inhibition, histological analyses, and toxicity assessments.Results MIL@DOX@ICG exhibited a uniform octahedral structure with a particle size of approximately 139 nm and high drug loading efficiencies for DOX (33.70%) and ICG (30.59%). The nanoplatform demonstrated pH-responsive drug release and potent photothermal effects. The generation of hydroxyl radicals via the Fenton reaction and reactive oxygen species production under NIR laser irradiation by MIL@DOX@ICG were confirmed. In vitro assessments revealed significant cytotoxicity of MIL@DOX@ICG against B16F10 cells under NIR laser irradiation, with improved efficacy in inhibiting cell proliferation and migration. In vivo studies confirmed the superior antitumor efficacy of MIL@DOX@ICG + NIR treatment, synergistically harnessing chemotherapy, photothermal therapy, photodynamic therapy, and chemodynamic therapy effects while maintaining excellent biocompatibility.Conclusion Our findings underscore the potential of MIL-101-NH2(Fe) nanoparticles as a versatile and effective platform for synergistic melanoma therapy, offering a promising strategy for overcoming the limitations of conventional treatment modalities.
研究领域:
肿瘤学
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纳米医学
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生物材料学
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DOI
PubMed
高影响因子
CHEMISTRY AND ECOLOGY
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2024
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IF 1.3
Zhenpeng Li,Dongmei Yan,Jun Li,Ziwei Mai,Fuchuan Huang
Hexavalent chromium (Cr(VI)) is regarded as a water pollutant because of its high toxicity in aquatic environments. In this study, polyethyleneimine-functionalised NH2-MIL-101(Cr) (PEI@NH2-MIL-101(Cr)) was fabricated by a facile wet impregnation method, and its effectiveness at removing Cr(VI) from wastewater was systematically investigated. As suggested by the experimental findings, pH was a significant determinant of Cr(VI) uptake by the fabricated PEI@NH2-MIL-101(Cr). Preferable depiction of adsorption system was achievable with the Langmuir adsorption model and the pseudo-order 2 kinetic model. At 288, 298, and 308 K, the highest adsorbability values were 241.55, 310.56, and 408.16 mg g−1, respectively. Processes like electrostatic attraction, reduction and chelation helped promote the Cr(VI) elimination. SO42− ions had a relatively large impact on the Cr(VI) adsorption compared with other coexisting ions such as NO3−, Cl− and H2PO4−1. Because of its properties of high adsorption capacity and Cr(VI) detoxification, the potential of PEI@NH2-MIL-101(Cr) in the Cr(VI) elimination from wastewater appears to be promising.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
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2025
·Vol. 36
·期 19
·1-15
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IF 2.8
Li Zi-Yan,Li Ya-Jun,Li Wei,Wang Ze-Hong,Zhao Zhao-Ye,Zhou Ting-Ting,Huang Yi-Rui,Wu Xiang-Feng,Zhang Peng-Liang,Zhen Zi-Yan,Ci Li-Jie
In this study, a photoelectrochemical sensor for the detection of glucose was developed by combining the unique properties of NH 2 -MIL-125 and Ti 3 C 2 film. The relationship between the microstructure of the samples and their performance in glucose detection was investigated. Experimental results demonstrated a linear decrease in the differential pulse voltammetry current of the Ti 3 C 2 /NH 2 -MIL-125-3 photoelectrochemical sensor with increasing glucose concentration. Below 200 μM, the relationship between DPV current and glucose concentration was found to be: I (mA) = − 3.86667 × 10 –8 ·c g (μM) + 3.66 × 10 –4 (c g denoted as the concentration of glucose). Above 200 μM, the relationship was: I (mA) = − 4.03049 × 10 –8 ·c g (μM) + 3.68268 × 10 –4 . Density functional theory calculations were in agreement with the experimental data. The Ti 3 C 2 /NH 2 -MIL-125-3 photoelectrochemical sensor demonstrates exceptional glucose detection capability. This technology has the potential to advance the development of MXenes/MOFs-based photoelectrochemical biosensors.
研究领域:
生物传感
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材料科学
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分析化学
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DOI
高影响因子
KOREAN JOURNAL OF CHEMICAL ENGINEERING
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2022
·Vol. 39
·期 7
·1839-1849
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IF 3.146
Zhang Xiaoting,Zhang Shusheng,Ouyang Gangfeng,Han Runping
A zirconium-based metal organic framework (UiO-66-NH 2 ) was prepared using a greener approach for the removal of hexavalent chromium (Cr(VI)) from solution. The characterization of UiO-66-NH 2 was performed using several methods, and the influence of the solution pH, adsorbent dosage, salt, adsorption time, Cr(VI) concentration and adsorption temperature on adsorption quantity was performed in batch mode. UiO-66-NH 2 can efficiently remove Cr(VI) through the synergistic effect of adsorption and reduction. At pH solution of 1.1 and solid-to-liquid ratio of 2 g·L −1 , the removal rate of 100 mg·L −1 Cr(VI) increased to 95.2%. The maximum adsorption capacity of UiO-66-NH 2 from Langmuir model was 252 mg·g −1 . The adsorption equilibrium process can be well described by Langmuir, Koble-Corrigan and Temkin models, while the kinetic process can be predicted by pseudo-second-order and Elovich model. UiO-66-NH 2 showed a good adsorption capacity in a wide range of pH (pH=1.1–10) and also had better regeneration performance after five cycles using 0.01 mol·L −1 NaOH; consequently, it can be a promising adsorbent for the removal of Cr(VI) from solution.
研究领域:
环境科学
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材料科学
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DOI
高影响因子
MATERIALS SCIENCE IN SEMICONDUCTOR PROCESSING
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2024
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IF 4.2
Z.H.A.O.-X.U.A.N. Jiang
In this investigation, UiO-66-NH 2 was effectively synthesized through a solvothermal approach, utilizing benzoic acid and hydrochloric acid (HCl) as modulating agents. This synthesis process intentionally introduced defects mediated by benzoic acid, and the degree of these defects was precisely adjusted by the concentration of HCl. Subsequently, the material underwent a covalent modification process through an amidation reaction, resulting in the attachment of tetrakis (4-carboxyphenyl) porphyrin (TCPP). The results demonstrated a significant improvement in the photocatalytic reduction of Cr(VI), showcasing a 125 % elevation in reduction efficiency as compared to the unmodified UiO-66-NH 2 material serving as the baseline. The performance enhancement is due to the synergistic effect of the defect structure and TCPP modification, which enhances the light absorption, promotes charge transfer and separation, reduces the recombination rate, and improves the adsorption capacity and light absorption efficiency of Cr(VI). This research introduces an innovative approach and a highly effective catalyst, offering a novel solution for modifying metal-organic frameworks (MOFs) and enhancing their photocatalytic performance in the reduction of Cr(VI).
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
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2018
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IF 6.578
Xiong-Fei Zhang,Yi Feng,Zhongguo Wang,Mingmin Jia,Jianfeng Yao
Incorporating metal-organic frameworks into cellulose matrix to prepare composite membranes is promising in gas-separation applications. In this study, UiO-66-NH 2 (Zr-based MOF) nanoparticles are wrapped into the densely packed cellulose nanofibrils (CNF-COOH) via a facile vacuum filtration process. The existence of acid-base interactions and electrostatic forces between UiO-66-NH 2 and CNF-COOH renders ideal interfacial morphology. Results show that UiO-66-NH 2 is cross-linked by -COOH groups and well-dispersed in the CNF matrix. The porous UiO-66-NH 2 strengthens the diffusion process of CO 2 molecules, thus elevating the permeation flux and separation factor simultaneously. The optimum separation performance is achieved over CM-1 membrane with a CO 2 permeability of 139 Barrer and a CO 2 /N 2 selectivity ratio of 46.
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Nanomaterials
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2019
·Vol. 9
·期 9
·1283
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IF 4.034
Hao Zhang,Xiaobo Shi,Jialiang Li,Parveen Kumar,Bo Liu
In this study, Zeolitic Imidazolate Framework-8 (ZIF-8)-loaded UiO-66-NH2was synthesized, characterized, and analyzed for its potential to efficiently remove dyes. The selective adsorption on ZIF-8-loaded UiO-66-NH2or its parent MOFs (UiO-66-NH2and ZIF-8) in the mixed dyes solution was explored, including anionic dye (methyl orange (MO)) and cationic dyes (methylene blue (MB) and rhodamine B (RhB)). ZIF-8-loaded UiO-66-NH2displayed much better selectivity to MB than its parent MOFs. Adsorption capacity of ZIF-8-loaded UiO-66-NH2(173 mg/g) toward MB was found to be 215% higher than UiO-66-NH2(55 mg/g). A kinetics study based on adsorption data demonstrated that the adsorption process most closely matched with the model of pseudo-second-order kinetic and Langmuir isotherm. The adsorption was an exothermic and spontaneous physical process as revealed by the values of thermodynamic parameters. Furthermore, reusability of ZIF-8-loaded UiO-66-NH2was investigated and revealed the significant regeneration efficiency in adsorption capacity for MB even after four adsorption cycles. Experimental results proved that the interaction between ZIF-8-loaded UiO-66-NH2and MB was mainly affected by the mechanism, for instance, electrostatic interaction as well as π–π stacking interactions.Keywords:ZIF-8;UiO-66-NH2composites;metal-organic frameworks;selective adsorption
研究领域:
材料科学
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环境科学
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DOI
PubMed
高影响因子
Surfaces and Interfaces
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2024
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IF 5.7
Pengfei Zhu,Shuang Qin,Mengrong Geng,Heyang Cao,Zhiliang Jin,Chuanyi Wang
Photocatalytic NO removal technology is considered as one of the most effective green methods for reducing atmospheric NO but there remains the problems of lower efficiency and poor stability of photocatalysts . Rapid recombination of photogenerated electron (e − ) and holes (h + ) is known as a key issue that causes low activity and poor stability of catalysts. Herein, we report a novel AgCu@UiO-66-NH 2 photocatalyst (AgCu@UN) that is made up of AgCu alloy on the surface of Zr-MOF (UiO-66-NH 2 ) by employing in-situ photodeposition method. The experimental results of photocatalytic NO removal indicated that the optimized 0.5Ag0.5Cu@UN sample with 0.5 mg of Ag and Cu exhibited the best NO removal efficiency of 63 % for ppb-level atmospheric NO, more higher than that of pure UiO-66-NH 2 (38 %). The characterizations suggested that the excellent photocatalytic performance of 0.5Ag0.5Cu@UN can be ascribed to the efficient charge separation and transfer and the visible-light-harvesting ability due to benefiting electron migration process between AgCu alloys and UN. Moreover, the enriched electrons around AgCu could be transferred to O 2 to generate more superoxide radicals (•O 2 − ), which could oxidize NO to the final product, nitrate (NO 3 − ). The present findings can provide some novel insights for the design of efficient MOF based photocatalysts to eliminate low concentrations of NO X .
研究领域:
材料科学
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环境科学
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化学工程
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DOI
高影响因子
CHEMOSPHERE
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2021
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IF 7.086
Peipei Huang,Lili Yao,Qing Chang,Yunhan Sha,Guodong Jiang,Shenghua Zhang,Zhe Li
The slow redox rate of Fe(III)/Fe(II) couples is a rate-limiting step for Fenton-like performance of Fe-MOFs. In this study, a series of catalysts (MIL-101) with various p-phthalic acid/2-aminoterephthalic acid (H 2 BDC/NH 2 –H 2 BDC) molar ratios were prepared using a simple and mild chemical method and applied for catalyzed degradation of bisphenol A (BPA). Interestingly, the –NH 2 modified MIL-101(Fe) can adjust Fe-Oxo node by increasing the electron density of Fe(III) in the presence of –NH 2 group with high electron density, thus forming Fe(II) in situ in MOFs. Meanwhile, the –NH 2 groups used as electron-donors can promote electron transfer , resulting in faster Fe(III)→Fe(II) half-reaction and active H 2 O 2 to continuously generate •OH radical. The BPA degradation and rate constant of Fe-BDC-NH 2 /H 2 O 2 system are 15.4-fold and 86.8-fold higher than that of Fe-BDC/H 2 O 2 system, respectively. The density functional theory (DFT) calculations showed that Fe-BDC-NH 2 possesses higher Fermi level energy (−4.88 eV) and lower activation energy barriers (0.32 eV) compared with Fe-BDC. Moreover, Fe-BDC-NH 2 showed good reusability and stability. This work offers a highly efficient and stable MOFs-based Fenton-like catalyst to rapidly degrade organic pollutants over a wide pH range for potential applications in wastewater treatment .
研究领域:
环境科学
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材料科学
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化学工程
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DOI
PubMed
高影响因子
JOURNAL OF MATERIALS RESEARCH
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2022
·Vol. 37
·期 21
·3761-3772
·
IF 2.909
Chen Junnan,Lin Wensong,Mai Xin,Yang Qian
In this work, the flower-like hierarchical Bi 2 WO 6 decorated with nano UiO-NH 2 -66 was fabricated by a two-step solvothermal method. The structure, composition, and morphology of the composites were characterized by XRD, FTIR, XPS, BET, and SEM. The photoelectrochemical properties of the composites were analyzed by transient photocurrent response, DRS, and PL spectra. It is found that hole (·h + ) plays a dominant role, and the hydroxyl radical (·OH) and superoxide radical (·O 2 − ) play a secondary role in the catalytic system after free radical trapping experiments. The results of electron spin resonance spin-trapping tests also confirm the mechanism. Compared with pure Bi 2 WO 6 or pure UiO-NH 2 -66, Bi 2 WO 6 /UiO-NH 2 -66 composites have much higher decomposition effectiveness of Rhodamine B under the same conditions. Furthermore, Bi 2 WO 6 /UiO-NH 2 -66 photocatalyst with 7 wt% of UiO-NH 2 -66 (denoted as BWO/UNH-7) kept the stable catalytic performance after five recycles, which may be used as a good photocatalyst for degrading organic matter in sewage. Graphical abstract
研究领域:
材料科学
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环境科学
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DOI
高影响因子
Particuology
·
2024
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IF 4.1
Jingchuan Wang,Junhong Luo,Yong Yao,Jiangfeng Song,Yan Shi
To improve room-temperature hydrogen storage, palladium (Pd) nanoparticles were innovatively decorated by carbon bridge onto the amino-group functioned Zr-terephthalate metal-organic framework (MOF) UiO-66 to reduce the diffusion energy barrier and then improve the hydrogen spillover effect. Powder X-ray diffraction shows broad Pd peak and retained UiO-66-NH 2 integrity after Pd decoration. The hydrogen uptake capacity show that UiO-66-NH 2 -Pd exhibits best hydrogen storage performance than UiO-66-NH 2 and pristine UiO-66. The hydrogen up taken in Pd decorated UiO-66 (UiO-66-NH 2 -1Pd) was close to 4 wt% under 20 MPa at room temperature. Density functional theory (DFT) calculations show that hydrogen adsorption energy of UiO-66-NH 2 -Pd was −0.5897 eV, which was much lower than that of UiO-66-NH 2 (−0.3716 eV) and UiO-66 (−0.2975 eV). Ultimately, Pd decorated NH 2 group functioned UiO-66 enable improve storage capacities through hydrogen spillover under ambient conditions which could satisfy the demand for sustainable energy, especially for the long-term storage energy media.
研究领域:
材料科学
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能源科学
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2024
·Vol. 59
·期 44
·20624-20639
·
IF 3.5
She Houde,Chen Dongxu,Huang Jingwei,Wang Lei,Chen Jiufu,Chen Xiaoping,Wang Qizhao
The removal of volatile organic compounds has been a long-standing challenge, and NH 2 -MIL125, with its large specific surface area, has shown great promise in this regard. However, its limited number of active sites hinders its widespread application. To address this limitation, we report the successful synthesis of a series of Co 3 O 4 -modified NH 2 -MIL125 metal–organic framework (MOF) composites with a lamellar structure. Notably, the optimized 35% Co 3 O 4 /NH 2 -MIL125 composite exhibited exceptional performance, achieving 85.59% degradation and 76.58% CO 2 conversion under simulated sunlight. Moreover, this composite demonstrated excellent stability, maintaining a degradation rate of 79.67% over 520 min. The enhanced performance is attributed to the large specific surface area of NH 2 -MIL125, as well as the Co 3 O 4 modification, which provides new active sites, enhances light utilization efficiency, accelerates the separation of photogenerated carriers, and facilitates the generation of reactive radicals. This in-situ growth strategy for modifying NH 2 -MIL125 with Co 3 O 4 offers a novel approach to expand the application scope of NH 2 -MIL125 and enhance its performance in toluene degradation. Graphical abstract
Characterization of layered Co 3 O 4 -modified NH 2 -MIL125 catalysts, evaluation of photocatalytic degradation performance of toluene, photogenerated carrier migration, and separation studies.
研究领域:
材料科学
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环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）