Materials Today Chemistry
·
2022
·
IF 7.613
An Li,Laihui Luo,Peng Du,Weiping Li,Marcin Runowski,Jun Zhou
The polychromatic emission and wide-range color tuning in the luminescent nanoparticles are currently of crucial importance, due to the development of color and white light-emitting diode (LED) devices, based on such lanthanide-doped nanostructured materials . By utilization of precipitation method, Tb 3+ -doped and Tb 3+ /Eu 3+ -codoped NaYbF 4 nanoparticles ( i . e . NPs) are synthesized. For Tb 3+ -doped NaYbF 4 NPs excited by 377 nm, green emission originating from Tb 3+ is observed, where its optimum state is obtained when Tb 3+ content is 25 mol% and the concentration quenching mechanism is found by electric dipole-dipole interaction. Moreover, due to the existence of energy transfer between Tb 3+ and Eu 3+ , polychromatic emissions are realized in Tb 3+ /Eu 3+ -codoped NaYbF 4 NPs as Eu 3+ content increases. Through analyzing emission decay times and emission spectra , it was confirmed that the energy transfer mechanism in the synthesized NPs is governed mainly by electric dipole-dipole interaction. Furthermore, the resultant NPs also own strong resistance to temperature, which is verified by temperature-dependent emission spectra , and the activation energies of Tb 3+ and Eu 3+ are 0.206 and 0.207 eV, respectively. In addition, by employing designed NPs as yellow-emitting components, the fabricated white-LED emits brightness warm white light with color coordinate of (0.385, 0.380), high color rendering index of 84.3 and low correlated color temperature of 3903 K. This work does not only offer an available route to develop NPs with polychromatic emissions but also devise promising luminescent materials for improving the performance of the phosphor-converted white-LED.
研究领域:
材料科学
·
光学工程
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2022
·Vol. 10
·期 45
·17163-17173
·
IF 8.067
Xiaoli Luo,Qichen Chen,Hongbo Guo,Cheng Chen,Qianqian Ren,Heng Zhang,Xiaowei He,Wu Zhao
As a new type of optical imaging, fluorescence molecular tomography (FMT) has great potential in the field of biomedicine. However, current fluorescent probes still have some limitations that make in vivo FMT imaging quite challenging. In this study, Cit-NaYb0.98−xF4:2%Tm3+/x%Sr2+ upconversion nanoparticles (UCNPs) were successfully prepared by a one-step hydrothermal method, which overcomes the shortcomings of most organic small molecular fluorescent dyes. Importantly, Sr2+ doping can not only significantly reduce the radius of NaYbF4 but also considerably enhance the 800 ± 10 nm emission by about 35.5 times. CCK-8 assay and confocal laser scanning microscopy images (CLSM) also showed that the toxicity of NaYb0.93F4:2%Tm3+/5%Sr2+ to HeLa cells was decreased due to size reduction. In vitro and in vivo experiments showed that the UCNPs have excellent FMT imaging quality. After using the Compressive Sampling Matching Pursuit (CoSaMP) algorithm for 3D reconstruction, the location error of the fluorophore center was small, and the reconstructed target shape was close to that of the real light source. The reconstruction results further proved the feasibility and efficiency of Cit-NaYbF4:2%Tm3+/x%Sr2+ UCNPs for in vivo FMT imaging. This kind of UCNPs has been applied to FMT imaging and 3D reconstruction in vivo for the first time, promoting the development of FMT technology.
研究领域:
生物医学工程
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光学成像
·
纳米材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF RARE EARTHS
·
2022
·
IF 4.632
Xiaoli Luo,Qichen Chen,Hongbo Guo,Heng Zhang,Xiaowei He,Wu Zhao
Fluorescence imaging techniques represent essential tools in in vitro , preclinical, and clinical studies. In this study, an improved one-step hydrothermal method to synthesize citric acid (CA) modified α -NaYbF 4 :2%Er 3+ nanocrystals was proposed. The introduction of various doping ions into NaYbF 4 :2%Er 3+ and the different valence states of the same ions affect both the crystal size and upconversion luminescence. Therefore, we investigated the upconversion luminescence enhancement of NaYbF 4 :2%Er 3+ by ion doping and find that the upconversion luminescence intensity of the upconversion nanoparticles (UCNPs) co-doped with 5 mol% Fe 2+ ions shows the greatest enhancement, especially for red emission at 654 nm. Furthermore, HeLa cells incubated with UCNPs allow for imaging with strong red upconversion emission detection. Confocal laser scanning microscope (CLSM) fluorescent images of HeLa cells indicate that NaYbF 4 :2%Er/5%Fe 2+ leads to a clear outline and improves visualization of the cell morphology. In addition, the CA coated NaYbF 4 :2%Er 3+ /5%Fe 2+ nanoparticles and NaYbF 4 :2%Er 3+ /5%Fe 2+ show low cytotoxicity in HeLa cells. Organ imaging reveals the efficiency of these UCNPs to analyze the lungs, liver, and spleen. Together, these results indicate that the Cit-NaYbF 4 :2%Er 3+ /5%Fe 2+ UCNPs are efficient nanoprobes for fluorescence molecular tomography.
研究领域:
生物医学工程
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材料科学
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纳米医学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED CATALYSIS B-ENVIRONMENTAL
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2022
·
IF 24.319
Syed Jalil Shah,Wenyuan Li,Ying Tang,Yang Hu,Shanliang Jiang,Hui He,Ruimeng Wang,Zhongxing Zhao,Zhenxia Zhao
Fabrication of broad-spectrum response photocatalysts in a controllable manner that can efficiently utilize solar light as much as possible remains a top priority target yet a challenging task. In this work, a facile approach of synchronous bottom-up growth was employed to construct UCNP/NMIL(Ti) nanohybrids via NH 2 -BDC (NH 2 -MIL-125-ligand) linkage between upconversion NaYbF 4 :Tm 3+ nanoparticles (~13-nm) and NH 2 -MIL-125. The ligand sharing integration strategy generated abundant oxygen vacancies and coordinatively-unsaturated-metal sites, efficiently enhanced light absorption, energy-transfer upconversion (UC-PL), photo-induced e - / h + generation, and their separation (CV, EIS, Photocurrent-density). Consequently, UCNP/NMIL(Ti) exhibited excellent acetaldehyde photodegradation activity, with 12.5–77.0-folds higher rate constants ( k a ) than those of state-of-the-art photocatalysts under visible light and high humidity. Furthermore, the photocatalytic activity of UCNP/NMIL(Ti) only declined from 96.0% to 92.5% after five cycling-runs, demonstrating its remarkable photo-catalytic stability. Considering these attributes, the current strategy provides an avenue to synthesize efficient UCNPs/MOF composites for widespread usage in a variety of commercial applications.
研究领域:
材料科学
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环境科学
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化学
✓ 已验证
DOI
高影响因子
BIOMATERIALS
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2014
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IF 8.312
Gan Tian,Xiaopeng Zheng,Xiao Zhang,Wenyan Yin,Jie Yu,Dongliang Wang,Zhiping Zhang,Xiangliang Yang,Zhanjun Gu,Yuliang Zhao
Multi-drug resistance (MDR) is a major cause of failure in cancer chemotherapy. Tocopheryl polyethylene glycol 1000 succinate (TPGS) has been extensively investigated for overcoming MDR in cancer therapy because of its ability to inhibit P-glycoprotein (P-gp). In this work, TPGS was for the first time used as a new surface modifier to functionalize NaYbF 4 :Er upconversion nanoparticles (UNCPs) and endowed the as-prepared products (TPGS-UCNPs) with excellent water-solubility, P-gp inhibition capability and imaging-guided drug delivery property. After the chemotherapeutic drug (doxorubicin, DOX) loading, the as-formed composites (TPGS-UCNPs-DOX) exhibited potent killing ability for DOX-resistant MCF-7 cells. Flow-cytometric assessment and Western blot assay showed that the TPGS-UCNPs could potently decrease the P-gp expression and facilitate the intracellular drug accumulation, thus achieving MDR reversal. Moreover, considering that UCNPs process efficient upconversion emission and Yb element contained in UCNPs has strong X-ray attenuation ability, the as-obtained composite could also serve as a dual-modal probe for upconversion luminescence (UCL) imaging and X-ray computed tomography (CT) imaging, making them promising for imaging-guided cancer therapy.
研究领域:
生物医学工程
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纳米医学
·
癌症治疗
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2020
·Vol. 22
·期 46
·8110-8117
·
IF 3.117
Zhiyuan Cheng,Hao Lin,Tong Liu,Yongjin Li,Shenghong Yang,Yueli Zhang
β-NaErF4:0.005Tm upconversion nanocrystals (UCNCs) with core–shell structure are quite popular due to efficient red upconversion luminescence. However, the traditional seed-mediated growth method is not continuous and quite time consuming, while the successive layer-by-layer strategy is unfriendly because of the usage of toxic sodium trifluoroacetate (Na-TFA). In this work, we utilized a novel one-pot strategy to synthesize β-NaErF4:0.005Tm with core–shell–shell structure. The morphology of the core could be significantly regulated. NaYbF4 and NaYF4 shells could be epitaxially grown on the core by simply adding fresh raw materials and heating to 300 °C, successively. Thanks to the suppression of surface quenching and energy back transfer from Yb3+ to Er3+, the population density of excited states of Er3+ (4I13/2, 4I11/2 and 4I9/2) was much improved, resulting in the tremendously enhanced upconversion intensity of β-NaErF4:0.005Tm@NaYbF4@NaYF4. This one-pot protocol could supply core–shell–shell red UCNCs with regular morphology, enhanced intensity and long-lasting decay lifetime, offering promising opportunities for applications such as bioprobing, anti-counterfeiting, photodynamic therapy, etc.
研究领域:
材料科学
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纳米技术
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光学
·
生物医学工程
✓ 已验证
DOI
高影响因子
ACS Applied Bio Materials
·
2026
·
IF 5.6
Qi Cai,Yue Li,Xuewei Ba,Piaoping Yang
The aberrant vascularization and uneven vascular distribution stemming from rapid tumor cell proliferation culminate arouse intra-tumoral hypoxia, which substantially compromises the therapeutic response to conventional chemotherapy, as well as photothermal therapy (PTT) and photodynamic therapy (PDT). In this work, we present an innovative α-NaYbF4:Tm@Cu2-xSe@ZnFe2O4-DOX nanoplatform that synergistically integrates PTT, Fenton reaction-enhanced chemodynamic therapy, PDT, and doxorubicin (DOX)-based chemotherapy under 980 nm near-infrared (NIR) light activation and weakly acidic environment-initiation. The 10 nm cubic-phase α-NaYbF4:Tm up-conversion cores were initially synthesized. Subsequently, low atomic number (Z) Cu2-xSe nanocrystal grown as photo-thermal conversion agent demonstrated significantly stronger X-radiation (X-ray) attenuation capabilities and enhanced computed tomography (CT) imaging performance compared to clinically used iopromide. Furthermore, zinc ferrite (ZnFe2O4) shell was obtained in hydrothermal synthesis manner. The 980 nm NIR-excited α-NaYbF4:Tm nanoparticles undergo efficient energy down-conversion, emitting photons that perfectly match the absorption spectrum of ZnFe2O4, thereby maximizing reactive oxygen species (ROS) generation through bandgap-engineered photoconversion. The tumor's glycolytic activity creates a hydrogen peroxide (H2O2)-rich microenvironment, enabling ZnFe2O4-mediated Fenton-like reactions that produce hydroxyl radicals (•OH) radicals, ultimately triggering oxidative damage and apoptotic cell death. It is noted that dual-mode photothermal therapeutic efficacy was achieved by Cu2-xSe and ZnFe2O4 as photothermal nanocrystal with up-conversion luminescence (UCL), magnetic resonance imaging (MRI) and CT multimodal imaging. DOX as anticancer chemotherapeutics was conjugated to form α-NaYbF4:Tm@Cu2-xSe@ZnFe2O4-DOX nanoplatforms. It remains effectively release of large quantities of DOX at tumor part conferred response to excessive lactic and carbonic acids generated in cancer cells. Our research may provide an insight for generalizing enhanced synergetic performance by NIR light-mediated PTT, Fenton reaction, PDT and chemotherapy. It is not a simple assembly of known components, but rather a multi-functional synergistic system constructed through ingenious core-shell structural design, capable of responding to near-infrared light and the tumor microenvironment. For the first time, this system seamlessly integrates up-conversion luminescence-mediated PDT, dual photothermal agent-enhanced PTT, self-supplying H2O2 Fenton reactions, and acid/heat dual-responsive chemotherapy into a single nanoplatform. Additionally, it incorporates multimodal imaging capabilities, providing an innovative and comprehensive solution to overcome the clinical challenge of tumor hypoxia.
✓ 已验证
DOI
高影响因子
Journal of Materials Chemistry C
·
2017
·Vol. 5
·期 37
·9579-9587
·
IF 5.256
Ji-Wei Shen,Zhiqing Wang,Jiawei Liu,Hua Li
In an effort to address the solvothermal control synthesis issues of hexagonal upconversion nanocrystals (UCNCs) without additional co-doping, especially for NaYbF4:Er, we find for the first time that the mostly used sodium sources of NaOH and sodium oleate function through a totally unexpected NaF–HF pathway rather than the commonly accepted pathway of each of them. Specifically, NaOH reacts with NH4F and converts to nano-sized NaF completely in methanol, leading to reduced NH4F decomposition/HF generation in NaOH based synthesis. By contrast, sodium oleate-oleic acid hybrid suppresses NaF generation, leading to enhanced NH4F decomposition/HF generation in sodium oleate based synthesis. HF-flask SiO2 reaction, HF-to-NaF etching and HF tail gas were also detected for the first time. Results show the nano-sized NaF and in situ generated HF play key roles in the formation of cubic monomers and the cubic-to-hexagonal transition of UCNCs, respectively. Inspired by these results, a facile binary sodium strategy was proposed to achieve control synthesis of high-quality and small-sized hexagonal UCNCs via simultaneous regulation of nano-sized NaF and HF levels. HF was also verified as an origin of Ostwald ripening for UCNCs. The impacts of Ostwald ripening on the evolution of UCNCs were thus investigated. Our findings not only offer an advanced growth mechanism, but also present an effective control synthesis tool for UCNCs.
研究领域:
材料科学
·
纳米技术
·
无机化学
·
发光材料
·
稀土纳米材料
✓ 已验证
DOI
高影响因子
ACS Nano
·
2018
·
IF 13.709
Jing Zuo,Langping Tu,Qiqing Li,Yansong Feng,Ivo Que,Youlin Zhang,Xiaomin Liu,Bin Xue,Luis J. Cruz,Yulei Chang,Hong Zhang,Xianggui Kong
Photoswitchable materials are important in broad applications. Recently appeared inorganic photoswitchable upconversion nanoparticles (PUCNPs) become a competitive candidate to surmount the widespread issue of the organic counterparts —photobleaching. However, current PUCNPs follow solely Yb3+/Nd3+ cosensitizing mode, which results in complex multilayer doping patterns and imperfectness of switching in UV–blue region. In this work, we have adopted a new strategy to construct Nd3+ free PUCNPs—NaErF4@NaYF4@NaYbF4:0.5%Tm@NaYF4. These PUCNPs demonstrate the superior property of photoswitching. A prominent UV–blue emission from Tm3+ is turned on upon 980 nm excitation, which can be completely turned off by 800 nm light. The quasi-monochromatic red upconversion emission upon 800 nm excitation—a distinct feature of undoping NaErF4 upconversion system—endows the PUCNPs with promising image-guided photoinduced “off–on” therapy in biomedicine. As a proof-of-concept we have demonstrated the imaging-guided photodynamic therapy (PDT) of cancer, where 800 nm excitation turns off the UV–blue emission and leaves the emission at 660 nm for imaging. Once the tumor site is targeted, excitation switching to 980 nm results in UV–blue emission and the red emission. The former is used to induce PDT, whereas the latter is to monitor the therapeutic process. Our study implies that this upconversion photoswitching material is suitable for real-time imaging and image-guided therapy under temporal and spatial control.
研究领域:
材料科学
·
生物医学工程
·
纳米技术
·
诊疗学
·
光学成像
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）