REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Wei Qin,Guanyin Qian,Haibin Tao,Junwei Wang,Jiayin Sun,Xiaofeng Cui,Yuanguang Zhang,Xianlong Zhang
This research focused on developing a series of (G1.0, G2.0, G3.0 and G4.0) PAMAM dendrimers modified attapulgite (ATP) sorbents (G1.0-G4.0 PAMAM-ATP) to remove Hg(II) from aqueous solution. The effects of several parameters including solution pH, contacting time, temperature and initial Hg(II) ion concentration were studied. Batch sorption results showed that the adsorption process was rapid and over 90% of Hg(II) was removed within 80 min at optimal pH 5.0. The adsorption capacity of PAMAM-ATP adsorbents followed the order of G2.0 > G1.0 > G3.0 > G4.0 and the maximum adsorption capacities significantly increased from 5 mg/g (raw ATP), 90 mg/g (amine modified ATP, M-ATP), 192.5 mg/g (polyacrylamine modified ATP, PAM-ATP) by previous similar studies to 200.8 mg/g (G2.0-PAMAM-ATP). Kinetics of adsorption was suitable for pseudo-second-order and controlled by chemical adsorption over a whole sorption range. The adsorption capacities increased as temperature rise from 283 to 303 K and the thermodynamics properties implied that the adsorption processes was spontaneous and endothermic. Thus, the adsorption capacities decreased when the temperature was above 303 K. The isotherm adsorption was described by Langmuir model well with monolayer behavior. A specific coordination between Hg(II) and the N, O atoms on the functional groups of PAMAM-ATP surface was determined by XPS analysis . Furthermore, the maximum adsorption capacity of the regenerated G2.0-PAMAM-ATP sorbents could still be higher than 90% after five cycles by acid treatment. The favorable adsorption capacity compared with other adsorbents exhibited that G2.0-PAMAM-ATP was an excellent renewable sorbent for Hg(II) removal.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
高影响因子
Biomaterials Science
·
2022
·Vol. 10
·期 15
·4271-4283
·
IF 7.59
Liao Zhang,Shumin Hu,Leitao Zhang,Wenlan Wu,Qiuli Cheng,Junbo Li,Ravin Narain
Developing nanomedicine with highly adaptive behaviors has shown great effectiveness in cancer treatment. However, the multi-functional integration of nano-therapeutic systems inevitably leads to complexity in the structure and impairs the operational efficiency or performance. Herein, we describe a novel nano-therapeutic system, G4-AB, capable of simultaneous dual conversions of the size and charge while targeting the acidic tumor microenvironment. G4-AB, containing a hydrophobic inner cavity for doxorubicin (DOX) loading, was synthesized by modifying amine-terminated 4th-generation polyamidoamine (G4-PAMAM) dendrimers with acylsulfonamide betaine (AB). Due to the dipole–dipole interaction among the AB moieties, G4-AB self-assembles to form micellar clusters with a zwitterionic surface. Possessing an anti-fouling property and suitable size, G4-AB exhibits optimized blood circulation under physiological pH conditions. Moreover, the extracellular pH value of the tumor microenvironment (pH 6.5) can trigger the protonation of acylsulfonamide, resulting in the cationization of AB and dissociation of G4-AB into unimolecular micelles (∼12 nm) due to electrostatic repulsion. The synergistic dual conversions further ensure drug accumulation with enhanced tumor penetration and cell internalization. The in vitro and in vivo experiments demonstrate that the G4-AB-DOX nano-therapeutic system possesses better antitumor efficiency and lower toxicity than free DOX or PEGylated PAMAM.
研究领域:
药学
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肿瘤学
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纳米医学
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产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2019
·Vol. 7
·期 9
·3918-3925
·
IF 5.251
Hailin Cong,Liping Zhou,Qingye Meng,Yixin Zhang,Bing Yu,Youqing Shen,Hao Hu
Polymer gels can be classified as chemical and physical gels, depending on the type of cross-link. Physical gels usually form by physical cross-linking, such as hydrogen bonding, van der Waals and/or p–p interactions, which can avoid the use of additional cross-linking agents. Polyamidoamine (PAMAM) dendrimers possess abundant active groups on their surfaces. Modified dendrimers have been used as versatile linkers in some projects. In this work, polymer gels composed of PAMAM dendrimers without any covalent bonding cross-linking agents were prepared. The number of amino groups and ester groups on the surface of the dendrimers was precisely regulated to help form hydrogen bonds between adjacent dendrimers. The prepared dendrimer-based polymer gels retain the properties of PAMAM dendrimers such as antibacterial properties, and the unique structures make the gels exhibit high compressive strengths but relatively low tensile strengths. Interestingly, the prepared gels show good anti-inflammatory properties in acute inflammation models of mice with ear edema. The inflammatory inhibition rate and hematoxylin–eosin (H&E) staining method were used to confirm the anti-inflammatory effect. This present study demonstrates that the dendrimer-based polymer gels achieved through hydrogen bonding could be a versatile platform for tissue engineering.
研究领域:
材料科学
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生物医学工程
·
药理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2018
·Vol. 8
·期 51
·29455-29463
·
IF 2.936
Hai-Zhen Zhang,Zhen-Liang Xu,Jing-Ying Sun
Nanofiltration (NF) membranes with simultaneous high rejection of divalent cations and anions and high water permeation were designed and fabricated via interfacial polymerization (IP) on three-channel capillary ultrafiltration (UF) membranes. MWCNTs-COOH were modified with poly(amidoamine) (PAMAM) and the as-synthesized MWCNTs-PAMAM were embedded into the inner polyamide skin-layer of the NF membranes by incorporating them into a piperazine (PIP) aqueous solution, followed by IP with trimesoyl chloride (TMC). The rigid MWCNTs and the dendrimer PAMAM molecules endow the as-fabricated NF membranes with high porosity and good hydrophilicity. Additionally, the –NH2 groups of PAMAM introduce some positive sites into the polyamide layer. The as-prepared NF membranes with incorporated MWCNTs-PAMAM exhibit a pure water flux of 48.7 L m−2 h−1 and 92.6% and 88.5% rejection for Na2SO4 and MgCl2, respectively, at 4 bar. Moreover, the NF membranes display high rejection for sulfates and metal cations, including heavy metal ions. The practicability of the membranes for mine-wastewater treatment was tested, and the membranes showed above 80% rejection of heavy metals and solution flux of about 30 L m−2 h−1. In addition, their separation performance and stability were satisfactory during the long-term run. The high rejection of the membranes for metal cations is ascribed to the positive sites offered by MWCNTs-PAMAM and the narrow membrane pores since both electrostatic repulsion and size exclusion play a role during membrane filtration. The good separation performance of the membranes for multivalent anions and heavy metal cations illustrates their potential for applications in heavy metal wastewater treatment.
研究领域:
环境科学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2021
·Vol. 50
·期 11
·6414-6425
·
IF 1.938
Fan Wentao,Du Yongqiang,Zhou Jianjun,Ma Xueqing,Liu Yingliang,Xu Shengang,Cao Shaokui
The introduction of polymer additives provides a simple effective method to modify perovskite grain boundaries to improve power conversion efficiency (PCE) and stability of perovskite solar cells (PSCs). In this work, the high-quality methylammonium lead triiodide (MAPbI 3 ) perovskite film is prepared by adding the protonated polyamide-amine dendrimer (NH 3 + -PAMAM) to the perovskite precursor solution to regulate the crystalline growth process. The cross-linked perovskite grain structure induced by dendritic NH 3 + -functionalized PAMAM macromolecules results in the formation of compact and pinhole-free perovskite film owing to the suppression of perovskite gain boundaries. Finally, the unsealed NH 3 + -PAMAM modified PSC device achieves the highest PCE value of 16.03%, representing an increase of 48% compared with the control PSC device. Also, the unencapsulated NH 3 + -PAMAM-modified PSC device retained 75% of initial PCE value after being exposed to an ambient environment for 20 days, which is obviously higher than 10% for the control device. The improvements of perovskite morphology and photovoltaic performance are attributed to the modification of NH 3 + -PAMAM dendrimers. Graphic abstract
研究领域:
材料科学
·
能源科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MOLECULAR STRUCTURE
·
2022
·
IF 3.841
Wei Qin,Xue Han,Junwei Wang,Xie Wang,Jianli Zhang
To design some excellent extractants for the separation of Zr(Ⅳ) and Hf(Ⅳ), a novel set of polyamidoamine dendrimers peripherally modified with salicylaldehyde (Abbreviated as PAMAM-SA) have been synthesized. UV-vis absorption and fluorescent spectrometry were used to study the selectivity of G.1.0, G2.0, G3.0 and G4.0 PAMAM-SA on Zr(Ⅳ) and Hf(Ⅳ) compared with other metal ions, and their extraction/separation performance on Zr(Ⅳ) and Hf(Ⅳ) was also investigated under different pH solutions. The results show that these dendrimers have superior selectivity on Zr(Ⅳ) and Hf(Ⅳ) as compared with Ca 2+ , Mg 2+ , Fe 3+ and Ni 2+ ions. The binding stoichiometry of G1.0, G2.0, G3.0 and G4.0 PAMAM-SA dendrimers with Zr(Ⅳ) is 1:4, 1:8, 1:10, 1:16 molar ratio determined by fluorescent titration respectively and the molar ratio of these dendrimers with hafnium is similar to that of zirconium. Both of the maximum extraction efficiency (EE%) on Zr(Ⅳ) and the separation coefficient (β Zr/Hf ) are following the order of G2.0-PAMAM-SA > G1.0-PAMAM-SA > G3.0-PAMAM-SA > G4.0-PAMAM-SA, and the maximum EE% on Zr(Ⅳ) is up to 98.9% and furthermore the β Zr/Hf is 1.52 for G2.0-PAMAM-SA at lower acid concentration compared with the reported extractants. The favorable higher EE% and β Zr/Hf indicate that G2.0-PAMAM-SA may be potentially employed as a highly selective and efficient extractant to enhance separating zirconium from hafnium.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF FOOD COMPOSITION AND ANALYSIS
·
2024
·
IF 4
Junhui Du,Haibin Liu,Hongshuo Chen,Chuanjin Cui,Wensi Zhang,Xuechao Zhang,Zhang Bin
A competitive electrochemical aptamer biosensor for the selective detection of Pb 2+ was developed in this study. The PAMAM@Au hybrid materials and the bioprobe MB-GNPs-ssDNA were synthesized with chemical methods . Modified electrode with carboxylated graphene oxide was prepared via electrodeposition . PAMAM@Au was immobilized on the modified electrode using the EDC/NHS crosslinker, and aptamer (Apt) was bound to PAMAM@Au hybrid materials using the glutaraldehyde crosslinker. The assembly of MB-GNPs-ssDNA/Apt/PAMAM@Au/GO/SPCE biosensors was achieved through immobilizing bioprobe onto electrodes, based on the theory of aptamer-complementary chain reactions. The fabricated biosensor was characterized through electrochemical experiments, SEM, AFM , TEM, XPS and FTIR . The biosensor's performance was evaluated in a series of Pb 2+ aqueous solutions by differential pulse voltammetry (DPV), and the results demonstrated this biosensor had excellent repeatability, stability, and specificity. The detection range spanned from 0.5 pM/L to 500 nM/L, with a detection limit of 5 fM/L. Consequently, the proposed biosensor can serve as a reliable analytical tool for the sensitive detection of lead ions .
研究领域:
生物化学
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF POLYMER RESEARCH
·
2018
·Vol. 25
·期 12
·1-12
·
IF 1.434
Chang Dan-Dan,Yang Wei-He,Dai Xiao-Hui,Wang Ji-Xiang,Chen Li,Pan Jian-Ming,Yan Yong-Sheng,Dai Yi-Rong
Glycoporphyrin dendrimers have received increasing attentions due to their distinct physical and chemistry properties, such as fluorescence and water solubility. They also acted as a promising photodynamic therapy (PDT) sensitizer and used in the study of carbohydrate-protein interaction. In this study, different generations of porphyrin-cored dendrimers consisting of glycosylated siloxane-poly (amido amine) typed dendron (PP-Si-PAMAM-D m -Lac, m = 1, 2, and 3), multifunctional specific-targeting sensitizers, had been synthesized via click reaction. The structure of PP-Si-PAMAM-D m -Lac was characterized by 1 H NMR, GPC, FT-IR, UV-vis and fluorescence analyses. This glycoporphyrin dendrimers, not only obtained high fluorescence quantum yield and singlet oxygen production efficiency, but also showed specific recognition of lectin and remarkable temperature-responsive property (20–80 °C). These properties proved a facile click synthetic strategy of glycosylated siloxane-poly (amido amine) typed dendrimers with multiple functions as a promising tumor-selective photsensitizer (PS) for PDT and also allow applications in highly sensitive fluorescent probes over a larger temperature window.
研究领域:
材料科学
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化学
·
生物医学工程
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2018
·Vol. 135
·期 32
·46550
·
IF 1.901
Hongwei Zhao,Bing Liao,Fuwei Nian,Yangyang Zhao,Kun Wang,Hao Pang
In this work, a polyamidoamine dendrimer-based polycarboxylic superplasticizer (DPC) with a crosslinked emanative structure was synthesized via simple free radical polymerization. 1 H-nuclear magnetic resonance and Fourier transform infrared spectroscopy measurements were used for structural characterization. The fluidity, rheology behavior, and compressive strength of the cement/DPC samples were investigated in detail. The DPCs performed better dispersion and dispersion maintaining capabilities, stronger water reduction capability, and higher adsorption amounts than the conventional comb-shaped superplasticizer. The dispersive capacity of the DPC increased with an increasing generation of polyamidoamine dendrimers. Besides, compared with conventional comb-shaped superplasticizer, the addition of DPC led to a delayed and lowered heat flow peak on the hydration of cement paste at early age of hydration process. Furthermore, compressive strength results showed that the cement/DPC samples performed higher compressive strength than blank cement samples. © 2018 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2018 , 135 , 46550.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2022
·Vol. 189
·期 12
·1-10
·
IF 6.408
Dai Yin,Jiang Wei,Zheng Yani,He Pei,Zhu Ruizhi,Fei Jianwen,Xu Wei,Liu Chunbo,Hong Junli
A selective method for the determination of myosmine (a tobacco alkaloid) was developed using molecularly imprinted polymers (MIPs) based on Fe 3 O 4 @SiO 2 and PAMAM dendrimers. Fe 3 O 4 @SiO 2 with excellent magnetism and rapid separation performance was chosen as carrier for the MIPs. Moreover, the MIPs modified with PAMAM dendrimers exhibited a regular structure and abundant functional groups, which improve the efficiency of imprinting sites. The myosmine concentration was measured by HPLC with PDA detector, and the UV detection wavelength was set to 200 nm. The linear range of this assay was 13.2–400 mg/L with a correlation coefficient of 0.999, and the detection limit was 4.0 mg/L (S/N = 3). The MIPs have been used for the determination of myosmine in cigarettes, and the recovery range was 84.2–93.5%, with RSD values in the range 0.41–3.1%. In conclusion, our MIPs combine advantages of simple preparation and remarkable selectivity, which gives them excellent application prospects for the sensitive determination of trace myosmine in tobacco products. Graphical abstract
研究领域:
分析化学
·
材料科学
·
烟草研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ANALYTICAL BIOCHEMISTRY
·
2015
·
IF 2.219
Chunxiang Zhang,Guangyu Shen,Youming Shen,Xiangyang Zhang
In this work, a novel thiol aromatic aldehyde was synthesized. It can be used as a substrate to directly immobilize antibodies on a gold electrode, for which no additional chemical cross-linker is required. It was also applied as a linker to prepare Fe 3 O 4 @Au/PAMAM/Ab 2 –horseradish peroxidase bioconjugates , which introduced multiple enzymes onto a sensing interface owing to the high surface-to-volume ratio of Fe 3 O 4 @Au nanoparticles and many functional groups of the poly(amidoamine) dendrimer (PAMAM). The introduced multiple enzymes greatly improved the detection signal. Under optimal conditions, the proposed electrochemical immunosensor exhibited desirable performance for detection of IgG in the range 0.005–50 ng ml −1 with a detection limit of 3 pg ml −1 based on a signal-to-noise ratio of 3. It has great potential application in the area of clinical analysis.
研究领域:
生物医学工程
·
分析化学
·
纳米技术
✓ 已验证
DOI
高影响因子
INTEGRATED FERROELECTRICS
·
2019
·
IF 0.486
Liping Zhou,Hao Hu,Yi-Xin Zhang,Qing-Ye Meng,Bing Yu,You-Qing Shen,Hai-Lin Cong
Dendrimers have become effective drug carriers and gene transfection vectors for medical biomaterials. In this experiment, UCNPs (NaGdF4:Tm, Yb@NaGdF4) and three-generation PAMAM dendrimers were prepared firstly; then NaGdF4:Tm, Yb@NaGdF4 was modified by Polyacrylic acid(PAA); PAMAM were grafted to the surface of the modified UCNPs by the reaction between amino groups and carboxyl groups; finally, O-nitrobenzaldehyde was grafted to the surface by Schiff base reaction.The synthesized upconversion materials were coated with PAA and PAMAM, then loaded with O-nitrobenzaldehyde to form spherical nanoparticles. The particle size of prepared nanoparticles is 75 ∼ 80 nm. The dendrimer complex can emit ultraviolet light to regulate the pH gradient of aqueous solution under the excitation of near-infrared light (980 nm), and can be used to kill cancer cells by changing the acidity of tissue cells; secondly, the cavity between dendrimers and dendrimers on the surface of the complex can be used in many fields such as drug delivery and gene transfection; the nanoparticles provide a new method for cancer treatment.
研究领域:
生物医学工程
·
纳米医学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）