CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Xueping Tan,Dongnan Guo,Yujie Wang,Wenli Xu,Xiaofang Hou,Junbo Zhang,Sicen Wang
Factor XIa (FXIa), a pivotal target in anticoagulant therapy, requires precise activity monitoring to assess coagulation status and bleeding risks. To address the limited sensitivity of conventional chromogenic methods, we developed a novel electrochemiluminescence (ECL) biosensor exploring the synergistic effects of MXene's superior conductivity and Prussian blue analogue's (PBA) large specific surface area. Transient absorption spectrometry was employed to determine the excited-state lifetime and to elucidate the functional role of MXene@PBA. Molecular docking and specificity constant analysis identified Mpr(mercaptopropionic acid)-TEARK-Fc(ferrocene) as an optimal peptide substrate. The MXene@PBA-enhanced biosensor quantifies FXIa-induced ECL signal changes via peptide cleavage, achieving a linear range of 1.0 × 10 −5 mIU/mL to 1 mIU/mL and an LOD of 3.7 × 10 −6 mIU/mL (S/N = 3) in human serum. Furthermore, the ECL biosensor demonstrated efficacy in FXIa inhibitor screening, firstly revealing salvianolic acid A and C as potent inhibitors (>60 % inhibition) and apigenin as a moderate inhibitor (~40 %). Molecular docking confirmed that these inhibitors competitively bind to FXIa's catalytic pocket (His57, Cys58, Ala190, Lys192, Ser195), overlapping with the substrate recognition site. This MXene@PBA-enhanced ECL biosensor establishes a robust strategy for both FXIa activity monitoring and therapeutic agent development.
研究领域:
生物传感器
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纳米材料
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电化学
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分析化学
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分子生物学
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药理学
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抗凝治疗
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表面科学
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产品关联
DOI
高影响因子
Bioactive Materials
·
2023
·
IF 18.9
Wenqian Zhang,Kangkang Zha,Yuan Xiong,Weixian Hu,Lang Chen,Ze Lin,Chenyan Yu,Wu Zhou,Faqi Cao,Hankun Hu,Bobin Mi,Guohui Liu
The diabetic wounds remain to be unsettled clinically, with chronic wounds characterized by drug-resistant bacterial infections, compromised angiogenesis and oxidative damage to the microenvironment. To ameliorate oxidative stress and applying antioxidant treatment in the wound site, we explore the function of folliculin-interacting protein 1 (FNIP1), a mitochondrial gatekeeper protein works to alter mitochondrial morphology, reduce oxidative phosphorylation and protect cells from unwarranted ROS accumulation. And our in vitro experiments showed the effects of FNIP1 in ameliorating oxidative stress and rescued impaired angiogenesis of HUVECs in high glucose environment. To realize the drug delivery and local regulation of FNIP1 in diabetic wound sites, a novel designed glucose-responsive HA-PBA-FA/EN106 hydrogel is introduced for improving diabetic wound healing. Due to the dynamic phenylboronate ester structure with a phenylboronic acid group between hyaluronic acid (HA) and phenylboronic acid (PBA), the hydrogel is able to realize a glucose-responsive release of drugs. Fulvic acid (FA) is added in the hydrogel, which not only severs as crosslinking agent but also provides antibacterial and anti-inflammatory abilities. Moreover, the release of FEM1b-FNIP1 axis inhibitor EN106 ameliorated oxidative stress and stimulated angiogenesis through FEM1b-FNIP1 axis regulation. These in vivo and in vitro results demonstrated that accelerated diabetic wounds repair with the use of the HA-PBA-FA/EN106 hydrogel, which may provide a promising strategy for chronic diabetic wound repair.
研究领域:
药理学
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生物医学工程
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伤口愈合
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糖尿病
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材料科学
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DOI
PubMed
高影响因子
Catalysis Science & Technology
·
2022
·Vol. 12
·期 12
·3826-3835
·
IF 6.177
Zhenyu Cai,Fenglei Zhang,Sibing Yu,Zhipeng He,Xinjie Cao,Lei Zhang,Kai Huang
The efficient utilization of CO2 is currently a major concern, and the preparation of a catalyst with high CO2 conversion and product selectivity has become a matter of interest for researchers. Here, we report a series of transition metal-doped CO2 hydrogenation catalysts MFe2O4 (M = Zn, Cu, Ni, Co) with K residue prepared by using PBA as the precursor. The physicochemical properties of the catalysts were characterized by XRD, SEM, TEM, XPS, N2 adsorption and desorption, and H2-TPR, and the catalytic performance was tested. The test results showed that ZnFe2O4 had the highest CO2 conversion of 57.39% and the highest C5+ yield of 39.30% at 320 °C, 3 MPa, H2/CO2 = 3 : 1 and space velocity of 12 000 mL g−1 h−1. ZnFe2O4 showed no significant deactivation after 32 h of continuous operation, indicating its potential as an industrial catalyst.
研究领域:
化学工程
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催化材料
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环境科学
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产品关联
DOI
高影响因子
Analytical Methods
·
2017
·Vol. 9
·期 30
·4439-4446
·
IF 1.9
Ping Zhang,Qian Yu,Yuhan He,Wentao Zhu,Zhiqiang Zhou,Lin He
The enantiomeric separation of fenpropathrin enantiomers on Lux Cellulose-1, Lux Cellulose-3 and Chiralpak IC chiral columns as well as enantioselective degradation of fenpropathrin in soil were investigated by reverse-phase high-performance liquid chromatography (RP-HPLC). The effects of the chiral stationary phase, mobile phase component, mobile phase ratio, temperature and thermodynamic parameters on resolution were carefully evaluated. Fenpropathrin enantiomers achieve a baseline separation (Rs = 2.30) on the Lux Cellulose-3 column with a mobile phase of methanol/water at a ratio of 85/15. Partial separations were achieved on Lux Cellulose-1 and Chiralpak IC columns with maximum Rs = 1.01 and Rs = 0.64, respectively. Enantioselective degradation of fenpropathrin enantiomers in soil was investigated based on the proposed separation method. The half-life (t1/2) of S-fenpropathrin and R-fenpropathrin was 17.8 days and 12.6 days, respectively, indicating that the degradation of fenpropathrin in soil was enantioselective, with R-fenpropathrin preferentially degraded. Furthermore, the formation and degradation of 3-PBA, the main metabolite of fenpropathrin, were also investigated in three soils. Soil microorganisms were confirmed as the main factor that is responsible for enantioselective degradation of fenpropathrin enantiomers in soil. Such results provide a new approach for fenpropathrin enantiomer separation and contribute to a comprehensive risk assessment of fenpropathrin at the enantiomer level.
研究领域:
环境科学
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农药化学
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微生物学
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DOI
高影响因子
TALANTA
·
2022
·
IF 6.556
Hao Feng,Fan Wang,Junhua Li,Qian Wu,Ying Cui,Lingzhi He,Xing Liu,Zeng Liu,Dong Qian,Haixia Tong
Lack of highly efficient, inexpensive, and easily available catalysts severely limits the practical applicability of electrochemically sensing assay towards 5-hydroxytryptamine (5-HT). Herein, four kinds of Fe–Co bimetallic Prussian blue analogues (FeCo–PBAs) with different molar ratios of Fe to Co were prepared using a simple coprecipitation method. Interestingly, Fe(III) in K 3 [Fe(CN) 6 ] can be reduced to Fe(II) by adding trisodium citrate dehydrate, which could offer a new clue to synthesize PBAs with Fe(II) core ions. With the optimizational FeCo-PBA synthesized at a 0.5/1 M ratio of Fe to Co as an electrocatalyst , the constructed sensor shows excellent comprehensive performance for the 5-HT assay with a high sensitivity of 0.856 μA μM −1 and an ultralow detection limit of 8.4 nM. Under the optimum conditions, linearity was obtained in the ranges of 0.1–10.0 μM and 10.0–200.0 μM and preferable recoveries ranged from 97.8% to 103.0% with relative standard deviation (RSD) < 4.0%. The integrated properties of FeCo-PBA can be comparable to previously reported electrocatalysts for the 5-HT assay including noble metal-based and expensive carbon (graphene and carbon nanotubes)-based electrocatalysts. The proposed sensor also exhibits outstanding selectivity, reproducibility, and practicality for real sample analyses. This work is the first report on the PBA-based sensor for the 5-HT assay, verifying the practicability of this high-performance sensor for the 5-HT assay.
研究领域:
生物化学
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分析化学
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产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2022
·Vol. 46
·期 18
·8611-8618
·
IF 3.925
Jing Huang,Qi Shan,Yanan Fang,Ning Zhao,Xiaomiao Feng
A new simple strategy to prepare Mn–Fe Prussian blue analogue (PBA) derived oxide micromotors through co-precipitation and heat treatment is demonstrated. The morphology of the precursors could be precisely controlled from cubic-like to spherical-like by introducing citrate. Because of the synergistic catalytic reaction of bimetallic Mn–Fe oxides, micromotors with different shapes could be powered efficiently in H2O2 solution. In particular, the obtained cubic Mn–Fe oxide micromotors showed strong propulsion at a speed of 71.21 μm s−1 in 1% H2O2 solution. With dual mechanisms of adsorption bubble separation (ABS) and Fenton oxidation, the cubic Mn–Fe oxide micromotors showed extraordinary removal ability for Rhodamine B (RhB) as a simulated pollutant and could remove up to 95.2% of RhB within 30 minutes. Magnetic Fe3O4 contained in the component not only could degrade organic pollutants, but also could be recycled by magnetic field and reused with high degradation efficiency. These dual-functional metal oxide catalytic micromotors provide a practical and environmentally friendly strategy for environmental restoration.
研究领域:
环境科学
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材料科学
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催化化学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2017
·
IF 6.198
Xiaoqing Ye,Wuye Pan,Shilin Zhao,Yuehao Zhao,Yimin Zhu,Jing Liu,Weiping Liu
Although an acceleration of male pubertal development has been observed, precisely which endocrine-disrupting chemicals (EDCs) might contribute to the advancing onset of puberty in boys remains unclear. Here, pyrethroids, a class of widely used insecticides that have been considered as EDCs, are proposed as new environmental risk factors. In this study, 463 boys at the age of 9–16 years old were recruited in Hangzhou, Zhejiang, China. The common metabolites of pyrethroids, 3-phenoxybenzoic acid (3-PBA), and 4-fluoro-3-phenoxybenzoic acid (4-F-3-PBA), as well as gonadotropins, including luteinizing hormone (LH) and follicle-stimulating hormone (FSH), were analyzed in urine samples. Pubertal development was assessed based on Tanner stages and testicular volume (TV). A positive association between 3-PBA and gonadotropins was found (p < 0.001), in which a 10% increase in 3-PBA was associated with a 2.4% and 2.9% increase in LH and FSH, respectively. Higher urinary levels of 3-PBA in boys were associated with 275% and 280% increase in the risk of being genitalia stage 3 (G3) and G4, respectively (p < 0.05). There was a significant (132%) induction in odd of being TV 12–19 mL with increasing 3-PBA concentration compared to being in TV < 4 mL (p < 0.05). For the first time to our knowledge, this work reports on an association of increased pyrethroid exposure with elevated gonadotropins levels and earlier pubertal development in boys.
研究领域:
环境科学
·
内分泌学
·
公共卫生
✓ 已验证
DOI
PubMed
高影响因子
LANGMUIR
·
2025
·
IF 3.9
Wen-Long Ren,Yi-kai Wang,Mingxing Zhang,Chengchen Zhang,Qian Huang,Yuyang Zeng,Zhi-Wen Lin,Kaige Guo,Dehao Xiong,Chen-Guang Zhu
The development of efficient catalysts to regulate the thermal decomposition and combustion behavior of ammonium perchlorate (AP) is essential for improving the energy output of solid propellants. In this study, a LaFe0.5Co0.5O3/Ni–Fe Prussian Blue Analogue (PBA) composite was designed to synergistically enhance the decomposition kinetics and combustion performance of AP. The composite integrates perovskite-type oxides with a conductive PBA framework, forming a bifunctional electronic–geometric catalytic interface. Systematic characterization revealed that the optimized Ni–Fe PBA effectively balanced oxygen vacancy generation, Fe2+/Fe3+ redox cycling, and a multistage pore structure. This led to a 106.9 °C reduction in AP’s thermal decomposition temperature and a 56.2% decrease in activation energy. Combustion tests demonstrated a 48.1% increase in burning rate, a 35.0% increase in flame area, and a 45.8% increase in luminescence intensity, which may be attributed to improved charge transfer and gas diffusion facilitated by interfacial synergy between the two components. This work offers a strategy for designing high-performance catalysts via interfacial engineering, with promising potential for broad applications in fuel energy modulation.
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产品关联
DOI
PubMed
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2022
·
IF 5.204
Yan Lv,Juguo Dai,Long Xia,Lili Luo,Yiting Xu,Lizong Dai
To avoid potential ecological and health problems caused by phosphorus-based flame retardants, a novel phosphorus-free PBA-Salen-Ni flame retardant is successfully synthesized in this work. In a nutshell, boron-containing metal complexes are prepared by nickel salts and chelating PBA-Salen molecule (PBA: p -phenylenediboronic acid). While the obtained material inherently has good compatibility and can endow polymers with good flame retardant properties at low addition levels. Besides, the char shielding layer and the “labyrinth effect” of the special porous char layer structure formed after the combustion of EP/PBA-Salen-Ni retard the transfer of volatile products, giving EP excellent smoke suppression properties. The results show that the limiting oxygen index value of the EP/PBA-Salen-Ni composites is increased from 25.6% (pure EP) to 30.5%, and it can pass the UL-94 V-0 rating when the addition amount is only 5wt%. Particularly, compared with pure EP, the total smoke production (19.9 m 2 ) and peak heat release rate (859.6 kW m −2 ) of EP/PBA-Salen-Ni composites are reduced by 36% and 33%, respectively. Therefore, this work provides a new idea for the rational design of phosphorus-free flame retardants that are mainly on condensed phase flame retardancy and have a good smoke suppression effect.
研究领域:
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
DYES AND PIGMENTS
·
2026
·
IF 3.9
Juan Wei,Yilong Li,Xinyan Chen,Xing Zhou,Lu Li
A PBA/Rh6G ratiometric sensing platform was constructed by simple fluorophore mixing. • The system enabled sensitive Ag + detection with a LOD of 6.8 × 10 −14 mol L −1 . • Ratiometric readout improved repeatability and enabled reliable analysis of real water samples. The sensitive and accurate detection of silver ions (Ag + ) is of considerable significance for environmental monitoring and health risk assessment. To address the susceptibility of single-channel fluorescence detection to variations in probe concentration, excitation intensity, and sample matrix effects, a dual-channel ratiometric fluorescence sensing system for Ag + detection was constructed by directly mixing 1-pyrenebutyric acid (PBA) and rhodamine 6G (Rh6G). In this system, PBA served as the Ag + -responsive unit and exhibited a characteristic emission at approximately 400 nm under excitation at 328 nm, with its fluorescence intensity decreasing as the total Ag + concentration increased. Rh6G provided a relatively stable reference signal at approximately 578 nm, and the fluorescence intensity ratio I 400 /I 578 was used as the ratiometric response parameter. Suitable conditions for dual-channel detection were established by systematically optimizing the concentrations of PBA and Rh6G, the DMSO volume fraction, pH, and reaction time. The results showed a good linear relationship between the ratiometric fluorescence signal and the logarithm of the total Ag + concentration (R 2 = 0.992), with a detection limit as low as 6.8 × 10 −14 mol L −1 . Preliminary analysis of spiked campus lake water samples yielded recoveries ranging from 95% to 105%. Without requiring complex nanomaterial synthesis or multistep surface functionalization, this method provides a simple strategy for constructing ratiometric fluorescence sensing systems for Ag + detection. Download: Download high-res image (310KB) Download: Download full-size image
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DOI
高影响因子
JOURNAL OF POWER SOURCES
·
2026
·
IF 8.4
Ke Fan,Tongxue Zhang,Shuai Liu,Wenting Cai,Nini Zhao,Xubin Zhang,Fumin Wang
The development of efficient and stable catalysts is key for alkaline water/seawater electrolysis. Herein, we report a cubic-structured NiFePBA@NiSe 2 catalyst. In 1 M KOH, it requires an overpotential of only 278 mV to reach 300 mA cm −2 with a Tafel slope of 33.5 mV dec −1 . It also shows outstanding oxygen evolution reaction (OER) performance in alkaline simulated seawater (1 M KOH + 0.5 M NaCl) and natural seawater (1 M KOH + seawater). Experimental and characterization results reveal that highly active Ni(Fe)OOH species form in situ on the catalyst surface during OER. The introduction of NiSe 2 not only facilitates electron transfer and phase transformation, but the resulting selenate (SeO 4 2− ) species effectively repel chloride ions, which is particularly beneficial for stable seawater electrolysis. Benefiting from these structural advantages, the catalyst exhibits remarkable stability of 1000 h at 500 mA cm −2 in alkaline seawater. Furthermore, two-electrode electrolyzer and membrane electrode assembly tests using this material as the anode in alkaline seawater confirm its practical application potential. This work provides a new route for designing high-performance bifunctional electrocatalysts based on interface engineering and surface reconstruction.
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产品关联
DOI
高影响因子
MICROCHEMICAL JOURNAL
·
2025
·
IF 5.1
Haoxiang Wang,Yuyang He,Ruoyu Wang,Mengqi Lu,Yuting Luo,Yiwei Sun,Dongpo Xu
An electrochemical sensor with a dual recognition strategy was designed using molecularly imprinted polymers (MIPs) and boric acid for the highly sensitive detection of rutin. The synthesized metal-organic framework (MOFs) is combined with phenylboronic acid, which increases the recognition area of phenylboronic acid and its recognition ability towards adjacent diol compounds. Meanwhile, the molecularly imprinted polymer (MIP) provides specific recognition for rutin. The dual recognition strategy is widely adopted in sensors, enhancing the specificity of the imprinted cavity and effectively addressing the influence of interfering substances in complex matrices. After optimizing the experimental parameters, the detection range of this sensor is from 1 nM to 200 nM, and the limit of detection is 0.43 nM, indicating that this sensor has high potential for practical applications.
研究领域:
分析化学
·
生物传感
·
药物分析
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）