Surfaces and Interfaces
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2026
·
IF 6
Zongyin Song,Yantao Huang,Yue Song,Linfeng Kang,Hangbin Zheng,Jinlin Long,Ying Wang,Xu Cui,Na Wen,Chaoming Zhou,Tianhua Zhou
A dual-defense erythrosine coating is developed via a simple method, combining PEGMA-antifouling with photocatalytic sterilization. • Covalent grafting enables stable ¹O₂ generation, achieving > 99.8% bacterial kill within 30 min and retaining > 99.7% after one month. • The optimized coating reduces bacterial adhesion by 97.8% ( Escherichia coli ), 85.6% (S. aureus), and 97.3% (P. aeruginosa). • The coating shows outstanding stability against chemical, mechanical, and thermal challenges for medical devices. Healthcare-associated infections arising from bacterial adhesion and biofilm formation on medical devices demand durable antibacterial surfaces. Conventional sterilization offers only transient protection, while existing active bactericidal or passive antifouling strategies each suffer from critical limitations—such as toxicity, resistance, or lack of killing ability. Herein, we develop a series of erythrosine-based coatings that integrate active photocatalytic sterilization with passive antifouling into a dual-defense surface via simple, scalable methods (spin-coating, spray-coating, or drop-coating). The optimal coating achieves bacterial adhesion reduction rates of 97.8% against Escherichia coli ( E. coli ), 85.6% against Staphylococcus aureus ( S. aureus ), and 97.3% against Pseudomonas aeruginosa ( P. aeruginosa ). Under visible light, it exhibits >99.8% bactericidal efficacy within 30 min. Notably, even after one month of ambient storage, the coating retains >99.7% antibacterial efficiency, underscoring its excellent long-term stability and practical utility. This erythrosine-based dual-functional coating offers a robust and translational strategy for combating device-associated bacterial infections, holding significant promise for broad applications in public health and clinical settings. A durable dual-defense coating is constructed via simple spin-coating, integrating a PEGMA-based hydration barrier with erythrosine-photosensitized ROS generation. This amphiphilic design synergizes passive antifouling with active photocatalytic killing, achieving long-lasting and broad-spectrum bacterial eradication and providing a robust strategy for combating device-associated infections. Download: Download high-res image (351KB) Download: Download full-size image
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高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 138
·期 21
·50463
·
IF 3.125
Chenxi Tu,Tong Zhou,Liwen Deng,Changyou Gao
The gradient surface shows enormous potential in the development of tissue engineering, biosensor, microfluidic control, and particle sorting. In this work, a poly(polyethyleneglycol methacrylate) (poly(PEGMA)) gradient surface was prepared through surface-initiated activators regenerated by electron transfer atom transfer radical polymerization (SI-AGRET ATRP). The effect of various parameters on the thickness growth of poly(PEGMA) film were analyzed, among which the excessive reducing agent was utmost important. The reducing agents supported the regeneration of Cu I and eliminated the disturbance of air, maintaining the "living polymerization" of poly(PEGMA) up to 73.1 nm under tested conditions. The physicochemical properties of the fabricated surfaces were characterized by ellipsometry, X-ray photoelectron spectroscopy, water contact angle. The thickness slope of gradient poly(PEGMA) was controllable in a nanoscale range. The gradient surface was further grafted with CRGD (Cys-Arg-Gly-Asp) peptides onto the poly(PEGMA- co -[glycidyl methacrylate]) blocks via the ring-opening reaction between epoxy and amino groups, which showed a gradient change in water contact angle and adhesion of endothelial cells.
研究领域:
生物材料
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组织工程
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细胞生物学
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高影响因子
Materials Science & Engineering C-Materials for Biological Applications
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2017
·
IF 4.164
Yingge Shi,Ruming Jiang,Meiying Liu,Lihua Fu,Guangjian Zeng,Qing Wan,Liucheng Mao,Fengjie Deng,Xiaoyong Zhang,Yen Wei
Polymeric fluorescent organic nanoparticles (polymer-FONs) have raised considerable research attention for biomedical applications owing to their advantages as compared with fluorescent inorganic nanoparticles and small organic molecules. In this study, we presented an efficient, facile and environment-friendly strategy to produce polymer-FONs, which relied on the self-polymerization of dopamine and polyethyleneimine (PEI) in rather mild conditions. To obtain the final polymer-FONs, aldehyde group-containing copolymers (named as poly(UA- co -PEGMA)) were synthesized by reversible addition–fragmentation chain-transfer polymerization using polyethylene glycol methyl ether methacrylate (PEGMA) and 1-undecen-10-al (UA) as monomers. The dopamine was conjugated onto poly(UA- co -PEGMA) through a multicomponent reaction between UA and dopamine to obtain poly(UA- co -PEGMA)-DA, which was further utilized for preparation of polymer-FONs through self-polymerization of dopamine and PEI. 1 H nuclear magnetic resonance, Fourier transform infrared spectroscopy, transmission electron microscopy and fluorescence spectroscopy were employed to characterize the structure, morphology, compositions and optical properties of these polymer-FONs. Cell viability and cell uptake behavior results suggested that these polymer-FONs possess good biocompatibility and can be potentially utilized for biomedical applications. More importantly, the method can be also applied to fabricate many other multifunctional polymer-FONs with great potential for biomedical applications.
研究领域:
材料科学
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纳米技术
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生物医学工程
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
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2026
·
IF 12.5
Jiajia Fan,Jinyuan Hu,Shengchi Bai,Xifan Li,Guijing Chen,Jia Chen,Sheng Chen,Baicang Liu
Developing high-performance anti-fouling ultrafiltration membranes is essential for treating shale gas wastewater (SGW), addressing its severe membrane fouling issues. This study reports the fabrication of polyvinylidene fluoride (PVDF)/PVDF-graft-poly(ethylene glycol) methyl ether methacrylate (PVDF-g-PEGMA) blended hollow fiber membranes via non-solvent induced phase separation for direct treatment of SGW. The influences of the copolymer doping ratio on microstructure, chemical composition, and hydrophilicity were systematically investigated. The addition of PVDF-g-PEGMA contributed to a favorable membrane morphology and significantly improved hydrophilicity. The 20 wt% PVDF-g-PEGMA modified membrane achieved a 64.4% increase in pure water flux while retaining over 95.9% rejection for both humic acid and bovine serum albumin. More importantly, in long-term filtration of SGW, the modified membrane demonstrated a stable permeation flux of ~30.4 L·m −2 ·h −1 , surpassing the performance of the unmodified membrane by 300% and reducing the cost of water treatment for unit flux by 17.6%. Analysis based on the extended Dragun-Landau-Verwey-Overbeek theory indicated that the incorporation of PVDF-g-PEGMA effectively reduced the attractive interaction energy between the membrane and pollutants. These results demonstrate that the PVDF-g-PEGMA blending modification not only significantly enhanced membrane permeability and anti-fouling performance under challenging real wastewater conditions but also achieved sustained flux and superior anti-fouling behavior during lab-scale SGW operation, thereby enabling water reuse with reduced maintenance demand.
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高影响因子
Journal of Materials Chemistry C
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2017
·Vol. 5
·期 34
·8788-8795
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IF 5.256
Xiaofang Qi,Jing Peng,Dongyan Tang,Ning Wang,Hongyun Zou
Molybdenum oxide nanomaterials have received increasing attention in recent years for their strong localized surface plasmon resonance (LSPR) absorption in the near-infrared (NIR) region and pH-dependent degradability. However, the rapid degradation of MoOx at physiological pH values would decrease the NIR photothermal effect. Here, we designed and prepared PEGMa–MoOx/p(NIPAM-co-MAA) microgels (NCs) exhibiting adjustable degradation. For that purpose, PEGMa (Mn = 400) modified MoOx was synthesized through a simple hydrothermal process. Then, PEGMa–MoOx with existing CC groups was continually polymerized with NIPAM and MAA through emulsion polymerization. MAA was introduced to provide an acidic microenvironment (pH at 3–5) to control the degradation rate of PEGMa–MoOx. The photothermal efficiency of the NCs could be maintained at 54% even after 14 days. Meanwhile, the NCs also displayed a pH-dependent thermal response. Moreover, PEGMa was added again in the emulsion polymerization process to elevate the photothermal efficiency, and the irradiation result indicated that the NCs could increase the temperature by 27 °C. The complex microgel integrates pH/temperature/photothermal triple response characteristics and exhibits huge potential for chemo-photothermal combination cancer therapy.
研究领域:
材料科学
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生物医学工程
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纳米医学
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DOI
高影响因子
CELLULOSE
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2017
·Vol. 24
·期 10
·4189-4203
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IF 3.417
Zhang Xiuqiang,Zhang Jinlong,Dong Lili,Ren Suxia,Wu Qinglin,Lei Tingzhou
We report a series of thermoresponsive cellulose nanocrystals (CNCs) decorated with poly(poly(ethylene glycol) methylacrylate) copolymers (poly(PEGMA)- g -CNCs) synthesized by surface initiated-atom transfer radical polymerization (SI-ATRP). The chemical structures and surface morphologies were subsequently confirmed by FT-IR, XPS, and AFM measurements. With regard to thermally responsive behavior, poly(PEGMA)- g -CNCs show tunable lower critical solution temperature (LCST) values in the range of 34–66 °C by varying the feeding ratios of comonomers. The reversible morphological transformation from individual nano-rod structures to larger globule aggregates was further verified by AFM during the LCST transition. These functionalized CNCs have potential as smart film filters and biosensors.
研究领域:
材料科学
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高分子化学
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DOI
高影响因子
Frontiers of Materials Science
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2017
·Vol. 11
·期 3
·223-232
·
IF 1.471
Wei Lulu,Lu Beibei,Li Lei,Wu Jianning,Liu Zhiyong,Guo Xuhong
A novel β-cyclodextrin-poly(2-(2-methoxyethoxy)ethyl methacrylate)- co -poly(ethylene glycol) methacrylate (abbreviated as: β-CD-(P(MEO 2 MA- co -PEGMA)) 21 ) was prepared by using the one-step strategy, and then the star-shaped copolymers were used in the atom transfer radical polymerization (ATRP). The structure of star-shaped β-CD-(P(MEO 2 MA- co -PEGMA)) 21 copolymers were studied by FTIR, 1 H NMR and gel permeation chromatography (GPC). The star-shaped copolymers could self-assembled into micelles in aqueous solution owing to the outer amphiphilic β-CD as a core and the hydrophilic P(MEO 2 MA- co -PEGMA) segments as a shell. These thermo-responsive starshaped copolymers micelles exhibited lower critical solution temperature (LCST) in water, which could be finely tuned by changing the feed ratio of MEO 2 MA to PEGMA. The LCST of star-shaped β-CD-(P(MEO 2 MA- co -PEGMA)) 21 copolymer micelles were increased from 35°C to 58°C with the increasing content of PEGMA. The results were investigated by DLS and TEM. When the temperature was higher than corresponding LCSTs, the micelles started to associate and form spherical nanoparticles. Therefore, β-CD-(P(MEO 2 MA- co -PEGMA)) 21 star-shaped copolymer micelles could be potentially applied in nano-carrier, nano-reactor, smart materials and biomedical fields.
研究领域:
材料科学
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高分子化学
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纳米技术
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高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
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2012
·Vol. 23
·期 6
·1499-1510
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IF 2.316
Wang Heyun,Feng Yakai,An Bo,Zhang Wencheng,Sun Minglin,Fang Zichen,Yuan Wenjie,Khan Massuri
Poly(ethylene glycol) methacrylate (PEGMA) was introduced into a polyurethane (PU) solution in order to prepare electrospun scaffold with improving the biocompatibility by electrospinning technology for potential application as small diameter vascular scaffolds. Crosslinked electrospun PU/PEGMA hybrid nanofibers were fabricated by a reactive electrospinning process with N , N ′-methylenebisacrylamide as crosslinker and benzophenone as photoinitiator. The photoinduced polymerization and crosslinking reaction took place simultaneously during the electrospinning process. The electrospinning solutions with various weight ratios of PU/PEGMA were successfully electrospun. No significant difference in the scaffold morphology was found by SEM when PEGMA content was <20 wt%. The crosslinked fibrous scaffolds of PU/PEGMA exhibited higher mechanical strength than the pure PU scaffold. The hydrophilicity of scaffolds was controlled by varying the PU/PEGMA weight ratio. The tissue compatibility of electrospun nanofibrous scaffolds were tested using human umbilical vein endothelial cells (HUVECs). Cell morphology and cell proliferation were measured by SEM, fluorescence microscopy and thiazolyl blue assay (MTT) after 1, 3, 7 days of culture. The results indicated that the cell morphology and proliferation on the crosslinked PU/PEGMA scaffolds were better than that on the pure PU scaffold. Furthermore, the appropriate hydrophilic surface with water contact angle in the range of 55–75° was favorable of improvement the HUVECs adhesion and proliferation. Cells seeded on the crosslinked PU/PEGMA (80/20) scaffolds infiltrated into the scaffolds after 7 days of growth. These results indicated the crosslinked electrospun PU/PEGMA nanofibrous scaffolds were potential substitutes for artificial vascular scaffolds.
研究领域:
生物材料学
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组织工程学
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DOI
PubMed
高影响因子
REACTIVE & FUNCTIONAL POLYMERS
·
2019
·
IF 3.074
Xiaolin Wang,Zhengping Liu,Liyan Huang
A novel pH and thermo dual-responsive graft copolymer , starch- graft -poly( N , N -diethyl aminoethyl methacrylate- co -poly(ethylene gly co l) methyl ether methacrylate) [starch-g-P(DEAEMA-co-PEGMA)], was successfully synthesized through single-electron transfer living radical polymerization (SET-LRP). The structure and molecular weight of the grafted chains were confirmed by 1 H NMR. These graft copolymers can self-assemble into micelles with starch backbone and PDEAEMA as the core and PPEGMA as the corona in water at pH 7.4. The critical micelle concentration (CMC) of the graft copolymers varied between 0.0313 and 0.1364 mg/mL, decreasing with an increase in the molecular weight of the grafted chains and the ratio of PDEAEMA and PPEGMA segments. The pH and thermo dual-responsive behaviors of starch-g-P(DEAEMA-co-PEGMA) micelles were investigated by DLS and TEM . As the pH decreasd from 8.0 to 5.5, the micelle sizes continued to increase due to the protonation of the PDEAEMA segments, and as the pH decreased to below 5.5, the micelles began to disassemble, which was verified by TEM observations. Upon heating, the size of the micelles decreased because of the shrinkage of the PDEAEMA segments. The pH and thermo dual-responsive behaviors of the starch-g-P(DEAEMA-co-PEGMA) micelles are reversible. Doxorubicin (DOX), a hydrophobic drug, was encapsulated in the micelles, and in vitro release from the drug-loaded micelles displayed good pH-responsive behavior.
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高影响因子
PROGRESS IN ORGANIC COATINGS
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2021
·
IF 5.161
Xinhua Liu,Hailong Liu,Hongliang Zheng,Yinchun Fang
Structural colors originating from melanin in nature have attracted great attention in recent years. Structural colorization is an eco-friendly dyeing method which may be a substitute of the traditional highly polluting dyeing method. In this study, the structural color originating from biomimetic melanin-like polydopamine (PDA) nanofilm coating on flexible silk fabric and its color performance have been studied. Five different bright structural colors were obtained through the different polymerization reaction time of PDA nanofilm coating. However, the prepared structural colors nanofilm coating exist cracking and poor colorfastness due to the capillary tension during the formation of PDA film and the weak interaction with fabric substrate. P(GMA-co-PEGMA) copolymer containing reactive epoxy groups was used to improve the interface bonding strength between PDA film and substrate by forming covalent bond. The introducing covalent bond will be beneficial for the improving interface bonding strength, thus to obtain high colorfastness structural color coating. This research would provide experimental basis for the fabrication of crack-free and high colorfastness structural color coating originating from biomimetic melanin-like PDA nanofilm which would achieve the application in textile colorization.
研究领域:
材料科学
·
纺织工程
·
纳米技术
·
色彩科学
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产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 65
·59946-59955
·
IF 3.289
Liangliang Dong,Yue Wang,Mingqing Chen,Dongjian Shi,Xiaojie Li,Chunfang Zhang,Hui Wang
We report a high performance and CO2-philic, comb copolymer consisting of poly(ethylene glycol) methyl ether methacrylate (PEGMA), polymethyl methacrylate (PMMA) and poly(N,N-dimethylaminoethyl methacrylate) (PDMAEMA) for use in composite membranes for CO2/N2 separation. Since the copolymers contain ethylene oxide (EO) groups and amino groups, the separation performance was expected to be enhanced by the synergistic effect of (1) the increased solubility of CO2 by dipole–dipole interactions between CO2 and EO units and (2) the enhanced CO2 transport by reversible reactions between CO2 and amino groups. The best separation performance was obtained from the PEDM5 composite membrane with 25 mol% of PEGMA, at which the CO2 permeability was 308 barrer and CO2/N2 selectivity was 38, which displays a potentially promising alternative for CO2 separation from N2.
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 56
·50993-51004
·
IF 3.289
Beibei Lu,Lei Li,Lulu Wei,Xuhong Guo,Jun Hou,Zhiyong Liu
Well-defined amphiphilic β-cyclodextrin (β-CD) star-shaped copolymers with poly(ε-caprolactone)–poly(2-(2-methoxyethoxy)ethyl methacrylate)-co-poly(ethylene glycol)methacrylate) (β-CD–(PCL–P(MEO2MA-co-PEGMA))21 were synthesized via ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP). These thermo-responsive copolymers exhibited a lower critical solution temperature (LCST) in water, which could be finely tuned by changing the feed ratio of PEGMA and MEO2MA. The LCST of star-shaped β-CD–(PCL–P(MEO2MA-co-PEGMA))21 increased from 26 to 62 °C with the increasing PEGMA content, the copolymers were characterized using Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1H NMR) and gel permeation chromatography (GPC). The star-shaped copolymers could self-assemble into micelles in aqueous solution due to their amphiphilic properties resulting from the hydrophobic β-CD and PCL core and the hydrophilic P(MEO2MA-co-PEGMA) segments, which was investigated by dynamic light scattering (DLS) and transmission electron microscopy (TEM). The in vitro DOX release studies showed that DOX released from drug-loaded micelles in a thermo-sensitive manner. CCK-8 assays demonstrated that these star-shaped copolymers could possess low cytotoxicity against HeLa cells, and the DOX-loaded micelles exhibited a higher inhibition of the proliferation of HeLa cells in comparison with free DOX. Moreover, the results from confocal laser scanning microscopy (CLSM) revealed that these polymeric micelles could efficiently deliver and release DOX into the nuclei of HeLa cells. This kind of biodegradable, biocompatible and stimuli-responsive copolymer could serve as a promising material for drug delivery.
研究领域:
高分子科学
·
药学
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生物医学工程
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纳米技术
·
药物递送系统
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DOI
高影响因子
危险品化学品经营许可证（带存储）