Journal of Nanomaterials
·
2020
·Vol. 2020
·期 1
·6014816
·
IF 1.98
Cijun Shuai,Chen Wang,Fangwei Qi,Shuping Peng,Wenjing Yang,Chongxian He,Guoyong Wang,Guowen Qian
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) has a great potential in bone repair, but unfortunately, the poor mechanical properties limit its further application. In this work, zinc oxide (ZnO) nanoparticles were incorporated into PHBV porous scaffold fabricated by selective laser sintering technique. It was because ZnO nanoparticles could provide nucleating sites for the orderly stacking of polymer chains, thereby enhancing the crystallinity of PHBV. It was well known that the mechanical properties of PHBV scaffold could be enhanced with the increase of crystallinity. More significantly, the released Zn 2+ would combine negatively charged cell membranes of bacterial through electrostatic interaction and consequently destructed the protein structure and resulted in the death of bacterial, which was highly desired in reducing the risk of implant infection. Results indicated that the relative crystallinity of scaffold with 3 wt.% ZnO increased remarkably from 38% to 64% compared to pure PHBV scaffold, which effectively enhanced the compression strength and modulus by 56% and 51.5%, respectively. Moreover, the scaffold had a favorable antibacterial activity. Cell culture experiments proved that the scaffold could promote the cell behaviors. The positive results demonstrated the scaffold may serve as a potential replacement in bone repair.
研究领域:
生物材料
·
组织工程
·
纳米医学
·
骨修复
·
抗菌材料
✓ 已验证
DOI
高影响因子
GREEN CHEMISTRY
·
2023
·
IF 9.8
Xianzhu You,Yating Zhou,Xuru Jin,Sheng Xiang,Xiaopeng Pei,Hua Zhou,Zhiyong Liao,Ying Tan
Traditional petroleum-based microbeads in personal care products are potentially harmful to the ecological environment and human health due to their non-biodegradability. Thus, it is essential to produce eco-friendly microbeads to replace the traditional ones. In this work, a facile and green method was used to manufacture biodegradable poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) microbeads for application in skin exfoliators. The PHBV microbeads were rapidly fabricated via a solvent exchange method wherein dimethyl isosorbide (DMI) acted as a green solvent and a polysorbate 80 aqueous solution was used as the antisolvent. The polymer solution concentration can reach a high of 15 wt%, enabling scalable production. The microbeads were biocompatible and harmless to both plants and aquatic organisms. Moreover, they were degradable in water environments containing microbes yet stable during storage in microbe-free water. Additionally, PHBV microbeads demonstrated excellent skin cleaning efficiency compared to other commercial materials. Therefore, as additives in exfoliation products, these eco-friendly PHBV microbeads have the potential to replace traditional petroleum-based microbeads.
✓ 已验证
产品关联
DOI
高影响因子
POLYMER BULLETIN
·
2021
·Vol. 79
·期 11
·9543-9562
·
IF 2.87
Gong Jiaying,Qiang Zhe,Ren Jie
A one-step reactive extrusion process has been demonstrated to toughen the poly(lactic acid) (PLA) blend without sacrificing its mechanical strength and degradability. Specifically, poly(lactic acid) (PLA), poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and the peroxide initiator were first introduced into the mixer and then heated at the elevated temperatures for triggering the grafting reaction during the extrusion. During this process, the thermal decomposition of PHBV results in the unsaturated bonds that can directly grafted onto the PLA backbones by free radical reactions. From this study, we found that PLA/PHBV blend with a mass ratio of 80/20 (PLA/PHBV) and 0.3 wt% 2,5-dimethyl-2,5-di(tert-butylperoxy)hexane (DBPH) is an optimized condition, leading to an improved elongation at break of 15.95%, which is 3.1 times of the PLA and 1.5 times of the PLA/PHBV blend without the initiator, while tensile strength exhibited very limited decreased compared to PLA. Overall, this work presents an environmentally friendly and industrial feasible approach to prepare bio-based toughened PLA for improving the elongation at break, while retaining the tensile strength and degradability.
研究领域:
材料科学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 9
·3307-3315
·
IF 7.393
Song Yang,Yue-Yi Wang,Ying-Nan Song,Li-Chuan Jia,Gan-Ji Zhong,Ling Xu,Ding-Xiang Yan,Jun Lei,Zhong-Ming Li
Ultrathin, flexible and lightweight characteristics are greatly desirable for next-generation wearable electromagnetic interference (EMI) shielding materials to address EM radiation pollution. Herein, we used poly(3-hydrobutyrate-co-3-hydroxyvalerate) (PHBV), which is a type of biodegradable and non-petroleum-based polymer, and silver nanowires (AgNWs) to fabricate ultrathin and flexible composite films with a sandwich structure via electrospinning, vacuum assisted filtration (VAF) and hot pressing in sequence. Owing to the highly conductive AgNW networks, the minimum sheet resistance and the maximum EMI shielding effectiveness (SE) of the obtained PHBV/AgNW film reached 0.5 Ω sq−1 and 45.9 dB, respectively, in X-band at a thickness of 18 μm. The films could meet the industry-accepted SE requirement (20 dB) at a high optical transparency of 74%. The specific EMI SE (SSE/t) of the film is up to 19 678 dB cm2 g−1, significantly surpassing those of most reported polymeric EMI shielding materials. Moreover, the sandwich structure of the PHBV wrapped AgNW layer could effectively prevent the shedding and corrosion of AgNWs. Thus, the PHBV/AgNW film has an outstanding EMI shielding reliability with a negligible change in EMI SE after exposure to harsh environmental conditions (acidic, alkali and saline solutions) and physical damage (1000 bending cycles and ultrasound for 60 min). This work provides a feasible strategy for the fabrication of ultrathin and flexible EMI shielding films, which will have promising prospects for applications in flexible electronics and wearable devices.
研究领域:
材料科学
·
环境科学
·
电子工程
✓ 已验证
产品关联
DOI
高影响因子
Journal of Water Process Engineering
·
2024
·
IF 6.3
Zhongshuo Xu,Yanfan Jiang,Wei Huang,Yuhui Wang,Xinshan Song
Sulfamethoxazole (SMX) is prevalent as one of the most frequently detected antibiotics in rivers worldwide, and is listed as one of the priority antibiotics in China based on the persistence, bioaccumulation, toxicity and resistance. Recently, the effect of SMX on aerobic granular sludge has attracted increasing interest. However, how SMX influences the biodegradable polymer supported denitrifying granular sludge is still obscure. Herein, two groups with or without exposure to 1 mg/L SMX with initial nitrate concentrations of 15, 30, and 50 mg/L were constructed. Results showed that there was a negligible difference on nitrate removal efficiencies between two groups under stable period (all exceeded 95 %) in batch bioreactors with an HRT of 24 h, supported by an insignificance difference ( p > 0.05). However, the decline in the first-order decay kinetic constants of nitrate removal rate, NAR and NIR activities verified a slight inhibition of SMX on denitrification. Meanwhile, SMX also had an impact on the chemical and microbial properties on granular sludge. SMX boosted the EPS secretion with more humic acid, a delicate rise in PN/PS ratios and a decrease in zeta potential of EPS all favored the microbes' survival under SMX stress. SMX shifted the microbial compositions, namely, the microbes directly involving in PHBV degradation ( Caldimonas , denitrificans Comamonas / Diaphorobacter ) were enriched instead of some denitrifying microorganism that could not directly utilize PHBV ( Denitratisoma , Azospira ). Additionally, even though sul1 and sul2 were enriched, which was not readily accessible to receiving waters due to a good settling properties of granular sludge. This work contributes to a deeper understanding of the impact of SMX on this system, and is of great significance for the operation of granular sludge system for nitrate removal under antibiotic's stress.
研究领域:
环境科学
·
微生物学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF POLYMER SCIENCE
·
2025
·
IF 3.6
Xinjiao Wang,Ping Liu,Xiaohong Chen,Honglei Zhou
The strength and hydrophilicity of nanofiber materials for tissue engineering have always been a significant challenge. This paper presents the design and preparation of PLA&Gel/PHBV core–sheath nanofibers that combine strength and super hydrophilicity using electrospinning technology. Compared to the original materials, the addition of gelatin simultaneously enhances both the strength and hydrophilicity of the materials, with the mechanical and hydrophilic properties of PLA&20 wt%Gel/PHBV nanofibers reaching optimal values of 7.45 MPa and 2.2°, respectively. The increase in strength is attributed to the entanglement effect caused by the gelatin molecular chains, which hinders the relative sliding of the molecular chains. The enhancement in hydrophilicity is due to the introduction of a large number of hydrophilic groups from Gel, improving the material's hydrophilicity. Additionally, the polar groups in gelatin and the emergence of a network pore structure significantly increase the material's water absorption rate. This work provides new insights into the design and preparation of nanofiber materials. Graphical A design and preparation method of electrospun fiber membranes with high strength and toughness and super-hydrophilicity.
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2023
·Vol. 13
·期 7
·1150
·
IF 5.3
Qiuyu Wang,Jianwei Ma,Shaojuan Chen,Shaohua Wu
Electrospinning has contributed substantially to the construction of nanofibrous scaffolds for potential tissue engineering and regenerative medicine applications. However, conventional electrospinning only has the ability to generate and collect nanofiber scaffolds with a randomly oriented fibrous pattern, which lack the necessary cell alignment guidance function. In this study, a novel electrospinning fiber-collecting device was designed and developed by setting a series of small pin-ring-structured collectors on a large plain plate. Specifically, we demonstrated that the pin-ring-structured collectors, which were constructed by inserting a metal pin into the center of a metal ring, could collect the as-electrospun nanofibers with radially oriented structures in an innovative manner. We first investigated the suitable polymeric concentration for electrospinning poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV), and the optimum electrospinning concentration of PHBV was found to be 12% (w/v) PHBV dissolved in hexafluoroisopropyl alcohol (HFIP). Then, 12% (w/v) PHBV solution was electrospun into radially oriented nanofiber scaffolds using our novel electrospinning strategy, and their various performances were further compared with conventionally randomly oriented nanofiber scaffolds that were also produced from 12% (w/v) PHBV solution. The results showed that the radially oriented PHBV nanofiber scaffolds exhibited obviously enhanced mechanical properties and decreased hydrophobicity compared with the randomly oriented PHBV nanofiber scaffold controls. Importantly, the biological properties of radially oriented PHBV nanofiber scaffolds were also demonstrated to be enhanced, compared with randomly oriented PHBV nanofiber scaffolds, by effectively inducing cell alignment and significantly promoting cell proliferation. In sum, the present study indicates that our as-prepared nanofiber scaffolds with a radially oriented pattern are of great interest for advanced applications, such as wound dressings and tissue-engineered scaffolds.Keywords:electrospinning;nanofiber scaffold;fiber alignment;biocompatibility;biomaterials
研究领域:
生物医学工程
·
组织工程
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2017
·
IF 4.811
Du Jun,Zhao Guomin,Pan Mingzhu,Zhuang Leilei,Li Dagang,Zhang Rui
Nanocellulose reinforced poly (3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) composites were prepared using melt compounding. The effects of nanocellulose types (CNCs and CNFs) and nanocellulose content (1, 2, 3, 4, 5, 6 and 7 wt%) on the crystallization, thermal and mechanical properties of PHBV composites were systematically compared in this study. The thermal stability of PHBV composites was improved by both CNCs and CNFs. CNFs with a higher thermal stability leaded to a higher thermal stability of PHBV composites. Both CNCs and CNFs induced a reduction in the crystalline size of PHBV spherulites. Furthermore, CNCs could act as a better nucleating agent for PHBV than did CNFs. CNCs and CNFs showed reinforcing effects in PHBV composites. At the equivalent content of nanocellulose, CNCs led to a higher tensile modulus of PHBV composites than did CNFs. 1 wt% CNCs/PHBV composites exhibited the most optimum mechanical properties.
研究领域:
材料科学
·
高分子科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2026
·
IF 3.1
Xu Zheng,Xiao Tian,Zhuolun Li,Xiangdong Wang,Shihong Chen
Poly(3-hydroxybutyrate-co-3-hydroxyvalerate) (PHBV) is a representative bio-based biodegradable polyester; however, its high crystallinity and brittleness severely restrict its practical applications. To improve its mechanical performance, a thermoplastic copolyester (TPC) elastomer (ET) was used as a toughening agent, and a reactive interfacial compatibilizer—poly(glycidyl methacrylate) (PGMA)—was synthesized to enhance interfacial adhesion between PHBV and the TPC-ET, improving their compatibility. Differential scanning calorimetry and Fourier transform infrared spectroscopy analyses indicated that the epoxy groups of PGMA formed hydrogen bonds with the PHBV and TPC-ET phases, strengthening intermolecular interactions and restricting blend crystallization. Rheological and scanning electron microscopy results revealed that the incorporation of PGMA improved the interfacial bonding, refined the dispersed-phase size, and produced a uniform sea–island morphology. Consequently, the mechanical properties of the PHBV/TPC-ET/PGMA blends considerably improved: the impact strength reached 17.58 kJ m −2 , elongation at break reached 8.23%, and tensile strength reached 27.5 MPa—representing improvements of 270.1%, 69%, and 190.4%, respectively, compared with those of pristine PHBV. The proposed strategy effectively toughens PHBV and increases its application potential in sustainable polymer materials.
✓ 已验证
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2011
·
IF 3.463
Jing Wang,Zongbao Wang,Jun Li,Bingjie Wang,Ji Liu,Peng Chen,Menghe Miao,Qun Gu
Chemically modified chitin nanocrystals were synthesized by grafting poly(3-hydroxybutyrate- co -3-hydroxyvalerate) (PHBV) onto chitin backbone via chlorination. Acetyl amino group was maintained in the reaction. The chemical structure and morphology of PHBV grafted chitin nanocrystals were characterized by Fourier transform infrared, Transmission electron microscopy and X-ray photoelectron spectroscopy. Contact angle measurement showed that the lipophilicity of chitin was improved by the surface modification. The effects of original chitin and PHBV-graft-chitin nanocrystals on the crystallizing and melting behavior of PHBV were studied by differential scanning calorimeter (DSC). The results indicated that both unmodified and modified chitin nanocrystals suppressed crystallization of PHBV. The melt point of PHBV was increased after being mixed with nanofillers.
研究领域:
材料科学
·
生物化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2025
·
IF 8.2
Yafei Wang,Xiaowei Huang,Jiayi Jiang,Qi Meng,Yiran Li,Wenwen Zhao,Shaojuan Chen,Shaohua Wu
The healing of diabetic wounds is a complex process involving multiple physiological mechanisms, which necessitates an appropriate microenvironment to effectively facilitate the healing process. Recently, advanced wound dressings constructed by functionalizing cotton nonwovens with appropriate structures and biological properties have aroused intensive interest in chronic wound treatment and care. The present study fabricated composite dressings by coating cotton nonwoven webs with UV-cross-linked methacrylated gelatin (Megel) hydrogels containing Salvia miltiorrhiza–Radix Puerariae/polyhydroxyalkanoate-loaded short nanofibers (SP: 632 ± 191 nm diameter, 2.9 ± 2.7 μm length). The composite dressings exhibited a uniform microporous structure (pore size: 24.2 ± 9.2 μm), superior water retention (85.8 ± 0.3% after 2 h), and markedly improved mechanical properties (Young’s modulus: 6.8 ± 1.3 MPa; elongation at break: 153.8 ± 10.4%). Additionally, they demonstrated excellent performance in swelling, biodegradation, and free radical scavenging. All composite dressings demonstrated excellent biosafety and rapid hemostasis in liver bleeding models. Critically, the Cotton&Megel + SP-3% dressing accelerated diabetic mouse wound closure to ∼98% within 18 days, which also reduced early inflammation and markedly improved regenerated tissue quality by promoting collagen deposition, angiogenesis, and hair follicle formation. These results indicate that our composite dressings made from SP, Megel hydrogel, and cotton nonwoven hold significant potential as advanced dressing candidates for diabetic wound treatment.
研究领域:
生物材料学
·
伤口修复
·
糖尿病并发症
·
药物递送系统
·
组织工程
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Lixia Jia,Weilong Wu,Qi Zhou,Yuanwei Li,Weizhong Wu
The solid carbon source (poly-3-hydroxybutyrate-co-3-hyroxyvalerate, PHBV) and manganese oxide mineral (Mn ore) were proposed firstly as co-substrates for eliminating nutrients and sulfamethoxazole (SMX) in this study. Results showed that high-rate nitrate and phosphate removal could be achieved in PHBV/Mn ore systems with the average efficiencies of 90% and 66.7%, respectively, although the addition of SMX decreased denitrification performance by 4.5–10.5%. SMX was removed mainly via biodegradation of enriched denitrifying microbes, with the average removal efficiency of 20–50% in PHBV/Mn ore systems, which was higher than that in PHBV systems. The existence of Mn ore markedly shaped the microbial community structure, leading to the dominant bacteria transforming from Microscillaceae to Sporomusaceae. The genera of Geobacto r, Desulfovibrio and Anaerovorax were found to maintain the stability of microbial system as keystone species. Surprisingly, large amount of Mn(II) was accumulated, which not only verify the involvement of Mn cycling in decontamination process, but also might explain the propagation of ARGs ( tnpA-04 and tnpA-05 ) in host microorganisms. Therefore, the optimized mixture proportion of PHBV and Mn ore should be further estimated avoiding Mn (II) accumulation in the effluent. On the whole, these results might shed light on new insight for advanced treatment of nutrients and emerging pollutants in biofilm reactors.
研究领域:
环境工程
·
微生物学
·
水处理
·
生物修复
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）