Polymer Chemistry
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2017
·Vol. 8
·期 14
·2189-2196
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IF 5.375
Houbo Zhou,Yi Chen,Christopher M. Plummer,Huahua Huang,Yongming Chen
This article demonstrates a new post-modification method to synthesize well-defined brominated polymers based on the bromination of hydroxyl-containing polymers. Bromination conditions for poly(2-hydroxylethyl methacrylate) (PHEMA) with diethylaminodifluorosulfinium tetrafluoroborate (XtalFluor-E), including solvents, bromine sources, additives, feeding ratios and reaction times were studied in detail. It was found that all –OH groups of PHEMA were quantitatively transformed to –Br groups and that the product maintained a narrow molecular weight distribution with a combination of XtalFluor-E, tetrabutylammonium bromide (TBAB) and 1,8-diazabicyclo(5.4.0)undec-7-ene( DBU) in dichloromethane for 24 h, at a feed ratio of [OH] : [XtalFluor-E] : [TBAB] : [DBU] = 1 : 5 : 5 : 5. Thus, well-defined poly(2-bromoethyl methacrylate) (PBEMA) and its copolymer poly(BEMA-co-MMA) were readily prepared via post-modification of the corresponding PHEMA and poly(HEMA-co-MMA) copolymer at room temperature followed by a simple precipitation procedure. This methodology was additionally applied to obtain α,ω-dibromo and mono-bromo terminated poly(ethylene glycol)s (PEGs) from the corresponding hydroxyl-capped PEGs. The facile and efficient bromination of hydroxyl-containing polymers has the potential to be a universal methodology for the synthesis of a diverse range of brominated polymers.
研究领域:
高分子化学
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材料科学
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DOI
高影响因子
POLYMER SCIENCE SERIES B
·
2015
·Vol. 57
·期 5
·460-472
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IF 0.577
Sa Zongpeng,Li Yapeng,Zhao Haochen,Hu Qi,Wei Jia,Wang Jingyuan
Through H-shaped macroinitiator glycol-chlorine((Cl) 2 -PEG-(Cl) 2 ) to initiate the ATRP reaction of 2-Hydroxyethyl Methacrylate (HEMA) we synthesized H-shaped copolymer (PHEMA) 2 - b -PEG- b -(PHEMA) 2 . After we modified the copolymer with histidine (His), the self-assembling and drug release behavior was studied. The morphology of the copolymer micelles and drug loaded micelles were examined by transmission electron microscope (TEM). Spherical micelles and core-shell structure with a diameter of 165 nm were obtained (at pH = 7.0). Due to the presence of imidazole-ring in histidine the copolymer show commendable pH-sensitivity, which made the copolymer potential application as drug carrier exhibiting good control-released property.
研究领域:
高分子化学
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药物递送系统
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生物材料
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DOI
高影响因子
Desalination and Water Treatment
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2024
·
IF 1
Jun Yin,Xinan Cai,Meng Chen
Pluronic F127-block-poly(2-hydroxyethyl methacrylate) (PHEMA-b-F127-b-PHEMA) was beforehand synthesized via the RAFT polymerization and used as an additive with polyethersulfone (PES) matrix to fabricate composite membranes by the phase inversion method. During the membrane formation process, the highly hydrophilic PHEMA blocks migrate spontaneously onto the membrane surfaces, which can be verified by the attenuated total reflectance-Fourier transform infrared spectroscopy. As a result, the composite membrane surface porosity and hydrophilicity were enhanced compared with the unmodified PES membrane. More importantly, the water permeability and anti-fouling ability of composite membranes were improved significantly. Furthermore, the PHEMA blocks enriched on the as-made PES composite membrane surface, which acted as an anchor to immobilize the initiating site. Therefore, a lot of functional polymers were effectively grafted onto the PES composite membranes by surface-initiated radical polymerization.
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DOI
高影响因子
SURFACE ENGINEERING
·
2014
·
IF 1.51
B. Chen,J. Chen,L. Yang,G. Zhao,G. Ding
Using electrodeposition of poly(hydroxyethylmethacrylate)–glycidyl methacrylate–salicylic acid (PHEMA-GMA-SA) in this study, the surface of stainless steel was modified by PHEMA to improve its surface properties of corrosion resistance and hemocompatibility for biomedical applications. Electropolymerisable SA was introduced on PHEMA-GMA by ring opening reaction of the epoxy group of GMA. Poly(hydroxyethylmethacrylate)–glycidyl methacrylate was synthesised by precipitation copolymerisation of HEMA and GMA in ethyl acetate. Ultraviolet spectrum was applied for calculating the degree of substitution of SA in the copolymer. Structure of the electrodeposited layer was verified by Fourier transform infrared. Polarisation curves and electrochemical impedance spectroscopy technologies were used to estimate the corrosion resistance of PHEMA modified stainless steel. The hemocompatibility of PHEMA modified stainless steel was determined by bovine serum albumin adsorption and platelet adhesion.
研究领域:
生物材料学
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电化学
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医学工程
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DOI
高影响因子
Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 12
·1734-1743
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IF 4.776
Shuhao Wang,Fei Zan,Yu Ke,Gang Wu
Introducing or grafting molecules onto biomaterial surfaces to regulate cell destination via biophysical cues is one of the important steps for biomaterial design in tissue engineering. Understanding how cells feel the substrate makes it easier to learn the mechanism behind cell–material interaction. In this study, on a glass substrate, we constructed poly-phenoxyethyl methacrylate (PHEMA) brushes having different lengths via a surface-induced atom transfer radical polymerization (SI-ATRP) method. FTIR-ATR and XPS tests of the formed polymer brushes indicate that these brushes have characteristic chemical structures of PHEMA; the polymer brush length revealed by the AFM tests increases linearly with reaction time. Cell lines of BMSCs, ATDC5, and human chondrocytes (HC) were cultured on these substrates to evaluate proliferation, adhesion, and differentiation. Our results demonstrated that the cells cultured on the substrates with short PHEMA brushes developed a spread morphology and organized actin fibers as compared to the cells cultured on those with long brushes. Different cell lines showed different responses depending on the PHEMA brush length. Cells cultured on long PHEMA brushes displayed a more rounded shape, higher gene expression of FAK and integrin, and lower gene expression of NCAM and N-cadherin as compared to those, especially ATDC5 cells, cultured on short PHEMA brushes. On PHEMA brushes with a long length, the cell lines express higher cartilage-specific genes including Sox9 and Col2 and GAG in ECM. The results suggest that polymer brushes having different lengths may interfere with the behavior of the cells cultured on them.
研究领域:
生物材料学
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组织工程学
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细胞生物学
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DOI
PubMed
高影响因子
ACS Applied Bio Materials
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2020
·
IF 0
Xinlin Yang,Mengmeng Cui,Jinsheng Zhou,Lu Zhang,Haohao Zhou,Zhongkuan Luo,Li Zhou,Huiyuan Hu
A poly(2-hydroxyethyl methacrylate) (pHEMA) hydrogel film was prepared by bulk polymerization. Then, it was surface modified by perfluorooctanoyl chloride to improve the anti-biofouling properties. Attenuated total reflectance-Fourier transform infrared (ATR-FTIR), X-ray photoelectron spectroscopy (XPS), scanning electron microscopy-energy dispersive X-ray spectroscopy (SEM-EDXS), and atomic force microscopy (AFM) analyses demonstrated that the uniform dense fluorinated layer had been successfully grafted onto pHEMA. The water contact angle (WCA) of the modified pHEMA film increased to 135°, while the surface energy decreased to 13.32 mN/m. The protein and bacterial adhesion properties of the modified pHEMA were decreased significantly. The in vitro cytotoxicity showed that the modified pHEMA was noncytotoxic. Thus, the fluorinated modification on the material surface was a convenient and effective method to establish a hydrophobic and anti-biofouling surface.
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DOI
PubMed
MATERIALS LETTERS
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2012
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IF 2.307
Meiling Chen,Jintang Zhu,Guijin Qi,Changcheng He,Huiliang Wang
Biological gels are generally anisotropic in both structures and mechanical properties , but conventional synthetic hydrogels are generally isotropic. We developed a directional freezing and radiation-induced polymerization and crosslinking (DFRPC) method to fabricate anisotropic hydrogels starting from monomers. The obtained poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogels show significant anisotropy in both microstructures and mechanical properties. The hydrogels exhibit an aligned porous structure along the freezing direction and an irregular porous structure in the vertical direction. Their elastic modulus and tensile stress in the parallel direction are significantly higher than those in the vertical direction, and the difference between the two directions decreases as the increase of HEMA concentration. This novel methodology offers a promising way to fabricate a wide variety of anisotropic hydrogels, and the anisotropic hydrogels may find practical applications in biomedical fields.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
Materials Horizons
·
2026
·
IF 11.4
Ziqi Wang,Hongyi Lv,Juan Zhang,Tianyue Zhang,Yishan Wang,Wanting Yuan,Yijing Zhang,Yuedong He,Lijuan Zhao,Zhongyi Zhu,Jinrong Wu,Yi Wang
Injectable hydrogels are attractive for minimally invasive soft-tissue repair, yet most systems undergo post-gelation swelling in aqueous environments, leading to dimensional instability and progressive mechanical deterioration. Here, we report a bacitracin-regulated poly(2-hydroxyethyl methacrylate) (PHEMA) hydrogel that exhibits in situ gelation together with intrinsic mild negative swelling under hydrated conditions. In this system, bacitracin serves as a multifunctional molecular regulator that not only accelerates gel formation under mild conditions but also modulates postgelation network evolution through multivalent hydrogen bonding and hydrophobic associations with PHEMA chains. As a result, the hydrogel undergoes a distinct hydration-driven network evolution rather than conventional swelling expansion, leading to spontaneous but mild volumetric contraction and improved structural stability in aqueous environments. Notably, this negative swelling behavior occurs directly under physiologically relevant hydrated conditions and without a pronounced overswelling stage. The resulting hydrogel displays enhanced mechanical robustness, resistance to water-induced structural degradation, and concentration-dependent antibacterial activity. By further incorporating estradiol-loaded mesoporous silica nanoparticles, the dimensionally stable network enables sustained bioactive release and promotes vaginal wound healing in vivo. More broadly, this work identifies bacitracinregulated hydration-driven network evolution as a route to controlling post-gelation volume behavior in injectable hydrogels and provides a design principle for soft-tissue repair in moist physiological environments.
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DOI
PubMed
高影响因子
FIBERS AND POLYMERS
·
2017
·Vol. 18
·期 5
·868-874
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IF 1.113
Zhao Jie,Hao Youwei,Cao Liqin,Wang Jide,Wang Wei,Wu Xiujuan
Poly(2-hydroxyethylmethacrylate) (PHEMA)/hydroxyapatite (HAP) nanocomposites were synthesized through a new route involving nano-sized HAP (nHAP) particles or modified nHAP mixed with monomer 2-hydroxyethylmethacrylate via in situ polymerization in supercritical carbon dioxide (scCO 2 ). Fourier-transform infrared spectroscopy showed phosphate peak increased with nHAP content in composite. X-ray diffraction patterns of PHEMA/nHAP revealed the presence of crystallized nHAP. Thermogravimetric analysis showed that the ultimate nHAP content in PHEMA/nHAP composites is consistent with its initial amount. Scanning electron microscopy revealed that nanocomposite particles are much smaller than PHEMA particles. PHEMA/nHAP composites with average diameter of approximately 600 nm were obtained in scCO 2 with 94 % yield. Mechanical properties of PHEMA/nHAP nanocomposites were better than those of PHEMA, and compressive modulus and strength of composites with 30 wt.% nHAP were 193 and 29 MPa, respectively. Nanocomposite adsorption toward bovine serum albumin was evaluated, and results indicated that analyte adsorption amount can reach up to 282 mg/g.
研究领域:
生物医学工程
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材料科学
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产品关联
DOI
高影响因子
JOURNAL OF BIOMATERIALS APPLICATIONS
·
2017
·
IF 2.31
Liu Jiang,Huaming Qian,Gang Chen,Chunyan Li,Guangjun Yan,Yanling Luo,Peng Liu,Yashao Chen
In this study, micropatterns on polypropylene films were fabricated via plasma pretreatment and UV-initiated graft polymerization. Firstly, radio-frequency plasma, which does not significantly influence bulk attributes of substrates due to limited penetration depth, was utilized to activate polypropylene films. Then, different sizes of micropatterns of poly(hydroxyethyl methacrylate) (PHEMA) were fabricated on the polypropylene films via UV-initiated graft polymerization of hydroxyethyl methacrylate by using photo-masks. Scanning electron microscopy, atomic force microscopy, X-ray photoelectron spectroscopy, and contact angle (CA) were employed to characterize changes of pristine polypropylene films and modified ones in surface morphology, roughness, hydrophilicity, free energy and the surface chemical composition. All of these confirmed the successful grafting of different sizes of PHEMA micropatterns on the polypropylene surface. Furthermore, the influence of PHEMA micropatterns on cell proliferation and cytotoxicity was evaluated in vitro. Analysis of cell behaviour indicated that PHEMA micropatterns of the appropriate size can promote cellular adhesion and proliferation, and the PHEMA-micropatterned polypropylene films had good biocompatibility. The approach presented here provides an alternative to synthesize on the surface of polypropylene films’ micropatterns with the aim of using them in a diverse array of applications.
研究领域:
材料科学
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生物医学工程
·
细胞生物学
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产品关联
DOI
PubMed
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2021
·Vol. 33
·期 1
·180-188
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IF 3.665
Yongli Shi,Mingbo Yang,Xiaofei Pan,Shasha Yu,Xiao Wang
The purpose of this paper is to fabricate novel nanoparticles (NPs) from a single disulfide bond-bridged block copolymer poly(hydroxyethyl methacrylate)-S-S-polycaprolactone (PHEMA-S-S-PCL). The novel biomaterial was synthesized by ring-opening polymerization and reversible addition–fragmentation chain transfer polymerization. The cargo-free NPs were fabricated with the solvent evaporation method, and studies on NPs' characterizations were carried out. The hydrogen nuclear magnetic resonance ( 1 H NMR) and Fourier transform infrared spectroscopy spectra confirmed the synthesis of PHEMA-S-S-PCL copolymer. Thermo-gravimetric analysis curves indicated that the obtained PHEMA-S-S-PCL copolymer had good thermostability. Transmission electron microscopy and dynamic light scatter results suggested that the cargo-free NPs were in round shapes with an average diameter of 103.6 ± 0.12 nm. The low critical micelle concentration of cargo-free NPs (7.9 × 10 −4 mg/ml) indicated that these NPs would keep their spherical shapes after being attenuated by abundant liquid (e.g., blood or body fluid). Furthermore, these NPs showed high stability at the presence of bovine serum albumin. Therefore, it could be speculated that these NPs would not be absorbed by proteins in blood, and they could be used as a candidate carrier for drug delivery.
研究领域:
材料科学
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生物医学工程
·
药剂学
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产品关联
DOI
高影响因子
MACROMOLECULAR CHEMISTRY AND PHYSICS
·
2020
·Vol. 221
·期 18
·2000157
·
IF 2.335
Ming Gao,Hang Lu,Rong-Hao Song,Lin Ye,Ai-Ying Zhang,Zeng-Guo Feng
To highlight whether γ-cyclodextrins (CDs) facilitate propargylamine monosubstituted β-CDs (PA-β-CDs) as end stoppers to get threaded onto a distal azide terminated poly(2-hydroxyethylmethacrylate) (PHEMA) homopolymer (PH-46-2N 3 ) to create linear and hyperbranched polyrotaxanes (PRs) via the in situ copper-catalyzed azide/alkyne cycloaddition (CuAAC), PH-46-2N 3 is self-assembled with a varying amount of γ-CDs in water and then subjected the CuAAC with PA-β-CDs to end-cap the resulting γ-CD-PHEMA polypseudorotaxanes (PPRs) into the γ-CD-PHEMA PRs. It demonstrates that γ-CDs cannot promote PA-β-CDs to be entrapped on the PHEMA chain most likely due to their different cavity size and molecular framework and linear PRs are always formed with up to 29% γ-CD coverage ratio along the PHEMA axis thereof.
研究领域:
高分子化学
·
超分子化学
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）