Scientific Reports
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2026
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IF 4.9
Chen Xia,Zeng Jing,Wang Kun,Song Yindong
Bacterial infection and persistent local inflammation severely hinder the healing of bone defects, and conventional bone repair materials fail to achieve antibacterial treatment and bone regeneration regulation at the same time. As mechanical cues can modulate cell behaviors and osteogenesis, piezoelectric materials can convert ultrasound stimulation into bioelectrical signals and reactive oxygen species for bacteriostasis and osteogenic regulation. In this work, we prepared a composite hydrogel by incorporating strontium titanate into crosslinked sodium alginate/ε-polylysine networks. This material exhibits obvious pH-responsive release in acidic inflammatory microenvironments and realizes highly efficient sterilization under ultrasonic assistance. In vitro experiments confirm its outstanding biocompatibility. It effectively regulates macrophage polarization to relieve inflammatory responses and greatly promotes the osteogenic differentiation of bone marrow mesenchymal stem cells. This study establishes a feasible fabrication strategy for multifunctional therapeutic hydrogels and provides a promising platform for the comprehensive treatment of clinically infected bone defects.
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DOI
高影响因子
MATERIALS LETTERS
·
2026
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IF 2.6
Fei Sheng,Xiaomei Liu,Yi Liu,Botao Zhang,Hua Li
Titanium alloy implants face persistent risks of bacterial infection and insufficient early osseointegration. In this work, a hierarchical micro/nano-structured hydroxyapatite (HA)-ε-polylysine (PL)-tannic acid (TA) composite coating was fabricated on sandblasted titanium alloy via a controlled drop-casting strategy. Surface roughness increased with deposition cycles and was tuned from 1.91 to 5.01 μm after eight cycles. The HA-PL/TA 8 coating exhibited excellent antibacterial activity (> 99.99%) against both Staphylococcus aureus and Escherichia coli , mainly attributed to the intrinsic antibacterial properties of PL and TA. The coating maintained structural integrity and antibacterial performance after 7-day PBS immersion. Meanwhile, the bioactivity of HA and hierarchical structure promoted MC3T3-E1 osteoblast adhesion and proliferation. This multifunctional coating provides a simple strategy for constructing antibacterial and cytocompatible interfaces on titanium implants.
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高影响因子
Materials Today Bio
·
2025
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IF 10.2
Mingxia Zhou,Linping Lu,Xinyu Xu,Yefan Zhou,Huan Fang,Xue Wang,Dongxu Li,Xiaoyan Li,Jiaqi Hua,Jiahe Liu,Yingxia Li,Libin Jiang,Qiuju Miao,Hongtao Wen,Jing He,Shenyu Yang
Ulcerative colitis (UC), a prevalent form of inflammatory bowel disease (IBD), manifests as chronic diarrhea, abdominal pain, and bloody mucoid stools. Current treatment approaches for UC are typically limited by inadequate targeted delivery, premature gastrointestinal degradation, and systemic off-target effects. To address these challenges, we engineered PL&GA@EUK, EUK-134 nanozymes encapsulated in polylysine (PL) and glycyrrhizic acid (GA) coacervate droplets. PL&GA@EUK exhibited potent superoxide dismutase- and catalase-mimetic activities, scavenging hydroxyl radicals and demonstrating anti-inflammatory efficacy in both in vivo and in vitro models. In mice with dextran sulfate sodium-induced colitis, oral administration of PL&GA@EUK for 14 days significantly ameliorated the disease activity index and colonic damage. By maintaining the integrity of the intestinal mucosal barrier and modulating redox homeostasis, it protects the intestinal epithelial cells against ferroptosis, ultimately attenuating colitis progression. 16S rDNA sequencing revealed that PL&GA@EUK significantly enriched beneficial commensals, while suppressing opportunistic pathogens. Metabolomic analysis further indicated that it modulates lipid peroxidation-associated metabolites by regulating the biosynthesis of polyunsaturated fatty acids. Crucially, PL&GA@EUK achieved enhanced colon-targeted delivery with minimal systemic toxicity, thereby overcoming the key limitations of conventional treatments. The multifaceted mechanism of PL&GA@EUK, involving reactive oxygen species scavenging, gut microbiome remodeling, and ferroptosis suppression, underscores its immense promise for the clinical management of IBD.
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DOI
PubMed
高影响因子
Inorganic Chemistry Frontiers
·
2021
·Vol. 8
·期 23
·5113-5123
·
IF 6.569
Runtian Kang,Hang Chen,Ruijie Ji,Haoyang Wang,Takatoshi Seto,Yuhua Wang
It is of great significance for white light-emitting diodes (wLEDs) to explore new, efficient and stable inorganic phosphors excited by wideband near-ultraviolet (n-UV) light. A new type of efficient emission-tunable Ce3+/Mn2+ doped Ca2YHf2Al3O12 (CYHAO) garnet phosphor which can be excited by n-UV light is studied in this work. Due to the effective energy transfer (ET) from Ce3+ to Mn2+ in CYHAO, CYHAO:0.09Ce3+,xMn2+ phosphors have a wide excitation band in the 370–470 nm region with a peak at 410 nm. Under excitation at 410 nm, all the samples show tunable color emission and match with the near UV chip. Through the decay time, it is determined that the energy transfer efficiency is as high as 88.83%. The calculated activation energy is about 0.217 eV, indicating the relatively good thermal stability. The cathodoluminescence (CL) properties show that the phosphor has a high saturation current and saturation voltage. A single component white LED is fabricated by using the CYHAO:0.09Ce3+,0.3Mn2+ phosphor and a 400 nm n-UV chip. It is worth noting that the detailed study of the energy transfer mechanism, thermal quenching mechanism and CL mechanism has reference value for the development of new co-doped phosphors.
研究领域:
材料科学
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光学工程
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高影响因子
CHEMICAL ENGINEERING JOURNAL
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2022
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IF 16.744
Xin Xu,Huijun Li,Zhouqing Xu
The development of multifunctional luminescent switch for the detection of different targets is highly desirable because of the complexity of the environment. In this paper, novel porous fluorescent Metal–Organic Framework (HPU-23), which can visually detect gaseous hydrogen chloride (HCl) and trace water from organic solvents through the fluorescence quenching phenomena, are designed. Besides, after the fluorescence of HPU-23 quenching by HCl, HPU-23 can be reopened by gaseous triethylamine (TEA) treatment. HPU-23 also could detect trace water from organic solvents. Although the quenching of fluorescence is also observed, the sensor after sensing H 2 O cannot be regenerated by any treatment. Besides, another Pb 2+ sensor is obtained when a new luminophore, i.e., tris(2,2′-bipyridine) dichlororuthenium(II) hexahydrate (Ru(bpy) 3 2+ ), is added into an aqueous system containing HPU-23. Therefore, our strategy is a promising broadcast for the development of multifunctional sensors.
研究领域:
材料科学
·
分析化学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2022
·
IF 8.025
Cui Cheng,Haowei Zhong,Yuan Zhang,Xiaoran Gao,Jianmin Wang,Jingfeng Liu,Xiao Han
Clinically, systemic antibiotic therapy and traditional dressings care are not satisfactory in treating chronic diabetic ulcers (DU). Therefore, we presented sprayable antibacterial hydrogel for effective treatment of DU by using antibacterial macromolecules (quaternized chitosan, QCS, Mn ≈ 1.5 × 10 5 ), photothermal antibacterial nanoparticles (ε-poly- l -lysine grafted graphene quantum dots, GQDs-ε-PL) and miocompatible macromolecules (benzaldehyde-terminated four-arm poly(ethylene glycol), 4 arm PEG-BA) as materials. The results revealed that the hydrogel could be in situ formed in 70–89 s through dynamic imine bonds crosslinking and exhibited a pH-dependent swelling ability and degradability. The hydrogel could respond to bacterial triggered acidic environment to play a synergistic effect of chemotherapy and xenon light irradiated PTT, leading to the rupture of the bacterial membrane and the inactivation of bacteria, promoting the migration and proliferation of fibroblast cell, enhancing the adhesion of platelet endothelial cell, and finally accelerating the healing of infected diabetic wound. Moreover, the hydrogel displayed self-healing, hemostatic, and biocompatible abilities, which could provide a better healing environment for wound and further promote wound healing. Hence, the multifunctional hydrogel is expected to be a potential dressing for the clinical treatment of DU.
研究领域:
生物医学工程
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材料科学
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药学
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DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 37
·24390-24396
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IF 4.036
Xiang Long,Ruixue Li,Jiamei Xiang,Shaogui Wu,Jiayang Wang
In this work, we synthesized ultrabright carbon dots (U-CDs) with photoluminescence quantum yield (PLQY) up to ∼100% using CA and EDA as precursors. When studying their interaction with the Pb2+ ion, we found that the PL quenching degree is independent of the U-CDs concentration. This feature provides great convenience for practical detection, which allows the standard curve determination and practical detection to be conducted under different U-CDs concentrations with detection error less than 20%. Based on the experimental observations, a possible mechanism is proposed to explain this phenomenon. To our best knowledge, this work has never been reported before and provides a new idea for the design of novel fluorescent sensors.
研究领域:
分析化学
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纳米科技
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环境科学
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DOI
PubMed
高影响因子
CRYSTENGCOMM
·
2024
·
IF 2.6
Yuwei Zhong,Xinran Li,Hao Zhang,Rong Zhang,Kaiwen Hu,Xuedong Zhou,Yi Xie
Despite the rising advances in the field of all-inorganic CsPb2Br5-based materials and their photoelectronic applications, the exploitation of facile synthetic procedures and enhancement of optical properties remain challenging. Herein, we report a facile room-temperature aqueous phase synthesis of orange-red-emitting cation-doped and codoped CsPb2Br5 materials with enhanced photoluminescence (PL) performance and stability. Only very weak broad PL peak at around 618 nm is observed in the undoped CsPb2Br5 microsheets. However, doping with Cu, and codoping with Cu/Mn, Cu/Zn or Cu/Cd significantly enhance the PL intensity of the resulting CsPb2Br5-based samples. The stability of the representative Cu-doped and various codoped CsPb2Br5 is evaluated under various conditions such as soaking in water, high temperature up to 150oC, and ambient environment at room temperature. This work provides facile and cost-effective path for large-scale and controlled synthesis of orange-red emmisive CsPb2Br5-based materials with enhanced optical performances, excellent environmental stability, and potentials in LEDs.
研究领域:
材料科学
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光电技术
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纳米技术
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化学
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高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
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2022
·
IF 10.319
Zhe Hu,Hanxu Lu,Wenjie Zhou,Jinxin Wei,Hanqing Dai,Hong Liu,Zhiyong Xiong,Fengxian Xie,Wanlu Zhang,Ruiqian Guo
Over the past few decades, I-III-VI quantum dots (QDs) have attracted considerable attention due to their large Stokes shifts, good eco-friendliness, and wide tunable emissions. In this work, a facile microwave-assisted aqueous route using glutathione (GSH) and citric acid (CA) as dual stabilizers is introduced to synthesize AgInGaS/ZnS (AIGS/ZnS) core/shell QDs. An exceptional photoluminescence quantum yield (PL QY) as high as 79% is successfully achieved, boosting the best performance of water-dispersible AIGS QDs. By varying the Ag/Ga ratio, the PL peak wavelength can be tuned from 547 to 616 nm, and luminescent hydrogel films with different colors are obtained by embedding AIGS/ZnS QDs in polyacrylamide/poly-vinyl alcohol (PAAm/PVA) hydrogels. The white light-emitting diode (WLED) with a high color rendering index (CRI) of 92.1 ( R 9 =92.0) and a correlated color temperature (CCT) of 3022 K is fabricated using QDs-PAAm/PVA hydrogel films in combination with a blue InGaN LED chip, indicating that the as-prepared QDs are competitive color-conversion materials for WLEDs.
研究领域:
材料科学
·
光学工程
·
纳米技术
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DOI
高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2017
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IF 5.401
Jianhua Lü,Yuqin Fu,Dongmei Wang,Changli Lü
Luminescent silver nanoclusters (NCs) decorated with temperature-responsive copolymer P(NIPAm-co-MQ) have been fabricated in aqueous solution as a new fluorescent pH stimuli-responsive functional materials. P(NIPAm-co-MQ) was prepared by a conventional free-radical copolymerization of isopropylacrylamide (NIPAm) as thermo-responsive units and 5-(2-methacryloylethyloxymethyl)-8-quinolinol (MQ) as coordinating groups. The obtained fluorescent Ag NCs with various sizes showed different morphologies from single sphere to chain structure induced by the copolymer ligand. Upon changing the temperature, the fluorescence intensity of the Ag NCs exhibited temperature triggered response simultaneously. The copolymer stabilized Ag NCs as a pH probe exhibited reversible pH-dependent PL properties over the pH range of 3.04–5.25. With the pH decreased, the fluorescence intensity of Ag NCs under a UV lamp decreased and it was almost completely quenched after pH 3.04. Also, the properties of this fluorescence change with pH are reversible.
研究领域:
材料科学
·
纳米技术
·
分析化学
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DOI
高影响因子
JOURNAL OF SOLID STATE CHEMISTRY
·
2023
·
IF 3.3
Jian-Peng Qin,Chun-Yang Pan
The toxicity of lead limits the commercial application of lead-based perovskites . Replacing lead with an environment-friendly metal is an excellent alternative strategy. Bi 3+ is an interesting choice being that it has satisfactory biological security and similar electron configuration to Pb 2+ . Series of hybrid Bi 3+ perovskites, (H 2 DMAPA)BiBr 5 ( 1 ), (H 2 DMAPA)BiBr 2 I 3 ( 2 ), (H 2 DMAPA) 2 AgBiBr 8 ( 3 ) and (H 2 EP) 2 AgBiBr 8 ( 4 ) were successfully prepared in this work. Their band gaps are 2.65, 2.21, 2.58 and 2.33 eV, respectively. The excitation wavelengths of 1 , 2 , 3 and 4 are 440, 355, 365 and 400 nm, and the corresponding PL emission peaks are located at 480, 580, 493 and 467 nm, respectively.
研究领域:
材料科学
·
光电
·
化学
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DOI
高影响因子
Food Bioscience
·
2025
·
IF 5.9
Shu-zhen Huang,Huan-huan Yin,Fang Tian,Liang Wang,Wen-jing Wu,Xiang Li,Yanrong Zhao,Xiao-ya Wang,Yun Li,Megan Terp,Ying-yi Mao,Jin-yao Chen
The effects of mono- and di-glycerides/phospholipids (MDG/PL) combinations on lutein and docosahexaenoic acid (DHA) bioavailability in SD rats subjected to subchronic feeding with oil and emulsion systems were explored. MDG/PL increased the relative bioavailability of lutein and DHA respectively by 125.43 % and 114.51 % in the oil system and 111.15 % and 113.94 % in the emulsion, promoted lutein accumulation in the liver and spleen, and decreased the amount of lutein excreted via the urine and feces in both systems. These results suggest that the MDG/PL combinations effectively improve lutein and DHA bioavailability, especially lutein, which makes it a potential emulsifier of lutein and/or DHA in formulas or other preparations. Further study should be oriented to visualize the particle size and interfacial configuration of the MDG/PL and investigate the optimal formulation of MDG/PL and lutein and DHA for practical application.
研究领域:
营养学
·
食品科学
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DOI
高影响因子
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