Antioxidants
·
2024
·Vol. 13
·期 7
·786
·
IF 6
Tiantian Liu,Bin Jiang,Baoqiang Fu,Changyi Shang,Haobin Feng,Tao Chen,Yan Jiang
Previous research has established a correlation between PM2.5 exposure and aging-related cardiovascular diseases, primarily in blood vessels. However, the impact of PM2.5 on cardiomyocyte aging remains unclear. In this study, we observed that extractable organic matter (EOM) from PM2.5 exposure led to cellular senescence in H9c2 cardiomyoblast cells, as characterized by an increase in the percentage of β-galactosidase-positive cells, elevated expression levels of p16 and p21, and enhanced H3K9me3 foci. EOM also induced cell cycle arrest at the G1/S stage, accompanied by downregulation of CDK4 and Cyclin D1. Furthermore, EOM exposure led to a significant elevation in intracellular reactive oxygen species (ROS), mitochondrial ROS, and DNA damage. Supplementation with the antioxidant NAC effectively attenuated EOM-induced cardiac senescence. Our findings also revealed that exposure to EOM activated the aryl hydrocarbon receptor (AhR) signaling pathway, as evidenced by AhR translocation to the nucleus and upregulation of Cyp1a1 and Cyp1b1. Importantly, the AhR antagonist CH223191 effectively mitigated EOM-induced oxidative stress and cellular senescence. In conclusion, our results indicate that PM2.5-induced AhR activation leads to oxidative stress, DNA damage, and cell cycle arrest, leading to cardiac senescence. Targeting the AhR/ROS axis might be a promising therapeutic strategy for combating PM2.5-induced cardiac aging.
研究领域:
心血管疾病
·
毒理学
·
细胞生物学
·
环境健康
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Food & Function
·
2021
·Vol. 12
·期 24
·12671-12682
·
IF 5.396
Jing-yi Ren,Bo-wen Yin,Xiang Li,Si-qi Zhu,Jin-liang Deng,Yi-ting Sun,Zhen-ao Zhang,Zi-hao Guo,Huan-ting Pei,Fan Zhang,Rui-qiang Li,Feng-ge Chen,Yu-xia Ma
Objective: This study aimed to elucidate the pharmacological effects of sesamin (Ses) and its mechanism of action towards PM2.5-induced cardiovascular injuries. Method: Forty Sprague Dawley (SD) rats were randomly divided into five groups: a saline control group; a PM2.5 exposure group; and low-, middle-, and high-dose Ses pretreatment groups. The SD rats were pretreated with different concentrations of Ses for 21 days. Afterward, the rats were exposed to ambient PM2.5 by intratracheal instillation every other day for a total of three times. The levels of inflammatory markers, including tumor necrosis factor-alpha (TNF-α), interleukin-1beta (IL-1β), and interleukin-6 (IL-6), and indicators related to oxidative responses, such as total superoxide dismutase (SOD), reduced glutathione (GSH), glutathione peroxidase (GSH-Px), and malondialdehyde (MDA), were measured in the blood and heart. The expression of ferroptosis-related proteins in heart tissues was determined via western blot and immunohistochemistry. Results: Ses pretreatment substantially ameliorated cardiovascular injuries in rats as evidenced by the decrease in the pathological score and collagen area. The decreased levels of SOD, GSH, and GSH-Px in the heart and serum were inhibited by Ses. In addition, Ses not only notably increased the activity of antioxidant enzymes but also reduced the levels of MDA, CK, LDH, CK-MB, IL-6, TNF-α, IL-1β, and IL-6. Furthermore, Ses pretreatment upregulated the expression levels of GPX4, SLC7A11, TFRC, and FPN1 and inhibited the expression levels of FTH1 and FTL. Conclusion: Ses pretreatment could ameliorate PM2.5-induced cardiovascular injuries perhaps by inhibiting ferroptosis. Therefore, Ses pretreatment may be a novel strategy for the prevention and treatment of PM2.5-induced cardiovascular injury.
研究领域:
药理学
·
心脏病学
·
毒理学
·
环境健康
✓ 已验证
DOI
PubMed
高影响因子
RSC Advances
·
2019
·Vol. 9
·期 30
·17473-17478
·
IF 3.049
Jian Chen,Zhiqiang Cheng,Yafeng Yuan,Jingjing Zhang,Jinshan Cao
In this study, design and fabrication of novel shape-controllable and aligned nanofibrous membranes with self-cleaning and robust mechanical properties is presented. Smooth and uniform nanofibers can be fabricated by blending polyamide 66 (PA66) and poly (vinyl butyral) (PVB) with a mass ratio of 6/4 during electrospinning. Subsequently, the prepared nanofibrous membranes were placed in a vacuum drying oven at a given temperature (90 °C) for heat treatment, and the morphology of the composite nanofibers was controlled by an external tensile force. It was found that the treatment temperature and external tensile force greatly affected the pore structures and orientation of the nanofiber membranes. In addition, the hydrophobicity, pore structure and mechanical properties of well-aligned nanofibrous membranes are better than those of non heat-treatment nanofibers. Moreover, the PA66/PVB nanofibrous membranes are used as air filters, and show an excellent removal efficiency of up to 99.99% for PM2.5.
研究领域:
材料科学
·
环境工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Chunxia Pang,Haijun Wang,Xiaoyan Lin
Atmospheric particulate matter (PM) pollution is a serious threat to human health, so the preparation of electret films with high efficiency and low resistance capturing particulate has attracted wide attention. Herein, a strategy for the fabrication of all-polymer hybrid electret fiber membranes by electrospinning is reported based on the ethyl cellulose (EC) and polystyrene (PS). The preparation conditions of electret fiber membrane were optimized by focusing on the effect of the mass ratio of EC/PS and the spinning time on the structure, surface potential and purification performance of fiber membrane. The result showed that the fiber membrane has a low fiber diameter of 572 ± 113 nm and porosity of 82.4%, and a better potential stability when the EC/PS mass ratio was 2.5/1 and the spinning time was 10 min. As a result of the enhanced effect of electrostatic attraction on particle capture, the EC/PS composite electret membrane could make the purification efficiency of PM2.5 reach to100% within 11 min. Moreover, the EC/PS composite electret membrane has the properties of ultra-light base weight of 1.08 g·m −2 , low air resistance of 28 Pa and long service life. Therefore, the all-polymer EC/PS electret nanofiber membranes have broad application prospects in the field of air purification .
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
Materials Research Express
·
2018
·Vol. 5
·期 3
·036416
·
IF 1.151
Yating Wang,Xiu Dai,Xu Li,Xinlong Wang
In this article, metal organic frameworks (MOFs) material is introduced in the poly (lactic acid) (PLA) by electrospinning to fabricate the nanocomposite membrane. The acrylic acid (AA) is grafted onto the membrane under UV light. The prepared membrane is studied by scanning electron microscopy (SEM), x-ray diffraction (XRD), thermogravimetry (TG), contact angle test and tensile strength test. The SEM image and XRD indicate that nano MOFs particles adhere to the membrane. Contact angle test shows that grafting AA on the composite fiber membrane improves its hydrophilicity effectively. TG analyses show that the particulate matter (PM) capture capacity of PLA membrane with 2 wt% ZIF-8 content is 22%, which rises to 37% after grafting.
研究领域:
材料科学
·
环境科学
✓ 已验证
DOI
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2020
·
IF 9.038
Xue Yang,Yi Pu,Yifei Zhang,Xiaofang Liu,Jianxin Li,Ding Yuan,Xin Ning
In this study, a new barium titanate@polyurethane/polysulfonamide (BaTiO 3 @PU/PSA) composite nanofibrous membrane with comprehensive properties for high temperature filtration and robust PM2.5 removal was successfully fabricated through the blending spinning of PU and PSA and the introduction of BaTiO 3 . As a consequence, the BaTiO 3 @PU/PSA membrane achieved the high capture efficiency of 99.99 % for fine particulates, low pressure drop of 39.4 ± 0.2 Pa, good mechanical property (13.27 MPa), sufficient flexibility, high thermal stability (up to 300 °C), favorable flame-retardancy as well as superior chemical resistance against acid and alkali. Especially, to intuitively reveal the relationship between the fiber structure, high temperature environment, gas velocity and filtration performance of the composite membrane, the filtration processes were carefully investigated through the analog simulation. More importantly, the BaTiO 3 @PU/PSA membrane exhibited high-efficiency PM2.5 purification capacity, and the removal efficiency kept stable after high temperature, acid or alkali treatment, ascribing to the advantageous structure of PSA, PU and BaTiO 3 . Overall, the BaTiO 3 @PU/PSA nanofiber membranes with versatility are a promising high-efficiency candidate for dust removal, particularly in harsh conditions.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF ASTHMA
·
2015
·
IF 1.802
Xingliang Zhang,Wenqing Zhong,Qingqi Meng,Qianwen Lin,Chao Fang,Xiulan Huang,Chengyan Li,Yuge Huang,Jianxin Tan
Objective: Epidemiological studies have shown that elevated concentrations of ambient particulate matter (aerodynamic diameter ≤2.5 μm; PM2.5) correlates with increased incidence of asthma. The aim of this study was to determine whether PM2.5 participates in the exacerbation of asthma. Methods: Effects of 1, 10 and 100 μg PM2.5 instilled intratracheally in ovalbumin (OVA)-sensitized or asthmatic mice were compared. Results: PM2.5 exposure in the OVA-sensitized and especially asthmatic groups increased Mch responsiveness in a dose-dependent manner. In OVA-sensitized groups, exposure to 1 μg of PM2.5 caused no detectable lung inflammation, while 10 and 100 μg of PM2.5 resulted in a slightly increased trend in numbers of neutrophils and macrophages. Compared with the asthmatic control group, both 10 and 100 μg of PM2.5 provoked a significant increase in eosnophils and neutrophils whereas only 100 μg of PM2.5 noticeably enhanced lymphocytes. In asthmatic groups, administration of 100 μg of PM2.5 greatly increased levels of the pro-inflammatory cytokine TNF-α and Th2-related cytokines IL-4 and IL-10 in bronchoalveolar lavage fluid, but it decreased Th1-related INF-γ. In addition, 10 and 100 μg of PM2.5 exacerbated inflammatory infiltration, goblet cell metaplasia and lung ultrastructure lesions in asthmatic mice. Conclusions: Our results suggested that acute exposure of PM2.5 could synergize with allergens in the subsequent challenge to aggravate the severity of asthma in sensitized mice, possibly by promoting a Th2-biased immune response.
研究领域:
环境卫生
·
免疫学
·
呼吸系统疾病
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Nan Jiang,Xuexin Hao,Zichen Wang,Minzhen Li,Dong Zhang,Rong Cao,Ruiqin Zhang,Haijun Zhang,Jiping Chen,Ningbo Geng
The extensive utilization of rubber-related products can lead to a substantial release of p -phenylenediamine (PPD) antioxidants into the environment. In recent years, studies mainly focus on the pollution characteristics and health risks of PM 2.5 -bound PPDs. This study presents long-time scale data of PPDs and N-(1,3-dimethylbutyl)-N′-phenyl- p -phenylenediamine quinone (6PPD-Q) in PM 2.5 and proposes the innovative use of PPDs as new markers for vehicular emissions in the Positive Matrix Factorization (PMF) source apportionment . The results indicate that PPDs and 6PPD-Q were detectable in 100 % of the winter PM 2.5 samples, and the concentration ranges of PPDs and 6PPD-Q are 15.6–2.92 × 10 3 pg·m −3 and 3.90–27.4 pg·m −3 , respectively, in which 6PPD and DNPD are the main compounds. Moreover, a competitive formation mechanism between sulfate, nitrate, ammonium (SNA) and 6PPD-Q was observed. The source apportionment results show that the incorporation of PPDs in PMF reduced the contribution of traffic source to PM 2.5 from 13.5 % to 9.5 %. In the traffic source factor profiles, the load of IPPD, CPPD, DPPD , DNPD and 6PPD reaches 91.8 %, 91.6 %, 92.9 %, 80.6 % and 87.2 %, respectively. It`s amazing that traditional markers of traffic source, which often overlap with coal burning and industrial sources, over-estimated the contribution of vehicles by one third or more. The discovery of PPDs as specific markers for vehicular emissions holds significant utility, particularly considering the growing proportion of new energy vehicles in the future. The results may prove more accurate policy implications for pollution control . Synopsis PPDs are excellent indicators of vehicle emissions, and PMF without PPDs over-estimated the contribution of traffic source to PM 2.5 .
研究领域:
环境科学
·
大气污染研究
✓ 已验证
产品关联
DOI
PubMed
高影响因子
URBAN FORESTRY & URBAN GREENING
·
2022
·
IF 5.766
Changkun Xie,Jiankang Guo,Lubing Yan,Ruiyuan Jiang,Anze Liang,Shengquan Che
Exploring the relationships between plant morphological structures and PM 2.5 (particulate matter < 2.5 µm in diameter) retention on leaf surfaces and determining the key factors will help to screen tree species with high-efficiency PM reduction and improve the air purification function of green spaces. PM 2.5 retention experiments were conducted in a wind tunnel using 1800 branches from 30 species with different morphological structures under wind speeds of 1, 3.5, and 8 m/s. Eight comprehensive variables (PC1–PC8) of plant morphological structure were extracted by principal component analysis , and their relationships with PM 2.5 retention and the main influencing factors were explored by stepwise regression models. Under all of the wind speeds, the totality characteristic (PC1) (composite variable of factors including volume and total surface area) and surface area/weight density (PC2) of plant branches and leaves were the two most significant influencing factors, and they had negative effects. In addition to the aforementioned two common key factors, the leaf size (PC5) and surface roughness (PC7) were the two key positive factors at wind speeds of 1 and 3.5 m/s, while the number of branches and leaves (PC3 and PC4, respectively) were the two key positive factors at a wind speed of 8 m/s. Generally speaking, with the increase of wind speed, the effect of leaf morphological characteristics on PM 2.5 retention decreased, while the crown structure characteristics became more significant. Compared with leaf morphological characteristics, the crown morphological structure variables had greater variability and a greater impact on PM 2.5 retention. Crown morphological structure should be given more importance in screening high-efficiency PM retention tree species.
研究领域:
生态学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Zhimin Hao,Juntao Wu,Chaolu Wang,Jingang Liu
Particulate matter (PM) pollution is a serious threat to human health. Zeolitic imidazolate framework-8 (ZIF-8) is a kind of metal-organic framework, and ZIF-8 not only can capture PM2.5 efficiently but also possesses excellent chemical and thermal stability. In this study, ZIF-8-modified soluble polyimide (PI) nanofibrous membranes were prepared via an electrospinning process. As a result, the PI-ZIF membrane shows high PM2.5 filtration efficiency (up to 96.6 ± 2.9%), superior thermal stability (up to 300 °C), good transmittance, excellent mechanical properties, and low pressure drop. The prepared PI-ZIF membrane with excellent comprehensive property shows a promising application in PM2.5 capture, especially in harsh conditions.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2019
·
IF 8.456
Xue Yang,Yi Pu,Shuxia Li,Xiaofang Liu,Zheshan Wang,Ding Yuan,Xin Ning
To address the challenge of high-temperature air filtration, a novel electreted polysulfonamide/polyacrylonitrile-boehmite (PSA/PAN-B) composite nanofiber based filter was developed via electrospinning for effective high-temperature dust removal. In this study, the spinnability of PSA was greatly improved by adding a small amount of PAN as an auxiliary polymer, and the introduction of a boehmite electret further significantly reinforced the properties of PSA fibers. As a result, the PSA/PAN-B membrane exhibited a high filtration efficiency (up to 99.52 ± 0.32%), low pressure drop (45.16 ± 1.39 Pa), excellent flexibility, good mechanical properties, high thermal stability (up to approximately 300 °C), and superior chemical resistance. Through data analysis and 3D simulation, the important benefits of the boehmite electret in the optimization of the PSA fibrous membrane performance were determined: it increases the charge storage capacity, constructs a rough surface morphology, improves the specific surface area, and enhances the mechanical properties. More importantly, the PSA/PAN-B film possessed a robust PM2.5 purification capacity, and the particulate matter removal efficiency was kept unchanged after high-temperature, acid, or alkali treatment—a performance derived from the intrinsic molecular structure of PSA. The PSA/PAN-B composite fibrous membrane, with excellent comprehensive properties, is a promising candidate for air filters, especially in harsh environments, further broadening the applications of PSA and providing new insight into the design of high-performance filters with high-temperature and corrosion resistance.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2021
·
IF 7.312
Zhimei Wei,Zhefu Wu,Qing Su,Chuanren Zhu,Hongye Zeng,Xiaojun Wang,Shengru Long,Jie Yang
Particulate matter 2.5 (PM 2.5 ) pollution has severely affected human health. It is urgent and essential to remove PM 2.5 from sources of pollution. However, filtration at the source of pollution remains challenging because most filters are not resistant to high temperature. Therefore, a polysulfonamide with novel molecular structure nanofiber filter in this work was developed by electrospinning technology for high-efficient air filtration. The polysulfonamide with m-phenyl substituted segments was successfully synthesized by the results of 1H NMR spectroscopy and fourier transform infrared spectroscopy. Moreover, the polysulfonamide nanofiber filters (PNFs) demonstrated excellent mechanical strength (7.2 MPa), high filtration efficiency (99.5 %), low pressure drop (111 Pa) for PM 2.5 filter, significant thermal stability (300 °C), and excellent flame retardancy. Furthermore, the PNFs with beaded-structure had a lower pressure drop (59 Pa) because the microspheres increased the distance between the fibers. Therefore, the PNFs will have great potential in the fields of high-temperature exhaust gas filtration, water purification, and protein separation.
研究领域:
材料科学
·
环境科学
·
医学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）