COLLOID AND POLYMER SCIENCE
·
2014
·Vol. 292
·期 5
·1061-1072
·
IF 2.41
Luo Yan-Ling,Yang Xiao-Li,Xu Feng,Chen Ya-Shao,Zhao Xu
pH-sensitive poly(methacrylic acid)- block -hydroxyl-terminated polybutadiene- block -poly(methacrylic acid) block copolymers were synthesized by atom transfer radical polymerization of t -butyl methacrylate and follow-up acidolysis. The copolymers can spontaneously assemble into stable and nearly spherical micelle aggregates in aqueous solution, with hydrodynamic diameters ( D
h
) from 51 to 92 nm and critical micelle concentration of 3.90–7.76 mg L −1 . Z eta potentials were found to be increased with increasing (monomer)/(initiator) molar ratios. A pH-dependent phase behavior is produced at approximately 5.4–5.6, as determined by D
h
and I
335 / I
332 fluorescence intensity ratios. The in vitro camptothecin (CPT) release was compositional and pH dependent, and the cumulative CPT release below pH 7.2 was higher than that in pH 7.4. They could inhibit the premature burst CPT release. The copolymer micelles were low in cytotoxicity even at a micellar concentration of 800 mg L −1 , and therefore they may be used as potential drug-delivery carriers.
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研究领域:
药剂学
·
高分子化学
·
生物医学工程
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高影响因子
POLYMER BULLETIN
·
2012
·Vol. 69
·期 5
·597-620
·
IF 1.532
Luo Yan-Ling,Yu Wei,Xu Feng
pH-sensitive hydrophilic poly(methacrylic acid)- b -poly(ethylene glycol)- b -poly(methacrylic acid) (PMAA- b -PEG- b -PMAA) triblock copolymers were synthesized through atom transfer radical polymerization, and were characterized by FT-IR, 1 H NMR, and GPC. The as-synthesized polymers can self-assemble into stable and almost spherical nanomicelles in aqueous solution with an average size range from 18 to 89 nm, depending on the micellar concentrations, while they assumed well-defined spherical morphologies in PBS solutions. The micellization behavior in different media was investigated by a fluorescence spectroscopy technique, UV–Vis transmittance, and dynamic light scattering measurements. The critical micelle concentration and size of the micelles decrease with the increasing the length or molecular weights of PEG and PMAA chains. A pH-dependent phase transition behavior produces at a pH value of about 5.2, and the stable pH micellization behavior varied within a narrow pH range from ca. 4.8 to 7.4. These triblock copolymers are generally low cytotoxicity at a micellar concentration below 400 mg L −1 , as revealed by the MTT assay. The prednisone release and release kinetics studies disclosed that these pH-sensitive polymeric micelles are good carriers for the drug delivery.
研究领域:
材料科学
·
药学
·
生物医学工程
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高影响因子
Soft Matter
·
2011
·Vol. 7
·期 11
·5348-5352
·
IF 4.457
Yin Wang,Guohua Jiang,Ming Zhang,Lina Wang,Rijing Wang,Xinke Sun
A series of novel shell cross-linked nanocapsules were facilely fabricated in an inverse miniemulsion reversible addition–fragmentation chain transfer (RAFT) system, in which poly(2-(dimethylamino)ethyl methacrylate) (PDMAEMA) acted as a stabilizer and macroinitiator. The as-prepared nanocapsules with PDMAEMA cores and poly(methylacrylic acid) (PMAA) shells, had a size of 220 nm and can be used as a carrier for the encapsulation of hydrophilic components such as inorganic salts.
研究领域:
材料科学
·
化学工程
·
纳米技术
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高影响因子
LANGMUIR
·
2011
·
IF 4.269
Cuie Wang,Qin Yan,Hong-Bo Liu,Xiao-Hui Zhou,Shou-Jun Xiao
Infrared spectroscopy was applied to investigate the well-known EDC/NHS (N-ethyl-N′-(3-(dimethylamino)propyl)carbodiimide/N-hydroxysuccinimide) activation details of poly(acrylic acid) (PAA) and poly(methacrylic acid) (PMAA) brushes grafted on porous silicon. Succinimidyl ester (NHS-ester) is generally believed to be the dominant intermediate product, conveniently used to immobilize biomolecules containing free primary amino groups via amide linkage. To our surprise, the infrared spectral details revealed that the EDC/NHS activation of PMAA generated anhydride (estimated at around 76% yield and 70% composition), but not NHS-ester (around 5% yield and 11% composition) under the well-documented reaction conditions, as the predominant intermediate product. In contrast, EDC/NHS activation of PAA still follows the general rule, i.e., the expected NHS-ester is the dominant intermediate product (around 45% yield and 57% composition), anhydride the side product (40% yield and 28% composition), under the optimum reaction conditions. The following amidation on PAA-based NHS-esters with a model amine-containing compound, l-leucine methyl ester, generated approximately 70% amides and 30% carboxylates. In contrast, amidation of PAA- or PMAA-based anhydrides with l-leucine methyl ester only produced less than 30% amides but more than 70% carboxylates. The above reaction yields and percentage compositions were estimated by fitting the carbonyl stretching region with 5 possible species, NHS-ester, anhydride, N-acylurea, unreacted acid, unhydrolyzed tert-butyl ester, and using the Beer–Lambert law. The different surface chemistry mechanisms will bring significant effects on the performance of surface chemistry-derived devices such as biochips, biosensors, and biomaterials.
研究领域:
表面化学
·
高分子化学
·
生物偶联
·
材料科学
·
生物传感器
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高影响因子
NEW JOURNAL OF CHEMISTRY
·
2015
·Vol. 39
·期 12
·9518-9524
·
IF 3.086
Lin Zhong,Tong Yang,Jian Wang,Cheng Zhi Huang
The catalysis of nanomaterials is interesting and attractive. Herein, electrospinning was employed to afford poly(methyl acrylate) (PMAA)–poly(vinyl pyrrolidone) (PVP) electrospun nanofibers. Next, in situ photosynthesis resulted in the formation of a uniform assembly of silver nanoparticles (AgNPs) over the electrospun fibers, generating AgNPs–PMAA–PVP electrospun nanofibers. The as-formed AgNPs–PMAA–PVP electrospun nanofibers were utilized for investigating the catalytic reduction of 4-nitrophenol (4-NP) in the presence of NaBH4. For the in situ synthesis, the available light sources used included sunlight, table lamps, and 365 nm UV lamps. The results showed that the AgNPs–PMAA–PVP electrospun nanofibers could catalyze the reduction of 4-NP in the presence of NaBH4, generating 4-aminophenol (4-AP), therefore reducing the toxicity of 4-NP. After the use of the AgNPs–PMAA–PVP electrospun nanofibers for up to 4 cycles, the catalytic efficiency remained as high as 90%, suggesting that the noble metal/polymeric electrospun nanofibrous catalyst is highly effective and reusable.
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ACS Applied Materials & Interfaces
·
2015
·
IF 6.723
Sha Jin,Jiaxun Wan,Lizheng Meng,Xiaoxing Huang,Jia Guo,Li Liu,Changchun Wang
The application of nanomaterials in intelligent drug delivery is developing rapidly for treatment of cancers. In this paper, we fabricated a new kind of protease/redox/pH stimuli-responsive biodegradable nanohydrogels with methacrylic acid (MAA) as the monomer and N,N-bis(acryloyl)cystamine (BACy) as the cross-linker through a facile reflux-precipitation polymerization. After that, the polyethylene glycol (PEG) and folic acid (FA) were covalently grafted onto the surface of the nanohydrogels for enhancement of their long in vivo circulation lifetime and active targeting ability to the tumor cells and tissues. This kind of nanohydrogels could be disassembled into short polymer chains (Mn < 1140; PDI < 1.35) both in response to glutathione (GSH) through reduction of the sensitive disulfide bonds and protease by breakage of the amido bonds in the cross-linked networks. The nanohydrogels were utilized to simultaneously load both hydrophilic drug doxorubicin (DOX) and hydrophobic drug paclitaxel (PTX) with high drug loading efficiency. The cumulative release profile showed that the drug release from the drug-loaded nanohydrogels was significantly expedited by weak acidic (pH 5.0) and reducing environment (GSH), which exhibited an distinct redox/pH dual stimuli-responsive drug release to reduce the leakage of drugs before they reach tumor site. In addition, the in vitro experiment results indicated that the multidrug-loaded system had synergistic effect on cancer therapy. Meanwhile, the acute toxicity and intravital fluorescence imaging studies were adopted to evaluate the biocompatibility and biotoxicity of the nanohydrogels, the experimental results showed that the PEG modification could greatly enhance the long in vivo circulation lifetime and reduce the acute toxicity (LD50: from 138.4 mg/kg to 499.7 mg/kg) of the nanohydrogels.
研究领域:
药学
·
生物材料学
·
肿瘤学
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DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2019
·
IF 7.015
Fei Wang,Mingrui He,Kang Gao,Yanlei Su,Runnan Zhang,Yanan Liu,Jianliang Shen,Zhongyi Jiang,Roni Kasher
Membrane fouling is a common bottleneck in the treatment of wastewater, seawater or brackish water containing bacteria and other living microorganisms. Simultaneously introducing passive antifouling strategies (fouling resistance and fouling release) and active antibacterial strategies (off-surface antibacterial and on-surface antibacterial) onto membrane surfaces seems a promising strategy. In the present study, we designed a new type of organic-inorganic composite modifier comprising organic polymer PHFBM-PMAA-PMTAC (poly [hexafluorobutyl methacrylate]-poly [methacrylic acid]-poly [(2-(methacryloyloxy) ethyl) trimethyl ammonium chloride]) and inorganic Ag nanoparticles (NPs) to introduce the active-passive integrated antifouling strategies through synergistic surface segregation. We found that the Ag NPs could promote the surface segregation of copolymer and in turn copolymer would promote the bulk dispersion of Ag NPs. The resulting membranes exhibited superior and persistent antifouling properties as well as antibacterial properties. In the separation of oil-in-water emulsion and yeast suspension, the flux decline of the membranes was merely 4.0%, while the flux recovery ratio was nearly 100%. Meanwhile, the membranes exhibited desired off-surface and on-surface antibacterial properties, in which the antibacterial efficiency for Escherichia coli was nearly 100% and the width of inhibition zone was 4 mm.
研究领域:
材料科学
·
环境工程
·
微生物学
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高影响因子
RSC Advances
·
2016
·Vol. 6
·期 89
·85885-85890
·
IF 3.289
Dongjian Shi,Xiaodong Zhang,Zhaokun Yang,Shirong Liu,Mingqing Chen
This paper presents fabrication of polyacrylamide (PAM) and PAM/poly(methacrylic acid) (PMAA) inverse opal photonic crystal hydrogels (IOHs) based on poly(styrene-acrylic acid) (PSA) template by a “Sandwich” method. SEM images showed the obtained IOHs had a three-dimensional ordered structure and extremely uniform pore size without over-layers and defects. The IOHs exhibited brilliant structural color by controlling the PSA particle size, MAA and cross-linker compositions. The color and Bragg diffraction peak of the IOHs responded to external stimuli such as pH, methanol and ethanol. The reflectance was red-shifted in low pH and blue-shifted in high pH and in the presence of methanol and ethanol. The effects of the MAA and cross-linker composition on the response properties of the IOHs were investigated. The PMAA in the IOHs provided –COOH groups that are apt to form hydrogen bonds with water, enhancing the response sensitivity.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2026
·
IF 8.7
Fangjun Wu,Juan Sun,Zheng Nie,Fujie Lai,Xudong Yang,Shaoyang Chen,Yang Wang
In the context of the ongoing normalisation of the SARS-CoV-2, the number of patients infected with the new coronavirus remains high on an annual basis. It is therefore imperative that individuals have access to rapid and cost-effective diagnostic tests. Conventional diagnostic tests,such as Reverse Transcription-Quantitative Polymerase Chain Reaction(RT-QPCR), Enzyme-Linked Immunosorbent Assay(ELISA) are costly and cumbersome, impeding their application in single-sample detection. This study has developed a cost-effective lateral flow immunoassay that rivals the sensitivity and simplicity of ELISA and colloidal gold tests, facilitating rapid and affordable detection of SARS-CoV-2 antigen. The synthesis of Fe 3 O 4 particles with a diameter of approximately 150 nm was initially conducted via a solvothermal method. Subsequently, the preparation of Fe 3 O 4 @PMAA particles with carboxyl groups, was undertaken through a reflux precipitation polymerization. Finally, the above particles were coupled with mouse anti-coronavirus SARS-CoV-2 N protein IgG by standard NHS/EDC methods to obtain Fe 3 O 4 @PMAA@IgG nanoprobe. This nanoprobe was then used as an immunoconjugate pad for the detection of the SARS-CoV-2 nucleoprotein. The nanoprobe-based method demonstrated significant advantages in cost-effectiveness and timeliness (with an assay duration of only 1 min), costing approximately $0.13 per sample. When used for SARS-CoV-2 antigen detection, this cost represents only 0.02% of that of RT-QPCR and 0.05% of that of ELISA.The detection limit of the lateral flow immunoassay is (0. 5 ng/mL).
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PubMed
高影响因子
Food Bioscience
·
2024
·
IF 4.8
Shuze Ren,Songming Li,Mahmoud Abou-Elsoud,Rui Cui,Xing Fu,Xi Huang
Phosvitin phosphopeptides (PPP) have a high ability to chelate mineral ions and promote calcium absorption. In this study, The Fe 3 O 4 nanospheres were first synthesized by hydrothermal method, then the three magnetic nanoparticles (Fe 3 O 4 @PDA@PMAA@PAMAM, Fe 3 O 4 @PDA@Ce 4+ , and Fe 3 O 4 @PDA@TiO 2 ) were obtained by layer modification on their surfaces, respectively. The magnetic nanoparticles were characterized by TEM, XRD, VSM, and Zeta potential. TEM analysis revealed that the nanoparticles were spherical and regular in shape. XRD diffraction analysis showed that the modified nanoparticles have a complete crystal structure. Meanwhile, PAMAM, Ce 4+ , TiO 2 , and other groups have been successfully modified on the nanoparticles. VSM hysteresis regression line results revealed that the magnetic nanoparticles are superparamagnetic. The three kinds of magnetic nanoparticles still maintained excellent enrichment performance after five times of repeated use. Fe 3 O 4 @PDA@TiO 2 has the best enrichment performance (167 mg g −1 ). The N/P ratio of the enriched PPP decreased from 1.36 to 0.98, which also showed that it had excellent PPP enrichment performance. Therefore, the modified magnetic nanoparticles could be an optimal PPP enrichment and purification material.
研究领域:
材料科学
·
纳米技术
·
生物化学
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DOI
高影响因子
Journal of Materials Chemistry B
·
2021
·Vol. 10
·期 14
·2617-2627
·
IF 6.331
Qisheng Ye,Rui Wang,Saitao Yan,Baoliang Chen,Xiaoying Zhu
Inspired by the stomatal feature of plant leaves, a photo-responsive membrane was developed to enhance the removal of irreversible membrane fouling and to control molecule release. Photo-responsive polymers were prepared by reacting the amine group of 4-amineazobenzene with about 3, 5 and 9 out of 12 carboxylic groups of PMAA which was grafted from P(VDF-CTFE) with a certain length. Subsequently, high-flux photo-responsive membranes (PRMs) were prepared from the heterogeneous polymers with different contents of photo-switchable azobenzene following a non-solvent-induced phase-inversion protocol. The pore size and surface hydrophilicity of PRMs could be reversibly increased by switching visible light to UV irradiation, which dramatically enhanced the backflushing efficiency on PRMs under UV irradiation. The “light-cleaning” process could recover more than 90% of the irreversible flux decline caused by typical organic foulant (BSA) and biological foulant (E. coli) on PRMs. The higher the content of azobenzene, the more obvious the pore size and hydrophilicity variation after light switching but the smaller the absolute pore size observed for PRMs. On the other hand, the light-switching gates of PRMs enabled the controlled release of molecules with different sizes. The novel PRM provided an efficient solution to mitigate irreversible membrane fouling and a light-triggered molecule release protocol, which would improve the membrane performance and further expand the application field of the membrane.
研究领域:
材料科学
·
化学工程
·
环境科学
·
生物技术
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DOI
PubMed
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 11
·1-12
·
IF 5.3
Nie Zheng,Sun Juan,Wu Fangjun,Lai Fujie,Yang Xudong,Chen Shaoyang,Wang Yang,Jiang Yong
A novel immunomagnetic bead was prepared and designed to be combined with a smartphone app for the rapid detection of SARS-CoV-2 antibody in serum. The nucleocapsid protein (N protein) of SARS-CoV-2 was immobilized on the prepared magnetic polymer microspheres (Fe 3 O 4 @PMAA) with core-shell structure by 1-(3-dimethylaminopropyl)-3-ethylcarbodiimid/N-hydroxy succinimide (EDC/NHS) to form the immunomagnetic beads (Fe 3 O 4 @PMAA-NP) capable of binding antibodies specifically. Combining its magnetic separability with the image analysis function of the smartphone app, a novel detection platform was established on a 96-well plate. The platform can realize rapid separation and colorimetric detection of antibodies within 30 min, and the detection limit is 0.5 µg/mL. This method has the advantages of portability, rapidity, high sensitivity and low cost, which is suitable for home self-test and on-site detection. This study not only provides an innovative method for the antibody detection of SARS-CoV-2 in serum, but also provides a favorable reference for the practical application of functionalized magnetic polymer materials in the medical field. Graphical
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PubMed
高影响因子
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