COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2025
·
IF 5.4
Zhijun Liu,Guoming Yuan,Hui Yang,Kunxin Wang,Yanghan Tao,Kun Wu,Jun Shi,Li Yang
Pressure sensitive adhesive (PSA) has great application potential in electronic packaging, flat panel display bonding and other fields. However, the low cohesion strength of these PSAs leads to their inherent low mechanical strength, which seriously hinders their application. In this study, PSA with dual network (DN) structure was prepared. Long chain polyurethane diacrylate (HPA) not only provides covalent cross-linking for linear acrylic polymers, but also provides non-covalent cross-linking of chain entanglements and hydrogen bonds, giving PSA excellent cohesion strength. DN-PSA not only has excellent bonding properties, but also has higher shear strength, its values are 21.9 N/25 mm and 92.5 KPa, respectively, which are increased by 16.5 % and 72.7 % compared with the control group. Although the DN structure reduces the elongation at break of PSA, it greatly increases the tensile strength of PSA, reaching 0.19 MPa. In addition, the PSA also has better heat resistance and higher light transmittance (> 90 %), which indicates that it is suitable for applications requiring high adhesion, cohesion and optical clarity, such as the bonding of flat panel displays.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
TALANTA
·
2023
·
IF 6.1
Ning Xia,Gang Liu,Yonghong Chen,Tong Wu,Lin Liu,Suling Yang,Yuanyuan Li
Simultaneous detection of active and inactive proteases is clinically meaningful for improving diagnostic specificity. In this work, we reported an electrochemical method for simultaneous immunoassays of active and total proteases. Magnetic beads (MBs) were used as the solid supports for immobilization of capture antibodies and enrichment of targets. For the detection of active protease, the proteolytic-reaction-based analysis was carried out by the generation of Cu 2+ -binding peptide, in which a label-free peptide was used as the proteolytic substrate. The redox potential of the resulting peptide-Cu 2+ complex was intrinsically distinguished from that of free Cu 2+ , thus allowing the “signal-on” detection of active protease. For the immunoassay of total protease in a sandwich-like format, electroactive metal-organic frameworks (Cu-MOFs) were used as the signal tags. The captured Cu-MOFs could directly produce a well-defined electrochemical signal from the reduction of Cu 2+ ions. The analytical performances of the immunoplatform were evaluated by determining the model analytes of free and total prostate-specific antigen (fPSA and tPSA) in buffer and serum. The detection limits were found to be 0.3 pM for fPSA and 2 pM for tPSA. This work proposed a new strategy for simultaneous detection of active and total proteases, which should be evaluable for clinical diagnosis and treatment of protease-relative diseases.
研究领域:
分析化学
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生物化学
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医学诊断
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蛋白质组学
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DOI
PubMed
高影响因子
Analytical Methods
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2024
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IF 2.7
Xin Hua,Tongxiao Zhao,Xueqin Gui,Baokang Jin
In this paper, a label-free electrochemical immunosensor for sensitive detection of prostate antigen (PSA) was developed based on a NiFe PBA/AuNPs composite. The prostate antigen antibody was immobilized and the immunosensor was constructed by using a glassy carbon electrode modified with a nanocomposite consisting of nickel–iron Prussian blue analog (NiFe PBA) and gold nanoparticles (AuNPs). Due to the good biological affinity of AuNPs for biomolecules, as well as the porous nanostructure and regular shape of NiFe PBA, NiFe PBA/AuNPs nanocomposites significantly improve the electron transport rate, while achieving excellent performance for the sensor. Due to the interaction between the antibody and the antigen on the modified electrode, the current signal of the NiFe PBA itself is reduced due to the redox changes in Fe2+ and Fe3+, which can be determined by differential pulse voltammetry (DPV). Therefore, the monitoring of prostate antigen detection is realized. Under optimal experimental conditions, the immunosensor exhibited excellent detection performance with a dynamic response range from 0.5 pg mL−1 to 1000 pg mL−1 for the PSA concentration and a detection limit of 0.23 pg mL−1 (S/N = 3). In addition, the PSA aptasensor has good selectivity, high stability, and satisfactory reproducibility and has broad potential in clinical research and diagnostic applications.
研究领域:
生物医学工程
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分析化学
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纳米技术
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产品关联
DOI
PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2024
·
IF 4.9
Shuwei Zhou,Qiong Wu,Qiaoxia Wang,Hong Fu,Fang Yang
Pigments and organic acids are among the most common impurities in complex sample matrices. Their presence in the samples often interferes with the detection of trace analytes. This study aimed to design and develop magnetic materials (GCB/Fe 3 O 4 -PSA) for the efficient purification of organic acids and pigment impurities in sample matrices. We employed the acid modification method to enhance the modification of magnetic Fe 3 O 4 by the primary secondary amine adsorption group (PSA), effectively boosting its adsorption performance. This modification technique not only retains the inherent adsorption characteristics of Fe 3 O 4 but also avoids the irreversible damage to Fe 3 O 4 ′s own adsorption by traditional grafting methods. Subsequently, Fe 3 O 4 -PSA and graphitized carbon black (GCB) were combined through a simple physical assembly method to prepare GCB/Fe 3 O 4 -PSA, which was used for the purification of pigments and organic acids in complex matrices. During the purification process, GCB/Fe 3 O 4 -PSA can be rapidly magnetically separated. After six reuses, the adsorption performance remains above 80 %, fully demonstrating the rapid purification ability and reusability potential of GCB/Fe 3 O 4 -PSA. Compared with unmodified Fe 3 O 4 , GCB/Fe 3 O 4 -PSA significantly enhanced the purification effect of complex matrices. Its adsorption capacities for chlorophyll and ascorbic acid increased by 276.9 % and 263.9 % respectively. After combining with the GCB/Fe 3 O 4 -PSA purification material, cathinones in complex matrix samples (tea, apples, carrots) were determined using UPLC-MS/MS. The recoveries in spiked samples ranged from 96.35 % to 104.17 %, with the RSDs < 3.02 %. Simultaneously, characterization methods such as SEM, FTIR, XRD, VSM, XPS, and BET were used to study the surface structure and chemical composition of GCB/Fe 3 O 4 -PSA. The above results highlight the outstanding performance of GCB/Fe 3 O 4 -PSA in the efficient purification of organic acids and pigments in complex matrices and also show its considerable application potential in the pretreatment of complex matrix samples.
研究领域:
分析化学
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材料科学
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DOI
高影响因子
INORGANIC CHEMISTRY COMMUNICATIONS
·
2021
·
IF 2.495
Dan Liang,Yunfeng Hu,Qiang Bao,Jian Zhang,Jiawei Feng,Penglai Sun,Yutong Ma,Hongsheng Zhang
Rho zeolite was successfully synthesized by hydrothermal synthesis adopting 18-crown-6 as template, and the cations (H + , Na + , K + , Cs + , Cd 2+ and Pb 2+ ) of different radii were introduced into the framework of Rho by ion exchange. The samples were characterized by XRD, SEM-EDX, ICP and N 2 -BET. The adsorption behavior of CO 2 and CH 4 on cation-exchanged Rho was measured, and the adsorption isotherm was fitted by Langmuir equation to study the adsorption performance of these zeolites. The adsorption results show that the pore size of Rho is not solely dependent on the cation radius, the different positions of the cations are also more crucial in pore size adjustment. In all researched Rho, the introduction of Cd 2+ and Pb 2+ can more significantly reduce the pore size, and completely restrict the entry of CH 4 , thereby further improving the CO 2 /CH 4 selectivity. Therein, Cd-Rho has the best adsorption performance, with considerable CO 2 adsorption capacity, and extremely high CO 2 /CH 4 selectivity and CO 2 working capacity, which provides a new clue for the development of adsorbents for CO 2 and CH 4 separation in PSA process.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
Materials
·
2024
·Vol. 17
·期 16
·4135
·
IF 3.1
Zijia Wang,Yawen Chang,Siyang Jia,Fujuan Liu
In this study, polyimide (PI) and polysulfonamide (PSA) were used as base materials, and polyethylene glycol (PEG) was added to successfully prepare PI/PSA/PEG nanofiber membranes through electrospinning technology. Subsequently, water etching was performed on the membranes, utilizing the water solubility of PEG to form the rough wrinkled structure, further enhancing the surface hydrophobicity. The experimental results showed that under the conditions of a spinning voltage of 10 kV, PI/PSA mass fraction of 15 wt.%, and PEG-to-PI/PSA mass ratio of 1/3, the obtained fiber membranes exhibit a uniform morphology (an average diameter of 0.73 µm) and excellent hydrophobicity (the initial water contact angle (WCA) reaching 130.4°). After PEG water etching, the surface of the PI/PSA/PEG hydrophobic membranes formed the rough wrinkled structure, which not only improved their mechanical properties but also further enhanced their hydrophobicity (the initial WCA increasing to 137.9°). Hence, fiber membranes are expected to have broad application prospects in fields such as waterproofing and moisture permeability.
研究领域:
材料科学
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化学工程
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2024
·
IF 8.1
Wang Boxuan,Bao Qiang,Chen Zhirui,Qiao Xue,Hu Yunfeng,Zhang Jian,Liang Dan,Sun Penglai,Xia Haiyue,Wang Xiangyang
Zeolite RHO, a microporous zeolite, has the great possibility for N 2 /CH 4 separation by regulating the size of the eight-membered ring window on the RHO framework. In this work, the ability of ion-exchanged RHO zeolites for N 2 /CH 4 separation is investigated, and a highly nitrogen selectivity adsorbents are developed. RHO samples were prepared by hydrothermal synthesis. Alkali metal cations (Na + , K + , Cs + ) was used for ion exchange. Adsorption equilibrium isotherms of N 2 and CH 4 were measured at normal temperature and fitted by the Langmuir equation. The adsorbent selection parameters ( S parameters) were calculated based on the working capacity and equilibrium selectivity of N 2 /CH 4 , which are used to comprehensively evaluate the selectivity of N 2 /CH 4 . The results indicate that the cations have effects on the regulation of the eight-membered ring window. In particularly, K-RHO no.2 sample which is obtained by ion exchange of K + cations exhibit the best N 2 /CH 4 separation performance, which is a potential nitrogen selective adsorbent. In addition, the product throughputs of RHO and the commercial adsorbent ETS-4 were compared by common PSA simulation process with essentially the same product purity and recovery. The results show that K-RHO no.2 has 36 % higher product throughput than ETS-4, which can compensate for the problem of low N 2 working capacity of ETS-4 in industrial application.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2018
·Vol. 43
·期 3
·1424-1430
·
IF 3.201
Jun-Tao Cao,Wen-Sheng Zhang,Hui Wang,Shu-Hui Ma,Yan-Ming Liu
A novel fluorescence (FL) immunosensor for prostate-specific antigen (PSA) detection was developed based on the Förster resonance energy transfer (FRET) between nitrogen and sulfur co-doped carbon dot functionalized silica nanospheres (Si/NS-CDs) and Au@Ag NPs. The strategy utilized the PSA primary antibody labeled luminescent Si/NS-CDs as donors and PSA secondary antibody labeled Au@Ag NPs as acceptors. In the presence of PSA, the bio-affinity of the antigen and antibody caused the Si/NS-CDs and Au@Ag NPs to approach at a close enough distance for the FL intensity of the Si/NS-CDs to decline owing to the FRET effect. By virtue of the excellent optical properties of the Si/NS-CDs nanoprobe, the quantitative analysis of PSA has been successfully realized using both FL spectroscopy and a naked-eye readout. The fluorometric results present the desirable analytical performance for PSA detection in the range from 5.0 pg mL−1 to 10 ng mL−1 with a detection limit of 0.95 pg mL−1 (S/N = 3). Moreover, satisfactory results for the determination of the PSA target in samples of human serum were obtained, showing the great promise of the method for application in biochemical analysis.
研究领域:
生物化学
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医学诊断
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纳米技术
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产品关联
DOI
高影响因子
Gels
·
2026
·Vol. 12
·期 9
·770
·
IF 6.4
Zhimin Liu,Chenxi Nie,Fengfeng Xiao,Mengyuan Chen,Ming Liu,Qi Feng,Changtao Yue
Lost circulation of oil-based drilling fluids (OBDFs) in deep, fractured formations remains a critical challenge, primarily due to the poor retention and low pressure-bearing capacity of conventional materials on oil-wet rock surfaces. To bridge this gap, this study reports the development and field application of a novel thermo-responsive gel (SBR−g−PSA). Synthesized by grafting highly lipophilic stearyl acrylate (SA) onto a flexible styrene–butadiene rubber (SBR) backbone, the microgel exploits a UCST-like (Upper Critical Solution Temperature) phase transition behavior. At surface temperatures, rigid styrene microdomains act as physical crosslinks, maintaining the particles in a compact, highly dispersible state. Under elevated downhole temperatures (120–180 °C), these microdomains relax, triggering the massive unfolding and physical entanglement of the octadecyl side chains. This in situ topological evolution generates a resilient three-dimensional network with a high thermal degradation temperature of 346.6 °C. Rheological and macroscopic sealing evaluations demonstrate that the gel effectively adapts to OBDFs, securely sealing 1–1.5 mm fractures and limiting fluid loss to within 5 mL under a 4 MPa differential pressure. Successful field application in the deep well Dashen-X reduced severe fluid leakage from 2.42 m3/h to zero. This intelligent thermo-responsive platform offers a robust, high-performance technological solution for precise lost circulation control in deep oil and gas exploration.
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高影响因子
Inorganics
·
2024
·Vol. 12
·期 9
·250
·
IF 3.1
Ye Li,Huiqing Yue,Quanli Zhang,Dumin Yan,Ziyi Li,Zhiwei Liu,Yingshu Liu,Yongyan Wang,Shifeng Wang,Xiong Yang
In oxygen production on plateaus, pressure swing adsorption (PSA) oxygen production is currently the most commonly used oxygen production method. In plateau regions, low pressure leads to a decrease in adsorbent nitrogen–oxygen separation performance, which affects the performance of PSA oxygen production, so it is particularly important to enhance adsorbent nitrogen–oxygen separation performance. In this paper, Li-LSX (lithium low-silicon aluminum X zeolite molecular sieve) adsorbents were modified using the liquid phase ion exchange method, and five kinds of modified adsorbents were obtained, namely AgLi-LSX, CaLi-LSX, ZnLi-LSX, CuLi-LSX, and FeLi-LSX, respectively. The influences of different metal ions and modification time lengths on the adsorbent nitrogen adsorption and nitrogen–oxygen separation coefficients were analyzed. Through theoretical calculations, the nitrogen and oxygen adsorption and separation performances of the modified adsorbents at different altitudes and low adsorption pressures were investigated. It is shown that the nitrogen adsorption capacity of the AgLi-LSX-1 adsorbent obtained from the modification experiment reaches 27.92 mL/g, which is 3.24 mL/g higher than that of Li-LSX; the nitrogen–oxygen separation coefficients of S1 and S2 are 19.24 and 7.54 higher, respectively; and the nitrogen–oxygen separation coefficients of S4 are 20.85 and 7.54 higher than those of Li-LSX, respectively. With the increase in altitude from 50 m to 5000 m, the nitrogen–oxygen separation coefficient of the AgLi-LSX-1 adsorbent increased rapidly from 20.85 to 57, and its nitrogen–oxygen separation coefficient S4 exceeded that of the Li-LSX adsorbent to reach 47.61 at an altitude of 4000 m. Therefore, the modified adsorbent AgLi-LSX-1 in this paper can enhance the performance of the PSA oxygen process for oxygen production in plateau applications.
研究领域:
材料科学
·
环境科学
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DOI
高影响因子
ANALYTICAL LETTERS
·
2022
·
IF 2.267
Jun-Tao Cao,Xiang-Mei Liu,Yi-Zhuo Fu,Shu-Wei Ren,Yan-Ming Liu
A spatial- and potential-resolved ratiometric electrochemiluminescent (ECL) immunosensor was developed for prostate specific antigen detection in a label-free mode. CdS quantum dots (CdS QDs) and luminol-gold nanoparticles (luminol-Au NPs) were the potential-resolved electrochemiluminescence emitters and H2O2 was used as a co-reactant. The cathodic signal from the CdS QD electrode served as the working signal and the anodic signal from luminol-Au NPs as the reference. For prostate specific antigen detection, several concentrations of prostate specific antigen were immobilized on the CdS QDs modified electrode and a fixed concentration of the prostate specific antigen was modified on the luminol-Au NPs modified electrode. The prostate specific antigen levels were quantified by the electrochemiluminescence signal ratio of the cathodic and anodic (ECLcathodic/ECLanodic). Under the optimized conditions, the ratio of the cathodic and anodic signals (ECLcathodic/ECLanodic) had a linear relationship with the logarithm of (C, g mL−1) of prostate specific antigen concentration from 1.0 × 10−11 to 1.0 × 10−7 g mL−1. The detection limit was 5.0 × 10−12 g mL−1. Prostate specific antigen was determined in human serum and the recoveries were from 80.0% to 107.0%. The label-free electrochemiluminescence immunosensor offers simplicity and reliability for human serum with potential for clinical application.
研究领域:
分析化学
·
生物传感器
·
纳米技术
·
医学诊断
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DOI
高影响因子
Drug Delivery and Translational Research
·
2026
·
IF 6.9
Cao Ruijie,Zhou Rongwei,Wang Chuancui,Shen Meizhu,Yu Jiangyue,Xu Hao,Guo Zhong
Acute lung injury (ALI) is characterized by uncontrolled inflammation and oxidative stress, driven largely by macrophage dysregulation. Despite their anti-inflammatory potential, flavonoids like quercetin (Qu) are limited by poor solubility and systemic toxicity. To address these challenges, this study developed a “bioactive co-assembly” nanomicelle platform (Qu@PSA-VES/diT-VES) based on polysialic acid (PSA) and a novel dimerized taurine-vitamin E succinate (diT-VES). Molecular docking simulations demonstrated that quercetin (Qu) exhibits an exceptionally high binding affinity for the VES hydrophobic core. Furthermore, the incorporation of diT-VES significantly enhanced the colloidal stability of the micelles through strengthened non-covalent interactions, effectively preventing disassembly during physiological circulation. Hydrophobic interactions and hydrogen bonding were identified as the primary driving forces for micellar stability. The carrier leverages PSA to specifically target the overexpressed Siglec-1 receptor on the surface of inflammatory macrophages, thereby mediating receptor-dependent endocytosis. Within the acidic and enzyme-enriched lysosomal environment, the micelles undergo pH/enzyme dual-responsive dissociation, facilitating the escape of the drug from the lysosomal barrier and its subsequent diffusion into the cytoplasm for pharmacological action. Additionally, the carrier components VES and taurine provide antioxidant and mitochondrial protection, respectively, synergizing with Qu to significantly induce the reprogramming of M1 macrophages toward the M2 phenotype in vitro. In a murine ALI model, the system demonstrated superior lung-targeting ability, significantly reducing the levels of pro-inflammatory cytokines (TNF-α, IL-1β, and IL-6) in bronchoalveolar lavage fluid and alleviating pulmonary edema and neutrophil infiltration. Experimental results indicated that under a lethal ALI challenge, the 72-h survival rate of mice in the treatment group was significantly increased from 16.7% to 83.3%, while maintaining excellent in vivo biocompatibility. This integrated "targeting-stabilization-synergy" nanoplatform provides a promising translational strategy for the treatment of macrophage-driven inflammatory disorders.
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DOI
PubMed
高影响因子
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