ACS Applied Materials & Interfaces
·
2024
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IF 8.3
Jinpeng Hu,Dezhi Zhang,Wenbao Li,Yan Li,Guorong Shan,Min Zuo,Yihu Song,Ziliang Wu,Lie Ma,Qiang Zheng,Miao Du
Marine biofouling, resulting from the adhesion of marine organisms to ship surfaces, has long been a significant issue in the maritime industry. In this paper, we focused on utilizing soft and hydrophilic hydrogels as a potential approach for antifouling (AF) coatings. Acrylic acid (AA) with a polyelectrolyte effect and N-(3-sulfopropyl)-N-(methacryloxyethyl)-N,N-dimethylammonium betaine (SBMA) with an antipolyelectrolyte effect were selected as monomers. By adjusting the monomer ratio, we were able to create hydrogel coatings that exhibited low swelling ratio in both fresh water and seawater. The Al(OH)3 nanoparticle, as a physical cross-linker, provided better mechanical properties (higher tensile strength and larger elongation at break) than the chemical cross-linker through the dynamic coordination bonds and plentiful hydrogen bonds. Additionally, we incorporated trehalose into the hydrogel, enabling the repair of the hydrogel network through covalent-like hydrogen bonding. The zwitterion compound SBMA endowed the hydrogel with excellent AF performance. It was found that the highest SBMA content did not lead to the best antibacterial performance, as bacterial adhesion quantity was also influenced by the charge of the hydrogel. The hydrogel with appropriate SBMA content being close to electrical neutrality exhibits the strongest zwitterionic property of PSBMA chains, resulting in the best antibacterial adhesion performance. Furthermore, the pronounced hydrophilicity of SBMA enhanced the lubrication of the hydrogel surface, thereby reducing the friction resistance when applied to the hull surface during ship navigation.
研究领域:
材料科学
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海洋生物学
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
·
2021
·
IF 9.381
Kai Ren,Xiang Ke,Zhu Chen,Yao Zhao,Lu He,Peng Yu,Jiaqi Xing,Jun Luo,Jing Xie,Jianshu Li
High friction of damaged cartilage requires long-acting lubricated additive, which can also effectively scavenge reactive oxidative species (ROS) produced by mechanically stimulated chondrocytes . In this study, xanthan gum (XG) was grafted by poly (sulfobetaine methacrylate) (PSBMA) (the [XG]/[SBMA] molar ratio is 1:5 or 1:10), forming nanoparticles and then conjugated with collagen II-binding peptide, finally obtaining CBPXGSB1/5 or CBPXGSB1/10. Therein, the CBPXGSB1/5 was chosen as optimal lubricated additive. The results show that hydrated effect of PSBMA side chains endows CBPXGSB1/5 with favorable lubrication property (COF is 0.063). Furthermore, the CBPXGSB1/5 combining lubrication property and specific binding capability together may achieve the long-acting lubrication for injured cartilage in medical field. The CBPXGSB1/5 also possesses antioxidation verified by DPPH assay and exhibits synergistically enhanced ROS ( OH, O 2 − and H 2 O 2 ) scavenging. Besides, cytotoxicity experiment demonstrates that CBPXGSB1/5 has good biocompatibility. Therefore, multifunctional CBPXGSB1/5 developed here may have promising application potential in osteoarthritis treatment.
研究领域:
材料科学
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生物医学工程
·
药学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Rong Chen,Xiangrong Dai,Rongjiao Sun,Yi Liao,Jiajia Dong,Ying Tan,Xuru Jin
Acute Lung Injury (ALI) is a clinical syndrome associated with various respiratory diseases and injuries. While inhalable drug delivery systems offer the advantage of direct pulmonary targeting and reduced systemic toxicity, their therapeutic efficacy is frequently compromised by the tracheobronchial mucus barrier. To address this limitation, we developed PCL-ss-PSBMA, a novel nanocarrier engineered to overcome the constraints of conventional micelle platforms, which typically depend on either hydrophilic coatings or single-response mechanisms. By integrating zwitterionic groups and disulfide bonds in a dual-functional design, PCL-ss-PSBMA achieves synergistic optimization of mucus barrier penetration and glutathione (GSH)-triggered drug release. In addition, the nanocarrier also exhibits excellent biocompatibility, further ensuring its safety in therapeutic applications. In an ALI murine model, PCL-ss-PSBMA@DEX markedly improved the delivery efficiency and utilization rate of dexamethasone (DEX) through its dual mechanisms of mucus penetration and stimulus-responsive drug release. This design not only enhances the deposition of the drug in the lungs but also achieves efficient treatment of ALI by precisely controlling drug release, demonstrating its potential as an advanced strategy for treating respiratory diseases.
研究领域:
药学
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纳米技术
·
呼吸医学
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生物医学工程
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药物递送系统
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2016
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IF 7.145
Jing Zhao,Yiwei Zhu,Guangwei He,Ruisi Xing,Fusheng Pan,Zhongyi Jiang,Peng Zhang,Xingzhong Cao,Baoyi Wang
For the selective water-permeation across dense membrane, constructing continuous pathways with high-density ionic groups are of critical significance for the preferential sorption and diffusion of water molecules. In this study, zwitterionic graphene oxides (PSBMA@GO) nanosheets were prepared and incorporated into sodium alginate (SA) membrane for efficient water permeation and water/alcohol separation. The two-dimensional GO provides continuous pathway, while the high-density zwitterionic groups on GO confer electrostatic interaction sites with water molecules, leading to high water affinity and ethanol repellency. The simultaneous optimization of the physical and chemical structures of water transport pathway on zwitterionic GO surface endows the membrane with high-efficiency water permeation. Using dehydration of water/alcohol mixture as the model system, the nanohybrid membranes incorporating PSBMA@GO exhibit much higher separation performance than the SA membrane and the nanohybrid membrane utilizing unmodified GO as filler (with the optimal permeation flux of 2140 g m–2 h–1, and separation factor of 1370). The study indicates the great application potential of zwitterionic graphene materials in dense water-permeation membranes and provides a facile approach to constructing efficient water transport pathway in membrane.
研究领域:
材料科学
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化学工程
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膜技术
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分离科学
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产品关联
DOI
PubMed
高影响因子
ANALYTICA CHIMICA ACTA
·
2023
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IF 6.2
Zhenying Xu,Yuanyuan Liu,Mingrui Lv,Xiujuan Qiao,Gao-Chao Fan,Xiliang Luo
The challenge of heavy biofouling in complex sweat environments limits the potential of electrochemical sweat sensors for noninvasive physiological assessment. In this study, a novel semi-interpenetrating hydrogel of PSBMA/PEDOT:PSS was engineered by interlacing PEDOT:PSS conductive polymer with zwitterionic PSBMA network. This versatile hydrogel served as the foundation for developing an anti-fouling wearable molecular imprinting sensor capable of sensitive and robust detection of tryptophan (Trp) in complex sweat. The incorporation of PEDOT:PSS conductive polymer into the semi-interpenetrating hydrogel introduced diverse physical crosslinks, including hydrogen bonding , electrostatic interactions , and chain entanglement. This incorporation considerably boosted the hydrogel's mechanical robustness and imparted commendable self-healing property. At the same time, the synergistic coupling between the well-balanced charge of the zwitterionic network and the high conductivity of the PEDOT:PSS polymer facilitated efficient charge transfer. The formation of the desired molecular imprinting membrane of semi-interpenetrating hydrogel was triggered by self-polymerization of dopamine (DA) in the presence of Trp. The designed biosensor demonstrated good sensitivity, selectivity and stability in detecting the target Trp. Notably, it also exhibited exceptional anti-fouling abilities, allowing for accurate Trp detection in complex real sweat samples, yielding results comparable to commercial enzyme-linked immunoassay (ELISA).
研究领域:
材料科学
·
生物传感器
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电化学
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可穿戴技术
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分析化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Baojin Chen,Renjie Yu,Jiaqi Wang,Yunxiang Feng,Yujie Zhang,Yanchao Mao,Chongxin Shan,Xudong Wang
Ionic conduction is a crucial property for electronic biomaterials used in bioelectronics, as the biological systems rely on ions to conduct electricity. Currently, biomaterials-based functional hydrogels emerged as a promising building block for bioelectronics owing to their natural biocompatibility. However, two critical challenges faced by this type of hydrogel are their low ionic conductivity and unmatched mechanical modulus with soft tissues, which are inherently related to their complex biopolymer chains. Here, by mimicking the ion-accelerating effect of ion channel receptors in neuron membranes, a biomaterials-based ionic hydrogel (BIH) is developed, which offers a high ionic conductivity of 7.04 S m −1 , outperforming conventional chitosan, cellulose, agarose, starch, and gelatin based ionic hydrogels. The sulfonate groups and quaternary ammonium groups on zwitterionic side chains of poly (sulfobetaine methacrylate) (pSBMA) construct artificial cation and anion channels, respectively. The highly branched polymer structure of pSBMA reduces chain entanglement and lowers the Young's modulus of BIH to 7.2 kPa. Compared with traditional biomaterials-based hydrogels, the BIH simultaneously possesses excellent ionic conductivity and tissue-matching softness. Such BIH offers substantially higher quality of electrocardiogram and electromyogram signals than those of commercial electrodes.
研究领域:
生物电子学
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生物材料科学
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高分子化学
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生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CARBOHYDRATE POLYMERS
·
2024
·
IF 10.7
Junjie Deng,Rufang Wei,Haofeng Qiu,Xiang Wu,Yanyu Yang,Zhimao Huang,Jiru Miao,Ashuang Liu,Haiyang Chai,Xiao Cen,Rong Wang
Restoration of the lubrication functions of articular cartilage is an effective treatment to alleviate the progression of osteoarthritis (OA). Herein, we fabricated chitosan- block -poly(sulfobetaine methacrylate) (CS-b-pSBMA) copolymer via a free radical polymerization of sulfobetaine methacrylate onto activated chitosan segment, structurally mimicking the lubricating biomolecules on cartilage. The successful copolymerization of CS-b-pSBMA was verified by Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and 1 H nuclear magnetic resonance. Friction test confirmed that the CS-b-pSBMA copolymer could achieve an excellent lubrication effect on artificial joint materials such as Ti6Al4V alloy with a coefficient of friction as low as 0.008, and on OA-simulated cartilage, better than the conventional lubricant hyaluronic acid, and the adsorption effect of lubricant on cartilage surface was proved by a fluorescence labeling experiment. In addition, CS-b-pSBMA lubricant possessed an outstanding stability, which can withstand enzymatic degradation and even a long-term storage up to 4 weeks. In vitro studies showed that CS-b-pSBMA lubricant had a favorable antibacterial activity and good biocompatibility. In vivo studies confirmed that the CS-b-pSBMA lubricant was stable and could alleviate the degradation process of cartilage in OA mice. This biomimetic lubricant is a promising articular joint lubricant for the treatment of OA and cartilage restoration.
研究领域:
材料科学
·
生物医学工程
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骨科
·
组织工程
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Ting He,Xiaoyun Wang,Zhaoyun Sun,Jiangwei Chen,Yangming Cheng,Qiang Chen,Rizhi Chen,Qingguo Li,Zhaoliang Cui
Extracorporeal membrane oxygenation (ECMO) system is a life-supporting technique that plays an important role in cardiopulmonary failure or heart transplantation. Blood passes through the oxygenator to expel carbon dioxide (CO 2 ) produced during the metabolic processes while supplementing the blood with oxygen (O 2 ) to maintain the patient's life. As the key part of the oxygenator, the membranes come into direct contact with the blood for gases exchange. Therefore, membranes should possess excellent hemocompatibility to inhibit thrombosis and hemolysis. In this work, an antithrombotic coating was constructed on the surface of poly-4-methyl-1-pentene (PMP) hollow fiber membranes based on the co-deposition of zwitterionic polymer and dopamine to reduce the protein adsorption and improve hemocompatibility of the pristine PMP membranes. The experimental results were confirmed that the protein adsorption and the clotting time of the modification coating on the surface of PMP hollow fiber membranes were 16.3 μg/cm 2 and 643 s, which were 70.58 % lower and 36.8 % higher than that of the commercial PMP hollow fiber membranes (55.4 μg/cm 2 and 470 s), respectively. Test devices of in vitro blood circulation and in vivo circulation in animals were established to evaluate blood compatibility and the blood-gas exchange performance of as-prepared membrane modules, respectively, the evaluation conditions of which are similar to those of the real ECMO system. Meanwhile, the corresponding results exhibited that the poly (sulfobetaine methacrylate) (PSBMA) modified coating had good oxygenation performance and biosafety, implying that the zwitterionic polymer could provide excellent hemocompatibility for gas-blood exchange membranes in ECMO systems.
研究领域:
生物医学工程
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材料科学
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血液动力学
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医疗器械
✓ 已验证
产品关联
DOI
高影响因子
MATERIALS & DESIGN
·
2023
·
IF 8.4
Susu Huang,Yuelin Fang,Boguang Yang,Prabhleen Kaur,Yanqing Wang,Jicheng Zhang,Qiaoying Hu,Xiaoye Yang,Yabin Zhang,Guangxi Zhai,Lei Ye
Postoperative adhesions are one of the most common complications post intraperitoneal surgery. Even after the adhesiolysis, the recurrence of adhesions is as high as 85%. Although zwitterionic-based materials have been reported for the application, unlike the conventional zwitterionic hydrogel, a series of poly (sulfobetaine methacrylate) grafted dextran derivatives (Dex-g-PSBMA) were synthesized by atom transfer radical polymerization (ATRP) reaction, making it fined controllable copolymer by its living polymerization property. Intriguingly, the Dex-g-PSBMA copolymer can self-assemble into a physical hydrogel under physiological conditions. When injected at the site of the lesions, it can immediately cover the wound area, and as the ion concentration increases, the chemical bonds dissociate and the hydrogel may degrade completely. In the abdominal wall-cecum injury adhesion model in rats, Dex-g-PSBMA hydrogel showed excellent anti-adhesion ability, effectively preventing postoperative abdominal wall-cecum adhesion. The mechanism exploration revealed that Dex-g-PSBMA hydrogel can take an effect on the TGF-β/Smad signaling pathway, which can inhibit the Smad3 and activate the Smad7 pathway, thereby reducing the probability of tissue fibrosis, reducing fibrin deposition, and resisting fibroblast adhesions. In conclusion, these findings demonstrated that this Dex-g-PSBMA physical hydrogel is a promising candidate for completely preventing post-surgical adhesions.
研究领域:
生物医学工程
·
材料科学
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外科研究
·
药剂学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2021
·
IF 8.742
Junwen Ding,Heng Liang,Xuewu Zhu,Daliang Xu,Xinsheng Luo,Zihui Wang,Langming Bai
Nanofiltration (NF)-based brackish water desalination has been labeled an emerging avenue for alleviating water scarcity, however, membrane fouling still restricts its broad application. Herein, zwitterion-modified membranes were prepared with polydopamine (PDA) and sulfobetaine methacrylate (SBMA) monomers via surface-initiated atom-transfer radical-polymerization (SI-ATRP) and named TFC-PDA-PSBMA. Compared with the control membrane, the TFC-PDA-PSBMA possessed enhanced hydrophilicity, lower negative charge and smaller pore size. Superior salt retention of Na 2 SO 4 and NaCl of up to 99.1% and 80.7% was obtained for TFC-PDA-PSBMA with only a 10% decrease in permeance. Furthermore, TFC-PDA-PSBMA exhibited an outstanding flux recovery of 92.1% during humic acid (HA) filtration. The mechanism driving the improved antifouling properties was analyzed from the aspects of the modified layer, free interfacial energy and hydration layer. TFC-PDA-PSBMA also exhibited superior antibiofouling with reducing 86.1% of E. coli colonies adhered on membrane surface. The SBMA layer and hydration layer acted together as a buffer layer with robust repulsion of foulants. In addition, the TFC-PDA-PSBMA membrane was applied in authentic brackish water desalination and exhibited superior selectivity, desalination and antifouling performance, which matched the simulated solution results well. A new concept of a “buffer layer” was proposed in this work, which may provide insight into antifouling membrane design during brackish water treatment.
研究领域:
水处理
·
膜科学
·
环境工程
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Jiahui Zhang,Wei Xin,Yechi Qin,Yuhao Hong,Zijie Xiahou,Kunxi Zhang,Peiliang Fu,Jingbo Yin
Based on “bottom-up” strategy, cell-laden 3D bioprinting is an important process of fabricating sophisticated biomimetic structures. Stem cell spheroids possess better biological properties and are advanced as printing units. However, efficient and convenient preparation, collection and printing of cell spheroids remains a challenge. The present study developed a composite granular hydrogel acted as “all-in-one” multi-functional bioink to realize Adipose-derived stem cell (ASC) spheroids Production and reorganization. Poly(sulfobetaine methacrylate) (PSBMA) based microspheres were fabricated and self-assembled to a granular hydrogel. Then, N -isopropylacrylamide (NIPAM) and SBMA were co-polymerized in-situ inside of assembled PSBMA microspheres to further crosslink the assembled microspheres, forming a composite granular hydrogel, which possesses bulk feature and shear-thinning, self-healing properties. Caves were created by compressing composite granular hydrogels into sugar particles that removed via dissolution in water. Due to the non-fouling feature and the porous structure, numerous ASC spheroids were formed spontaneously inside the porous composite granular hydrogel, which were transferred conveniently to 3D printer. The spheroids-laden composite granular hydrogels showed well-performed extrudability and fidelity, realizing reorganization of the produced spheroids to the stable 3D constructs for further in vitro culture . ASC spheroids in granular hydrogel after 3D printing showed high level of viability and stemness, as well as efficient chondrogenic/osteogenic/adipogenic differentiation. The composite granular hydrogel thus shows potential toward stem cell researches such as organoids construction. The results of both in vitro drug toxicity and in vivo cartilage regeneration experiments showed spheroids-laden granular hydrogel is promising in drug screening and tissue regeneration.
研究领域:
组织工程
·
干细胞生物学
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生物打印
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材料科学
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再生医学
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE & TECHNOLOGY
·
2022
·
IF 10.319
Liwei Sun,Lingjie Song,Xu Zhang,Shuaishuai Yuan,Shifang Luan
Hierarchical polymer brushes have been considered as an effective and promising method for preventing implant-associated infections via multiple antibacterial mechanisms. Herein, a bacterial phosphatase responsive surface with hierarchical zwitterionic structures was developed for timely dealing with the polymeric implant-associated bacterial infection. The hierarchical polymeric architecture was subtly realized on model polypropylene (PP) substrate by sequential photo living grafting of poly (2-(dimethylamino) ethyl methacrylate (PDMAEMA) bottom layer and zwitterionic poly (sulfobetaine methacrylate) (PSBMA) upper layer, followed by the conversion of the PDMAEMA into the zwitterionic structure via successive quaternization and phosphorylation reactions. Owing to shielding the bottom polycations, the hierarchical zwitterionic polymer brushes guaranteed the surface with the optimal biocompatibility under the normal physiological environment. Once bacteria are invaded, the surface bactericidal activity of the bottom layer can be rapidly and automatically activated owing to the transition triggered by bacterial phosphatase from zwitterion to polycation. Additionally, ameliorated by the upper layer, the hierarchical surface showed obvious adhesion resistance to dead bacterial cells and notably migrated the cytotoxicity of exposed polycation after completion of the bactericidal task. As a proof-of-principle demonstration, this self-adaptive hierarchical surface with sensitive bacterial responsiveness and biocompatibility showed great potential in combating hernia mesh-related infection. This work provides a promising and universal strategy for the on-demand prevention of medical device-associated infections.
研究领域:
材料科学
·
生物材料
·
聚合物化学
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生物医学工程
·
感染控制
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）