INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2024
·
IF 7.7
Jiayin Gao,Yaoyao Wang,Yuqing Yu,Mengxiang Zhu,Wen Kong,Genyan Liu,Xiaogang Luo
Catalytic reduction of p -nitrophenol is usually carried out using transition metal nanoparticles such as gold, palladium , silver , and copper, especially palladium nanoparticles (Pd NPs), which are characterized by fast reaction rate, high turnover frequency , good selectivity, and high yield. However, the aggregation and precipitation of the metals lead to the decomposition of the catalyst, which results in a significant reduction of the catalytic activity. Therefore, the preparation of homogeneous stabilized palladium nanoparticles catalysts has been widely studied. Stabilized palladium nanoparticles mainly use synthetic polymers . Cellulose microspheres , as a natural polymer material with low-cost and porous fiber network structure, are excellent carriers for stabilizing metal nanoparticles . Cellulose microspheres impregnated with palladium metal nanoparticles were carbonized to have a larger specific surface area and highly dispersed palladium nanoparticles, which exhibited excellent catalytic activity in the catalytic reduction of p -nitrophenol. In this work, the cellulose carbon-based microspheres palladium (Pd@CCM) catalysts were designed and characterized by SEM, TEM , EDS, XRD, FTIR, XPS , TGA , BET, and so on. Furthermore, the catalytic performance of Pd@CCM catalysts was investigated via p -nitrophenol reduction, which showed high catalytic activity. This catalyst also exhibited excellent catalytic performance in the Suzuki-Miyaura coupling reaction. Linking aromatic monomer and benzene through Suzuki-Miyaura coupling was presented as an effective route to obtaining biaryls , and the synthesis method is low-cost and simple. In addition, Pd@CCM showed desirable recyclability while maintaining its catalytic activity even after five recycles. This work is highly suggestive of the design and application of the heterogeneous catalyst .
研究领域:
材料科学
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催化化学
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DOI
PubMed
高影响因子
APPLIED CATALYSIS A-GENERAL
·
2023
·
IF 5.5
Qian Wang,Limei Sheng,Xuan Guo,Rong Chen,Chengjie Zhou,Fu Yang
Dynamic kinetic resolution (DKR) of chiral amines with enzyme and noble metal has been widely concerned in chemistry, biology and pharmacy fields. While the synergistic effect and long-term stability of enzyme-noble metal in catalysts remain challenging. In this paper, several functional polymers were designed and employed as the carrier of lipase and palladium (Pd) for one-pot DKR of α-phenethylamine. By modulating the multisite weak force (MSWF) of the polymers on the active centers, the optically pure product with high conversion (>99%) and ee (>99%) were obtained and the designed catalyst Pd@PE-2OH_CalB showed superior stability to other commercial catalysts, such as Pd/C and Novozym 435. Additionally, the heterogeneous chemoenzymatic catalysts could be easily recovered and recycled up to seven times without sacrificing efficiency. Further investigation revealed that the enhanced catalytic performance depended on MSWF formed by the abundant ionic sites, functional groups, and lots of hydrogen bonds of poly(ionic liquid)s.
研究领域:
化学
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生物化学
·
制药工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2021
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IF 6.953
Hao Liu,Ya-nan Qin,Hao-yu Li,Li-xue Gai,Qing-da An,Shang-ru Zhai,Zuo-yi Xiao,Li Cui
Noble metal-based catalytic material with maximum utilization is of prime attraction for conserving rare metal resources. Herein, highly dispersion Ni nanoparticles (NPs)-modified N-doped mesoporous carbon material (Ni-N@C) was fabricated by pyrolysis of Ni 2+ /Histidine cross-linked alginate hydrogels. In a step forward, the obtained Ni-N@C nanocatalyst was treated by the solution of Pd 2+ , and tiny amount of Pd NPs were deposited on the surface of Ni via the reducibility of Ni to achieve the high dispersion of precious metals material. In the degradation of highly-concentration p-nitrophenol, the catalyst presents excellent performance which could completely degrade pollutants within a very short period. It was demonstrated that pre-embedded Ni NPs could not only increase the efficiency of Pd NPs but also endow the facile separation characteristic to the catalyst. Besides, the catalyst maintained favorable catalytic capacity even after five reaction cycles. In brief, this work may provide novel guidance for the maximum utilization of noble metal-modified mesoporous N-doped carbon-supported catalysts in practical applications of industrial and the treatment highly-concentration p-nitrophenol.
研究领域:
材料科学
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环境科学
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DOI
PubMed
高影响因子
Catalysts
·
2018
·Vol. 8
·期 10
·443
·
IF 3.465
Kai Zheng,Chao Shen,Jun Qiao,Jianying Tong,Jianzhong Jin,Pengfei Zhang
Novel magnetically recyclable Fe3O4@Pd nanoparticles (NPs) were favorably synthesized by fixing palladium on the surface of nitrogen-doped magnetic nanocomposites. These catalysts were fully characterized by Fourier-transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), transmission electron microscopy (TEM), thermogravimetric analysis (TG), and X-ray photoelectron spectroscopy (XPS). The prepared catalyst exhibited good catalytic activity for Suzuki–Miyaura coupling reactions of aryl or heteroaryl halides (I, Br, Cl) with arylboronic acids. These as-prepared catalysts could be readily isolated from the reaction liquid by an external magnet and reused at least ten times with excellent yields achieved. In addition, using this protocol, the marketed drug crizotinib (anti-tumor) could be easily synthesized.Keywords:heterogeneous catalyst;magnetically;palladium catalysts;nitrogen-doped;Suzuki coupling;crizotinib
研究领域:
有机化学
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材料科学
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药物合成
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DOI
高影响因子
JOURNAL OF ORGANOMETALLIC CHEMISTRY
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2026
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IF 2.7
Zheng Li,Yi Dou,Chang-Liang Sun,Valerian Dragutan,Xueqing Wang,Baodi Zhang,Jiaying Li,Zhixiong Luo,Fu Ding
Integrating homogeneous catalytically active components onto solid supports represents a primary strategy for the heterogenization of homogeneous catalysts. The purpose is to streamline catalyst separation and recovery processes while enhancing stability and reusability, all while retaining the inherent advantages of homogeneous catalysts. In this study, we synthesized immobilized Pd(II) complexes loaded with 3.5 nm palladium nanoparticles in a single step by incorporating imidazole precursors into porous organic polymer (POP) backbones through free radical polymerization. This process was conducted without resorting to complex synthetic conditions or toxic monomers, utilizing DMF as both solvent and reductant precursor. Pd NPs@POP-Pd was synthesized and thoroughly characterized by FT-IR, PXRD, ICP-OES, XPS, BET, TEM, EDX, and TGA studies. The Pd(0) and Pd(II) contained in the catalyst play a synergistic activating-stabilizing effect that enabled the Pd NPs@POP-Pd to exhibit excellent catalytic performance towards Suzuki reactions between phenylboronic acid and a wide range of aryl halides at an ultra-low Pd loading of 1.92 mmol%. Notably, this catalyst can be recycled 9 times in pure ethanol while maintaining efficient catalytic activity throughout its use.
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DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 8
·1-17
·
IF 5.3
Liang Jintao,Li Canru,Zhou Yu,Fan Lingling,Liu Lin,Liang Jianlu,Tan Xiaohong,Zhou Zhide,Li Guiyin
Golgi protein 73 (GP73) is highly expressed in hepatocellular carcinoma (HCC) and considered a sensitive serum biomarker for HCC diagnosis. Herein, a label-free electrochemical aptasensor for ultrasensitive detection GP73 based on nitrogen-doped reduced graphene oxide-ferrocene-platinum@palladium nanoparticles (NRGO-Fc-Pt@Pd NPs) was constructed. The NRGO-Fc-Pt@Pd NPs offered excellent conductivity, biocompatibility, and large surface area, serving as both an electrode modifier and a redox probe due to Fc's good electroactivity. GP73 aptamer (GP73 Apt ) was covalently bound with the NRGO-Fc-Pt@Pd NPs to form the signal probe. When GP73 specifically bound to GP73 Apt to form GP73-GP73 Apt complex and fell off from the electrode, it leads to an increased Fc(Fe(II)/Fe(III)) peak current in differential pulse voltammetry (DPV) due to the enhancing of the sensing interface's electroactivity. Under optimized conditions, the label-free electrochemical aptasensor demonstrated a linear relationship with GP73 concentration in the range 1.0 ng/mL-300 ng/mL, with R 2 of 0.99594 and a limit of detection (LOD) of 0.3524 ng/mL. In addition, the aptasensor showed good specificity, reproducibility, and stability. Furthermore, the developed aptasensor was applied to detect the GP73 in actual serum samples with good recoveries (97.85%-107.48%) and relative standard deviations (RSDs) (0.37%–7.85%) via the spiked recovery method. All the results may provide a new approach for HCC clinical detection. Graphical
研究领域:
生物医学工程
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肿瘤学
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分析化学
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纳米材料
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DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
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IF 10.383
Yiming Wang,Haimeng Tian,Hong Li,Xinchen Deng,Qiao Zhang,Yongjian Ai,Zejun Sun,Yu Wang,Lei Liu,Ze-Nan Hu,Xinyue Zhang,Rongxiu Guo,Wenjuan Xu,Qionglin Liang,Hong-bin Sun
Cascade reactions take advantage of step-saving and facile operation for obtaining chemicals. Herein, catalytic hydrogenation of nitroarene coupled condensation with β-diketone to afford β-ketoenamines is achieved by an integrated nanocatalyst, Pd-e@UiO-66. The catalyst has the structure of an acid-rich metal–organic framework (MOF), UiO-66-encapsulated electron-rich Pd nanoparticles, and it reconciles the electron-effect contradiction of cascade catalytic reactions: catalytic hydrogenation requires an electron-rich catalyst, while condensation requires electron-deficient Lewis acid sites. The catalyst showed good activity, high chemoselectivity, and universal applicability for the synthesis of β-ketoenamines using nitroarenes. More than 30 β-ketoenamines have been successfully prepared with up to 99% yield via the methodology of relay catalysis. The catalyst exhibited excellent stability to maintain its catalytic performance for more than five cycles. Furthermore, we conducted an in-depth exploration of the reaction mechanism with theoretical calculations.
研究领域:
化学
·
催化材料科学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Materials & Interfaces
·
2022
·
IF 10.383
Hao Zhao,Guanhua Liu,Yunting Liu,Xilin Liu,Hanxi Wang,Huaxun Chen,Jing Gao,Yanjun Jiang
Cascade catalysis that combines chemical catalysis and biocatalysis has received extensive attention in recent years, especially the integration of metal nanoparticles (MNPs) with enzymes. However, the compatibility between MNPs and enzymes, and the stability of the integrated nanocatalyst should be improved to promote the application. Therefore, in this study, we proposed a strategy to space-separately co-immobilize MNPs and enzymes to the pores and surface of a highly stable covalent organic framework (COF), respectively. Typically, Pd NPs that were prepared by in situ reduction with triazinyl as the nucleation site were distributed in COF (Tz-Da), and organophosphorus hydrolase (OPH) was immobilized on the surface of Tz-Da by a covalent method to improve its stability. The obtained integrated nanocatalyst Pd@Tz-Da@OPH showed high catalytic efficiency and reusability in the cascade degradation of organophosphate nerve agents. Furthermore, the versatility of the preparation strategy of COF-based integrated nanocatalyst has been preliminarily expanded: (1) Pd NPs and OPH were immobilized in the triazinyl COF (TTB-DHBD) with different pore sizes for cascade degradation of organophosphate nerve agent and the particle size of MNPs can be regulated. (2) Pt NPs and glucose oxidase were immobilized in COF (Tz-Da) to obtain an integrated nanocatalyst for efficient colorimetric detection of phenol.
研究领域:
催化
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纳米技术
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生物化学
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材料科学
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Jinglong Fang,Guanhui Zhao,Xue Dong,Xuan Li,Juncong Miao,Qin Wei,Wei Cao
An electrochemiluminescence (ECL) analytical platform was proposed for ultrasensitive detection of amyloid-β proteins (Aβ) based on the ECL resonance energy transfer (ECL-RET). In this work, gold nanoparticles-functionalized graphitic carbon nitride nanosheets (g-C 3 N 4 @Au NPs) and palladium nanoparticles-coated Metal organic framework (Pd NPs@NH 2 -MIL-53) were synthesized, which were as ECL donor and ECL acceptor respectively. A strong cathode ECL emission was obtained from the g-C 3 N 4 @Au NPs when used K 2 S 2 O 8 as its co-reactant. Here, Au NPs not only was used as an accelerator to enhance and stabilize the ECL signal, but also a connector for attaching Aβ antibody. In addition, NH 2 -MIL-53(Al) was selected as a label material for supporting Pd NPs to synergistically increase the intensity and range of UV-visible absorption. The ECL signal of g-C 3 N 4 @Au NPs was intensely decreased when the ECL acceptor probe Pd NPs@NH 2 -MIL-53 was incubated onto the modified GCE by way of the specific recognition. Under the optimal condition, a wide detection range from 10 fg/mL to 50 ng/mL and a low detection limit of 3.4 fg/mL (S/N = 3) were obtained. In consideration of favorable specificity, stability and reproducibility, the proposed method was successfully applied for Aβ detection in actual human serum samples and could be a potential analytical tool for sensitive molecular trace detection in clinical analysis.
研究领域:
分析化学
·
生物医学工程
·
临床诊断
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DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2023
·Vol. 58
·期 36
·14299-14314
·
IF 4.5
Xu Chenzhe,Qiu Yue,Wang Zheng,Gao Zifei,Liu Cai,Sun Yanran,Zhang Haitao,Ma Juanjuan,Liu Lin,Liu Chao,Tong Zhiwei
A facile one-step hydrothermal approach was proposed to fabricate Pd nanoparticles decorated Mg–Al layered double hydroxide nanosheets (denoted as Pd NPs/Mg–Al LDH composite), wherein polyvinylpyrrolidone (PVP) functioned as both a reductant and stabilizer. The resulting samples were characterized by XRD, SEM, TEM, XPS and BET techniques. The effect of synthetic parameters during the hydrothermal reaction including PVP dosage and temperature on the size and distribution of Pd NPs was investigated in details. Pd nanoparticles with an average particle size of 3.6 nm were uniformly supported onto Mg–Al LDH nanosheets under the optimal conditions. The obtained Pd NPs/Mg–Al LDH composite could serve as an efficient heterogeneous catalyst for the Heck reaction between iodobenzene and methyl acrylate, achieving a high yield of 95.8% within 60 min at 100 °C. Furthermore, Pd NPs/Mg–Al LDH was highly stable and reused 6 times without significant loss of its catalytic activity.
研究领域:
化学
·
催化材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）