RSC Advances
·
2020
·Vol. 10
·期 41
·24507-24514
·
IF 3.119
Peihong Li,Xueyan Dai,Lijie Qu,Yanlong Sui,Chunling Zhang
Peptide-containing hydrogels have become a research hotspot due to their unique secondary structure and biocompatibility. Herein, we used amino-terminated F127 as a macroinitiator to initiate the ring-opening polymerization of L-lysine(z)-NCA, and the obtained oligo(lysine)-modified F127 (FL) had degrees of polymerization of lysine of 2, 5, and 8. The results showed that the FL hydrogels had reversible temperature-dependent sol–gel transitions, and the introduction of lysine increased the critical gel temperature. In the dilute solution of FL, the micelle size increased and aggregated as the pH increased; the micelle grew into a rod-like shape under alkaline conditions. Scanning electron micrographs showed that the interior of the FL hydrogel had a more complete porous structure. The FL-2 hydrogel loaded with 5-fluorouracil exhibited an approximately linear release trend within 12 h and has good biocompatibility. Therefore, FL hydrogels have potential applications in the field of biomedicine.
✓ 已验证
DOI
PubMed
高影响因子
POLYMER ENGINEERING AND SCIENCE
·
2022
·Vol. 62
·期 6
·1811-1822
·
IF 2.573
Jian Chen,Chuang Zhou,Wei Cai,Fuxiang Huang,Chunyan Zhang,Liangliang Cao,Fancheng Meng
Ceramic/polymer nanocomposites have been extensively explored for dielectric capacitor application due to their high energy storage performance and ease of processing, flexibility, and low cost. However, improving compatibility between inorganic and organic materials is of great significance and has been a long-standing challenge. In this work, the polymer surfactant Pluronic™ F127 was employed to perform surface modification of BaTiO 3 through a facile solution process. The compatibility between BaTiO 3 nanoparticles and P (VDF-HFP) can be remarkably strengthened by the affinity between F127 polymer chains and the organic matrix. Structural defects such as pores, cracks, and agglomeration of inorganic particles were obviously reduced, and interfacial polarization has been significantly enhanced. The discharged energy density U d and charge–discharge efficiency η reach up to 5.0 J/cm 3 and 58.1% under the breakdown strength of 3740 kV/cm for the nanocomposite containing 1 vol% BT@F127. These dielectric properties are clearly better than the nanocomposite using unmodified BT, as well as similar hybrids reported previously.
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2013
·
IF 2.108
Yi Yang,Xiao Chen,Dandan Huang,Wei Ye
Being considered as building blocks, the inorganic nanodimer particles such as Ag-Fe 3 O 4 , Cd-Se and Pt-Fe 3 O 4 , have attracted much attention because of their capability of dual surface functionalization and potential applications in field-emission, data storage and photovoltaic devices. For these motivations and as a continuation of our previous study, a gel with flower-like morphology based on Ag-Fe 3 O 4 nanodimers has been constructed with the carboxylated cyclodextrin (MAH-CD) and Pluronic F127 molecules in mixed solvent of cyclohexane and water. The morphology of Ag-Fe 3 O 4 nanodimers and structure of MAH-CD were characterized by transmission electron microscopy (TEM) and nuclear magnetic resonance (NMR) respectively. The mechanism of gel formation is discussed along with the data obtained from rheological measurement, thermogravimetric analysis (TGA), scanning electron microscopy (SEM), Fourier transformation infrared spectroscopy (FTIR) and X-ray diffraction (XRD). Each Ag-Fe 3 O 4 particle was coated by lots of MAH-CD molecules, which were threaded by F127 chains. The gel fabrication is controlled by the inclusion of MAH-CD with F127, the interaction between the carboxyl group and the Fe 3 O 4 surface. The cyclohexane molecules in gel were trapped with F127 by cyclodextrin, which may be packed orderly through hydrogen bond. Meanwhile, the Fe 3 O 4 side of nanodimers provides the anchoring position for carboxyl group to induce the formation of gel. Such an Ag-Fe 3 O 4 nanodimer initiated gel can be used either based on Ag side for catalytic and sensing properties, or based on superparamagnetism from Fe 3 O 4 side.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 48
·30250-30261
·
IF 3.108
Xin Liu,Yuebin Li,Jian He,Tingting Zhao,Changmei Chen,Haoshuang Gu,Xingguo Wang
A novel anticancer drug PFPSNT, paclitaxel (PTX)-loaded polymeric F127/P123 silica nanocapsules conjugated with TRAIL (tumor necrosis factor (TNF)-related apoptosis-inducing ligand), was designed and synthesized. Transmission electron microscopy (TEM), dynamic light scattering (DLS), UV-vis absorption and particle size analysis revealed that the synthesized PFPSNT was a spherical particle with a size of 24 nm and excellent colloidal stability. Drug loading efficiency (DL%) and encapsulation ratio (ER%) were 0.39% and 26.5%, and its cumulative release profile was linear. In vitro study showed that PFPSNT had marked cytotoxic and apoptotic activities towards HepG2 (liver cancer cell line) and CaSki (cervical cell line) cells with the IC50 values of 921.07 ng mL−1 and 236.24 ng mL−1, respectively. The antitumor efficacy of PFPSNT was evaluated by using a HepG2-xenografted BALB/c nu/nu mice model. In vivo study showed PFPSNT markedly inhibited HepG2 hepatocellular carcinoma, and its antitumor efficacy was more superior than those of TRAIL, PTX or PTX/F127/P123 silica nanocapsules. Our studies provided a novel strategy to synthesize anticancer nanodrugs with mutiple functions, and demonstrated that PFPSNT was a very effective anticancer drug. This novel nanodrug should be a promising drug for targeted cancer therapy to treat complex cancers.
✓ 已验证
产品关联
DOI
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yujuan Chen,Abdur Rauf Khan,Dexin Yu,Yujia Zhai,Jianbo Ji,Yikang Shi,Guangxi Zhai
Traditional cancer therapies carry a risk of serious side effects and toxicity. Developing an alternative treatment modality that is highly effective, has low toxicity and is noninvasive is urgently required. Here, we exploited molybdenum oxide (MoOx) nanosheets as a drug carrier and degradable photothermal agent to provide a chemo-photothermal combination cancer therapy. The MoOx nanosheets were synthesized by a one-pot hydrothermal method and then modified with pluronic F127 to improve physiological stability and biocompatibility. The F127-modified nanosheets (MoOX@F127) showed ultrahigh drug loading efficiency (DLE) of doxorubicin (DOX) (DLE%; 65%, W (load DOX) /[W (load DOX) + W MoOx@F127 ]), strong near-infrared (NIR) absorption and desirable pH-dependent degradability. After intravenous injection, MoOx@F127 nanosheets were degraded at physiological pH and were rapidly excreted from normal organs, while they were effectively accumulated and retained long-term in the more acidic tumor tissue. This simultaneously ensured effective tumor ablation after NIR irradiation and avoided long-term retention and toxicity in vivo . Compared to chemotherapy or photothermal therapy alone, in vitro and in vivo tumor ablation studies have shown a notably improved synergistic effect of the combination therapy. Our study presents a multifunctional nanosystem with a desirable degradability for chemo-photothermal combination cancer therapy that has great potential in biomedical applications.
✓ 已验证
DOI
PubMed
高影响因子
JOURNAL OF DISPERSION SCIENCE AND TECHNOLOGY
·
2020
·
IF 1.701
Ziling Li,Yousheng Huang,Shengfeng Peng,Xing Chen,Liqiang Zou,Wei Liu,Chengmei Liu
We prepared liposomes consisting of different ratios of phospholipid and pluronic F127 (F127-Lps), then evaluated the effect of matrix on the morphology, stability and carriers’ property of liposomes. The particle size of liposomes was significantly decreased after pluronic F127 modification. Pluronic F127 at low ratio may incorporate into liposomes and form spherical and lamellar structure, while pluronic F127 at high ratio can form mixed aggregates with spherical micelles and lamellar vesicles. The membrane stability of liposomes was enhanced with increasing of pluronic F127 ratio. Curcumin was encapsulated into F127-Lps (cur-F127-Lps) with an entrapment efficiency of 89%. The higher the ratio of pluronic F127 was, the slower the release rate of curcumin. First order model was the main release mechanism for curcumin loaded liposomes. These results are useful for designing liposome-based food delivery systems that can be used in functional foods.
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 6
·期 54
·49263-49271
·
IF 3.289
Shaoyu Lü,Nannan Gao,Zhen Cao,Chunmei Gao,Xiubin Xu,Xiao Bai,Chen Feng,Mingzhu Liu
Tumor-specific drug delivery is still a challenge in cancer therapy. Passive tumor targeting strategies, such as the enhanced permeability and retention (EPR) effect, cause nanocarriers to accumulate in tumors. However, this strategy can not provide specific tumor targeting. In this study, Pluronic F127 (PF127), a block copolymer which can inhibit drug efflux transporters in cancer therapy, was modified to form tumor-specific micelles with a natural polysaccharide, chondroitin sulfate (ChS), which imparts the site-specific property. A facile and efficient method based on Schiff base reaction was developed to facilitate both basic and clinical research. A series of PF127–ChS micelles with different ratios of PF127 and ChS were fabricated and evaluated in terms of size, morphology, drug loading efficiency and drug release behavior. Spherical micelles with a mean diameter of 155–241 nm were obtained. Their critical micelle concentration (CMC) was significantly reduced in contrast to PF127 micelles and their stability was enhanced. Doxorubicin (DOX) was loaded into the hydrophobic core of PF127 or adsorbed by ChS through electrostatic interactions with the negative charges of chondroitin sulfate. In vitro DOX release studies showed that DOX release from the micelles was enhanced at acidic pH values compared to physiological pH. A cytotoxicity assay (MTT) determined that the micelles possess significantly lower toxicity. Confocal microscopy and flow cytometry analysis indicated that DOX loaded micelles could efficiently release DOX inside cells by specific cellular uptake. These outcomes revealed that PF127–ChS micelles could be exploited as carriers for anti-tumor drugs for site-specific therapy of solid tumors.
✓ 已验证
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
·
2021
·
IF 5.268
Baohuan Wu,Sixiang Sai,Keke Li,Xingchen Sun,Jingtian Han,Baocheng Tian
Drugs that are topically applied on the eyes have low bioavailability, which has always been an important problem. In this study, maleimide functionalized, voriconazole (VCZ) loaded mixed micelles (Mal-VCZ-MM) were designed. Pluronic F127 and phospholipid were used as materials, and maleimide was used as an adhesive. The prepared Mal-VCZ-MM was nearly spherical with a particle size of 84.45 ± 1.39 nm and a zeta potential of − 20.3 ± 0.29 mV. The encapsulation efficiency of Mal-VCZ-MM was 95.33 ± 0.06%, and it had high stability with a critical micelle concentration value of 1.28 × 10 -4 mg/mL. CCK-8 assay showed that its cytotoxicity was lower than that of free VCZ solution (VCZ-Sol). Both quantitative and qualitative analyses of the HCE-T cellular uptake showed that the cellular internalization of Mal-C6-MM was significantly stronger than that of C6-MM. The endocytosis pathway was macropinocytosis-mediated, cavernous-mediated, and energy-dependent. In vitro results against Candida albicans showed that the diameters of the antifungal inhibition zones of VCZ-Sol, VCZ-MM, and Mal-VCZ-MM were 15.5 ± 0.50 mm, 24.0 ± 0.71 mm, and 31.5 ± 1.12 mm, respectively. The antifungal effect of Mal-VCZ-MM was significantly higher than that of VCZ-Sol and VCZ-MM ( P < 0.001). This study shows that Mal-VCZ-MM is a highly effective hydrophobic ophthalmic drug-delivery carrier that can improve the therapeutic effect of the drug.
✓ 已验证
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2022
·
IF 5.195
Bin Du,Mengmeng Zhao,Yuehua Wang,Lili Yu,Qingqing Jiao,Yimeng Bai,Genyang Cheng
The oxidative stress and activation of the fibrosis pathway are essential pathological mechanisms of acute kidney injury (AKI). In this article, we designed a drug delivery system that could effectively improve oxidative stress and relieve fibrosis by the combination of precise targeting, solubilization, and reducing the toxicity of nano-transport system to strengthen the efficacy of AKI. Folic acid (FA) was used as the targeting molecule, and curcumin (Cur) and resveratrol (Res), which are Chinese medicine monomers with anti-inflammatory and antioxidant effects, were used as model drugs. Here, the targeting nanosystem (Cur/ [email protected] /TPGS) co-loaded with Cur and Res was successfully synthesized. Finally, the comprehensive therapeutic effect of the nanosystem was evaluated through the targeted and pharmacodynamic researches on the AKI models induced by cisplatin (CDDP) in vitro and in vivo . The studies in vitro proved that the nanosystem could not only specifically target HK-2 cells and promote the effective accumulation of Cur and Res in the kidney, but also effectively improve oxidative stress by eliminating reactive oxygen species (ROS), stabilizing mitochondrial membrane potential (MMP), and reducing the expression of apoptosis-related proteins. The studies in vivo showed that the nanosystem could effectively play the role of anti-oxidation, anti-inflammatory and alleviate fibrosis to reduce the apoptosis and necrosis of renal tubular cells. The nanosystem could coordinately repair damaged HK-2 cells by improving oxidative stress, inhibiting inflammation and tissue fibrosis, which provided a new idea for the treatment of AKI.
✓ 已验证
DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
·
2026
·
IF 9
Ying Wang,Linlin Geng,Xiaoya Wang,Jianwen Wei,Xuecong Ma,Lei Liao
Amine-modified adsorbents exhibit remarkable potential for efficient CO 2 capture. In this study, a series of amine-based bifunctional solid adsorbents for CO 2 capture was synthesized via an impregnation method. Fe Zr cyanide frameworks were first functionalized with Pluronic F127, followed by the immobilization of diethanolamine (DEA) and tetraethylenepentamine (TEPA) at different loadings (20–40 wt%). Among the resulting materials, FZ(F)-D35% (DEA) and FZ(F)-T35% (TEPA), exhibited the maximum CO 2 adsorption capacity at 45 °C, reaching 1.846 and 2.377 mmol·g −1 . Compared with the unmodified material (FZ), which exhibits an adsorption capacity of 0.989 mmol/g, they increased by 47% and 59%, respectively. After 6 adsorption-desorption cycles, FZ(F)-D35% and FZ(F)-T35% still retained 93.4% and 95.2% of their original capacities, respectively, exhibiting excellent cycling stability. Kinetic analysis indicated that the adsorption process followed the Avrami model (R 2 = 0.999), suggesting a dual mechanism involving both physisorption and chemisorption. Infrared spectroscopy further confirmed the formation of carbamate and hydrogen bonding during the CO 2 adsorption, highlighting the critical synergistic role played by amine groups and hydroxyl groups in the CO 2 adsorption mechanism. It can therefore be inferred that the CO 2 adsorption mechanism is consistent with the zwitterion mechanism. These findings highlight the potential of amine-functionalized Fe Zr cyanide frameworks as robust, regenerable adsorbents for moderate-temperature CO 2 capture.
✓ 已验证
产品关联
DOI
高影响因子
MOLECULAR AND CELLULAR BIOCHEMISTRY
·
2022
·Vol. 478
·期 2
·241-247
·
IF 3.842
Zhou Quan,Cai Xu,Huang Ying,Zhou Youliang
Curcumin (CUR) is an extract of Curcuma longa Linn., which has various pharmacological activities. The instability, low water solubility and bioavailability of CUR greatly limit its clinical application. This work prepared Pluronic F127-liposome-encapsulated curcumin (CUR-LIP-F127) and explored its functional role in wound healing. Liposome-encapsulated curcumin (CUR-LIP) and CUR-LIP-F127 were prepared. Human keratinocyte cell line (HaCaT) was treated with CUR, Pluronic F127-liposome (LIP-F127) and CUR-LIP-F127, or combined with ML385 (Nrf2 inhibitor). The expression of mRNAs and proteins was detected by quantitative real-time PCR and western blotting. MTT and wound healing assays were performed to detect cell viability and migration. CUR, LIP-F127 and CUR-LIP-F127 all had no influence on cell viability of HaCaT cells. CUR-LIP-F127 treatment significantly accelerated cell migration and enhanced the expression of nuclear factor erythroid-related factor 2 (Nrf2) and kelch-like erythroid cell-derived protein 1 (Keap1) in HaCaT cells with respect to CUR or LIP-F127 treatment. ML385 treatment impaired CUR-LIP-F127-mediated promotion of migration and up-regulation of Nrf2 and Keap1 in HaCaT cells. This work demonstrated that CUR-LIP-F127 activated Nrf2/Keap1 signaling pathway to promote migration of HaCaT cells, suggesting that CUR-LIP-F127 may contribute to wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2023
·
IF 6.2
Tao Wang,Haowei Fang,Subate Yalikun,Jinyan Li,Yuqing Pan,Kunxi Zhang,Jingbo Yin,Haiyan Cui
Developing strong anti-inflammatory wound dressings is of great significance for protecting inflammatory cutaneous wounds and promoting wound healing. The present study develops a nanocomposite Pluronic F127 (F127)-based hydrogel dressing with injectable, tissue adhesive, and anti-inflammatory performance. Briefly, Ce3+/tannic acid/ulinastatin nanoparticles (Ce3+/TA/UTI NPs) are fabricated. Meanwhile, α-lipoic acid is bonded to the ends of F127 to prepare F127-lipoic acid (F127LA) and its nanomicelles. Due to the gradual viscosity change instead of mutation during phase transition, the mixed Ce3+/TA/UTI NPs and F127LA nanomicelles show well-performed injectability at 37 °C and can form a semisolid composite nanohydrogel that can tightly attach to the skin at 37 °C. Furthermore, ultraviolet (UV) irradiation without a photoinitiator transforms the semisolid hydrogel into a solid hydrogel with well-performed elasticity and toughness. The UV-cured composite nanohydrogel acts as a bioadhesive that can firmly adhere to tissues. Due to the limited swelling property, the hydrogel can firmly adhere to tissues in a wet environment, which can seal wounds and provide a reliable physical barrier for the wounds. Ce3+/TA/UTI NPs in the hydrogel exhibit lipopolysaccharide (LPS)-scavenging ability and reactive oxygen species (ROS)-scavenging ability and significantly reduce the expression of inflammatory factors in wounds at the early stage, accelerating LPS-induced wound healing.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）