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Horseradish Peroxidase/Hydrogen Peroxide-Cross-Linked Quaternized Chitosan/Protocatechualdehyde Hydrogels with Strong Antioxidant and Photothermal Antibacterial Properties for Infected Burn Wounds

Jingmei Liu,Chen Zhang,Hua Zhao,Yachao Yu,Chenghao Li,Pei Cheng,Pengyuan Liu,Fangxia Guan,Yanting Zhang,Minghao Yao

Burns, a severe form of trauma, often cause significant skin damage due to bacterial infection and severe inflammation. Hydrogel, due to its remarkable physicochemical properties, shows great potential as a biomaterial for managing localized burn wounds. In this study, we designed a hydrogel composed of quaternized chitosan (QCS) and protocatechualdehyde (PA), cross-linked via Schiff’s base reaction and horseradish peroxidase (HRP) and hydrogen peroxide (H2O2) catalysis. This hydrogel exhibits multiple functionalities, including tissue adhesion, strong antioxidant, and antibacterial activities, as well as rapid hemostasis. HRP and H2O2 catalyze the polymerization of PA monomer and color darkening, endowing the hydrogel with near-infrared (NIR) responsiveness and a photothermal antimicrobial property. Moreover, within a murine model of full-thickness burn injury, the hydrogel assisted by NIR irradiation efficiently inhibits bacterial infection, promotes angiogenesis and collagen deposition, and mitigates inflammatory response. Our study demonstrates that the HRP/H2O2-catalyzed QCS-PA (QP) hydrogel possesses excellent antioxidant, antibacterial, and anti-inflammatory properties, offering a new therapeutic strategy for wound healing.