JOURNAL OF APPLIED POLYMER SCIENCE
·
2021
·Vol. 139
·期 17
·52041
·
IF 3.125
Zhiyuan Song,Jie Wang,Qian Tao,Yang Yu,Hui Zhang,Chuanqun Hu,Hongyu Cen,Xuan Zheng,Tao Hu,Chonggang Wu
Zn-salt poly(styrene– ran –cinnamic acid) (SCA–Zn) ionomers were successfully synthesized via the melt neutralization of poly(styrene– ran –cinnamic acid) (SCA), which has a comparable molecular weight ( = 217,000) to commercial polystyrene (PS), with different mass fractions of ZnO (0.62, 1.6, and 3.9 wt.%) and the successful synthesis was confirmed by Fourier transform infrared spectroscopy. The mechanical properties, heat resistance, and processibility of the PS, SCA, and SCA–Zn samples were characterized. Compared to SCA, the three SCA–Zn ionomers exhibited significantly higher α cN values, with the ionomers containing 1.6 and 3.9 wt.% ZnO were 11.4% and 68.6% higher than that of SCA, respectively. Compared to commercial PS, SCA–Zn also exhibited significant improvements in heat resistance (glass transition temperature and vicat softening temperature both improved by about 20 °C) and impact toughness ( α cN values of the ionomers containing 1.6 and 3.9 wt.% ZnO were 69.6% and 156.5% higher than that of PS), while the processability of SCA–Zn was not significantly worse than that of PS. This method efficiently improves both the toughness and heat resistance of PS, providing an efficient way to expand the market application of styrenic resins.
研究领域:
高分子材料
·
材料科学
✓ 已验证
产品关联
DOI
高影响因子
Journal of Macromolecular Science Part B-Physics
·
2022
·
IF 1.366
Qian Tao,Jie Wang,Zhiyuan Song,Hui Zhang,Yang Yu,Chuanqun Hu,Hongyu Cen,Xuan Zheng,Tao Hu,Chonggang Wu
Poly(styrene-ran-cinnamic acid) (SCA) Zn-salt ionomers (SCA‒Zn) bearing increasing contents (0, 0.23, 0.55, 1.3, 3.0, and 5.5 mol%) of Zn2+ ions were successfully synthesized by solution neutralization of the SCA with Zn2+ ions at room temperature. As the ion content of the SCA‒Zn increased from 0 to 5.5 mol%, the size and the aggregation number of the ionic aggregates did not change significantly, because the increase in ion content led to a monotonic increase in the number density of ionic aggregates, while the number of ions participating in the aggregates to form ionic aggregates was essentially fixed. Furthermore, the Tg values of the SCA‒Zn increased slowly as the Zn2+ ion content increased, and the linear increase rate with Zn2+ ion content was ∼0.8 °C mol−1, which was quite different from the reported increase rate in the Tg values of the matrix phase with Na+ ion content of 3–6 °C mol−1. This appeared to be caused by the steric hindrance effect of the adjacent groups of –COO− ions in the SCA and the long-distance electrostatic attraction. In addition, the degree of ionization of the SCA‒Zn was too low to cause large changes in thermal stability.
研究领域:
高分子化学
·
材料科学
·
物理化学
✓ 已验证
DOI
高影响因子
EUROPEAN POLYMER JOURNAL
·
2019
·
IF 3.621
Wenxin Huang,Zepeng Mao,Zhiren Xu,Bo Xiang,Jun Zhang
The core-shell polymeric polyacrylate-graft-poly(acrylonitrile-ran-styrene) (ASA) has been explored for the polymer industry due to its excellent properties. However, it has been a longstanding challenge to synthesize large size-tunable particles by the conventional batch polymerization. In this paper, an accurate method, i.e. pre-emulsion semi-continuous polymerization, is applied to prepare ASA polymeric particles, which makes a series of different particle sizes (100–450 nm) of the crosslinked poly(butyl acrylate) (PBA) inner core coated with a hard shell using the poly(acrylonitrile-ran-styrene) (AS) copolymer . Specifically, the feed modes and proportion of seed are investigated to tune the particle size. The results show that the PBA seed microsphere in pre-emulsion semi-continuous polymerization is enlarged by accurate feed rate, but not in batch polymerization. A possible mechanism for the growth of the PBA core is proposed that secondary particles from homogeneous nucleation in semi-continuous feed mode is less than that of batch mode, which attenuate the impact on the growth of core particle. The size and morphology of resulting particles are characterized using various analytical techniques including the transmission electron microscopy (TEM), the scanning electron microscopy (SEM) and the dynamic light scattering (DLS). Core-shell separates phase corresponding to different glass transition temperatures is evaluated using differential scanning calorimeter (DSC) analyses indirectly. Moreover, the mechanical properties including impacts and tensile strengths are also analyzed. This study thus highlights a detailed strategy to tune polymeric particles related to different properties and the nucleating mechanism of seed emulsion polymerization that governs structure, particle size and distribution of ASA polymer with a bespoke structure for various application.
研究领域:
高分子化学
·
材料科学
✓ 已验证
DOI
高影响因子
Chinese Journal of Natural Medicines
·
2022
·
IF 3.887
Si-Li ZHENG,Dong-Ning ZHANG,Yan-Fen DUAN,Fang HUANG,Lin-Tao HAN,Guo-Yan MO
Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) is traditional Chinese medicine that has been used to treat diarrhea caused by acute enteritis (AE) and bacillary dysentery in Xinjiang (China) for many years. However, the potential therapeutic mechanism of MMRAC for AE and its regulatory mechanism on host metabolism is unclear. This study used fecal metabolomics profiling with GC/MS and 16S rRNA gene sequencing analysis to explore the potential regulatory mechanisms of MMRAC on a dextran sulfate sodium salt (DSS)-induced mouse model of AE. Fecal metabolomics-based analyses were performed to detect the differentially expressed metabolites and metabolic pathways. The 16S rRNA gene sequencing analysis was used to assess the altered gut microbes at the genus level and for functional prediction. Moreover, Pearson correlation analysis was used to integrate differentially expressed metabolites and altered bacterial genera. The results revealed that six intestinal bacteria and seven metabolites mediated metabolic disorders (i.e., metabolism of amino acid, carbohydrate, cofactors and vitamins, and lipid) in AE mice. Besides, ten altered microbes mediated the differential expression of eight metabolites and regulated these metabolisms after MMRAC administration. Overall, these findings demonstrate that AE is associated with metabolic disorders and microbial dysbiosis. Further, we present that MMRAC exerts protective effects against AE by improving host metabolism through the intestinal flora.
研究领域:
药理学
·
微生物学
·
代谢组学
·
胃肠病学
✓ 已验证
DOI
PubMed
高影响因子
Polymers
·
2025
·Vol. 17
·期 8
·1030
·
IF 4.9
Chaoqun Wang,Tong Wu,Yidi Li,Jie Liu,Yanshai Wang,Kefeng Wang,Yang Li,Xuefei Leng
Amphiphilic block copolymers with complex topologies (e.g., star and brush topologies) have attracted significant attention in drug delivery owing to their superior performance over linear micelles. However, their precise synthesis and structure–property relationships require further investigation. In this study, hydroxylated polybutadiene with adjustable topology and hydroxyl group density was employed as a macroinitiator to synthesize well-defined amphiphilic poly (ethylene oxide)- b -poly( ε -caprolactone- ran - δ -valerolactone) (PEO- b -P(CL- ran -VL)) copolymers via ring-opening polymerization (ROP). A series of linear, star, linear–comb, and star–comb copolymers were prepared as curcumin-loaded micellar carriers for the study. The self-assembly behavior, drug encapsulation efficiency, and in vitro release profiles of these copolymers in aqueous environments were systematically investigated. The results demonstrated that increasing the branch length of star–comb copolymers effectively reduced micelle size from 143 to 96 nm and enhanced drug encapsulation efficiency from 27.3% to 39.8%. Notably, the star–comb architecture exhibited 1.2-fold higher curcumin encapsulation efficiency than the linear counterparts. Furthermore, the optimized star–comb nanoparticles displayed sustained release kinetics (73.38% release over 15 days), outperforming conventional linear micelles. This study establishes a quantitative structure–property relationship between copolymer topology and drug delivery performance, providing a molecular design platform for programmable nanocarriers tailored to diverse therapeutic requirements of various diseases.
研究领域:
药剂学
·
高分子化学
·
纳米医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
BIOMEDICAL CHROMATOGRAPHY
·
2023
·Vol. 37
·期 11
·e5732
·
IF 1.8
Hailing Huang,Bailu Duan,Sili Zheng,Yan Ye,Dongning Zhang,Zhuang Huang,Shanshan Wang,Fengyun Zhang,Ping Huang,Fang Huang,Lintao Han
The current study utilizes a comprehensive network pharmacology and metabolomics analysis to investigate the mechanism of action of Ma-Mu-Ran Antidiarrheal Capsules (MMRAC) for the treatment of ulcerative colitis (UC). In this study, we established a mouse model of UC using dextran sulfate sodium. Colonic tissues were collected from mice and then subjected to hematoxylin and eosin staining, as well as histopathological analysis, to assess the therapeutic effect of MMRAC. Furthermore, we assessed the mechanisms through which MMRAC combats UC by employing integrated metabolomics and network pharmacology strategies. Lastly, we validated the key targets identified through western blot and molecular docking. An integrated network of metabolomics and network pharmacology was constructed using Cytoscape to identify eight endogenous metabolites involved in the therapeutic action of MMRAC on UC. Further comprehensive analyses were focused on four key targets and their associated core metabolites and pathways. The results of western blot and molecular docking demonstrated that MMRAC could modulate key targets and their expression levels. The cumulative results indicated that MMRAC restored intestinal function in UC, reduced inflammatory responses, and alleviated oxidative stress by influencing the methionine and cysteine metabolic pathways, as well as the urea cycle. In addition, it had an impact on arginine, proline, glutamate, aspartate, and asparagine metabolic pathways and their associated targets.
研究领域:
药理学
·
代谢组学
·
炎症性肠病
·
网络分析
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Polymers
·
2020
·Vol. 12
·期 3
·584
·
IF 3.426
Zixin Yu,Jie Wang,Peihua Li,Dachuan Ding,Xuan Zheng,Chuanqun Hu,Zhinan Gao,Tao Hu,Xinghou Gong,Chonggang Wu
A half-critical weight-average molecular weight (M¯w) (approximately 21,000 g mol−1), high-ion-content Zn-salt poly(styrene–ran–cinnamic-acid) (SCA–Zn) ionomer was successfully synthesized by styrene–cinnamic-acid (10.8 mol %) copolymerization followed by excess-ZnO melt neutralization. At 220 °C, the SCA–Zn’s viscosity was only approximately 1.5 magnitude orders higher than that of commercial polystyrene (PS) at 102s−1, and the PS/SCA–Zn (5–40 wt %) melt blends showed apparently fine, two-phased morphologies with blurred interfaces, of which the 95/5 and 90/10 demonstrated Han plots suggesting their near miscibility. These indicate that any PS–(SCA–Zn) processability mismatch was minimized by the SCA–Zn’s half-criticalM¯wdespite its dense ionic cross-links. Meanwhile, the SCA–Zn’s Vicat softening temperature (VST) was maximized by its cross-linking toward 153.1 °C, from that (97.7 °C) of PS, based on its half-criticalM¯wat which the ultimate glass-transition temperature was approximated. Below approximately 110 °C, the PS/SCA–Zn (0–20 wt %) were seemingly miscible when theirVSTincreased linearly yet slightly with the SCA–Zn fraction due to the dissolution of the SCA–Zn’s cross-links. Nevertheless, the 60/40 blend’sVSTsignificantly diverged positively from the linearity until 111.1 °C, revealing its phase-separated morphology that effectively enhanced the heat resistance by the highly cross-linked SCA–Zn. This work proposes a methodology of improving PS heat resistance by melt blending with its half-criticalM¯w, high-ion-content ionomer.Keywords:polystyrene;heat resistance;blending modification;poly(styrene–ran–cinnamic acid);ionomer
研究领域:
材料科学
·
高分子化学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）