JOURNAL OF CHEMICAL TECHNOLOGY AND BIOTECHNOLOGY
·
2026
·
IF 2.4
Mingzhu Sun,Linlin Zhao
BACKGROUND Bio-based oleic acid pentaerythritol ester (PETO) is a crucial green feedstock for high-end high-temperature lubricants. Existing synthesis processes are hindered by low catalytic efficiency, high energy consumption, and suboptimal yields. OBJECTIVE This study aims to develop an efficient, low-energy green synthesis process for PETO. METHOD A ‘dibutyltin oxide (DBTO) + tetrabutylammonium bromide (TBAB)’ dual-catalyst system was used, and the transesterification process was optimized by ‘single-factor prescreening—Box-Behnken response surface optimization’. RESULTS The optimization model showed high reliability (R 2 > 0.99). Under optimized conditions (DBTO 1.56%, TBAB 0.7%, 269.86 °C, molar ratio 4.71:1, 4 h), PETO yield reached 96.89%, far exceeding conventional processes. TBAB synergistically enhances DBTO's catalytic efficiency by reducing interfacial resistance, and no water-carrying agent is needed. SIGNIFICANCE The integrated DBTO+TBAB dual-catalyst and RSM system provides a green, scalable PETO synthesis solution, facilitating industrial application and conforming to sustainable manufacturing principles. © 2026 Society of Chemical Industry (SCI).
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INDUSTRIAL CROPS AND PRODUCTS
·
2020
·
IF 4.244
Xianhe Cheng,Yinwei Cheng,Nijia Zhang,Shuang Zhao,Hao Cui,Hongli Zhou
Analytic hierarchy process (AHP) combined with response surface methodology (RSM) was used to optimize the purification processes of the crude flavonoids of Carex meyeriana Kunth (CMK). The bioactivities of flavonoids were evaluated in terms of antioxidant and antimicrobial activities. The weighted coefficients of comprehensive scoring method on AHP included recovery, purity, and decolorization rate. The optimal results were as follows: the sample concentration was 3.04 mg/mL, the ethanol concentration was 70.33 %, pH was 2.93, the elution velocity was 2.95 Bv/h, and the comprehensive score was 75.52 ± 0.53 % ( n = 3). The purified flavonoids of CMK (PFCMK) were compared with a reference substance through ultra high-performance liquid chromatography and ultraviolet spectra. Results of composition analyses were as follows: (−)−gallocatechin, 5−Caffeoylquinic acid, (−)−naringin, myricetin, luteolin, and isorhamnetin. The IC 50 values of 2,2–dIphenyl–1-picrylhydrazyl (0.034 mg/mL), hydroxyl radical method (0.643 mg/mL), and reducing power (0.025 mg/mL) showed that PFCMK had strong antioxidant activity. The minimum inhibitory concentrations on Bacillus pumilus, Bacillus subtilis, and Escherichia coli were 1.75, 1.75, and 0.875 mg/mL, respectively. PFCMK can be prepared as an antioxidant and antimicrobial for natural pharmaceutical, cosmetic products, and other industrial products.
研究领域:
药理学
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化学工程
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植物科学
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分析化学
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高影响因子
Foods
·
2025
·Vol. 15
·期 1
·71
·
IF 5.1
Shufeng Yin,Yiyao Wang,RuiXue Zhao,Ning Zhao,Hao Liu,Yining Tang,Ningbo Qin,Yiwei Dai,Xinping Lin
Inoculated fermentation can enhance the flavor, nutrition, and functionality of juice. The lactic acid bacteria (LAB) are commonly used as starter cultures. This study screened LAB for orange juice fermentation and optimized fermentation factors using response surface methodology (RSM) to improve GABA content in orange juice. A total of 52 LAB strains were screened, andLacticaseibacillus paracaseiZY (Lcb. paracaseiZY) andLacticaseibacillus rhamnosusSN12 (Lcb. rhamnosusSN12) presented higher GABA yields and adaptability to substrates. The optimized fermentation factors for GABA enhancement in orange juice were as follows: initial pH of 5.5, fermentation temperature of 37 °C, soluble solids content of 12.0 °Bx, inoculum ratio ofLcb. paracaseiZY toLcb. rhamnosusSN12 as 1:1, inoculum size of 6 Log CFU/mL, and fermentation time of 96 h. Under these optimized conditions, the GABA content reached 0.89 g/L, representing a 39.06% increase compared to uninoculated orange juice. This indicates that RSM-based optimization is conducive to increasing GABA content in orange juice and provides a scientific basis for the development of GABA-enriched functional fermented juices.
研究领域:
食品科学与技术
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微生物学
·
功能食品
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生物加工
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PubMed
高影响因子
INDUSTRIAL CROPS AND PRODUCTS
·
2025
·
IF 6.2
Manmin Zhang,Yan Huang,Hongzi Lai,Hongming Zhang,Guanle Li,Xiaoxiao Dai,Qihe Yang,Cuihua Liu,Lubin Zhang,Xiaonan Zhang
Landmark fruit Citrus maxima (Burm.) is highly productive, but by-products can cause environmental pollution. This study simulates the storage conditions of Citrus maxima at various stages after harvest and models the nutrient content and changes in different by-products. An organic acid deep eutectic solvent (OADES) was configured using six organic acids as hydrogen bond donor (HBD) in combination with choline chloride (ChCl); and the yields of essential oils and pectin were optimized using response surface methodology. The study showed that the OADES configured with oxalic acid as the HBD had the highest extraction rate. The results of electronic nose (E-nose) combined with GC-MS showed that the volatile odors of the essential oils were mainly from β-Myrcene (38 %), D-Limonene (37 %), and β-Pinene (4.3 %). When the raw materials were stored for more than 30 days, the yields of essential oils were decreased by 27.68 %, and the composition was mainly a decrease of 4.3 % in the proportion of sesquiterpenes and an increase of 7 % in alcohols. After 60 days of storage, the yield decreased by 27.68 %, the composition was mainly mono sesquiterpenoids decreased by 21.8 % and alcohols increased by 20.8 %. In addition, throughout the storage period (0–60 d), the pectin yield increased and then decreased, with a denser structure and more thermally stable and methylated pectin compared to the pre-extraction grapefruit peel. The research results not only provide new methods for green and energy-saving extraction technologies, but also offer valuable insights for optimizing the storage and reproduction practices in the citrus industry.
研究领域:
植物学
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食品化学
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绿色化学
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分析化学
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农业科学
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2017
·Vol. 314
·期 3
·1607-1618
·
IF 1.282
Liu Huijun,Qi Caixia,Feng Zhiyuan,Lei Lanlin,Deng Shanxia
The adsorption of thorium(IV) was studied using a novel supramolecular polyrotaxane based on β-cyclodextrin derivatives. The effects of pH, contact time, Th(IV) initial concentration and adsorbents dosage on the adsorption of thorium(IV) by polyrotaxane were optimized using Box–Behnken design of response surface methodology. Analysis of variance and correlation coefficients showed that the predicted model was consistent with the experimental data well. The adsorption best fitted to the Langmuir model indicated that the adsorption process happened on homogeneous surface. The thermodynamic parameters (∆ G
0 < 0, ∆ H
0 > 0, ∆ S
0 > 0) demonstrated that the adsorption of Th(IV) ions onto polyrotaxane was spontaneous and endothermic.
研究领域:
环境科学
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化学工程
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材料科学
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高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
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2023
·Vol. 107
·期 3
·548-559
·
IF 2.5
Pan Zixin,Liang Xiaoping,Yan Su,Zeng Jing,Bai Jinshuo,Zhang Dequan,Yang Guixiang,Liu Zhifeng
Electrochromic glass, one of the green energy-saving building materials, get more and more attention. The advancement of efficient ion storage film become a hot topic of research. The porous V 2 O 5 ion-storage film was prepared by sol-gel method using polyethylene glycol (PEG) as the pore-former. The peak current of porous V 2 O 5 films heated at 300 °C increased substantially due to the volatility temperature of PEG at 285 °C. The mutual effects of the PEG content, heat treatment temperature, and heat treatment time on the structure and electrochromic properties of porous V 2 O 5 film were investigated by the response surface method (RSM). The results show that the influence extent on ion storage is: heat treatment temperature > PEG content > heat treatment time. Under optimized process parameters of PEG content 6.2 g/100 mL sol, heat treatment time 4 h, heat treatment temperature 310 °C, the porous V 2 O 5 film exhibited excellent ion storage capacity (87.28 mC·cm −2 ). The electrochromic device (ECD) with optimized porous V 2 O 5 ion-storage film as the counter electrode of electrochromic WO 3 film has been successfully assembled, which shows fascinating performance with high optical contrast (87.8% at 550 nm) and fast response time (bleaching/coloring: 4.5/3.7 s). Graphical Abstract
研究领域:
材料科学
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能源技术
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JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY
·
2018
·
IF 2.297
Yaqin Sun,Jing Zhang,Ruonan Bo,Ning Ou,Pengfei Gu,Zhenguang Liu,Yuanliang Hu,Jiaguo Liu,Yi Wu,Deyun Wang
The main purpose of this study was the preparation, optimization, characterization, and in vitro immunological activity evaluation of the polysaccharides of Atractylodes macrocephala Koidz-loaded nanostructured lipid carriers (PAMK-NLC). Both the blank NLC and PAMK-NLC were prepared using melt-emulsification and ultra-sonication techniques. The optimization of preparation conditions were a stearic acid to caprylic/capric triglyceride mass ratio of 2:1, a poloxamer 188 to soybean lecithin mass ratio of 2:1, and an ultrasound time of 12 min; these parameters were identified using response surface methodology (RSM). Under these conditions, the encapsulation efficiency was around 76.85% and the polydispersity index was around 0.281, indicating a good dimensional distribution. Furthermore, the potential of PAMK-NLC to enhance immunological activity in vitro was investigated in murine splenic lymphocytes. The results showed that PAMK-NLC could significantly stimulate lymphocyte proliferation and increase the ratio of CD4 + to CD8 + T cells. In conclusion, these findings indicated that PAMK-NLC possessed an efficient immunological activity, and that NLC is suitable for the delivery and protection of PAMK in clinical use.
研究领域:
药剂学
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免疫学
·
纳米技术
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高影响因子
ACS Sustainable Chemistry & Engineering
·
2022
·
IF 9.224
Liting Ti,Xueru Sheng,Haiyuan Jia,Qingwei Ping,Ning Li
Self-condensation of biomass-derived cyclopentanone is an attractive reaction for sustainable aviation fuel production. Ball-milling is an effective method for this reaction. However, the effect of process parameters on product yield has not been explored and is still unclear. In this work, the process parameters in the ball-milling process are optimized by orthogonal experiment and subsequently investigated by the response surface methodology. Rotate speed is a critical index for dimer yield, and catalyst dosage is an essential index for trimer yield and selectivity. In addition, a life cycle assessment of both ball-milling and magnetic stirring methods is conducted to reveal the difference between the two methods. The ball-milling method shows relatively excellent economic and environmental potential impact, especially for the toxic consumption of marine aquatic organisms, which is a 38.2% reduction compared to the magnetic stirring method. The ball-milling method introduced in cyclopentanone self-condensation is more sustainable and economical than the magnetic stirring method.
研究领域:
化学工程
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环境科学
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能源科学
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高影响因子
ENERGY
·
2025
·
IF 9.4
Xin Li,Jie Zhu,Shengli Niu,Yue Zheng,Yang Xu
Biodiesel, known for its low carbon emissions and renewability, offers a promising alternative to fossil diesel. Support loading and additive modification are effective strategies for synthesizing high-performance heterogeneous catalysts. This study modified ZSM-5 zeolite with the addition of divalent barium ions and tetravalent cerium ions to develop the novel acid-base dual-activity Ba-Ce/ZSM-5 catalyst for biodiesel production from the acidified palm oil through transesterification. Characterization results show that the synergistic loading of the divalent barium ions and the tetravalent cerium ions generates snowflake-like particles on the multi-porous ZSM-5 surface and increases the density of catalytic active sites. Compared to the pure ZSM-5, the Ba40-Ce15/ZSM-5 catalyst exhibits nearly a five-fold increase in average pore size and forms the hierarchical pore structure. This modification reduces the diffusion resistance of triglycerides during transesterification. The catalyst retains excellent activity even in the presence of 5.00 wt% free fatty acids and moisture. With optimization by Response Surface Methodology with Box-Behnken Design (RSM-BBD), the maximum biodiesel yield of 97.48 % is achieved at the alcohol-to-oil molar ratio of 14.95 : 1, reaction temperature of 149.6 °C, catalyst amount of 6.73 wt%, and reaction duration of 2 h. Compared to previously reported catalysts, the Ba40-Ce15/ZSM-5 catalyst exhibits superior performance in increasing biodiesel yield while offering greater cost-effectiveness.
研究领域:
化学工程
·
催化化学
·
可再生能源
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高影响因子
RESEARCH ON CHEMICAL INTERMEDIATES
·
2018
·Vol. 44
·期 4
·2889-2911
·
IF 1.674
Qi Caixia,Liu Huijun,Deng Shanxia,Yang AoHui,Li Zhendong
The inclusion complex (sulfated-β-CD@NAA) of sulfated β-cyclodextrin and α-naphthylacetic acid was synthesized for adsorption of low concentrations of thorium from aqueous solutions. The structure and property of sulfated-β-CD@NAA were characterized by Fourier transform infrared spectroscopy, thermogravimetric, X-ray diffraction, proton nuclear magnetic resonance, specific surface area measurement and scanning electron microscopy. The characterization analysis confirmed the formation of new solid phase. The results indicated that α-naphthylacetic acid embedded into the cavity of sulfated β-cyclodextrin partly from the secondary face and the thermal stability of inclusion complex was significantly increased. The experiments were designed by Box–Behnken design combined with response surface methodology. The adsorption parameters of pH value, contact time, initial concentration were used as the independent variables and their effects were investigated on the Th(IV) adsorption capacity. Second-order polynomial regression models were derived and analysis of variance was utilized to judge the adequacy of the chosen models. The maximum Th(IV) adsorption capacity (12.75 mg g −1 ) was achieved under the following conditions: pH value 2.5, contact time 35 min, initial concentration 30 mg L −1 . Prediction of models was in good agreement with experimental results. The experimental adsorption kinetic data followed a pseudo-second-order equation with the correlation of 0.9996, indicating the chemical adsorption. The obtained equilibrium isotherm data were fitted well with Langmuir model in the concentration range considered. The thermodynamic parameters ( ∆H 0 < 0, ∆S 0 < 0, ∆G 0 < 0) indicated that the adsorption process was exothermic and spontaneous. Regeneration of Th(IV)-loaded sulfated-β-CD@NAA with 0.1 M HNO 3 solution, and the regenerated sulfated-β-CD@NAA can be reused for adsorption of Th(IV).
研究领域:
环境科学
·
化学工程
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高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Gul Muhammad,Jingjing Wang,Wenlong Xiong,Yongkun Lv,Shen Zhang,Anqi Zhao,Parisa Jahanbakhsh-Bonab,Alexei Solovchenko,Jingliang Xu,Md. Asraful Alam
The intention of the present study was to develop a green and sustainable extraction procedure to obtain lutein from microalgae. A series of acidic and polyol based deep eutectic solvents (DESs) were synthesized to establish a novel pretreatment process. Response surface methodology (RSM) was adopted to analyzese the significance of pretreatment parameters with high prediction levels of lutein yield. Amongst all the DESs-assisted pretreatment, polyol based ChCl:Gly (1:2) DES obtained the maximum lutein yield at the following optimal conditions: biomass-to-DES ratio, 3:34.6; temperature, 26 °C; time, 40 min. Lutein extraction was optimized by one-factor-at-a-time approach, and results showed that 1.35 mg/g lutein could obtained at 40 °C for 20 min with a biomass-to-solvent ratio of 30 mg/mL. The recyclability of the DES ChCl:Gly (1:2) was also tested and showed satisfactory results up to three cycles. The mechanism of lutein extraction using ethyl acetate was explored by molecular dynamics.
研究领域:
化学工程
·
生物技术
·
可持续化学
·
提取技术
·
微藻生物技术
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高影响因子
ACS Omega
·
2024
·
IF 3.7
Rui Wang,Chaolong Rao,Qiuyan Liu,Xiong Liu
Zanthoxylum alkylamides, as a numbing substance in Zanthoxylum bungeanum has many physiological effects. However, the numbing taste and unstable properties limited its application. This study aimed to optimize the preparation process of Zanthoxylum alkylamides liposomes by response surface methodology (RSM) and to investigate the in vitro absorption characteristics of the liposomes through the Caco-2 cell monolayer model. The process parameters of liposomes were as follows: Zanthoxylum alkylamides was 15 mg, phospholipid–feedstock ratio was 6.14, phospholipid–cholesterol ratio was 8.51, sodium cholate was 33.80 mg, isopropyl myristate was 29.49 mg, and the theoretical encapsulation efficiency of the prepared liposomes could reach 90.23%. Further, the particle size of the liposomes was 155.47 ± 3.16 nm, and the ζ-potential was −34.11 ± 4.34 mV. Meanwhile, the liposomes could be preserved for 14 days under the condition that the content of Zanthoxylum alkylamides was less than 2 mg/mL and the preservation temperature was lower than 25 °C. Moreover, the uptake characteristics of the Zanthoxylum alkylamides liposomes in the Caco-2 cell monolayer model were also investigated. The results showed that the Zanthoxylum alkylamides liposomes could be taken up and absorbed by Caco-2 cells. Also, the Zanthoxylum alkylamides liposomes had a better uptake performance than the unembedded Zanthoxylum alkylamides and conformed to the passive uptake.
研究领域:
药学
·
药物递送系统
·
生物药剂学
·
药代动力学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）