JOURNAL OF APPLIED POLYMER SCIENCE
·
2024
·Vol. 141
·期 30
·e55692
·
IF 2.7
Yang Meng,Mengke Shi,Wenbo Feng,Lingji Zhang,Hongzhong Zhang,Xiaojing Zhang
This study prepares a series of hollow-structured CS/SA/POSS composite gel spheres with a diameter of ~2.5 mm by using hydrophilic Janus-type polyhedral oligomeric silsesquioxane (AS-POSS) as a crosslinking agent in combination with sodium alginate and chitosan via electrostatic adsorption/free radical polymerization. As the content of POSS increases, the wall thickness of the gel spheres also increases from 20 to 30 μm, leading to a more compact and smooth wall structure in the polymerized CS/SA/POSS composite gel spheres. Additionally, the introduction and polymerization of POSS significantly enhance the stability, drug loading rate, and entrapment rate of the gel spheres, providing them with improved drug release capabilities. For hydrophilic drug doxorubicin, the loading rate and encapsulation rate reach 41.2% and 79.9%, respectively, while for the hydrophobic drug ibuprofen, they are 14.7% and 76.3%. Compared to some previously reported drug-loaded gel materials, the gels prepared in this study demonstrate relatively higher drug loading performance. Thus, these hollow-structured CS/SA/POSS composite gel spheres hold promise as innovative drug carriers in the biomedical field.
研究领域:
材料科学
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生物医学工程
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产品关联
DOI
高影响因子
JOURNAL OF MATERIALS SCIENCE-MATERIALS IN ELECTRONICS
·
2023
·Vol. 34
·期 20
·1-8
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IF 2.8
Wang Fenjing,Chen Kejian,Yi Xuran,Shen Yang,Lin Yanni,Zhou Zheqi
Self-healing memristor devices were fabricated in this study using a cost-effective and structurally uncomplicated hydrogel consisting of polyvinylalcohol, sodium alginate, and sodium tetraborate. The device is environmentally friendly, biocompatible, possesses a good switching ratio (~ 50), stable memristor under long time run (> 2000 s), and is able to mimic the learning and forgetting functions. In addition, the device could complete the self-healing process at room temperature to rapidly recover its structure and the memristor function. Therefore, it shows great potential for bioelectronics, data storage, and data encryption.
研究领域:
材料科学
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电子学
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生物电子学
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DOI
高影响因子
Gels
·
2025
·Vol. 11
·期 10
·766
·
IF 5.3
Ning Wang,Ming He,Longjiao Wang,Chuanjie Lei,Linyufan Xiao,Yingjie Li,Shuan Liu
An optical fiber sensor based on a HEMA/AM/SA interpenetrating polymer network (IPN) hydrogel is proposed for monitoring the concentration of Pb2+. The Fabry–Perot interference cavity is constructed from a single-mode fiber, a ceramic ferrule, and an IPN hydrogel layer. P (HEMA co AM)/SA IPN hydrogel films were prepared by a step-by-step crosslinking method, which had good mechanical properties, swelling properties, and Pb2+adsorption capacity. The Pb2+concentration changes cause the interference spectrum shift of the sensor. By monitoring the wavelength shift under different Pb2+concentrations, the sensor sensitivity in the range of 0~1 ppm Pb2+concentration in solution is 5.0743 nm/ppm with 0.994 linearity. The influence of different proportions of IPN hydrogel on the performance of the sensor was studied. In the range of 10–90% HEMA, higher sensitivity is obtained by a small weight ratio of HEMA/AM. The sensor stability, repeatability, selectivity, dynamic response, and temperature response are also investigated in experiments. Experimental results demonstrate that the proposed sensor exhibits good stability, sensitivity, repeatability, and selectivity. Owing to its compact structure, straightforward fabrication, low cost, and good sensing performance, this sensor shows strong potential for application in monitoring Pb2+concentrations.
研究领域:
生物医学工程
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环境监测
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传感器技术
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功能材料
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分析化学
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF MEMBRANE SCIENCE
·
2024
·
IF 8.4
Hongxu Liu,Junhao Xie,Jingxuan Zhao,Ruijia Wang,Yuchao Qi,Ziwei Lv,Yang Yu,Shulin Sun
The industrial wastewater filtered by water treatment membranes is very complex in practical applications, therefore, it is a challenge to prepare a membrane with large pore size and high flux that can efficiently separate various wastewater containing pollutants of different scales. To solve this problem, an SA-TiO 2 hydrogel-coated PVDF-g-IL composite fibre membrane with super hydrophilicity, anti-pollution, and pH-responsive self-cleaning properties has been designed and prepared by electrostatic spinning and layer-by-layer coating techniques in the present work. The super hydrophilic gel layer on the surface gives the composite membrane efficient separation capability while maintaining rapid passage of the aqueous phase; the underlying PVDF-g-IL fibre membrane is positively charged and removes not only anionic/cationic pollutants by electrostatic repulsion or attraction but also creates an ionic bond with oppositely assigned SA so that the gel layer tightly bond to the base membrane. The PVDF-g-IL@SA-TiO 2 membrane achieves stable and efficient separation of oil-water emulsions and dye wastewaters with a high filtration flux while retaining a retention rate higher than ∼95%. After multiple self-cleaning cycles, the ultra-thin gel layer still offers satisfactory durability with ≈100% flux recovery. This study provides a promising new strategy for designing efficient multiple contaminant separation and simpler self-cleaning membranes.
研究领域:
材料科学
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环境工程
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DOI
高影响因子
BMC BIOLOGY
·
2024
·Vol. 22
·期 1
·1-19
·
IF 4.4
Jiang Hexiang,Sun Yi,Li Fengyang,Yu Xibing,Lei Siyu,Du Sulan,Wu Tong,Jiang Xuan,Zhu Junhui,Wang Jun,Ji Yalu,Li Na,Feng Xin,Gu Jingmin,Han Wenyu,Zeng Lei,Lei Liancheng
Background Ribosomal protein SA (RPSA) of human brain microvascular endothelial cells (HBMECs) can transfer from the cytosol to the cell surface and act as a receptor for some pathogens, including Streptococcus suis serotype 2 (SS2), a zoonotic pathogen causing meningitis in pigs and humans. We previously reported that SS2 virulence factor enolase (ENO) binds to RPSA on the cell surface of HBMECs and induces apoptosis. However, the mechanism that activates RPSA translocation to the cell surface and induces ENO-mediated HBMEC apoptosis is unclear.Results Here, we show that RPSA localization and condensation on the host cell surface depend on its internally disordered region (IDR). ENO binds to the IDR of RPSA and promotes its interaction with RPSA and vimentin (VIM), which is significantly suppressed after 1,6-Hexanediol (1,6-Hex, a widely used tool to disrupt phase separation) treatment, indicating that ENO incorporation and thus the concentration of RPSA/VIM complexes via co-condensation. Furthermore, increasing intracellular calcium ions (Ca2+) in response to SS2 infection further facilitates the liquid-like condensation of RPSA and aggravates ENO-induced HBMEC cell apoptosis.Conclusion sTogether, our study provides a previously underappreciated molecular mechanism illuminating that ENO-induced RPSA condensation activates the migration of RPSA to the bacterial cell surface and stimulates SS2-infected HBMEC death and, potentially, disease progression. This study offers a fresh avenue for investigation into the mechanism by which other harmful bacteria infect hosts via cell surfaces’ RPSA.
研究领域:
微生物学
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细胞生物学
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病理学
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分子生物学
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2023
·
IF 5.2
Xiang-Hua Ling,Yue-Feng Tang,Guo-Zhi Han
The composite of hydrogels and noble metal nanoparticles has wide applications in the field of functional materials . In this paper, we developed a novel and green strategy to synthesize a kind of composite hydrogel microspheres containing silver nanoparticles and β-cyclodextrin (β-CD) modified sodium alginate (β-CD@SA@Ag) without use of strong reducing reagent. First, β-CD was chemical linked to SA by epichlorohydrin (ECH) to form the β-CD modified polymer (β-CD@SA). then AgNO 3 was added to the as-prepared polymer solution , in which silver nanoparticles were formed by the reducing power of β-CD units. Subsequently, by reversed-phase emulsion method and ionic cross-linking, a kind of β-CD@SA@Ag hydrogel microspheres were obtained. The structure and morphology of the composite material were characterized in detail by Fourier infrared spectroscopy (FT-IR), thermogravimetric analysis (TG), scanning electron microscope (SEM), transmission electron microscope (TEM) and X-ray diffraction (XRD). Test data indicated that silver nanoparticles evenly dispersed in the composite material. On the basis, the adsorption and catalytic performances of the β-CD@SA@Ag hydrogel microspheres were studied towards to the reduction of aromatic nitro compounds. Research results showed that the β-CD@SA@Ag hydrogel microspheres had excellent catalytic activity along with high environmental adaptability. whether in pure water, tap water or river water, aromatic nitro compounds can be completely reduced within 2–13 min. Moreover, the morphology of microspheres of the composite material endows the composite material with high stability and reusability. We believe that our work would provide a new idea for the green synthesis of organic-inorganic composite functional materials .
研究领域:
材料科学
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环境化学
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纳米技术
·
催化
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产品关联
DOI
高影响因子
EUROPEAN FOOD RESEARCH AND TECHNOLOGY
·
2020
·Vol. 246
·期 9
·1857-1865
·
IF 2.366
Yang Fanfan,Xu Long,Liu Xiang,Chen Chen,Dias Alberto C. P.,Zhang Xiaoying
Abstract Bisphenol S (BPS) is a major alternative to Bisphenol A (BPA) newly applied in food packing material and disrupts reproductive and developmental endpoints through endocrine pathways. This study aimed to develop a rapid, sensitive, and accurate chemiluminescence immunoassay (CLIA) for the detection of BPS in canned beverage. Anti-BPS monoclonal antibody (mAb) was generated by immunizing Balb/c mice with immunogen (BPS–BSA conjugation). CLIA assay conditions, including 3-[9-(((3-( N -succinimidyloxycarboxypropyl) [4-methxylphenyl] sulfonyl) amine) carboxyl]-10-acridiniumyl)-1-propanesulfonate inner salt (NSP-SA-NHS) labeling ratio (1:40), antigen concentration (1 μg mL −1 ) and antibody titer (1:8000; 125 ng mL −1 in PBS (0.01 M, pH 7.4)) were determined, respectively. The half inhibition concentration (IC 50 ), detection limit (IC 10 ), and working range of the CLIA in canned beverage were 0.04, 1.48, and 0.32–5 ng mL −1 , respectively. Cross-reactivity with other bisphenols (4,4′-thiodiphenol, Bisphenol F, 4,4′- dihydroxy benzophenone, Bisphenol A and Bisphenol B) was less than 0.56%, and the recovery rates of BPS in canned beverage ranged from 80 to 109.2% (intra-assay) and from 82 to 108.4% (inter-assay). The results of CLIA were compared with high-performance liquid chromatography–UV (HPLC–UV) analysis, showing a good correlation of 0.956. After proper sample pre-treatment, this method allows relatively large amounts of sample analysis in a limited time period (30 min). Thus, it was deemed suitable and efficient for routine screening of BPS in canned beverage. Graphic abstract
研究领域:
分析化学
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环境科学
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食品安全
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免疫学
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毒理学
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DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2021
·Vol. 45
·期 12
·5605-5620
·
IF 3.591
Yuhua Niu,Xingxing Han,Jie Song,Liangxian Huang
Novel magnetic gel beads were successfully fabricated via a polyvinyl alcohol (PVA) and sodium alginate (SA) double-cross-linked network and loaded with ferroferric oxide@potassium humate (Fe3O4@KHA) nanoparticles. The PVA/SA/Fe3O4@KHA gel beads were found to exhibit an excellent removal efficiency for methylene blue (MB) dye and Pb(II). The physicochemical properties of these gel beads were systematically characterized using Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction, thermogravimetric analysis, scanning electron microscopy, zeta analysis, Brunauer–Emmett–Teller analysis and vibrating sample magnetometry. The adsorption process was found to follow a pseudo-second-order kinetic model and the experimental data were in good agreement with the Langmuir model, with maximum adsorption capacity values of 781.92 and 347.19 mg g−1 for MB and Pb(II) at 298 K, respectively. The thermodynamic measurements demonstrate that adsorption onto these gel beads was spontaneous, endothermic, and driven by an increase in the system entropy. Furthermore, FT-IR and X-ray spectroscopy investigations demonstrate that the mechanism through which Pb(II) was removed mainly involved chelation by the carboxyl groups, whereas MB adsorption takes place via H-bonding and electrostatic interactions. Notably, PVA/SA/Fe3O4@KHA showed high selectivity for MB adsorption. Additionally, the prepared magnetic gel beads could be readily regenerated and efficiently reused for several cycles and their excellent magnetic properties can simplify the adsorbent separation process.
研究领域:
环境科学
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材料科学
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化学工程
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产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2019
·
IF 9.518
Jia Li,Junlin He,Chengli Zhang,Jun Chen,Weiran Mao,Chao Yu
In this study, a dual-type responsive electrochemical biosensor was developed for the quantitative detection of α2,6-sialylated glycans (α2,6-sial-Gs), a potential biomarker of tumors. The gold nanorods (AuNRs), which exhibited great specific surface area, as well as good biocompatibility , was synthesized by the way of seed growth method. Furthermore, a biotin-streptavidin (biotin-SA) system was introduced to improve the immunoreaction efficiency. Accordingly, a label-free biosensor was fabricated based on AuNRs-SA for the quick detection of α2,6-sial-Gs by recording the signal of differential pulse voltammetry (DPV). Furthermore, to expand the ultrasensitive detection of α2,6-sial-Gs, a carboxylated single-walled carbon nanohorns/sulfur-doped platinum nanocluster (c-SWCNHs/S-PtNC) was synthesized for the first time as a novel signal label, which showed an excellent catalytic performance. The usage of c-SWCNHs/S-PtNC could significantly amplify the electrochemical signal recorded by the amperometric i-t curve. Herein, a sandwich type biosensor was constructed by combining the AuNRs-SA on the electrode and c-SWCNHs/S-PtNC (signal amplifier). The label-free biosensor possessed a linear range from 5 ng mL −1 to 5 μg mL −1 with a detection limit of 0.50 ng mL −1 , and the sandwich-type biosensor possessed a wide linear range from 1 fg mL −1 to 100 ng mL −1 with a detection limit of 0.69 fg mL −1 . Furthermore, the biosensor exhibited excellent recovery and stability, indicating its potential for use in actual samples.
研究领域:
生物化学
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分析化学
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纳米技术
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生物传感器
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产品关联
DOI
PubMed
高影响因子
LWT-FOOD SCIENCE AND TECHNOLOGY
·
2023
·
IF 6
Qianqian Chen,Li Yu,Huifen Zhou,Haofang Wan,Yangyang Zhang,Haitong Wan,Jiehong Yang
The Box-Behnken design-response surface methodology (BBD-RSM) and Back-propagation neural network prediction model optimized by Simulated annealing (SA-BPNN) were used to optimize the extraction process of Astragali radix - Paeoniae radix alba by the green natural deep eutectic solvent (NADES), and the antioxidant activity of them was discussed. The best NADES for extracting Astragali radix - Paeoniae radix alba need to be screened out. The comprehensive evaluation value of the extraction yield was used as the index. The BBD-RSM and SA-BPNN were established for prediction and optimization. The antioxidant activity of Astragali radix - Paeoniae radix alba in vitro and in vivo was studied by detecting 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical scavenging rate and ferric reducing antioxidant power (FRAP) and the expression levels of SOD, MDA and GSH-Px in rat plasma. The results showed that the best NADES formula screened was Betaine-Urea (Bet-Ur). Compared with the BBD-RSM, the SA-BPNN had a higher degree of fitting, the comprehensive evaluation value was higher, and the error between tested and predicted value was smaller, which was more suitable as a prediction model for the extraction yield of Astragali radix - Paeoniae radix alba . Through the determination of antioxidant kits and oxidative factors, the results showed that Astragali radix - Paeoniae radix alba had antioxidant activity in vitro and in vivo . The study on the extraction process optimization and antioxidant activity of Astragali radix - Paeoniae radix alba were expected to provide a theoretical basis for its effective utilization.
研究领域:
药学
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分析化学
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生物技术
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药理学
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产品关联
DOI
高影响因子
Nanomedicine-Nanotechnology Biology and Medicine
·
2021
·
IF 6.458
Haiting Xu,Ruifeng Luo,Lingling Dong,Xiulan Pu,Qiyan Chen,Naijing Ye,Shanshan Qi,Xiaoqin Han,Wenbiao Nie,Chaomei Fu,Yichen Hu,Jinming Zhang,Fei Gao
An oral nanoparticle (NPs) encapsulated in chitosan/alginate hydrogel (CA-Gel) with dual-sensitive in pH and reactive oxygen species (ROS) was developed to load curcumin (CUR) based on the intracellular-specific characteristics of macrophages. Chondroitin sulfate (CS) wrapped PBAE-SA-PAPE with intracellular pH/ROS dual-sensitive characteristics and CUR via a simple nanoprecipitation method to form NPs (CS-CUR-NPs), and mixed CA-Gel to acquire the final preparation (CS-CUR-NPs-Gel). CS-CUR-NPs displayed an ideal average particle size (179.19 ± 5.61 nm) and high encapsulating efficiency (94.74 ± 1.15%). CS showed a good targeting ability on macrophages and the CA-Gel contribution in protecting NPs from being destroyed in the upper gastrointestinal tract . As expected, CS-CUR-NPs-Gel could significantly alleviate inflammation in DSS-induced UC mice via TLR4-MAPK/NF-κB pathway. This study is the first to attempt to design a novel pH/ROS dual-stimulated release strategy in helping intracellular CUR delivery and anticipated for efficient anti-UC therapy.
研究领域:
药学
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纳米技术
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炎症性肠病
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药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ACS Applied Energy Materials
·
2022
·
IF 6.959
Xiuwei Sun,Xue Bai,Qian Wang,Ying Lu,Shuxia Liu
Most reported proton-conducting materials use water molecules as media for proton transport, but their low operating temperatures (below the boiling point of water) and humidity-dependent conductivity limit their extensive applications. This motivated researchers to explore high-temperature proton-conducting materials employing nonaqueous media. The acid–base adduct HPW-SA formed by Keggin-type phosphotungstic acid (H3PW12O40, abbreviated as HPW) and sulfamic acid (SA) shows high proton conductivity in the high-temperature region (160–190 °C), owing to its proton mobility remarkably enhanced by its solid–liquid transition. Inspired by this, we encapsulated the HPW-SA adduct into the cages of MIL-101 by the postsynthetic method to prepare the composite HPW-SA@MIL-101, aiming at taking full advantage of the proton conduction feature of the HPW-SA adduct while avoiding the problems of flowing away and corrosion caused by the independent use of HPW-SA adduct. As expected, HPW-SA@MIL-101 exhibits high proton conductivity (0.85 × 10–3–1.1 × 10–3 S cm–1) in the range of 160–190 °C. Its proton transfer activation energy (Ea) is 0.58 eV in the range of 160–190 °C, which indicates that proton migration is dominated by the diffusion effect following a vehicle mechanism. In addition, the proton conductivity of HPW-SA@MIL-101 did not decrease after six cycles of heating and cooling tests, showing good repeatability and stability.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）