ACS Omega
·
2025
·
IF 4.3
Zixi Wu,Chunxiang Huang,Leyi Li,Jinxiang Cao,Yingjie Liu,Qing Ye,Jinlong Li
The paper presents experimentally determined solubility results of lithium bromide in ionic liquid + water and assesses the effect of the addition of ionic liquids (ILs) on the solubility of lithium bromide (LiBr) in water. The solubility of LiBr in pure water has been determined and compared to the literature data. It is known that LiBr aqueous solutions are widely used as working fluids in low-temperature thermal energy recovery systems. However, the aqueous LiBr solution is easy to crystallize, which could cause equipment corrosion. One of the possibilities for improving the properties of the H2O/LiBr refrigerant system is the use of an additive to increase the solubility of LiBr in water. Three ILs were selected as an additive: 1-ethyl-3-methylimidazolium acetate ([EMIM][OAc]), 1-ethyl-3-methylimidazolium bromide ([EMIM]Br), and 1-butyl-3-methylimidazolium bromide ([BMIM]Br). In this study, new empirical parameters for the calculation of LiBr solubility in water were provided. A reasonable prediction of phase equilibrium data is made using the COSMO-SAC model. The NRTL equation is also calculated. The maximum deviation of COSMO-SAC is 7.56%, and the deviation of the other calculations is less than 2%. These experimental and theoretical findings offer valuable insights into the selection and optimization of working fluids in absorption cycle systems.
研究领域:
化学工程
·
热力学
·
材料科学
·
物理化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Expert Opinion on Drug Delivery
·
2024
·
IF 5
Zhutian Zhang,Qian Ma,Zhaoxing Dai,Jiaxu Hong,Jifeng Gu,Rong Shi,Jianjiang Xu,Yaling Ma,Xinghuai Sun,Jianguo Sun
Background Glaucoma is one of the major irreversible blinding eye diseases in the world. Reducing intraocular pressure (IOP) is the primary treatment option, and taking eye drops daily is the common method. However, short drug duration and poor bioavailability of eye drops may lead to unsatisfied therapeutic effects and inadequate patient compliance.Methods A brimonidine-loaded silicone rubber insert (BRI@SR@PT) was prepared by loading brimonidine into a surface-modified silicone rubber ring, followed by polydopamine/thermoplastic polyurethane coatings. The physical properties, in vitro cytocompatibility and drug release of BRI@SR@PT were investigated. The BRI@SR@PT was administrated in the conjunctival sac of rabbit eyes, and its in vivo drug release, IOP-lowering efficacy and biosafety were assessed.Results The BRI@SR@PT presented great thermal stability and excellent elasticity. The BRI@SR@PT was able to release BRI sustainably for 28 days with little toxicity in vitro. Compared to BRI eye drops, the BRI@SR@PT effectively lowered IOP for 21 days based on the sustained BRI release with great biosafety when administrated in conjunctival sac of rabbit eyes in a noninvasive fashion.Conclusions The conjunctival sac insert (BRI@SR@PT), as a promising drug-delivery platform, may provide a sustained IOP-lowering treatment for patients with ocular hypertension or glaucoma, without the need for invasive procedures.
研究领域:
药剂学
·
眼科医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Advanced Science
·
2024
·
IF 14.3
Rendy Hosea,Wei Duan,Ian Timothy Sembiring Meliala,Wenfang Li,Mankun Wei,Sharon Hillary,Hezhao Zhao,Makoto Miyagishi,Shourong Wu,Vivi Kasim
Spindle assembly checkpoint (SAC) is a crucial safeguard mechanism of mitosis fidelity that ensures equal division of duplicated chromosomes to the two progeny cells. Impaired SAC can lead to chromosomal instability (CIN), a well-recognized hallmark of cancer that facilitates tumor progression; paradoxically, high CIN levels are associated with better therapeutic response and prognosis. However, the mechanism by which CIN determines tumor cell survival and therapeutic response remains poorly understood. Here, using a cross-omics approach, YY2 is identified as a mitotic regulator that promotes SAC activity by activating the transcription of budding uninhibited by benzimidazole 3 ( BUB3 ), a component of SAC. While both conditions induce CIN, a defect in YY2/SAC activity enhances mitosis and tumor growth. Meanwhile, hyperactivation of SAC mediated by YY2/BUB3 triggers a delay in mitosis and suppresses growth. Furthermore, it is revealed that YY2/BUB3-mediated excessive CIN causes higher cell death rates and drug sensitivity, whereas residual tumor cells that survived DNA damage-based therapy have moderate CIN and increased drug resistance. These results provide insights into the role of SAC activity and CIN levels in influencing tumor cell survival and drug response, as well as suggest a novel anti-tumor therapeutic strategy that combines SAC activity modulators and DNA-damage agents.
研究领域:
癌症生物学
·
分子生物学
·
细胞生物学
·
遗传学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2022
·
IF 4.601
Kai Zhang,Yonggang Zhao,Mingli Ye,Chaoyan Lou,Yan Zhu
The hydrophobicity of polymer-based anion exchangers is a persistent problem in suppressed anionic chromatography (SAC) due to its adverse effect on chromatographic performance. Herein we describe polyelectrolyte-grafted anion exchangers with modified hydrophilic intermediate layers. The anion exchangers were functionalized by successively grafting a linear cationic condensation polymer (LCCP), a preprepared polyelectrolyte. The carboxylic/hydroxylic intermediate layers formed during thiol-radical-mediated polymerization exert distinct effects on the phase capacity and hydrophobicity. The separation of typical inorganic anions, polarizable anions, and organic acids shows that the anion exchangers display good performance in SAC mode.
研究领域:
分析化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Coatings
·
2021
·Vol. 11
·期 7
·816
·
IF 2.881
Ziang Xu,Guiying Xu,Beibei Han,Kun Wang,Hui Ge,Baigang An,Dongying Ju,Maorong Chai,Lixiang Li,Weimin Zhou
To provide an effective method of green aquaculture, the photocatalysts of CuO/ZrO2/CB/coal-tar-pitch-SAC, which have visible light sterilization capacity, were successfully fabricated by coating ZrO2and CuO on the surface of CB/coal-tar-pitch-SAC. The structures of synthesized CuO/ZrO2/CB/coal-tar-pitch-SAC were investigated by XRD, XPS and SEM measurements in detail. It was observed that CuO/ZrO2/CB/coal-tar-pitch-SAC materials possess obvious heterojunction structure and excellent visible light sterilization capacity when the prepared weight ratio of CuO, ZrO2and CB/coal-tar-pitch-SAC is controlled as 0.03:0.3:1. Our studies can provide a beneficial reference for the design of photocatalysts with sterilization capacity in visible light.Keywords:photocatalyst;heterojunction;coal tar pitch;green aquaculture;ZrO2
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
·
2023
·Vol. 24
·期 2
·1663
·
IF 5.6
Huan Jiang,Jiabao Hu,Huihui Xie,Man Zhang,Chunyang Guo,Youyi Zhang,Yaya Li,Cheng Zhang,Shanliang Xu,Danli Wang,Xiaojun Yan,Yajun Wang,Xubo Wang
The pharyngeal sac is a comparatively rare organ in the digestive tract among teleost fishes. However, our understanding of this remarkable organ in the silver pomfret (Pampus argenteus) is limited. In the present study, we examined the various morphological and histological characteristics of the pharyngeal sac using histochemical techniques and electron microscopy. The pharyngeal sac showed unique characteristics such as well-developed muscular walls, weakly keratinized epithelium, numerous goblet cells, and needle-like processes on the papillae. The porous cavity of the papillae contained numerous adipocytes and was tightly enveloped by type I collagen fibers. These structures might provide mechanical protection and excellent biomechanical properties for grinding and shredding prey. A comparison of gene expression levels between the pharyngeal sac and esophagus using RNA-seq showed that phenotype-associated genes (epithelial genes and muscle genes) were upregulated, whereas genes related to nutrient digestion and absorption were downregulated in the pharyngeal sac. These results support the role of the pharyngeal sac in shredding and predigesting food. Overall, these findings provide a clearer understanding of the pharyngeal sac morphology and explain the morphological adaptations of the digestive tract for feeding on gelatinous prey. To our knowledge, this is the first report on pharyngeal sac gene expression inP. argenteus.Keywords:Pampus argenteus;pharyngeal sac;morphology;papilla;transcriptome
研究领域:
生物学
·
分子生物学
·
动物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ENERGY & FUELS
·
2017
·
IF 3.091
Shoutao Ma,Qiang Yu,Yafei Hou,Jinfang Li,Yuan Li,Zhanhua Ma,Lanyi Sun
Coal tar is a byproduct of low temperature coal carbonization. The separation of the compounds has great significance since its main component is the mixture of phenols and hydrocarbons. In this paper, the separation of specific phenolic compounds from model coal tar (phenols + hexane) was studied. The solvent was screened by empirical analysis, the universal quasichemical functional group activity coefficient (UNIFAC), and conductor-like screening model COSMO-SAC (segment activity coefficient). COSMO-SAC was used to calculate the capacity, selectivity, and performance index of solvents. Finally, the monoethanolamine (MEA) was selected as the solvent to extract the phenols. The liquid–liquid equilibrium for the ternary mixture of phenols + hexane + MEA was measured at 303.15 K and 323.15 K under atmospheric pressure, and the results showed that MEA provided a high distribution coefficient, efficiency, and selectivity for phenols. Meanwhile, the extraction process of phenols was simulated based on the nonrandom two-liquid (NRTL) model, for which binary interaction parameters were obtained through calculations of phase equilibrium. The results showed that the purity of phenols can achieve more than 99.5 wt % using MEA as a solvent.
研究领域:
化学工程
·
分离科学
·
热力学
·
燃料化学
·
环境化工
✓ 已验证
DOI
高影响因子
DESALINATION
·
2023
·
IF 9.9
Xueying Gao,Zhenzhen Fu,Yanfei Sun,Dewei Wang,Xiaoxuan Wang,Zishan Hou,Jinrui Wang,Xia Liu,Shiyu Wang,Shuyun Yao,Huiying Zhang,Shuyuan Li,Zheng Tang,Weijie Fu,Kaiqi Nie,Jiangzhou Xie,Zhiyu Yang,Yi-Ming Yan
While MnO 2 has been identified as a potent agent in the desalination process , its efficacy is significantly impeded by its inherent poor electrical conductivity and substantial ion diffusion barriers . By orchestrating an interfacial electron bridge within the MnO 2 /g-C 3 N 4 heterostructure , reinforced through N p z -Mn d z 2 orbital hybridization, we have managed to significantly boost both SAC and SAR in the HCDI process. The reinforced N p z -Mn d z 2 orbital hybridization triggers a substantial electron transition from g-C 3 N 4 to MnO 2 , culminating in a high Mn d z 2 electron occupancy. Further analysis reveals the formation of a Mn N chemical bond at the MnO 2 /g-C 3 N 4 interface, operating as an essential electron transfer bridge from g-C 3 N 4 to MnO 2 . This process concurrently initiates a rise in the Mn d z 2 orbital energy level, equipping the Mn d z 2 electron with superior redox activity. With these enhancements, the manufactured MnO 2 /g-C 3 N 4 exhibits exemplary performance, boasting an improved SAC of 68 mg g −1 and SAR of 3.6 mg g −1 min −1 with a decreased energy consumption of 0.7224 kWh kg −1 at 1.2 V. This innovative work offers an unconventional roadmap for activating electron redox activity and thereby accelerating charge transfer in transition metal oxides .
研究领域:
材料科学
·
环境科学
·
电化学
·
水处理
✓ 已验证
产品关联
DOI
高影响因子
ELECTROCHEMISTRY
·
2025
·
IF 1.7
Hongyu CHEN,Ru TIAN,Jianke LI,Beibei HAN,Guoku LIU,Shiyu YIN,Guiying XU,Kun WANG,Fukuan WANG,Baigang AN,Dongying JU,Weimin ZHOU
TiO2 as a semiconductor photocatalyst has been extensively utilized in the purifications of water and air. However, the wide band gap of TiO2 necessitates its activation by ultraviolet irradiation, when it is utilized as a photocatalyst. To enhance the photocatalyst performance of TiO2, constructing the heterojunction containing TiO2 is considered as a highly effective method. To unfold the actual application, iron metal oxides are firstly utilized to construct the heterojunction of TiO2/α-Fe2O3, and the synthesized TiO2/α-Fe2O3 heterojunction was successfully coated on the surface of coal tar pitch based spherical activated carbons (CTP-SACs). The structures of TiO2/α-Fe2O3/CTP-SACs are verified by the X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS) and transmission electron microscopy (TEM). The results of UV-vis absorption spectroscopy supports that TiO2/α-Fe2O3/CTP-SACs are promising candidates for the natural light photoncatalysis. It is believed that the exceptional conductivity of CTP-SACs enhances the activity of the photocatalyst, resulting in the TiO2/α-Fe2O3/CTP-SACs exhibiting remarkable sterilization effects under natural light. For instance, the TiO2/α-Fe2O3-60-CTP-SAC shows an excellent sterilization rate (89 %) for the fish culture water under the irradiation of natural light for 20 min. Associating with the excellent liquidity of CTP-SACs, it is considerable that TiO2/α-Fe2O3/CTP-SACs possess the captivating application prospects in a field of the feeding water treatment.
研究领域:
材料科学
·
环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING SCIENCE
·
2025
·
IF 4.3
Hongwei Kang,Qingzhi Lv,Guoxuan Li,Zhigang Lei
Investigating the volatility of inorganic salts during distillation is essential for optimizing the distillation process of salt-containing solutions for the purification of electronic-grade chemicals, lithium extraction from salt lakes, and seawater desalination. This study proposes a new theory of the distillation salt effect: when inorganic salts are dissolved in a solid form at atmospheric pressure, they exhibit volatility in that solution. Atmospheric distillation experiments. These experiments confirmed the volatility of the inorganic salts in the solution and provided vapor–liquid equilibrium (VLE) data for each salt’s aqueous solution. Finally, a method for predicting the VLE behavior of inorganic salt solutions was developed using a combination of molecular dynamics (MD) simulations, quantum chemical (QC) calculations, and the conductor-like screening model-Segment Activity Coefficient (COSMO-SAC) model. This method successfully predicted the VLE behavior of LiCl, NaCl, and KCl aqueous solutions at low salt concentrations ( x s < 0.05), the predicted values aligned well with the experimental data.
研究领域:
化学工程
·
物理化学
·
热力学
·
计算化学
·
分离过程
✓ 已验证
产品关联
DOI
高影响因子
Signal Transduction and Targeted Therapy
·
2022
·Vol. 7
·期 1
·1-17
·
IF 38.104
Zeng Hao,Pan Ting,Zhan Meiling,Hailiwu Renaguli,Liu Baolin,Yang Hua,Li Ping
Endothelial-to-mesenchymal transition (EndoMT), the process wherein endothelial cells lose endothelial identity and adopt mesenchymal-like phenotypes, constitutes a critical contributor to cardiac fibrosis. The phenotypic plasticity of endothelial cells can be intricately shaped by alteration of metabolic pathways, but how endothelial cells adjust cellular metabolism to drive EndoMT is incompletely understood. Here, we identified 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 (PFKFB3) as a critical driver of EndoMT via triggering abnormal glycolysis and compromising mitochondrial respiration. Pharmacological suppression of PFKFB3 with salvianolic acid C (SAC), a phenolic compound derived from Salvia miltiorrhiza , attenuates EndoMT and fibrotic response. PFKFB3-haplodeficiency recapitulates the anti-EndoMT effect of SAC while PFKFB3-overexpression augments the magnitude of EndoMT and exacerbates cardiac fibrosis. Mechanistically, PFKFB3-driven glycolysis compromises cytoplasmic nicotinamide adenine dinucleotide phosphate (reduced form, NADPH) production via hijacking glucose flux from pentose phosphate pathway. Efflux of mitochondrial NADPH through isocitrate/α-ketoglutarate shuttle replenishes cytoplasmic NADPH pool but meanwhile impairs mitochondrial respiration by hampering mitochondrial iron-sulfur cluster biosynthesis. SAC disrupts PFKFB3 stability by accelerating its degradation and thus maintains metabolic homeostasis in endothelial cells, underlying its anti-EndoMT effects. These findings for the first time identify the critical role of PFKFB3 in triggering EndoMT by driving abnormal glycolysis in endothelial cells, and also highlight the therapeutic potential for pharmacological intervention of PFKFB3 (with SAC or other PFKFB3 inhibitors) to combat EndoMT-associated fibrotic responses via metabolic regulation.
研究领域:
心脏病学
·
细胞代谢
·
药理学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHEMICAL ENGINEERING OF JAPAN
·
2020
·Vol. 53
·期 9
·526-532
·
IF 0.651
Lianzhong Shen,Guiying Xu,Beibei Han,Hui Ge,Shigekazu Kato,Youyuan Dai,Kun Wang,Fei Sun,Weimin Zhou
In this study, carbon black (CB) and carbon (coal-tar pitch-based spherical activated carbon (SAC)) were used to successfully fabricate composite-type SAC (CB/coal-tar-pitch-SAC), and its surface was coated with TiO2 to produce the composite material TiO2/CB/coal-tar-pitch-SAC. CB helps in decreasing the pore size of CB/coal-tar-pitch-SAC and increasing its specific surface area and total pore volume, which can be verified by the Brunauer–Emmett–Teller (BET) method. Practically, TiO2/CB/coal-tar-pitch-SAC can sterilize the bacteria present in the water. This study intensively verifies the high reusing sterilization capacity of TiO2/CB/coal-tar-pitch-SAC. The results indicate that TiO2/CB/coal-tar-pitch-SAC can effectively improve the water environment.
研究领域:
环境科学
·
材料科学
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）