International Journal of Nanomedicine
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2022
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IF 7.033
Xin Zhang,Yang Zhang,Ning Wang,Yetong Shen,Qing Chen,Lu Han,Bo Hu
NCs (1:1:4, 6 μL) to synergistically reduce the viability of HCT116 cells to 15.63± 2.90%.Conclusion: By using NIR-irradiation, the “transitive” nanoheaters can remotely control the activity of both bacteria (germinated from spore) and cancer cells. This discovery provides basis and a feasible plan for controllable safer treatment of bacteria therapy, especially anaerobes with spores in hypoxic areas of the malignant solid tumors.
研究领域:
癌症研究
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生物医学工程
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纳米技术
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治疗递送系统
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DOI
PubMed
高影响因子
Reaction Chemistry & Engineering
·
2023
·Vol. 8
·期 8
·1993-2000
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IF 3.9
Shichun Weng,Wei Feng,Wenqian Wu,Zichao Guo,Junjie Li,Huanhuan Chen,Liping Chen,Wanghua Chen
3-Amino-4-amidoximinofurazan (AAOF) is an important precursor for the synthesis of high energy furazan energetic materials. The traditional batchwise synthesis approach has the shortcomings of low productivity and high possibility of thermal runaway. This article aims to develop a continuous-flow and safe synthesis approach for AAOF. To achieve this goal, the precipitation problems appearing in the oximation and cyclization reaction stages have been first tackled by diluting the hydroxylamine hydrochloride and sodium hydroxide solution with water, which also reduced the thermal risk of AAOF synthesis. The continuous-flow platform for AAOF synthesis has been established, and the continuous-flow operation parameters have been optimized. The optimal temperatures for the nitrosation–rearrangement coupling reaction, neutralization reaction, oximation and cyclization were 15 °C, 15 °C, 25 °C and 115 °C, respectively. The optimal set retention times for these four stages were 15 min, 5 min, 60 min and 10 min, respectively. The continuous-flow synthesis approach offered an optimal yield of AAOF (95%), which is comparable to the result of batch operation. The total flow rate of the whole process is 10.34 mL min−1, and the final productivity is calculated to be about 0.546 mol h−1 of AAOF. The main merits for the continuous-flow synthesis of AAOF include the following: (1) the reaction time is only one-third of that for batch operation and (2) continuous-flow operation is inherently safe due to the lower liquid holdup and stronger temperature control ability. This work is supposed to be beneficial to the continuous and safe synthesis of AAOF.
研究领域:
化学工程
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能源材料科学
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DOI
高影响因子
ACS Applied Materials & Interfaces
·
2022
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IF 10.383
Pengfei Shan,Yingwen Lu,Weilin Lu,Xiangping Yin,Haiwei Liu,Daai Li,Xiaoyue Lian,Weiping Wang,Zhongyu Li,Zhihui Li
The low utilization efficiency of pesticides exerts an adverse impact on the environment and human health. Polymer-related controlled-release nanosized pesticide systems provide a promising and efficient way to overcome the problem. In this work, a biodegradable and light-responsive amphiphilic polymer was synthesized via 1,1,3,3-tetramethylguanidine-promoted polyesterification under mild conditions (low temperature, no vacuum, and no inert gas protection). We used this polymer to fabricate a light-triggered controlled-release nanosized pesticide system. The herbicide, 2,4-dichlorophenoxyacetic acid (2,4-D), was selected as a model drug to show its potential as a controlled-release pesticide system. It was found that the 2,4-D-loaded polymeric nanoparticles were stable without the treatment of UV, while the release rate of 2,4-D from the nanoparticles gradually increased after treatment with UV light. Pot trial showed that the 2,4-D-loaded polymer nanoparticles showed a good herbicidal effect. Finally, toxicity studies suggested that the polymer can reduce toxicity to nontarget organisms.
研究领域:
环境科学
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材料科学
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农业科学
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DOI
高影响因子
Surfaces and Interfaces
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2025
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IF 6.3
Farva Ilyas,Wenruo Li,Luzheng Zhao,Xu Han,Haoyuan Zhu,Zhongsheng Wen
Zinc metal anodes offer a cost-effective and safe solution for large-scale energy storage, yet uncontrolled Zn 2+ deposition often leads to dendrite formation, compromising separator integrity and the performance of zinc-ion hybrid supercapacitors (ZIHSs). In this study, we address this challenge by employing a 3D long-range ceramic alumina separator, which effectively inhibits dendrite growth and enhances the overall performance and safety of ZIHSs. The incorporation of this ceramic separator in non-aqueous triethyl phosphate (TEP) electrolyte resulted in a significant improvement in cycle stability compared to the traditional Celgard 2500 separator. Our analysis reveals that the ceramic separator enhances zinc plating kinetics and creates a stable electrolyte interface, leading to a dendrite-free zinc electrode that maintains performance for over 3000 h at 1 mA cm −2 and up to 3 mAh cm −2 . Furthermore, Zn|ceramic separator|PANI full cells achieved an 85 % retention rate after 10,000 cycles at 2 A g −1 . This multi-component alumina-based ceramic separator offers a promising approach to advancing long-lasting and high-performance ZIHSs.
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DOI
高影响因子
MACROMOLECULES
·
2018
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IF 5.914
Sheng Wang,Songqi Ma,Qiong Li,Wangchao Yuan,Binbo Wang,Jin Zhu
Conventional thermosets are built by nonrenewable fossil resources and are arduous to be reprocessed, recycled, and reshaped due to their permanent covalent cross-linking, and their flammability makes them unsafe during use. Here, for the first time, we synthesized a novel Schiff base precursor from abundant and renewable lignin derivative vanillin and produced malleable thermosets (Schiff base covalent adaptable networks (CANs)) combining high performance, super-rapid reprocessability, excellent monomer recovery, and arbitrary permanent shape changeability as well as outstanding fire resistance. The Schiff base CANs exhibited high glass transition temperatures of ∼178 °C, tensile strength of ∼69 MPa, tensile modulus of ∼1925 MPa, excellent flame retardancy with UL-94 V0 rating and V1 rating, and high LOI of ∼30%. Meanwhile, three Schiff base CANs showed high malleability with the activation energy of the bond exchange of 49–81 kJ mol–1 and could be reprocessed in 2–10 min at 180 °C. These Schiff base CANs provide a prime example to foster the development of advanced thermosetting materials from renewable bioresources.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
ADVANCED MATERIALS
·
2021
·Vol. 33
·期 42
·2102134
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IF 30.849
Yi-Hong Tan,Gong-Xun Lu,Jian-Hui Zheng,Fei Zhou,Mei Chen,Tao Ma,Lei-Lei Lu,Yong-Hui Song,Yong Guan,Junxiong Wang,Zheng Liang,Wen-Shan Xu,Yuegang Zhang,Xinyong Tao,Hong-Bin Yao
Electrolyte engineering via fluorinated additives is promising to improve cycling stability and safety of high-energy Li-metal batteries. Here, an electrolyte is reported in a porous lithium fluoride (LiF) strategy to enable efficient carbonate electrolyte engineering for stable and safe Li-metal batteries. Unlike traditionally engineered electrolytes, the prepared electrolyte in the porous LiF nanobox exhibits nonflammability and high electrochemical performance owing to strong interactions between the electrolyte solvent molecules and numerous exposed active LiF (111) crystal planes. Via cryogenic transmission electron microscopy and X-ray photoelectron spectroscopy depth analysis, it is revealed that the electrolyte in active porous LiF nanobox involves the formation of a high-fluorine-content (>30%) solid electrolyte interphase layer, which enables very stable Li-metal anode cycling over one thousand cycles under high current density (4 mA cm −2 ). More importantly, employing the porous LiF nanobox engineered electrolyte, a Li || LiNi 0.8 Co 0.1 Mn 0.1 O 2 pouch cell is achieved with a specific energy of 380 Wh kg −1 for stable cycling over 80 cycles, representing the excellent performance of the Li-metal pouch cell using practical carbonate electrolyte. This study provides a new electrolyte engineering strategy for stable and safe Li-metal batteries.
研究领域:
材料科学
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电化学
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储能
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电池技术
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DOI
高影响因子
Communications Materials
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2026
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IF 9.1
Lu Leihao,Cheng Qichao,Cai Jiangfeng,Zhang Yumao,Bao Qing,Miao Yao,Yue Hui,Zhang Ying,Wu Yi,Yang Shuxu,Mao Chuanbin,Yang Mingying
Long-term pharmacological intervention is essential for managing chronic diseases, yet continuous administration of antithrombotic agents often increases bleeding risk, posing a major clinical challenge. Here, we designed a multifunctional drug delivery platform composed of large-aperture mesoporous silica (Mas) coated with silk fibroin (SF) or sustained heparin sodium (HS) release. The well-defined mesoporous structure enables high drug loading, while the biocompatible SF coating regulates release kinetics, suppresses burst release, and prolongs therapeutic efficacy. This dual structural system enhances antithrombotic performance while mitigating hemorrhagic risk. In vitro studies demonstrated improved hemocompatibility and reduced cytotoxicity of SF-Mas/HS compared with free HS. In vivo thrombosis models further confirmed effective inhibition of thrombus formation without excessive bleeding. By integrating inorganic mesoporous carriers with natural protein coatings, SF-Mas/HS provides a safe and efficient strategy for long-term antithrombotic prevention, highlighting the potential of biomaterial-assisted delivery systems to balance efficacy and safety in chronic disease management.
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高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2020
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IF 5.774
Yunyan Peng,Yuan Liu,Jinyue Dai,Lijun Cao,Xiaoqing Liu
Sustainable and economically feasible treatment on oily sewage is of great significance. Herein, the benzoxazine monomer (C-fa) derived from renewable feedstock was facilely in-situ polymerized on the skeleton of melamine sponge (MS), accompanied with SiO 2 nanoparticles (NPs). Due to the robust hydrophobicity of poly(C-fa) and the as constructed nano-micro hierarchical structure, the as-fabricated porous composite (PBZ-SiO 2 -MS) showed wide applicability in oily sewage remediation, including selective absorption of layered oil/water mixture, separation of surfactant stabilized W/O and O/W emulsion with ultrahigh separation efficiency (higher than 99.9%) and satisfactory permeation flux (1300 L m −2 h −1 ). In addition, the remarkable flame retardancy of polybenzoxazine and MS, as well as its high absorption speed and capacity, endowed PBZ-SiO 2 -MSs with great ability to confine the flame range and prevent the potential explosion when spilled oil is ignited. This easy fabricated, low cost and versatile PBZ-SiO 2 -MSs illustrated an ingenious example of the integration of the high material performance and green chemistry concept.
研究领域:
环境科学
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材料科学
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产品关联
DOI
高影响因子
MOLECULES
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2022
·Vol. 27
·期 8
·2571
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IF 4.927
Zhiyuan Yang,Tong Ye,Fei Ma,Xinhong Zhao,Lei Yang,Guifang Dou,Hui Gan,Zhuona Wu,Xiaoxia Zhu,Ruolan Gu,Zhiyun Meng
Uncontrolled hemorrhage from trauma or surgery can lead to death. In this study, chitosan/kaolin (CSK) and chitosan/montmorillonite (CSMMT) composites were prepared from chitosan (CS), kaolin (K), and montmorillonite (MMT) as raw materials to control bleeding. The physiochemical properties and surface morphology of CSK and CSMMT composites were analyzed by Fourier transform infrared spectrometry (FT-IR), X-ray diffraction (XRD), scanning electron microscopy (SEM), zeta potentials, and X-ray fluorescence (XRF). The hemostatic mechanism was measured in vitro by activated partial thromboplastin time (APTT), prothrombin time (PT), in vitro clotting time, erythrocyte aggregation, and thromboelastogram (TEG). The hemostasis ability was further verified by using tail amputation and arteriovenous injury models in rats. The biocompatibility of CSK and CSMMT was evaluated by in vitro hemolysis, cytotoxicity assays, as well as acute toxicity test and skin irritation tests. The results show that CSK and CSMMT are promising composite materials with excellent biocompatibility and hemostatic properties that can effectively control bleeding.Keywords:chitosan;kaolin;montmorillonite;hemostatic material;hemorrhage control
研究领域:
材料科学
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生物医学工程
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止血
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产品关联
DOI
PubMed
高影响因子
LANGMUIR
·
2022
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IF 4.331
Chaonan Li,Ya Wang,Zihao Wang,Xiaogang Li
Although paraquat is a widely used herbicide, it is toxic to humans if ingested or absorbed through an open wound. To improve the safety of paraquat, a new formulation of paraquat based on photoresponsive polymers was exploited. Photoresponsive β-cyclodextrin polymer microspheres (AZO-CD) were synthesized via a host–guest interaction between β-cyclodextrin and azobenzene. AZO-CD were characterized by Fourier transform infrared spectrometry, circular dichroism, ultraviolet (UV) spectrophotometry, and thermogravimetric analysis, and their photoresponsiveness was also evaluated. AZO-CD were used to load paraquat, which yielded photoresponsive paraquat-loaded microspheres. For the paraquat-loaded microspheres, irradiation with UV light or sunlight induced the isomerization of azobenzene into the cis form. Then, the cis-azobenzene was liberated from the cavities of the β-cyclodextrin. The paraquat-loaded microspheres released paraquat continuously over time. Furthermore, under UV light, the herbicidal capacity of the paraquat-loaded microspheres against barnyard grass was comparable to that of free paraquat at the same dose. Our findings show that loading paraquat into AZO-CD provides a safe and environmentally friendly herbicide formulation.
研究领域:
农业化学
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环境科学
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材料科学
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产品关联
DOI
PubMed
高影响因子
Journal of Energy Chemistry
·
2023
·
IF 13.1
Qiang Lv,Yajie Song,Bo Wang,Shangjie Wang,Bochen Wu,Yutong Jing,Huaizheng Ren,Shengbo Yang,Lei Wang,Lihui Xiao,Dianlong Wang,Huakun Liu,Shixue Dou
Solid polymer electrolytes (SPEs) are one of the most promising alternatives to flammable liquid electrolytes for building safe Li metal batteries. Nevertheless, the poor ionic conductivity at room temperature (RT) and low resistance to Li dendrites seriously hinder the commercialization of SPEs. Herein, we design a bifunctional flame retardant SPE by combining hydroxyapatite (HAP) nanomaterials with N-methyl pyrrolidone (NMP) in the PVDF-HFP matrix. The addition of HAP generates a hydrogen bond network with the PVDF-HFP matrix and cooperates with NMP to facilitate the dissociation of LiTFSI in the PVDF-HFP matrix. Consequently, the prepared SPE demonstrates superior ionic conductivity at RT, excellent fireproof properties, and strong resistance to Li dendrites. The assembled Li symmetric cell with prepared SPE exhibits a stable cycling performance of over 1200 h at 0.2 mA cm −2 , and the solid-state LiFePO 4 ||Li cell shows excellent capacity retention of 85.3% over 600 cycles at 0.5 C.
研究领域:
材料科学
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电化学
·
能源存储
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产品关联
DOI
高影响因子
POLYMERS FOR ADVANCED TECHNOLOGIES
·
2023
·Vol. 34
·期 11
·3631-3643
·
IF 3.4
Lei Li,Yishen Chen,Xuejun Lai,Hongqiang Li,Xingrong Zeng
Phosphorus-nitrogen intumescent flame retardant (IFR) is one of the most promising halogen-free flame retardants in enhancing the fire safety of polypropylene (PP), but its efficiency needs to be further improved. Herein, a novel single-component polyphosphazene IFR containing pentaerythritol caged phosphate (PEPA) functionalized titanium carbide nanosheet (MXene), named PZS-MXene, was prepared. When the amount of PZS-MXene was 25 wt%, PP/PZS-MXene classed a UL-94 V-0 rating with the limiting oxygen index of 32.7%. Compared with PP, its peak of heat release rate, total heat release rate and total smoke production rate were reduced by 74.5%, 33.0%, and 19.8%, respectively. The flame-retardant mechanism revealed that PZS-MXene quenched high-active free radicals to inhibit the degradation of PP during the combustion. MXene rapidly catalyzed the carbonization of PZS to form high-quality intumescent char layer on its surface. Besides, MXene acted as the supporting skeletons and exerted the layered barrier effect to improve the compactness of the intumescent char layer, thus effectively inhibited the degradation and combustion of PP. This work provided new insights for the efficient halogen-free flame-retardant PP.
研究领域:
材料科学
·
阻燃材料
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）