SENSORS AND ACTUATORS A-PHYSICAL
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2026
·
IF 5.1
Bin Zhou,Qiao Chen,Zhirui Zhao,Yuanyuan Qin,Xin Tian,Jiajing Zhong,Rui Li,Mengjie Shou,Pingan Yang,Decheng Wu
A highly flexible double-network ion-conductive hydrogel pressure sensor was developed. • The sensor achieves a 0.5 Pa detection limit, 343.428 kPa⁻¹ sensitivity, and a 50 ms response time. • An intelligent system tracks finger, knee, and mouth-opening movements in real time during rehabilitation. With the rapid development of wearable healthcare and intelligent rehabilitation technologies, flexible pressure sensors with excellent skin conformability and high sensitivity are highly desired for precise physiological monitoring. Here, we report an ion-conductive hydrogel pressure sensor based on a double-network architecture. Through rational compositional design and surface microstructuring, the hydrogel exhibits mechanical softness comparable to human skin while simultaneously enhancing the interfacial electric double-layer effect, leading to significantly improved pressure sensitivity. The sensor achieves a high sensitivity of 343.4 kPa⁻¹ within the low-pressure regime of 0–40 kPa, an ultralow detection limit of 0.5 Pa, and fast response/recovery times of 50 ms. Moreover, the device maintains excellent stability over 16,000 loading–unloading cycles. By integrating a signal acquisition circuit and a real-time monitoring platform, the sensor enables quantitative tracking of human motions, including finger bending, knee joint movement, and restricted mouth opening. This work provides a promising strategy for the development of high-performance electronic skin and wearable rehabilitation monitoring systems. Download: Download high-res image (135KB) Download: Download full-size image
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PROGRESS IN ORGANIC COATINGS
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2022
·
IF 6.206
Hongxuan Yang,Kaili Jin,Helan Wang,Zhuizhui Fan,Tengfei Zhang,Ziqiang Liu,Zaisheng Cai
Hydrophilic anti-fogging coating has become a research hotspot due to its good anti-fogging performance and easy preparation. In this work, a zwitterionic anti-fogging coating with anti-fouling and self-healing properties was prepared by (Methacryloyloxy)ethyldimethyl-(3-sulfopropyl) (SBMA) and Itaconic acid (IA). And the antifogging performance of the coating has been improved due to -COOH from IA. The high light transmittance (over 95%) can be observed after anti-fogging test. We use amide bonds to connect the coating to the glass slide, which greatly improves the water resistance and durability. The coated glass can maintain anti-fogging property after being immersed in water for 7 days or stored for over 200 days. Results show that the anti-fogging coating has good self-healing function and oil stain resistance. The contact angle of the coated glass slide is 8.17°, and shows a good super hydrophilicity. This anti-fogging coating provides great potential for applications in medical, food industry, transportation .etc.
研究领域:
材料科学
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表面化学
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Journal of Materials Chemistry B
·
2017
·Vol. 5
·期 24
·4595-4606
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IF 4.543
Jiang Wu,Chaochao He,Huacheng He,Chaoqun Cheng,Junyi Zhu,Zecong Xiao,Hongyu Zhang,Xiaokun Li,Jie Zheng,Jian Xiao
Conventional 2-hydroxyethyl methacrylate (HEMA)-based hydrogels have an inverse relationship between optical transparency (OP) and oxygen permeability (Dk) as a function of water content. While the higher water content favors the oxygen permeability of HEMA-based hydrogels, it also causes poor optical transparency due to the water-induced scattering center effect. Here, we propose and demonstrate that the incorporation of zwitterionic [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl) ammonium hydroxide (SBMA) with HEMA hydrogels enables the achievement of both properties (OP = 98% and Dk = 54.7) in hydrogels at high water contents of 84%, and both values are much higher than those of pure HEMA hydrogels (OP = 2.3% and Dk = 17.5 barriers). HEMA–SBMA hydrogels are crosslinked by electrostatic interactions between the zwitterionic SBMA groups and hydrogen bonds between the HEMA groups. The introduction of SBMA into HEMA not only increases the quantity and quality of strongly binding water inside the networks, but also affects the porous structure of the gels, both of which are correlated with OP and Dk. Moreover, hybrid HEMA–SBMA hydrogels demonstrate their excellent antifouling function to prevent nonspecific protein adsorption in vitro, as well as their biocompatibility and hemocompatibility when implanted in mice in vivo. A combination of these excellent properties of HEMA–SBMA hydrogels (high water content, high optical transparency, high oxygen permeability, good antifouling function, and low foreign-body reaction) makes them highly promising for contact lens-based ophthalmic applications. This work, in line with our other HEMA–CBMA hydrogels, offers a new strategy to design hybrid hydrophilic-zwitterionic materials for improving their multi-faceted properties of interest, beyond the conventional designs of hydrophilic–hydrophilic and hydrophilic–hydrophobic materials.
研究领域:
材料科学
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聚合物化学
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生物医学工程
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PubMed
高影响因子
EUROPEAN POLYMER JOURNAL
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2026
·
IF 6.8
Shiyun Lin,Jinghua Tan,Qihang Xv,Deqiang You,Sheng Cao,Xiaojian Wang
Ureteral stents are critical medical devices for the treatment of urinary obstruction, facilitating urine drainage and postoperative recovery. Clinically, stents are prone to bacterial adhesion and colonization, which leads to urinary tract infections in up to 30%–50% of patients. Meanwhile, minerals in urine tend to readily deposit on their surfaces and form encrustations. To address these issues, we developed a multifunctional double-network hydrogel coating, (P(AAm-co-SBMA)/SA-Ca 2+ ), through physical and chemical crosslinking. The crosslinking density of the hydrogel was optimized by adjusting the SBMA concentration. Compared with uncoated polyurethane ureteral stents, the coated stents exhibited a low friction coefficient of 0.28, a reduction of over 83%, which significantly improved surface lubricity. More importantly, the coated ureteral stents showed synergistic antibacterial adhesion (up to 90%) and anti-encrustation deposition properties. In vitro simulated urine experiments demonstrated that encrustation deposition was reduced by 84.46% after short-term immersion (14 days) and by 75.48% after long-term immersion (21 days). This novel coating provides an effective surface modification solution for solving the problems of ureteral stent infection and encrustation formation, holding significant clinical translation value.
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JOURNAL OF MEMBRANE SCIENCE
·
2018
·
IF 6.578
Jicui Dai,Yichao Dong,Cong Yu,Yaxin Liu,Xiangguo Teng
A novel N115-g-PSBMA membrane containing zwitterionic groups was successfully prepared by grafting the zwitterionic SBMA (sulfobetaine methacrylate) onto Nafion 115 (N115) via SI-ATRP (surface-initiated atom transfer radical polymerization) technique. The N115-g-PSBMA membrane has shown higher hydrophilicity , lower vanadium permeability, higher coulombic efficiency and energy efficiency than that of commercial N115 membrane for VRB (vanadium redox flow battery) application. At the current density of 40–80 mA cm −2 , the average energy efficiency of the VRB with N115-g-PSBMA membrane has reached up to 87.3%, which is 2.6% higher than that of the VRB with N115 membrane at the same current densities. The method is expected to present a new direction to prepare novel separators with both excellent performances and low cost for VRB application.
研究领域:
能源材料
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高分子科学
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电化学储能
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高影响因子
CARBOHYDRATE POLYMERS
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2025
·
IF 12.5
Fan Wang,HuaQing Zhang,ChunLing Liu,Wen Bao,YaJuan Hu,Xieraili Maimaitiyiming
PVA-based conductive hydrogels have enormous potential for applications in wearable flexible electronic devices, but their low ionic conductivity and mechanical strength hinder their practical utility. To address this challenge, we propose a PVA-based incorporating metal salt and zwitterion. We use PA(phytic acid) and HPMC (hydroxypropyl methylcellulose) - compatible properties to prepare PSBMA 1 -PMAZ 1.5 interpenetrating conductive hydrogel with good electrical signal responsiveness, repeatability, compression resistance, and low hysteresis (≤11.68 %). The hydrogel-based flexible strain sensor has a wide detection range, high sensitivity (GF = 1.1 at 0 − 600 %), stable electrical signal response to variations in temperature and humidity, and human movement detection capabilities. The detection range of hydrogel - based supercapacitors is 25 °C - 40 °C, which indicates that the device assembled with activated carbon as the electrode has good capacitance characteristics, and the multifunctional characteristics of PSBMA 1 -PMAZ 1.5 hydrogels are poised to serve as a demonstration for a new generation of flexible electronic products.
研究领域:
材料科学
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生物医学工程
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PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2025
·
IF 2.8
Xiangrong Li,Yanfei Fang,Peiyan Cheng,Tingping Lei,Xigui Wang,Tianliang Lin
This study developed an interface-functionalized ultra-high-molecular-weight polyethylene (UHMWPE) by incorporating a strongly hydratable zwitterion, sulfobetaine methacryloxyethyl (SBMA), to enhance its wear resistance under synovial fluid lubrication. Composite materials with SBMA gradients (0–7.5 wt%) were prepared via melt blending. Pin-on-disc tribological tests demonstrated that at 7.5 wt% SBMA loading, the friction coefficient decreased by 37% under an 8 N load, while the volumetric wear rate reduced by 49% at a 30 N load. Multiscale characterization revealed dual synergistic mechanisms: (1) interfacial hydration reinforcement - the sulfonate group in SBMA formed hydrogen-bonded hydration layers, decreasing the contact angle from 69° to 56° and suppressing wear through hydration lubrication; and (2) structural influence - SBMA prevents crystallization by acting as a plasticizer. But as concentration rises, SBMA aggregates, reducing the plasticizing impact and enhancing mechanical qualities. This study provides a novel strategy that combine superior hydration effect to enhance tribological performance of UHMWPE.
研究领域:
材料科学
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高分子科学
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摩擦学
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生物医学工程
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表面工程
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Polymers
·
2025
·Vol. 17
·期 16
·2230
·
IF 4.9
Zexing Deng,Litong Shen,Qiwei Cheng,Ying Li,Qianqian Liu,Xin Zhao
Conventional conductive hydrogels are susceptible to swelling in aquatic environments; which compromises their mechanical integrity; a limitation that poses a potential challenge to their long-term stability and application. In this study, a zwitterionic ion-conductive hydrogel was fabricated from polyvinyl alcohol (PVA), acrylic acid (AA), and [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SMBA), forming a dual-network structure. A copolymer of zwitterionic SBMA and AA formed the first network, and PVA formed the second network by repeated freeze–thawing. The equilibrium state of zwitterionic SBMA was modulated by AA to protonate the SBMA, which resulted in the conversion of -SO3−to -SO3H; thus, hydrogels had the anti-swelling property driven by electrostatic repulsion. In addition, the prepared hydrogels possessed excellent mechanical properties (tensile strength of 0.76 MPa, elongation at break of 322%, and compressive strength of 0.97 MPa at 75% compressive strain) and remarkable anti-swelling properties (80% swelling after 120 h of immersion). Owing to the zwitterionic nature of SBMA, the hydrogel also showed inherent antimicrobial properties and high electrical conductivity, which could be capable of monitoring human movement and physiological signals. This work provides a facile strategy for designing hydrogels with remarkable mechanical properties and anti-swelling characteristics, expanding the application environment of hydrogels in flexible sensing
研究领域:
材料科学
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高分子科学
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生物医学工程
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柔性电子学
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传感器
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MATERIALS CHEMISTRY AND PHYSICS
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2023
·
IF 4.6
Ziheng Li,Binbin Wang,Qihang Xu,Deqiang You,Wei Li,Xiaojian Wang
Due to similar properties to that of cartilage, hydrogels are considered as promising candidates for cartilage repair. However, it is still a challenge to synthesize hydrogel combining high strength and low friction like natural cartilage. In this work, we synthesized a dual-crosslinked zwitterionic P(AAm-co-AAc-co-SBMA)/Fe 3+ hydrogel, in which a zwitterionic monomer [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)(SBMA) was used to improve the hydrophilicity of the polymer chain. The results showed that the hydrogel exhibited significantly improved tensile strength (9.9 MPa) and compressive strength (207.6 MPa), which was due to the physical crosslinking points introduced by SBMA. Moreover, the zwitterionic hydrogel achieved an ultra-low friction coefficient (CoF) of 0.04 in water. The results provide a new approach for cartilage repair materials with considerable strength and low friction.
研究领域:
材料科学
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生物医学工程
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组织工程
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高影响因子
EUROPEAN POLYMER JOURNAL
·
2023
·
IF 6
Leqi Wu,Sui Wang,Jie Mao,Zhiyong Guo,Yufang Hu
In this study, a conductive double network cross-linked hydrogel with anti-swelling and shape memory was successfully prepared by [2-(methacryloyloxy)ethyl]dimethyl-(3-sulfopropyl)ammonium hydroxide (SBMA), polyvinyl alcohol (PVA), and tannic acid (TA). The hydrogel is formed by SBMA radical polymerization to form the first layer of the network and PVA freeze-thawing to form the second layer of the network. The conversion of -SO 3 - on the SBMA structure to -SO3H in the presence of TA and the electrostatic repulsion between -N + (CH 3 ) 3 reduces the osmotic pressure and achieves an anti-swelling effect. The prepared hydrogels have good mechanical properties tensile strength of 1.4 MPa, elongation at break of 287.52 %, and compressive strength of 2.36 MPa at 80 % strain. The structure of SBMA forms ion channels with stable conductivity, simulating the realization of underwater monitoring movements. In addition, the hydrogel can recover its original shape in a few seconds at 60 °C and has a 99 % inactivation rate against E. coli and S. aureus within 24 h, which can provide new ideas for the biomedical field.
研究领域:
材料科学
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生物医学工程
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高分子化学
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生物材料
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高影响因子
International Journal of Peptide Research and Therapeutics
·
2019
·Vol. 26
·期 4
·1839-1846
·
IF 1.219
Liu Lei,Liu Jie,Cui Qi,Jia Bo-Yan,Pei Zhi-Hua,Odah Kokou Ayefounin,Wang Yi-Ming,Dong Wen-Long,Kong Ling-Cong,Ma Hong-Xia
Proline-rich antimicrobial peptides (PR-AMPs) have attracted much interest as they target Gram-negative and do not act by lytic mechanisms. In this study, a novel hybrid peptide OM19R was designed based on the Oncocin and MDAP-2. OM19R showed specific and improved potency against Escherichia coli ( E. coli ), Salmonella and Shigella standard strains compared to parental peptides. The minimum inhibitory concentrations (MICs) ranged from 1 to 2 μM. However, the activity against Klebsiella pneumoniae ( K. pneumoniae ) was inhibited. The dependence of the SbmA protein for OM19R activity was also studied by a gene-knockout strain. The confocal laser scanning microscopy further revealed that OM19R could rapidly penetrate into E. coli cells without membrane damage. In summary, the hybrid peptide OM19R is a strong cell-selective antibacterial peptide and a promising specific antibacterial agent.
研究领域:
微生物学
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药学
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分子生物学
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生物技术
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高影响因子
Biomaterials Science
·
2020
·Vol. 9
·期 3
·882-891
·
IF 6.183
Zecong Xiao,Xinyao Zheng,Ying An,Kangning Wang,Junwen Zhang,Huacheng He,Jiang Wu
Growth factors (GFs) have been well known for their therapeutic effects on wound healing. Due to their vulnerable biostability, biomaterial carriers are usually used to deliver GFs to maintain their bioactivity. Among the carriers, PEG hydrogels are the most widely applied. But the uncontrolled release of GFs and their immunogenicity dramatically retard the application of PEG hydrogels as carriers of GFs. Herein, FGF2 loaded zwitterionic sulfobetaine methacrylate (SBMA) hydrogels were developed, and it was revealed that these hydrogels were more effective in delivering FGF2 for wound healing than were PEG hydrogels. In vitro studies demonstrated that SBMA hydrogels could successfully prolong the release of FGF2, which effectively maintained the bioactivity of FGF2. Further in vivo investigation showed that SBMA hydrogels could efficiently accelerate wound regeneration by promoting granulation tissue formation, collagen deposition, cell proliferation and migration, reepithelialization and angiogenesis. All results validated that SBMA hydrogels were promising substituents of PEG hydrogels for delivering FGF2 for wound regeneration.
研究领域:
生物材料
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组织工程
·
伤口愈合
·
药物递送系统
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PubMed
高影响因子
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