CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Heng Li,Deguang Wang,Zixun Wang,Wenjie Chen,Yuxin Guo,Han Liang,Yanqiu Zhao,Qi Wang,Yiqian Huang,Wei Jing,Pengfei Wei,Bo Zhao,Binbin Guan,Min Zhang,Jing Yu,Xudong Xiang
Postoperative complications, such as air leakage, inflammation, and pleural adhesion, present considerable clinical challenges following lung resection procedures. These complications critically affect pulmonary recovery. In this study, we report a novel multifunctional self-adhesive bio-patch SIS-PEG-AC, which synergistically combines the biological activity of small intestinal submucosa (SIS), the effective sealing air leaks provided by polyethylene glycol (PEG) coating, and the anti-inflammatory effects of asiaticoside (AC). Compared to SIS, which exhibited limited tissue adhesion (0.73 kPa), the SIS-PEG-AC patch demonstrated a 30-fold increase in adhesiveness, achieving robust tissue adhesion (23.31 kPa) and significantly enhanced reparative capacity. AC delivered from the PEG hydrogel coating in a sustained manner, promoting the polarization of macrophages to M2 phenotype, to suppressing pro-inflammatory cytokine expression, thereby establishing a pro-regenerative ecological environment. The results of 28-day implantation on rat lung injury and 70-day implantation on pig lung wedge resection showed, the SIS-PEG-AC achieved excellent wound sealing, minimized postoperative pleural adhesions and significantly accelerated lung tissue regeneration. Compared with traditional synthetic polymers, the SIS-PEG-AC patch exhibited reduced adverse reactions, superior host tissue integration, and heightened control of the regenerative microenvironment, providing a promising approach to mitigate postoperative complications. Overall, this multifunctional patch demonstrates considerable clinical potential in lung repair, offering an effective strategy for thoracic surgical interventions.
研究领域:
生物医学工程
·
再生医学
·
胸外科
·
生物材料
·
药物递送系统
·
组织工程
✓ 已验证
产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Boqi Li,Yufeng Gao,Xiaohu Luo,Chuanzhi Hu,Mingyu Deng,Jinghua Chen,Gao Min
Natural extracellular matrices (ECM) provide a more accurate simulation of the cellular growth environment, making them excellent substrate materials for in vitro cell culture. The porcine small intestinal submucosa (SIS) is one of the most widely used natural ECM that display superior bioactivity. However, decellularization operations often result in fiber breakage and failure to recover mechanical strength in the SIS. In the current study, 2,3-dialdehyde cellulose (DAC) was synthesized and cross-linked with SIS gel to form hydrogels. The introduction of DAC into the SIS matrix resulted in a tunable increase in stiffness, which was instrumental in promoting stem cell adhesion and spreading, crucial factors for osteogenic differentiation. The cytotoxicity assessment confirmed the biocompatibility of the SIS-DAC hydrogels indicating their suitability for prolonged cell culture. Moreover, the degradation rate of the hydrogel could be effectively controlled by adjusting the DAC content, addressing the rapid degradation issue associated with SIS gels. This work confirmed the feasibility of using cellulose derivatives to modulate the mechanical properties of matrix gels and influence cell differentiation which offers a valuable experimental foundation for the development of advanced matrix gels tailored for cell culture and regenerative medicine applications.
研究领域:
生物材料
·
组织工程
·
干细胞研究
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2024
·
IF 6.1
Jie Tan,Zecai Chen,Zhen Xu,Yafang Huang,Lei Qin,Yufeng Long,Jiayi Wu,Hantao Yang,Xuandu Chen,Weihong Yi,Ruiqiang Hang,Min Guan,Huaiyu Wang,Ang Gao,Dazhi Yang
The 3D printed scaffolds constructed from polymers have shown significant potential in the field of bone defect regeneration. However, the efficacy of these scaffolds can be markedly reduced in certain pathological conditions like diabetes, where the altered microenvironment complicates the integration of these polymers with the host tissue. In this study, the bioactivity of 3D-printed PLGA scaffold is augmented through integration of hydroxyapatite, icariin, and small intestine submucosa (SIS), a form of decellularized extracellular matrix (dECM). In vitro and in vivo studies demonstrate that this functionalized scaffold not only provides desirable immunoregulatory effect, but also facilitates angiogenesis and osteogenesis during the subsequent process. This functionalization approach holds significant promise in advancing the treatment of bone defects within the diabetic population, paving a step forward in the application of polymer-based 3D printing technologies in regenerative medicine.
研究领域:
再生医学
·
生物医学工程
·
组织工程
·
糖尿病研究
·
生物材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Biomaterials Science
·
2021
·Vol. 9
·期 23
·7895-7910
·
IF 6.843
Guangxiu Cao,Wei He,Yubo Fan,Xiaoming Li
The repair of abdominal wall defects is currently a clinical challenge. A naturally derived extracellular matrix (ECM) such as small intestine submucosa (SIS) has received great attention in abdominal wall defect repair because of its remarkable bioactivity, biodegradability and tissue regeneration. The match between material degradation and tissue remodeling is very important for the realization of ideal repair effectiveness. In this study, a near-infrared (NIR) fluorescent dye Cy5.5 NHS ester was used to label ECM-based (ECMB) composites consisting of SIS and chitosan/elastin electrospun nanofibers for monitoring material degradation. The tissue remodeling in the ECMB composites for a full-thickness abdominal wall defect repair was systematically investigated by a series of tests including wall thickness measurement, muscle regeneration analysis and angiogenesis assessment. The main findings were: (1) real-time and noninvasive degradation monitoring of the ECMB composites until complete degradation could be realized by chemical conjugation with a Cy5.5 NHS ester. (2) In a full-thickness abdominal wall defect model, the explant thickness could be used as an intuitional indicator for evaluating the tissue remodeling efficiency in the ECMB composites, and the accuracy of this indicator was verified by various examinations including collagen deposition, angiogenesis, and muscle regeneration. The present study could provide new insight into evaluating tissue repair effectiveness of the ECMB composites.
研究领域:
生物医学工程
·
组织工程
·
再生医学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2016
·Vol. 1
·期 6
·1073-1078
·
IF 0
Qi-Zhi Zhong,Li-Wei Zhang,Yang Ou,Bai-Heng Wu,Ling-Shu Wan,Zhi-Kang Xu
Ultrathin perforated honeycomb-patterned membranes show promise for high-resolution separation, in which the mechanical strength and chemical stability of membranes are very important. Here we report facile and versatile modification methods for preparing cross-linked honeycomb membranes with tunable mechanical and chemical properties. Commercially available polystyrene-b-polyisoprene-b-polystyrene (SIS), which contains double bonds for post modification, together with an amphiphilic block copolymer was utilized as the membrane-forming material. Robust and self-standing honeycomb membranes were obtained by the rapid vapor diffusion cross-linking of S2Cl2 in 5 min. X-ray photoelectron spectroscopy (XPS) and energy dispersive X-ray spectroscopy (EDX) results demonstrate effective cross-linking. The cross-linked membranes show excellent resistance to organic solvents and other harsh environments. Water flux measurements indicate that the cross-linked membranes can endure trans-membrane pressure as high as 0.12 MPa. The cross-linked membranes are stable in a wide temperature range. Another cross-linking method based on thiol–ene click chemistry is also proved to be able to form robust membranes with both improved stabilities and controllable surface properties. Moreover, the cross-linked perforated honeycomb membranes can be used for separation under higher operation pressure.
研究领域:
材料科学
·
化学工程
·
膜技术
✓ 已验证
DOI
Nature Communications
·
2024
·Vol. 15
·期 1
·1-14
·
IF 14.7
Su Han,Zhong Yu,Wang Changhong,Liu Yu,Hu Yang,Li Jingru,Wang Minkang,Jiao Longan,Zhou Ningning,Xiao Bing,Wang Xiuli,Sun Xueliang,Tu Jiangping
Sulfide electrolytes represent a crucial category of superionic conductors for all-solid-state lithium metal batteries. Among sulfide electrolytes, glassy sulfide is highly promising due to its long-range disorder and grain-boundary-free nature. However, the lack of comprehension regarding glass formation chemistry has hindered their progress. Herein, we propose interstitial volume as the decisive factor influencing halogen dopant solubility within a glass matrix. We engineer a Li 3 PS 4 -Li 4 SiS 4 complex structure within the sulfide glassy network to facilitate the release of interstitial volume. Consequently, we increase the dissolution capacity of LiI to 40 mol% in 75Li 2 S-25P 2 S 5 glass. The synthesized glass exhibits one of the highest ionic conductivities among reported glass sulfides. Furthermore, we develop a glassy/crystalline composite electrolyte to mitigate the shortcomings of argyrodite-type sulfides by utilizing our synthesized glass as the filler. The composite electrolytes effectively mitigate Li intrusion. This work unveils a protocol for the dissolution of halogen dopants in glass electrolytes.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）