INORGANIC CHEMISTRY COMMUNICATIONS
·
2026
·
IF 5.4
Yanan Liu,Cong Li,Shihao Zhu,Zhicong Xue,Yaxuan Wang,Wenxi Xia,Yao Chen,Muxing Zhou,Dongzhi Yang,Yufeng Liu
Superoxide dismutase (SOD) is a pivotal metalloenzyme for mitigating oxidative stress, yet its practical use is constrained by extraction, purification, and scale-up challenges. Porphyrinic MOF nanozymes offer cost-effective, stable, and tunable SOD mimetics, but the roles of mixed metalloporphyrins and framework architecture remain underexplored. Here, we synthesized two porphyrinic MOF series derived from PCN-223, featuring elliptic distortions along either the major or minor axis, by co-assembling TCPP–Mn and TCPP–Cu at defined ratios. Both frameworks share TCPP and Zr 6 O 4 (OH) 4 nodes but differ in topology. Materials were characterized by SEM, PXRD, UV–vis, and zeta potential; SOD-like activity was quantified using a WST-8 superoxide assay, and intracellular ROS scavenging was assessed in RAW 264.7 cells. The SOD-like activity is governed primarily by the fraction of catalytically active metal centers—Mn–porphyrin sites outperform Cu analogues—and secondarily by framework morphology, with negligible dependence on particle size. In both series, activity increases monotonically with TCPP–Mn content; at Mn/Cu = 0.8/0.2, mixed-ligand MOFs approach or exceed their single-ligand Mn counterparts. Morphology modulates performance: the minor axis PCN-223 derivatives exhibit lower activity than the major axis PCN-223 analogues. In cells, the minor axis PCN-223–Mn 0.8 Cu 0.2 shows stronger ROS scavenging than the major axis PCN-223–Mn 0.8 Cu 0.2 , likely due to smaller particle size enhancing uptake, but with higher cytotoxicity at elevated doses. These results identify metal-center speciation and morphology as the principal design levers for SOD-mimetic porphyrinic MOFs and provide a basis for engineering efficient, application-tailored antioxidative nanozymes.
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高影响因子
BIOSENSORS & BIOELECTRONICS
·
2023
·
IF 12.6
Pengyan Wei,Zhuozhe Li,Yifeng E,Yuying Jiang,Peng Chen,Li Li,Thomas F. Krenzel,Kun Qian
The nonchiral sensor concept based on a sodalite (SOD) zeolite loaded Cu x S (Cu x S@SOD) catalyst is proposed as a sensing platform for chiral cysteine (Cys) determination. Chiral Cys is analyzed by the difference of binding capacity between Cu x S catalysts. The observed current in amperometric i-t curve (A i-t C) is always positive for the L-cysteine (L-Cys), while it is negative for the D-cysteine (D-Cys). Under differential pulse voltammetry (DPV) method, the characteristic current peak for the Cu x S@SOD moves to right (positive potential position) with the addition of L-Cys while it moves to left (negative potential direction) with the addition of D-Cys, respectively. Cyclic voltammetry (CV) is consistent with DPV and discusses the diffusion control mechanism. In this work, the ultra-trace determination of cysteine enantiomers reaches the limit of detection (LOD) of 0.70 fM and 0.60 fM by the highly efficient Cu x S catalyst restrained in the nanosized SOD zeolite cages of the opening window pores, respectively. The sensor opens up a novel potential prospect for achiral composite in the field of chiral recognition through electrochemical methods with extra-low concentration.
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高影响因子
Journal of Functional Biomaterials
·
2023
·Vol. 14
·期 11
·548
·
IF 4.8
Hao Liu,Yujie Zhang,Mingzhen Zhang,Zhaoxiang Yu,Mingxin Zhang
Ulcerative colitis (UC) is a refractory chronic inflammatory disease involving the colon and rectum, falling under the category of inflammatory bowel disease (IBD). The accumulation of reactive oxygen species (ROS) in local tissues has been identified as a crucial contributor to the escalation of inflammatory responses. Therefore, eliminating ROS in the inflamed colon is a promising approach to treating UC. Nanomaterials with intrinsic enzyme-like activities (nanozymes) have shown significant therapeutic potential in UC. In this study, we found that platinum nanoparticles (Pt NPs) exhibited remarkable superoxide dismutase (SOD) and catalase (CAT) cascade catalytic activities, as well as effective hydroxyl radical (•OH) scavenging ability. The in vitro experiments showed that Pt NPs could eliminate excessive ROS to protect cells against oxidative stress. In the colitis model, oral administration of Pt NPs (loaded in chitosan/alginate hydrogel) could significantly alleviate UC, including reducing the colon length, the damaged epithelium, and the infiltration of inflammatory cells. Without appreciable systemic toxicity, Pt NPs represent a novel therapeutic approach to UC and are expected to achieve long-term inflammatory remission.Keywords:ulcerative colitis;platinum (Pt NPs);nanozymes;hydrogels;ROS scavenging
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PubMed
高影响因子
CERAMICS INTERNATIONAL
·
2024
·
IF 5.1
Xinzhe Zhou,Li Guan,Huanrong Li
The white LEDs with high performance and excellent luminous quality is of high importance for developing the current lighting industry, and high thermally stable blue phosphors play a critical role in the preparation of white LEDs. Herein, we reported a facile way to obtain highly efficient blue Eu 2+ -doped celsian phosphor with excellent thermal stability by a phase transformation of Ba 2+ -exchanged SOD Zeolite strategy. The structure of phosphors changed from nepheline to celsian with the doping of Ba 2+ , and the maximum emission intensity blue-shifts from 550 nm to 450 nm under the excitation of 370 nm. The PLQY is determined to be 56 %, 96 % and 82 % for the phosphor with Ba 2+ doping concentration being 0, 1.49 and 1.86, respectively, and the luminescence intensity at 423 K is can be 80 %, 102 % and 93 % of its intensity at room temperature. Finally, the package of the LED device based on our yellow and blue phosphors together with the commercial red CaAlSiN 3 :Eu 2+ phosphor is constructed to show warm white light with the CCT of 3705 K and a high CRI of 97.7. This study provides a facile way for obtaining satisfactory phosphors for high-quality lighting.
研究领域:
材料科学
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光学工程
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高影响因子
Heliyon
·
2024
·
IF 3.4
C H E N Wen-Tao,Ying-Yang Zhang,Qiang Qiang,Ping Zou,Ying Xu,Chengjun Sun,Iftikhar Hussain Badar
In this study, we investigated the antioxidant properties of dry-cured beef crude peptide (BPH) at different storage periods. The combination characteristics of different concentrations of Phe-Asp-Gly-Asp-Phe (FDGDF) and superoxide dismutase (SOD) at different temperatures were analyzed by ultraviolet-visible spectroscopy, fluorescence spectroscopy, and FT-IR spectroscopy, combined with the detection of a SOD activity detection box. It was found that FDGDF could improve the activity of SOD by changing its secondary structure. Bonds were formed at O32/O40/O52 using quantum chemical simulation calculations, and the Fukui index was higher than that of most atoms, indicating that these atoms were more likely to participate in the reaction. SPR biological force analysis showed that FDGDF and SOD were in a fast binding and dissociation mode. This study revealed the theoretical basis for studying the antioxidant mechanism of dry-cured beef and provided ideas for developing new dry-cured beef products.
研究领域:
食品科学
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生物化学
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分子生物学
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PubMed
高影响因子
ACS Applied Materials & Interfaces
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2022
·
IF 10.383
Xu Jin,Wei Zhang,Jie Shan,Jia He,Haisheng Qian,Xulin Chen,Xianwen Wang
Various injury defense and repair functions are performed by the skin. Free radicals secreted after injury cause oxidative stress and inflammatory responses, which make wound healing difficult. However, the current metal nanomaterials for wound repair do not have sufficient catalytic activity or complex material design and cannot properly fit wounds. Therefore, it is imperative to develop more effective therapeutic approaches. This study investigated the effect of Ni4Cu2 hollow nanospheres composited with F127 hydrogel on promoting wound healing by applying them to wounds. Ni4Cu2 hollow nanospheres exhibited a superior spatial structure, contained many catalytic sites, and could be synthesized in a simple manner. In vitro experiments showed that Ni4Cu2 hollow nanospheres had superoxide dismutase-like activity and promoted fibroblast migration, angiogenesis, and macrophage polarization. F127, which is a thermosensitive, nontoxic, phase-change and porous hydrogel material, has proven to be an effective choice for injectable and sprayable medical dressings. Ni4Cu2 hollow nanospheres were mixed with F127 hydrogel without significantly affecting its performance. In addition to adapting to the complex, irregular gaps of acute wounds, the mixture lengthened the nanozyme release time, which enhanced healing. Based on the animal experiments, the Ni4Cu2/F127 composite hydrogel effectively promoted wound healing, epithelial regeneration, and the formation of skin appendages such as hair follicles in mice. Furthermore, the Ni4Cu2/F127 composite hydrogel was nontoxic to animals and had high biological safety. The Ni4Cu2/F127 composite hydrogel has provided an innovative strategy to develop composite hydrogels for the treatment of acute skin wounds.
研究领域:
材料科学
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纳米技术
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生物医学工程
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伤口愈合
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生物材料
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PubMed
高影响因子
ADVANCED MATERIALS
·
2026
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IF 29.1
Zhiqiang Li,Ben Wu,Weihua Li,Enrico Marsili,Kun Tang,Kuoyang Sun,Zhifu Cao,Yupeng Zhang,Hui Huang,Xiaofeng Li,Guocheng Wang
Osteoarthritis (OA) is driven by a vicious cycle of inflammation and reactive oxygen species (ROS). While cobalt-based metal-organic framework (MOF) nanozymes are potent catalase (CAT) mimics, their therapeutic efficacy is crippled by an inherently weak superoxide dismutase (SOD)-like activity that prevents full-chain ROS scavenging. Here, we resolve this imbalance through an innovative “pre-embedding/activation” strategy. This approach involves pre-embedding Zn 2+ into a cobalt-based framework to create a stable yet activatable precursor. The subsequent dopamine (DA)-driven “activation” then remodels the latent Zn/Co-N coordination sites, unlocking an efficient SOD-to-CAT catalytic relay by synergistically amplifying the SOD-like activity for seamless elimination of the entire ROS cascade. This powerful scavenging capability restores mitochondrial function and reprograms macrophages toward an anti-inflammatory M2 phenotype by inhibiting the ROS-mediated S100A8/NF-κB signaling axis and its destructive positive feedback loop. The resulting immunomodulation translates to profound therapeutic outcomes in a rat OA model, where it simultaneously promotes chondrocyte anabolism to achieve significant cartilage repair while suppressing peripheral nerve sensitization to provide sustained pain relief. Our work thus establishes nanoscale interfacial reconstruction as a powerful and rational platform for engineering sophisticated catalytic relays within nanozymes for advanced biomedical applications.
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高影响因子
Foods
·
2024
·Vol. 13
·期 7
·981
·
IF 4.7
Chang Liu,Jianing Wang,Dan Hong,Zhou Chen,Siting Li,Aijin Ma,Yingmin Jia
Rumexpatientia L.×Rumextianshanicus A. Los(RRL), known as “protein grass” in China, was recognized as a new food ingredient in 2021. However, the cultivation and product development of RRL are still at an early stage, and no peptide research has been reported. In this study, two novel antioxidant peptides, LKPPF and LPFRP, were purified and identified from RRL and applied to H2O2-induced HepG2 cells to investigate their antioxidant properties. It was shown that 121 peptides were identified by ultrafiltration, gel filtration chromatography, and LC-MS/MS, while computer simulation and molecular docking indicated that LKPPF and LPFRP may have strong antioxidant properties. Both peptides were not cytotoxic to HepG2 cells at low concentrations and promoted cell growth, which effectively reduced the production of intracellular ROS and MDA, and increased cell viability and the enzymatic activities of SOD, GSH-Px, and CAT. Therefore, LKPPF and LPFRP, two peptides, possess strong antioxidant activity, which provides a theoretical basis for their potential as food additives or functional food supplements, but still need to be further investigated through animal models as well as cellular pathways.
研究领域:
食品科学
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生物化学
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药理学
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Journal of the American Chemical Society
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2023
·
IF 15
Chao Ma,Xiaona Liu,Yang Hong,Nana Yan,Chenyang Nie,Jing Wang,Peng Guo,Zhongmin Liu
The pure-silica zeolite plays a crucially important role in the gas separation of alkane/alkene, the low-k dielectric material, and the robust matrix for confining metal species during catalysis. However, the environmentally friendly synthesis of pure-silica zeolites is still challenging since (1) the toxic fluoride or dealuminum seeds are inevitably utilized through the hydrothermal synthesis and (2) it will also take a longer crystallization time. Herein, we present an efficient method called the OSDA-mismatch approach for the fluoride- and seed-free synthesis of pure-silica zeolites using Si-SOD (enriched 4-rings) as the sole silica source. This approach allows for the rapid and green synthesis of 15 pure-silica zeolites (CHA, *BEA, EUO, SFF, STF, -SVR, *-SVY, DOH, MTN, NON, *MRE, MEL, MFI, MTW, and *STO). Furthermore, distinct crystallization mechanisms of two significant pure-silica CHA- and *BEA-type zeolites (denoted as Si-CHA and Si-BEA) are investigated in detail by advanced characterization techniques such as FIB, 3D ED, 4D-STEM, HRTEM, Raman, and 29Si MAS NMR. More importantly, Si-CHA displays promising propane/propylene separation performance even better than the one synthesized in the presence of toxic HF. In addition, the incorporation of Zn species within Si-BEA fabricated by this approach also renders superior performance on propane dehydrogenation.
研究领域:
材料科学
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化学工程
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环境科学
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PubMed
高影响因子
Molecular Medicine Reports
·
2017
·Vol. 16
·期 6
·9361-9366
·
IF 1.692
Weixin Zhu,Weihong Qiu,Ailan Lu
Cerebral stroke is a kind of acute cerebrovascular disease with high incidence, morbidity and disability. Treatments against various types of cerebral stroke are limited at preventive measurements due to the lack of effective therapeutic method. The present study aimed to investigate the protective effect of cryptotanshinone (CPT) on cerebral stroke, and investigate the possible mechanism involved in order to develop a novel therapy against stoke. The phosphoinositide 3‑kinase membrane translocation of cerebral stroke rats pretreated with CPT at various concentrations were measured, as well as the phosphorylation of protein kinase B (AKT) and endothelial nitric oxide synthase (eNOS). Additionally, the expression level of B‑cell lymphoma 2 (Bcl‑2), Bcl‑2‑associated X protein (Bax) and vascular endothelial growth factor were also assessed using western blotting and reverse transcription‑quantitative polymerase chain reaction. Furthermore, biochemical tests were used to measure the activity of superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) in both the cerebral cortex and peripheral blood. As a result, CPT‑pretreated rats presented declined phosphoinositide 3‑kinase (PI3K) and AKT expression levels, indicating that the PI3K/AKT signaling pathway was inhibited. Increased Bcl‑2 and NO levels in both the cerebral cortex and peripheral blood demonstrated the anti‑apoptosis and blood vessel protection effect of CPT. Furthermore, increased SOD activity and declined MDA levels demonstrated suppressed lipid peroxidation. In conclusion, CPT exhibited a protective effect against cerebral stroke through inhibition of the PI3K/AKT‑eNOS signaling pathway. These results suggested the potential of CPT as a promising agent in the treatment of cerebral stroke.
研究领域:
神经科学
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药理学
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分子生物学
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PubMed
高影响因子
MOLECULES
·
2022
·Vol. 27
·期 9
·2618
·
IF 4.927
Jiao Zhou,Xinyue Lin,Shuangshuang Liu,Zhanbin Wang,Dongchao Liu,Yonghong Huo,Dehai Li
Inonotus hispidushas various health-promoting activities, such as anticancer effects and immune-stimulating activity. The commercialization of valuable plant triterpenoids faces major challenges, including low abundance in natural hosts and costly downstream purification procedures. In this work, orthogonal design was used to compound methyl jasmonate (MeJA), salicylic acid (SA), oleic acid, and Cu2+, and the effects of combinations on the total triterpenes biosynthesized were studied. The optimal combination was screened out and its effect on the activity of PAL, CAT, and SOD was studied. The optimal concentration of oleic acid was 2% when MeJA was 100 mol/L, and the total triterpenoid content and mycelia production were 3.918 g and 85.17 mg/g, respectively. MeJA treatment induced oxidative stress, and at the same time increased the activity of related defense enzymes. Oleic acid is thought to regulate cell permeability by recombining cell membranes. It promotes the material exchange process between cells and the environment without affecting cell growth. When oleic acid was used in combination with MeJA, a synergistic effect on triterpene production was observed. In conclusion, our findings provide a strategy for triterpenoid enrichment ofI. hispidus.Keywords:Inonotus hispidus;combination of elicitors;defense enzyme;triterpenoid
研究领域:
药理学
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真菌学
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生物化学
·
天然产物化学
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PubMed
高影响因子
Marine Drugs
·
2021
·Vol. 19
·期 12
·652
·
IF 5.118
Liping Wang,Yiwen Hou,Rong Wang,Qi Pan,Debao Li,Han Yan,Zuyue Sun
This study investigates the inhibitory effect of astaxanthin (AST) on testosterone-induced benign prostatic hyperplasia (BPH) in rats. Except for the sham operation, BPH model rats were randomly assigned to five groups: the BPH model control rats, AST-treated BPH model rats (20 mg/kg, 40 mg/kg, and 80 mg/kg), and epristeride (EPR)-treated BPH model rats. After treatment, as compared with the BPH model control rats, the prostate and ventral prostate weights of the AST-treated rats decreased, while there was a marked decline in the 80 mg/kg AST-treated rats. The same effect was also observed in the prostate index and ventral prostate index. The proliferation characteristics of epithelia observed in the BPH model control group were gradually alleviated in the AST-treated rats. As compared with the BPH model control rats, lower epithelial thicknesses of prostates and fewer secretory granules in epithelia were observed in the AST-treated rats. The superoxide dismutase (SOD) activity of prostates increased in all the AST-treated rats with a significant increase in the 40 mg/kg and 80 mg/kg AST-treated rats. The testosterone (T) and dihydrotestosterone (DHT) levels of prostates in the AST-treated groups were lower than those in the BPH model control group, and a significant decline was found in the T level of prostates in the 40 g/kg and 80 mg/kg AST-treated rats and the DHT level of prostates in the 40 mg/kg AST-treated rats. These results indicate that AST might have an inhibitory effect on T-induced BPH in rats, possibly due to SOD activity regulation and T and DHT levels.Keywords:astaxanthin;benign prostatic hyperplasia;pharmacodynamics;SOD activity
研究领域:
药理学
·
泌尿外科
·
内分泌学
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PubMed
高影响因子
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