JOURNAL OF THE CHINESE CHEMICAL SOCIETY
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2017
·Vol. 64
·期 2
·231-238
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IF 0.935
Jie Wu,Zongmei Wu,Xuejiao Sun,Shichao Yuan,Ruling Zhang,Qingliang Lu,Yueqin Yu
Sodium alginate (SA) was combined with poly( N -isopropylacrylamide) (PNIPAAm) to prepare thermosensitive hydrogels through semi-interpenetrating polymer network (semi-IPN) and fully interpenetrating polymer network (full-IPN). The thermosensitive, swelling, mechanical, and thermal properties of pure PNIPAAm, SA/PNIPAAm semi-IPN, and Ca-alginate/PNIPAAm full-IPN hydrogels were investigated. The formation of semi-IPN and full-IPN significantly improved the hydrogels’ swelling capability and mechanical properties without altering their thermosensitivity. 5-Fluorouracil (5-Fu) was selected as a model drug to study the release behaviors of the hydrogels. It was found that in vitro controlled drug release from semi-IPN hydrogels showed an initial release burst, followed by a slower and sustained release, before reaching equilibrium. Full-IPN hydrogels showed slow and sustained release during the whole process. Temperature and pH were found to affect the rate of drug release. Ca-alginate/PNIPAAm full-IPN hydrogels have potential application as drug delivery matrices in controlled drug release.
研究领域:
生物材料
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药剂学
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高分子科学
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组织工程
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药物递送系统
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DOI
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
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2016
·Vol. 134
·期 15
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IF 1.866
Ming He,Buning Zhang,Yao Dou,Guoqiang Yin,Yingde Cui
Feather keratin (FK), which can be extracted from waste feathers, is a kind of biodegradable and renewable protein resource and it has a great potential in the field of materials such as keratin sponges, films, and microcapsules. The aim of the current study was to investigate the blend modification of FK-based films using sodium alginate (SA). A series of FK-based films blended with different ratios of SA were prepared by the casting process. The cross-section of blend films had a compact and homogeneous structure and no distinct phase separation was observed, indicating the favorable compatibility between FK and SA. The result of DSC analysis, in which there was a change in crystal structure, confirmed the interaction between FK and SA in the blend films. The FTIR spectra pointed out that the main interaction between the two components would be through the formation of hydrogen bonds. The incorporation of SA to FK significantly enhanced the strength and maintained the extensibility of the resultant films. The water vapor permeability reached its lowest level when the ratio of FK to SA was 7:3. Moreover, the blend films exhibited a relatively high level of transparency with SA content below 30%. These improvements by incorporation of SA provided the potential to expand the application of FK-based films in packing and bio-medical industries. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2017 , 134 , 44680.
研究领域:
材料科学
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高分子科学
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生物聚合物
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包装技术
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生物医学工程
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DOI
高影响因子
CARBOHYDRATE POLYMERS
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2018
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IF 5.158
Xing Wei,Hejian Xiong,Dongfang Zhou,Xiabin Jing,Yubin Huang
Protein crosslinked nanogels which combine the merits of nanogels and the specific biological activity from protein have emerged as fascinating protein delivery systems. However, the fragility and low density of reactive group in proteins, especially low electric density of neutral proteins seriously limited the fabrication of protein crosslinked nanogels without affecting their bioactivities. Here, we demonstrated a facile ion-assisted method to fabricate neutral protein crosslinked nanogels. Oxidized sodium alginate (OSA) with aldehyde groups and low viscosity was successfully synthesized, which could reversibly form nanogels via addition and removal of divalent cation. Subsequently, hemoglobin and myoglobin were used as representative neutral proteins to fabricate stable protein crosslinked OSA nanogels under the assist of divalent cation followed by in situ Schiff base formation between OSA and proteins. The mild fabrication condition guaranteed the structural integrity and bioactivity of proteins in the obtained protein crosslinked nanogels. This ion-assisted method was expected to bring a new opportunity for fabricating versatile functional biohybrid nanogels systems.
研究领域:
纳米技术
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生物医学工程
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材料科学
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药学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
NEW JOURNAL OF CHEMISTRY
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2018
·Vol. 42
·期 21
·17756-17761
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IF 3.201
Shen Zhang,Feng Wei,Xiaojun Han
Capsaicin, an active ingredient in red pepper, shows great antibacterial activity. Herein, a series of sodium alginate/pullulan composite films incorporated with different concentrations of capsaicin were fabricated. Their physico-chemical properties were systematically investigated. With the increased content of capsaicin, the transmittance, elongation at break, and moisture content of the films decreased, whereas the tensile strength, water vapor permeability, and surface contact angle increased. Furthermore, the liquid culture tests revealed that the composite films exhibited good antibacterial performance against E. coli and S. aureus. The practical application of these antibacterial films for apple protection also exhibited a positive result, which makes it possible to use them in food packaging.
研究领域:
食品科学
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微生物学
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产品关联
DOI
高影响因子
COMPOSITES PART B-ENGINEERING
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2020
·
IF 7.635
Limei Liang,Tingting Hou,Qianqian Ouyang,Lei Xie,Saiyi Zhong,Puwang Li,Sidong Li,Chengpeng Li
To endow antibacterial activity and maintain good porosity, oxidized sodium alginate (OSA) sponge was functionalized via polydopamine/silver composite nanospheres (PDA/AgNSs). It is found that uniform PDA spheres (around 1.7 μm) can be successfully coated on OSA sponge surface without compromise of the OSA sponge integrity and porosity using absolute ethanol as optimized solvent. Particularly, the newly-produced PDA spheres can crosslink with the OSA sponge via the Schiff-base condensation, leading to improved stability. On the other hands, those PDA spheres can be served as the active sites to realize the growth of silver nanoparticles (around 50–70 nm) on PDA spheres surface, leading to the formation of novel PDA/AgNSs. Further analysis indicates that our proposed OSA/PDA/AgNSs sponge shows high blood compatibility, low cell cytotoxicity, good hemostatic performance as well as superior inhibitory activity against P. aeruginosa , S. aureus and E. coli . In conclusions, our proposed strategy opens a new route for antimicrobial sodium alginate dressing development.
研究领域:
生物材料学
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医学工程
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微生物学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES B-BIOINTERFACES
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2022
·
IF 5.999
Ting Wang,Wanwan Yi,Yu Zhang,Hang Wu,Hengwei Fan,Jiulong Zhao,Shige Wang
Recently, the healing of chronic wounds such as extensive burns has become a serious and intractable clinical problem. Avoiding wound infection and retaining an appropriate level of moisture around wounds are significant challenges in wound care. Herein, a dual-network hydrogel composed of sodium alginate (SA) and platelet-rich plasma (PRP) was designed to facilitate the wound healing. The preparation of hydrogel was achieved through a simple one-step thrombin activation process. The morphological characterization results revealed the three-dimensional network structure of the hydrogel. Then, certain levels of epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF) were detected in phosphate buffer solution (PBS) cultured hydrogel, which led to the possibility of cell proliferation and vascular regeneration. When topically applied to the wound skin of rats, the hydrogel presented high wound closure effectiveness. In conclusion, this strategy provides a simple and feasible approach to overcoming the shortcomings of conventional wound dressings.
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产品关联
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
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2023
·
IF 4.2
Junxian Pei,Guopeng Chen,Zining Li,Zuwei Zhou,Aofei Chen,Shangzhen Xie,Xingchi Jiang
Seawater covers 75% of the Earth’s surface, and it exists in nature as a vast resource. Harvesting energy from this tremendous resource provides a promising green approach to tackle the problem of electricity shortage. Herein, we develop a simple and effective ion-selective hydrogel membrane to harvest the osmotic energy from seawater and salt solutions at room temperature. Sodium alginate hydrogel, an ion-transport medium with numerous functional groups and a hierarchical porous structure, shows excellent ion-transport and ion-sieving capability in salt solutions. A single device can output a 0.16 V open-circuit voltage and 0.048 μW power in real seawater. Through a simple serial connection, the output voltage of the device can be further linearly improved to charge capacitors and thus light a light-emitting diode (LED) lamp. This research provides a new direction of material selection for hydrovoltaic electricity generation technology, which is conducive to expanding the practical applications of energy harvesting.
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2023
·
IF 8.2
Chao Wang,Xuezhen Feng,Shibin Shang,He Liu,Zhanqian Song,Haibo Zhang
In this work, a class of bio-based hydrogels (LN-NH-SA hydrogel) were prepared from aminated lignin and sodium alginate. The physical and chemical properties of the LN-NH-SA hydrogel were fully characterized using field emission scanning electron microscopy , thermogravimetric analysis , fourier transform infrared spectroscopy , N 2 adsorption–desorption isotherms, and other techniques. LN-NH-SA hydrogels were tested for the adsorption of dyes (methyl orange and methylene blue). The LN-NH-SA@3 hydrogel showed better adsorption efficiency for MB with a maximum adsorption capacity of 388.81 mg·g −1 , a bio-based adsorbent with a high adsorption capacity. The adsorption process followed the pseudo-second-order model and fitted to the Freundlich isotherm equation. More importantly, LN-NH-SA@3 hydrogel maintained 87.64 % adsorption efficiency after 5 cycles. Overall, the proposed hydrogel with environmentally friendly and low cost is promising for the absorption of dye contamination.
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING RESEARCH & DESIGN
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2022
·
IF 4.119
Hong Zhang,Ling Chu,Jiuling Wang,Qilong Guo,Wenbo Zhang
Sodium alginate composite beads were synthesized using iron/nickel decorated palygorskite as filler by calcium chloride crosslink and applied to remove tetracycline (TC) from water efficiently. The beads were characterized using X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), scanning electron microscope (SEM) and X-ray photoelectron spectroscopy (XPS). The results suggested that the synergistic effect of nano iron/nickel and palygorskite could improve the adsorption performance of the beads for TC greatly. Batch adsorption experiments showed that the adsorption process fitted the Sips model and the maximum adsorption capacity of TC could reach 189.86 mg/g at 298 K, which was 31.6 times than that of pure sodium alginate and 4 times than that of palygorskite. The beads could be easily separated from water after adsorption using a mesh sieve. The adsorption mechanisms were mainly contributed to electrostatic attraction , π-π accumulation, hydrogen bond, silicate bond, chelation and ion exchange. In addition, the site energy distribution found that the surface of the adsorbents showed more heterogeneity at higher temperatures. The prepared beads could thus be used as a promising adsorbent for TC from water.
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产品关联
DOI
高影响因子
Frontiers in Cardiovascular Medicine
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2022
·
IF 5.846
Wenqing Gao,Han Wang,Yanwu Liu,Qin Tang,Peng Wu,Tingting Lin,Tong Li,Di Sun
Thromboembolism caused by the use of extracorporeal membrane oxygenation (ECMO) remains common among patients with existing heart diseases and contributes to significant morbidity and mortality during the COVID-19 pandemic. Various surface modification strategies have been proposed, showing that the methacrylated alginate (MA-SA) hydrogel layer is transparent, which aids the observation of the thromboembolism from the inner wall of the tubing. In the combined dynamic and static blood of ECMO tubing inner surface in vitro experiments, it was also demonstrated that the adhesion of blood clots to the surface of vessels was remarkably reduced, and the MA-SA-based hydrogel coating could significantly prolong the activated partial thrombin time and block the endogenous coagulation. The favorable properties of natural polysaccharides of hydrogel coatings make them the best surface material choices to be applied for blood-contacting medical devices and significantly improve anticoagulant performance.
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产品关联
DOI
PubMed
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Guoqing Xiao,Fangzhou Li,Yuanyuan Li,Chunyan Chen,Chunlin Chen,Qian Liu,Wanxin Chen
Herein, the utilization of organic hydrogels to solve the problems of weak adhesion and low recurrence resistance of water has been investigated, but the application of organic hydrogels has been modest due to the harsh experimental conditions and expensive synthetic materials. In this paper, a biomass-based composite hydrogel P (SA/CMC/PNIPAM) based on sodium alginate (SA), sodium carboxymethylcellulose (CMC) and N-Isopropyl acrylamide (NIPAM) was prepared by free radical polymerization . The water absorption multiplicity and flame retardant properties of the composite hydrogel were investigated by water absorption multiplicity experiments and characterization analysis. The results implicated that the water absorption capacity of the hydrogel with SA addition was significantly improved compared with the sample without SA addition, and the water absorption rate was increased by 55% under the same conditions. In addition, the cone calorimetry results indicated that the boards immersed in the SA-added hydrogel had the longest ignition time of 79 s compared to the blank board. The values of heat release rate (HRR) (113.1 kW/m 2 ), and total heat release (THR) (29.3 MJ/m 2 ) indicated the best flame retardant performance of the SA-added hydrogel.
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产品关联
DOI
高影响因子
SOLAR ENERGY MATERIALS AND SOLAR CELLS
·
2024
·
IF 6.3
Maoqing Tang,Cong Qi,Linfei Yue
As an environmentally friendly seawater desalination method, solar interface evaporation is considered to be a promising solution to ease the freshwater shortage. In this paper, porous Cu-Fe 3 O 4 /sodium alginate/polyacrylamide hydrogel was prepared by double chemical crosslinking method using sodium alginate, polyacrylamide and Cu-Fe 3 O 4 nanoparticles with good SPR effect as raw materials. The effects of Cu-Fe 3 O 4 nanoparticle concentration, light intensity and salt water concentration on the evaporation performance of hydrogel evaporator were studied. It was found that under the light intensity of 1 sun, the evaporation efficiency and thermal efficiency of 3.5 wt% seawater in the hydrogel evaporator containing Cu-Fe 3 O 4 nanoparticles with a concentration of 0.26 % can reach 64.7 % and 95.24 %, respectively. In addition, the Cu-Fe 3 O 4 /sodium alginate/polyacrylamide hydrogel evaporator has good reusability and salt self-cleaning ability. The seawater desalination experiment in real environment shows that the hydrogel evaporator with low cost benefit has broad application prospects in the field of seawater desalination.
研究领域:
材料科学
·
环境科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）