JOURNAL OF HAZARDOUS MATERIALS
·
2024
·
IF 12.2
Yongzhen Dong,Jiawei Liu,Liqin Kong,Dongyang Deng,Long Wu,Yiping Chen
This study presents the development of a magnetic relaxation switching (MRS) immunosensor for the sensitive detection of chlorpyrifos (CPF) with a signal amplification strategy using Pd/Cu-TCPP(Fe) hybrid nanosheets and polydopamine (PDA). Pd/Cu-TCPP(Fe) nanosheets, which exhibit high peroxidase-like activity and excellent storage stability, making them suitable replacements for natural enzymes in biosensors, are further functionalized with goat anti-mouse IgG (Ab 2 ) to construct an immunosensor. The mechanism relies on the competition between free CPF and the immobilized bovine serum albumin-CPF conjugates for antibody binding, which modulates the aggregation of magnetic nanoparticles (MNPs) that are related to the transverse relaxation time. The optimized immunosensor shows a linear detection range from 0.5 ng/mL to 100 ng/mL and a limit of detection (LOD) of 0.24 ng/mL, outperforming traditional enzyme-linked immunosorbent assay (ELISA) methods by achieving an LOD that is about 9 times lower. Real sample analysis demonstrates the applicability of the Pd/Cu-TCPP(Fe)-PDA-MRS immunosensor for detecting CPF residues in tomato and water samples, with results well consistent with those obtained using gas chromatography. This work highlights the potential of nanomaterials in enhancing the performance of MRS immunosensors for pesticide residue analysis in environmental and food safety monitoring.
研究领域:
分析化学
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环境科学
·
食品安全
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DOI
PubMed
高影响因子
SCIENCE OF THE TOTAL ENVIRONMENT
·
2022
·
IF 10.753
Fujing Deng,Jiani Liu,Zhe Xie,Saishuai Li,Menghong Hu,Daohui Lin,Youji Wang
As a good carrier of contaminants, nanotitanium dioxide (nTiO 2 ) can absorb organic pollutants, producing toxicological effects on organisms. However, the complex effects of nTiO 2 with contaminants on marine mussels are still unclear. In this study, we exposed mussels to tris (2-chloropropyl) phosphate (TCPP) 100 μg/L (T1), 0.5 mg/L nTiO 2 + 100 μg/L TCPP (T2), 1.0 mg/L nTiO 2 + 100 μg/L TCPP (T3) and control (0 nTiO 2 + 0 μg/L TCPP) treatments, and assessed the combined effects of TCPP with nTiO 2 on the thick-shelled mussel Mytilus coruscus by detecting the activities of gill pyruvate kinase (PK), hexokinase (HK), lactate dehydrogenase (LDH) and succinate dehydrogenase (SDH), also gill acetylcholine (Ach) and muscle lactic acid (LD) contents and gut microbiota after 14-d exposure. Compared with the control group, PK activity was increased significantly, but SDH, LDH activities and LD content were decreased significantly in T1, with the addition of nTiO 2 , there were not significantly different in T3. However, Ach content in T3 was significantly higher than the control and T1. Moreover, KEGG of the gut microbiota via 16 s rRNA sequencing showed that most pathways returned to the control level in T3. The results showed that TCPP affected the respiratory metabolism of mussels, changed the community structure of intestinal microflora in mussels, and nTiO 2 alleviated the toxicity of TCPP. Our study provides new insights for ecological risk assessment of TCPP in bivalves in the complex aquatic environment and the novel role of nTiO 2 in regulating the toxicity of TCPP.
研究领域:
环境科学
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海洋生物学
·
毒理学
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DOI
PubMed
高影响因子
Materials Chemistry Frontiers
·
2022
·Vol. 6
·期 15
·2114-2121
·
IF 8.683
Xiangnan Wang,Zeyu Feng,Congyang Ye,Haofeng Zang,Yonghua Lu,Hongli Zhang,Gang Zou
Smart materials with programmable shape deformation and synergistic shape/fluorescence variation are highly desired in various practical applications, such as bio-inspired multifunctional robots and machines. However, it is still quite challenging to construct smart surfaces with dynamic fluorescence and morphology from MOFs, which potentially introduce superior performance. Herein, we proposed to utilize Zn-TCPP MOFs and polyurethane to construct a smart hybrid gel, which could exhibit synergistic dynamic fluorescence and reconfigurable patterns upon treating with pure water. Their reversible fluorescence variation as well as the swelling of the surface could be observed even directly by the naked eye. Based on the above results, we designed a dual-response rewriting pattern and flower-like artificial actuator with simultaneous fluorescence variation and shape deformation performance. This study would be of great fundamental value in the rational design of novel smart materials and surfaces.
研究领域:
材料科学
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化学工程
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DOI
高影响因子
LUMINESCENCE
·
2024
·Vol. 39
·期 3
·e4720
·
IF 3.2
Ximan Zhang,Yun Zhang,Lina Zhao
Developing effective means for detecting contamination in milk during production, processing, and storage is both important and challenging. Tetracycline (TC), due to its use in treating animal infections, is among the most prevalent organic pollutants in milk, posing potential and significant threats to human health. However, efficient and in situ monitoring of TC remains lacking. Nevertheless, we have successfully developed a highly sensitive and selective fluorescence method for detecting TC in milk using a metal–organic framework material made from Yb-TCPP (ytterbium-tetra(4-carboxyphenyl)porphyrin). The calculated Stern–Volmer constant ( K SV ) was 12,310.88 M −1 , and the detection limit was 2.44 × 10 −6 M, surpassing previous reports. Crucially, Yb-TCPP fluoresces in the near-infrared region, promising its development into a specific fluorescence detection product for practical TC detection in milk, offering potential application value.
研究领域:
分析化学
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环境科学
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食品科学
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产品关联
DOI
PubMed
高影响因子
MOLECULES
·
2023
·Vol. 28
·期 6
·2687
·
IF 4.6
Liudi Ji,Qi Wang,Xiaqing Gong,Jiamin Chen,Xiaoming Zhu,Zeyu Li,Peng Hu
Dopamine (DA) is an important neurotransmitter. Abnormal concentration of DA can result in many neurological diseases. Developing reliable determination methods for DA is of great significance for the diagnosis and monitoring of neurological diseases. Here, a novel and simple electrochemical sensing platform for quantitative analysis of DA was constructed based on the Cu-TCPP/graphene composite (TCPP: Tetrakis(4-carboxyphenyl)porphyrin). Cu-TCPP frameworks were selected in consideration of their good electrochemical sensing potential. The graphene nanosheets with excellent conductivity were then added to further improve the sensing efficiency and stability of Cu-TCPP frameworks. The electrochemical properties of the Cu-TCPP/graphene composite were characterized, showing its large electrode active area, fast electron transfer, and good sensing performance toward DA. The signal enhancement mechanism of DA was explored. Strong accumulation ability and high electrocatalytic rate were observed on the surface of Cu-TCPP/graphene-modified glassy carbon electrode (Cu-TCPP/graphene/GCE). Based on the synergistic sensitization effect, an ultrasensitive and simple DA electrochemical sensor was developed. The linear range is 0.02–100 and 100–1000 µM, and the detection limit is 3.6 nM for the first linear range. It was also successfully used in detecting DA in serum samples, and a satisfactory recovery was obtained.
研究领域:
神经科学
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生物医学工程
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分析化学
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产品关联
DOI
PubMed
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2021
·
IF 10.618
Yu Wang,Xitong Zhou,Wanxin Dong,Qinsong Zhong,Xinxin Mo,He Li
In this work, we synthesized Fe-Tcpp@ICG(ICG, Indocyanine green) with light stimuli-response through 5,10,15,20-tetrakis (4-carboxyphenyl) porphyrin (Fe-Tcpp) loaded ICG by electrostatic adsorption. The morphology and properties of Fe-Tcpp and Fe-Tcpp@ICG were characterised by ultraviolet–visible absorption spectrometer, X-ray diffraction, thermogravimetric analyzer and transmission electron microscope , respectively. A non-enzymatic photoelectrochemical sensor based on Fe-Tcpp@ICG was constructed to quantitatively detect hydrogen peroxide in tumor microenvironment . Under the optimal conditions, the linear range of detecting hydrogen peroxide was 0.01–50 mmol/L with detection limit of 0.2 μmol/L (S/N = 3). This sensor proposed a simple, fast, sensitive and label-free method for the detection of hydrogen peroxide. Moreover, the results also showed that the Fe-Tcpp@ICG can catalyze the decomposition of hydrogen peroxide to generate singlet oxygen, which can kill tumor cells. These indicated that this material was expected to be used for detecting hydrogen peroxide and inhibition of tumor cell growth.
研究领域:
生物化学
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纳米技术
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癌症研究
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DOI
PubMed
高影响因子
CHEMOSPHERE
·
2020
·
IF 5.778
Hang Liu,Hua Yin,Shaoyu Tang,Hui Peng,Xiaolong Yu,Guining Lu,Zhi Dang
In this work, the prepared mesoporous TiO 2 was employed to eliminate the environmental risk induced by the combined pollution (tris-(2-chloroisopropyl) phosphate (TCPP) and Cd 2+ ). The prepared material was characterized by X-ray diffraction (XRD), UV–vis diffuse reflectance spectra (UV-DRS), Raman imaging spectrometer (Raman), N 2 adsorption/desorption isotherm and X-ray photoelectron spectroscopy (XPS). In the combined pollution system, the prepared TiO 2 simultaneously exhibited a higher adsorption and photocatalytic activity for Cd 2+ and TCPP at neutral condition, respectively. The adsorption of Cd 2+ and photo-degradation of TCPP by mesoporous TiO 2 followed pseudo-second-order and pseudo-first-order kinetics model, respectively. The removal efficiency of TCPP was improved from 67% to 100% when the concentration of co-existed Cd 2+ increased from 0.5 mg L −1 to 2 mg L −1 , due to the fact that the adsorbed Cd 2+ on the surface of TiO 2 scavenged electron and thus inhibited the photo-generated electron-hole pairs recombination. In addition, six degradation intermediates were determined by high resolution mass spectrum (HRMS) and potential transformation pathways of TCPP under the co-existence of Cd 2+ were proposed. The results suggested that rapid and high-efficient simultaneous removal of Cd 2+ and TCPP was feasible, which laid the basis for the remediation of other combined pollution in the future.
研究领域:
环境科学
·
材料科学
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产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2025
·
IF 13.2
Jiawei Li,Zejing Chu,Shimeng Wang,Haipeng Liu,Biao Dong
Photodynamic antibacterial based on metal organic framework (MOF) structure shows broad application prospects. But it is limited by the problem of hypoxia in the bacterial microenvironment. The oxygen-producing nanozyme strategy is the key to solving the problem. In this work, MnO 2 oxygen-producing nanozyme was introduced on the basis of the metal organic framework Cu-TCPP to obtain Cu-TCPP@MnO 2 , which can produce oxygen synchronously during PDT. Moreover, under the excitation of 660 + 808 nm dual laser irradiation, the synergistic treatment of PDT, CDT and PTT was achieved. In the in vitro antibacterial experiment, the inhibition rate of Cu-TCPP@MnO 2 against Staphylococcus aureus under dual laser excitation can reach 99.9 %, and the biofilm removal rate is close to 80 %. The inhibition rate of Escherichia coli is also as high as 99.5 %. In the in vivo treatment of mouse models, the wound area was only 2.39 % after 13 days, achieving efficient sterilization, controlling inflammation and promoting tissue repair. This synergistic antibacterial strategy has shown remarkable effects in wound healing giving the material great potential for medical applications.
研究领域:
生物医学工程
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纳米医学
·
感染与免疫
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产品关联
DOI
高影响因子
MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 9
·1-15
·
IF 5.3
Wu Yuqi,Shan Xueling,Zhao Ziyu,Jiang Ding,Yan Guoping,Wang Wenchang,Shiigi Hiroshi,Hu Zhibang,Chen Zhidong
A dual-ligand strategy was employed to construct an electrochemiluminescence (ECL) sensing platform based on dual-ligand Tb-MOF and Ag 3 PO 4 @TCPP for sensitive detection of chloramphenicol (CAP), demonstrating its potential applications in environmental monitoring and food safety. The dual-ligand Tb-MOF can be used as a co-reactant promoter, facilitating the rapid electroreduction of S 2 O 8 2− to generate more oxidative mediator SO 4 •− , thereby enhancing the luminescence efficiency of the luminescent material Ag 3 PO 4 @TCPP. Furthermore, the integration of Ag 3 PO 4 @TCPP emitter could effectively overcome the aggregation-caused quenching (ACQ) effect of TCPP and then increase the luminescence intensity by seven-fold, which was attributed to the efficient electron transfer and energy transfer between Ag 3 PO 4 and TCPP. Additionally, ECL spectra and electron spin resonance (ESR) spectra were utilized to investigate the possible ECL mechanism of the dual-ligand Tb-MOF/Ag 3 PO 4 @TCPP system. As a proof of concept, we successfully established an ECL biosensor for detecting CAP, which displayed a wide linear range (10 −6 ~ 10 −15 M) and low detection limit (8.29 × 10 −16 M), demonstrating practical feasibility. This study introduces a dual-ligand strategy to enhance ECL signals, expands the application scope of dual-ligand lanthanide MOFs, and provides new insights into designing high-performance sensing platforms. Graphical
研究领域:
分析化学
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材料科学
·
环境监测
·
食品安全
·
生物传感技术
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Energy Storage
·
2023
·
IF 9.4
Shuai Zhang,Ying Huang,Jiaming Wang,Song Zhang,Xiaopeng Han,Xu Sun
With the development of electronic technology, portable and wearable electronics are becoming increasingly indispensable in our lives, which promotes a high demand for flexible power supplies. To develop lightweight, flexible, and high performance energy storage devices, we have prepared MXene and Co-TCPP nanosheet composites (CoMX) with excellent electrochemical properties by electrostatic self-assembly. Co-TCPP is inserted between MXene layers and successfully improves ion accessibility and enhances electrochemical performance. CoMX film electrodes fabricated by vacuum filtration show high specific capacitance (1591.7 mF/cm 2 ) and exhibit excellent cycling stability, with a capacity retention rate of 99.81 % after 8000 cycles. Flexible all-solid-state supercapacitors (SC) assembled with CoMX film and interdigital electrodes both exhibit excellent capacitance performance. The in-plane SC exhibits competitive specific capacitance (330.0 mF/cm 2 ) and energy density (37.13 μWh/cm 2 at 450 μW/cm 2 ). The specific capacitance and energy density of interdigital SC achieve 89.9 mF/cm 2 and 12.9 μWh/cm 2 , respectively. The competitive performance of both devices makes them highly promising for flexible energy storage devices.
研究领域:
材料科学
·
能源存储技术
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产品关联
DOI
高影响因子
FOOD CHEMISTRY
·
2023
·
IF 8.8
Xiaohai Yan,Yahong Yuan,Tianli Yue
Patulin (PAT) is a potentially harmful mycotoxin to human health and is known to contaminate apple juice. In this work, we developed a ratiometric fluorescence aptasensor using tetrakis(4-carboxyphenyl)porphyrin (H 2 TCPP)-treated octahedral UiO-66-NH 2 (defined as UiO-66-TCPP) to detect PAT. This 2-aminoterephthalic acid and H 2 TCPP functionalized metal-organic framework showed multiple adsorption effects (hydrogen bonding and π–π stacking) on the aptamer (Apt) and served as a quenching material. When the target PAT bound specifically to the Apt, the fluorescence of the 6-carboxyfluorescein-labeled Apt would recover, and the fluorescence of the H 2 TCPP ligand remained unchanged. This ratiometric fluorescence property improved the accuracy of PAT detection. Moreover, the introduction of the H 2 TCPP ligand enhanced the quenching efficiency of UiO-66-NH 2 , thus improving the sensitivity of the fluorescent aptasensor (UiO-66-TCPP vs. UiO-66-NH 2 : 0.0162 ng/mL vs. 1.8 ng/mL). In addition, we used UiO-66-TCPP to detect PAT in apple juice samples. This work provides a good paradigm for the construction of ratiometric fluorescence aptasensors with high sensitivity and accuracy.
研究领域:
食品科学
·
分析化学
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产品关联
DOI
PubMed
高影响因子
APPLIED SURFACE SCIENCE
·
2023
·
IF 6.7
Jiaqian Zhang,Jinjuan Xue,Zhenbo Wu,Mingxin Wang,Yiting Lv,Zhaoxia Chen,Shuaishuai Ma
In this work, we fabricated a multifunctional membrane by in-situ growth of tetrakis (4-carboxyphenyl) porphyrin-doped UiO-66-NH 2 on stainless steel mesh (SSM), denoted as TCPP/UiO@SSM, for gravity-driven oil–water/seawater mixtures separation and visible-light-driven bacterial inactivation. The as-prepared membrane exhibited high permeation flux (up to 46312 ± 1583 L m −2 h −1 ) as well as separation efficiency (above 98%) towards various oil–water/seawater mixtures separation, which resulted from the rough hierarchical structure and the inherent super-wettability. In particular, the membrane can effectively deal with viscous oil fouling to achieve a desired flux recovery ratio (FRR) after separating crude oil from water, attributing to the self-cleaning property originated from the photo-active TCPP/UiO. Furthermore, the as-fabricated TCPP/UiO@SSM has the ability to efficiently inactivate typical Gram bacteria (6 log units) in water under visible light . Both the oil–water separation and photocatalytic sterilization performances of TCPP/UiO@SSM are superior to UiO@SSM. The doping of photosensitive TCPP in UiO-66-NH 2 not only improved the hydrophilicity, but also enhanced the photocatalytic activity by creating a Z-scheme heterojunction to promote the separation of charge carriers and amplify the photothermal effect. This work provides a new platform for water disinfection and the treatment of oily wastewater containing viscous oil phase based on UiO metal–organic framework.
研究领域:
材料科学
·
环境科学
·
光催化技术
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）