SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2020
·
IF 3.232
Aisen Li,Yan Liu,Changjiang Bi,Weiqing Xu,Zhiyong Ma,Haining Cui,Shuping Xu
The effects of the high pressure on two single crystals , pyrene and N , N -diphenyl-4-(pyren-1-yl)aniline (TPA-Py), were studied by in situ fluorescent and Raman spectroscopies . During the compression, the pyrene with one structureless excimer emission band showed a continuous bathochromic-shift. In contrast, with the pressure increasing to 10.36 GPa, TPA-Py previously dominated with the hybridized local and charge transfer (HLCT) excited state gradually exhibited a new band at longer wavelengths, which is assigned to a new excited state species with the intramolecular charge transfer (ICT) state, caused by the pressure-induced changes on its molecular configuration. Accompanied by the spectral changes, a sequential color variation from blue to cyan was observed, giving a change to yellow and then red. The significant broadening of the full-width half-maximum (FWHM) of the TPA-Py is observed due to the enhanced dipole-dipole interaction and the existence of pressure gradient . Both pyrene and TPA-Py showed the delayed recovery of the luminescence in the compression-decompression cycle, which results from the poor reversibility of electronic structure caused by the compression-induced piezochromic effect. Furthermore, the evolutions of the Raman spectra of pyrene and TPA-Py indicated that the pressure-induced reversible transformation is caused by the molecular conformational change. This study is a deeper understanding of the structure-property relation of the HLCT species and will be a helpful reference for the regulation of photoluminescence in these intramolecular electron donor-acceptor crystal materials.
研究领域:
材料科学
·
光物理
·
高压物理
·
发光材料
·
光谱学
✓ 已验证
DOI
高影响因子
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY
·
2022
·
IF 4.831
Dan Li,Peipei Zhou,Yufei Hu,Gongke Li,Ling Xia
Triphenylamine functionalized polyhedral oligomeric silsesquioxane (POSS@TPA) was prepared using the Friedel-Crafts reaction with tris(4-bromophenyl)amine (TPA) as the functional monomer and polyhedral oligomeric silsesquioxane (POSS) as the framework. The as-prepared POSS@TPA has a stable structure and accomplished pore performance, allowing for the selective adsorption of Sudan I and result in the fluorescence quenches of POSS@TPA. Thus, the POSS@TPA could be used as sensors to fluorescence detect 0.12–7.4 mg/L Sudan I, with a detection limit of 0.091 mg/L. Moreover, the POSS@TPA have good reuseability can be reused more than 5 cycles after washing. Noteworthily, the response time of POSS@TPA for determination was as short as 1 min. Furthermore, the sensor was effectively used to determine Sudan I in cakes with excellent recoveries (86.4–108.8 %) and relative standard deviations (2.5–4.9 %). The results matched those of high-performance liquid chromatography (HPLC). Our work shows great potential in terms of the rapid detection of food safety.
研究领域:
食品安全
·
分析化学
✓ 已验证
DOI
高影响因子
JOURNAL OF MEDICINAL CHEMISTRY
·
2024
·
IF 6.8
Zhiming Xing,Jiangyu Yan,Yongxiang Miao,Yawen Ruan,Haojun Yao,Youkang Zhou,Yingqun Tang,Guorui Li,Zhibin Song,Yiyuan Peng,Jing Huang
Lethal lipid peroxidation caused by reactive oxygen species occurs in different types of programmed cell death, especially in ferroptosis. Ferroptosis inducers, which serve as small-molecule probes, can provide insight into the mechanism of ferroptosis and facilitate drug discovery. The classical ferroptosis inducers indirectly lead to lipid peroxidation; thus, it is difficult to explore lipid regulation during the ferroptotic process. In this study, we designed two quinazolinone-based lipophilic probes BODIQPy-TPA and QPy-TPA, which proved to directly induce lipid peroxidation by light irradiation in vitro. The probe BODIQPy-TPA, which was mainly distributed in the endoplasmic reticulum (ER), specifically triggered ferroptosis in B16 and HepG2 cells upon light irradiation. As a comparison, the probe QPy-TPA, which was mainly distributed in lipid droplets (LDs), induced cell death by a nonferroptotic pathway. Further lipidomic analysis revealed that these two probes caused different patterns of lipid regulation and lipid peroxidation, suggesting that ferroptosis might activate distinct lipid regulation.
研究领域:
细胞生物学
·
药理学
·
化学生物学
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Essential Oil Bearing Plants
·
2022
·
IF 1.971
Chunlian Li,Xiaobin Lin,Qiuyang Cai,Weicheng Zhang,Xianyi Wu,Zekai Tan,Lewen Yao,Shiyuan Huang,Yanghe Yuan,Lanyue Zhang
The perennial herb Alpinia oxyphylla Miq. (Zingiberaceae) is an important traditional medicinal plant in China. The present study evaluated the chemical composition of A. oxyphylla essential oil (AOEO) using GC-MS. The AOEO contained 55 compounds, including nootkatone (20.12%), valencene (12.26%), and ethyl-p-methoxycinnamate (5.00%). Previous studies have shown that AOEO possesses significant antioxidant and antibacterial activities. However, the anti-inflammatory effect of AOEO on tissue plasminogen activator (TPA)-induced ear edema is yet to be reported. In this study, TPA-induced ear edema was used to investigate the anti-inflammatory activity of AOEO. Hematoxylin and eosin staining of mouse tissue sections indicated that AOEO reduced the degree of edema, and immunohistochemistry experiments revealed that AOEO inhibited the expression of tumor necrosis factors, such as cyclooxygenase 2 (COX-2), interleukin-6 (IL-6), and nuclear factor-kappa B (NF-κB). A. oxyphylla is a commonly used traditional Chinese medicine with good biological activity. Analysis of the species potential geographical distribution and diversity indicated that the species can be rationally protected and exploited. Based on the chemical composition and biological activity of AOEO, further research and development should effectively promote the development of medicine, food, and cosmetics industries. The potential distribution of A. oxyphylla under current climatic conditions was predicted using DIVA-GIS and geographic information from herbarium specimens and other documents. The species predicted distribution spanned more than 12 provinces in China and was the most extensive in Hainan. Under current climatic conditions, A. oxyphylla is suitable for growing and expanding its population in the warm, humid regions of southern China.
研究领域:
植物学
·
药理学
·
生物化学
✓ 已验证
DOI
高影响因子
ACS Applied Materials & Interfaces
·
2024
·
IF 8.3
Junjun Su,Xinyi Zhang,Zixuan Dong,Hongfei Pan,Fei Zhang,Xianggao Li,Shirong Wang,Zhijian Chen
In this study, a series of dopant-free, low-cost hole-transporting materials (HTMs) based on triphenylamine-functionalized azadipyrromethene dyes 1–3 (TPA-ADPs 1–3) were designed and synthesized. The properties of these new HTMs were investigated by optical spectroscopy, cyclic voltammetry, thermogravimetric analysis, differential scanning calorimetric, atomic force microscopy, and X-ray diffraction, as well as theoretical calculations. The results indicated that the TPA-ADPs 1–3 presented well-matched energy levels with perovskite, higher hole mobility, as well as more effective defect passivation at the perovskite/HTM interface by the coordination interaction between the ADP moiety and the undercoordinated Pb2+. The n-i-p perovskite solar cells (PSCs) employing HTMs 1–3 as well as doped Spiro-OMeTAD were fabricated and characterized. The TPA-ADP 1-based PSCs exhibited the best performance with a champion power conversion efficiency (PCE) of 22.13% and an fill factor of 0.81, which was superior to that of the devices based on the doped Spiro-OMeTAD. Long-term device performance studies indicated that the TPA-ADP 1-based PSCs maintained 80% of the initial PCE after 1800 h of storage in the ambient condition of 40–60% RH, which was also higher than the stability of doped Spiro-OMeTAD-based devices under the same conditions.
研究领域:
材料科学
·
能源技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
DYES AND PIGMENTS
·
2022
·
IF 5.122
Le Wang,Xiaohong Pan,Shuzhi Tang,Yaqi Wang,Haixing Shi,Huanhuan Wang,Wenzhen Liu,Zhuo Chen
The skin microbiota is an inseparable component of the skin barrier structure, which participates in the stabilization or impairment of the barrier function as well as the development of many skin diseases. In order to maintain the stability of skin bacteria community structure, people pay more and more attention to protecting probiotics, such as bacilli, and killing pathogens, such as Gram-positive cocci. We herein report a negatively charged photosensitizer TPA-3NBA with aggregation-induced emission (AIE) characteristics, which was synthesized by one-step reaction, can selectively and rapidly stain (within 0.5 min) and effectively kill Gram-positive cocci (killing 6.0 log 10 of Staphylococcus aureus at a concentration of 1 μM) without affecting bacilli under white light irradiation. This selective bacterial imaging makes it possible to quickly identify locally bacterial infection. Furthermore, the normal concentration of divalent ion (Ca 2+ ) in human body can significantly promote the absorption of TPA-3NBA by Gram-positive cocci, thus improving its antibacterial activity. To the best of our knowledge, this is the first photosensitizer to be reported with good performance in selective bacterial imaging and removal of Gram-positive pathogenic cocci, indicating its potential application prospect in targeted antimicrobial therapy.
研究领域:
微生物学
·
药理学
·
皮肤病学
✓ 已验证
产品关联
DOI
高影响因子
Advanced Healthcare Materials
·
2022
·Vol. 11
·期 16
·2200416
·
IF 11.092
Xingping Quan,Yan Han,Pengde Lu,Yuanfu Ding,Qingfu Wang,Yiyang Li,Jianwen Wei,Qiaoxian Huang,Ruibing Wang,Yonghua Zhao
Thromboembolic stroke is typically characterized by the activation of platelets, resulting in thrombus in the cerebral vascular system, leading to high morbidity and mortality globally. Intravenous thrombolysis by tissue plasminogen activator (tPA) administration within 4.5 h from the onset of symptoms is providing a standard therapeutic strategy for ischemic stroke, but this reagent simultaneously shows potential serious adverse effects, e.g., hemorrhagic transformation. Herein, a novel delivery platform based on Annexin V and platelet membrane is developed for tPA (APLT-PA) to enhance targeting efficiency, therapeutic effects, and reduce the risk of intracerebral hemorrhage in acute ischemic stroke. After preparation by extrusion of platelet membrane and subsequent insertion of Annexin V to liposomes, APLT-PA exhibits a high targeting efficiency to activated platelet in vitro and thrombosis site in vivo, due to the binding to phosphatidylserine (PS) and activated platelet membrane proteins. One dose of APLT-PA leads to obvious thrombolysis and significant improvement of neurological function within 7 days in mice with photochemically induced acute ischemic stroke. This study provides a novel, safe platelet-biomimetic nanomedicine for precise thrombolytic treatment of acute ischemic stroke, and offers new theories for the design and exploitation of cell-mimetic nanomedicine for diverse biomedical applications.
研究领域:
药剂学
·
神经科学
·
纳米技术
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Journal of Materials Chemistry C
·
2021
·Vol. 9
·期 14
·4888-4894
·
IF 7.393
Xiaoping Guo,Shijie Zhen,Tianchang Ouyang,Shangxiong Zhou,Qiwen Pan,Dandan Yang,Jianhao Chen,Guoping Dong,Zujin Zhao,Jianrong Qiu,Ben Zhong Tang
With the wide use of micro–nano photonic devices in on-chip optical communication, physical and chemical sensing, organic microlasers have gained increasing attention owing to their special advantages including high integration, easy preparation and excellent optical properties. However, traditional microlasers suffer from the “aggregation-caused quenching” (ACQ) effect of gain molecules and high lasing thresholds. In this contribution, we meticulously designed organic microlaser assemblies based on an “aggregation-induced emission” (AIE) fluorophore for its unique characteristics. An innovative AIE fluorophore, namely triphenylamine-benzo[1,2-b:4,5-b′]-dithiophene 1,1,5,5-tetraoxide (TPA-BDTO), with highly efficient emission at the aggregated state is employed to hybridize with the PMMA matrix, obtaining microbottles with an ultra-smooth surface via the self-assembled strategy. Benefiting from the spatially well-separated intensity based on the prolate shape of the TPA-BDTO–PMMA microbottle, we realize a single-mode microlaser in a microbottle with an appropriate pump power via precise manipulation. Moreover, the TPA-BDTO–PMMA microlaser is demonstrated as an axial tensile strain sensor with high sensitivity (0.34 pm με−1), high resolution, real-time response and simple structure, which create new opportunities for organic microlasers and even lay a foundation for the research of lab-on-chips.
研究领域:
光学
·
材料科学
·
传感器技术
✓ 已验证
产品关联
DOI
高影响因子
Communications Biology
·
2023
·Vol. 6
·期 1
·1-13
·
IF 5.9
Guo Wenbin,Duan Jingjing,Shi Zhengguang,Yu Xue,Shao Zongze
Evidence for microbial biodegradation of polyethylene terephthalate (PET) has been reported, but little is known about the PET biodegradation process and molecular mechanism by marine microorganisms. Here, we show the biodegradation of PET by the membrane-anchored PET esterase from the marine bacterium Rhodococcus pyridinivorans P23, elucidate the properties of this enzyme, and propose the PET biodegradation by this strain in biofilm. We identify the PET-degrading enzyme dubbed PET esterase through activity tracking. In addition to depolymerizing PET, it hydrolyzes MHET into TPA under acid conditions. We prove that it is a low and constitutively transcribed, membrane-anchored protein displayed on the cell surface. Furthermore, we also investigate the microbial groups possessing PET esterase coupled with the TPA degradation pathway, mainly in the phyla Proteobacteria and Actinobacteriota . Clarification of the microbial PET biodegradation in the marine environment will contribute to the understanding of bioremediation of marine PET pollution.
研究领域:
环境微生物学
·
生物技术
·
海洋污染
✓ 已验证
产品关联
DOI
PubMed
高影响因子
TALANTA
·
2012
·
IF 3.794
Baomei Huang,Xibin Zhou,Zhonghua Xue,Guofan Wu,Jie Du,Di Luo,Tao Liu,Jing Ru,Xiaoquan Lu
Efficient and stable quenching of electrochemiluminescence of Ru(bpy) 3 2+ /TPA by malachite green(MG) and crystal violet(CV) at the glass carbon (GC) electrode is reported. A novel quenching mechanism has been proposed. Resonance energy transfer from the excited-state luminophore Ru(bpy) 3 2+⁎ to MG/CV and dynamic quenching are suggested as the mechanism for quenching ECL. The quenching mechanism is discussed in detail based on UV–visible absorption spectra, cyclic voltammograms, ECL curves and fluorescence methods . MG shows more efficient quenching than CV. Moreover, the quenched ECL intensity versus the concentration of MG and CV are linear over the concentration ranges of 8×10 −10 –8×10 −7 M and 3.46×10 −9 –5.5×10 −7 M, respectively. The corresponding limit of detection (LOD) was 1.0×10 −10 M for MG and 1.1×10 −10 M for CV ( S / N =3).
研究领域:
分析化学
·
电化学
·
发光光谱学
·
传感器与生物传感器
✓ 已验证
DOI
高影响因子
MACROMOLECULES
·
2019
·
IF 5.997
Ningwei Sun,Kaixin Su,Ziwei Zhou,Xuzhou Tian,Zhao Jianhua,Danming Chao,Daming Wang,Franziska Lissel,Xiaogang Zhao,Chunhai Chen
Electrofluorochromic (EFC) materials have aroused great interest owing to their interesting ability of tuning fluorescence in response to the applied potential. However, some crucial characteristics, such as response speed, fluorescence contrast, and switching stability, are still not well realized to meet the requirements of practical applications. Herein, we designed and synthesized a novel polyamide-bearing aggregation-induced emission (AIE)-active tetraphenylethylene (TPE) and a highly conjugated triphenylamine (TPA) pendant group. The rational combination of the highly conjugated TPA and TPE caused the resultant polymer to exhibit highly integrated electrochromic (EC) and EFC performances including multiple color-changing (colorless to green to blue), fast response speed (1.8/1.1 s for EC and 0.4/2.9 s for EFC process), high fluorescence contrast (82 at the duration time of 20 s), and excellent long-term stability over 300 cycles. The strategy of AIE functionality by combing a highly conjugated redox unit demonstrates a synergistic effect to prepare high-performance emission/color dual-switchable materials, greatly promoting their applications in sensors, smart windows, and displays.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
Nanomaterials
·
2022
·Vol. 12
·期 13
·2222
·
IF 5.719
Ye Tian,Qilin Wei,Hui Peng,Zongmian Yu,Shangfei Yao,Bao Ke,Qiuyan Li,Bingsuo Zou
Blue-luminescence materials are needed in urgency. Recently, zero-dimensional (0D) organic metal halides have attractive much attention due to unique structure and excellent optical properties. However, realizing blue emission with near-UV-visible light excitation in 0D organic metal halides is still a great challenge due to their generally large Stokes shifts. Here, we reported a new (0D) organic metal halides (TPA)2PbBr4single crystal (TPA+= tetrapropylammonium cation), in which the isolated [PbBr4]2−tetrahedral clusters are surrounded by organic ligand of TPA+, forming a 0D framework. Upon photoexcitation, (TPA)2PbBr4exhibits a blue emission peaking at 437 nm with a full width at half-maximum (FWHM) of 50 nm and a relatively small Stokes shift of 53 nm. Combined with density functional theory (DFT) calculations and spectral analysis, it is found that the observed blue emission in (TPA)2PbBr4comes from the combination of free excitons (FEs) and self-trapped exciton (STE), and a small Stokes shift of this compound are caused by the small structure distortion of [PbBr4]2−cluster in the excited state confined by TPA molecules, in which the multi-phonon effect take action. Our results not only clarify the important role of excited state structure distortion in regulating the STEs formation and emission, but also focus on 0D metal halides with bright blue emission under the near-UV-visible light excitation.Keywords:self-trapped exciton;0D organic metal halides;photoluminescence mechanism;blue emission;excited state structure distortion
研究领域:
材料科学
·
光学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）