Theranostics
·
2020
·
IF 8.579
Xie-an Yu,Mi Lu,Yingping Luo,Yiting Hu,Ying Zhang,Zhiming Xu,Shuaishuai Gong,Yunhao Wu,Xiao-Nan Ma,Bo-Yang Yu,Jiangwei Tian
Rationale: Despite considerable advances, the reactive oxygen species (ROS)-mediated cancer treatment suffers from the problems of up-regulation of adaptive antioxidants in cancer cells as well as side effects to normal cells. Therefore, development of a new generation of cancer-specific nanomedicine capable of amplifying oxidative stress would be of great interest for accurate and effective cancer treatment. Methods: Herein, transferrin (Tf)-decorated, dihydroartemisinin (DHA), L -buthionine-sulfoximine (BSO), and CellROX-loaded liposomal nanoparticles (Tf-DBC NPs) were developed for precise cancer theranositcs. Tf-DBC NPs could specifically recognize cancer cells via Tf-Tf receptor binding and be uptaken into the lysosomes of cancer cells, where Tf-DBC NPs were activated to release Fe(II), DHA, and BSO. ROS was generated by DHA in the presence of Fe(II), and GSH was depleted by BSO to disrupt the redox balance in cancer cells. Furthermore, CellROX, as a fluorescent probe for imaging of intracellular oxidative stress, was used to monitor the therapeutic efficacy. Results: The integration of Tf, DHA, and BSO into the acidic pH-responsive liposomes selectively and effectively killed cancer cells and prevented the oxidative injury to normal cells. The high oxidative state was visualized at the tumor site and the amplification of oxidative stress enabled tumor eradication by Tf-DBC NPs, demonstrating the successful implementation of this novel strategy in vivo . Conclusion: Our study provides a new paradigm for the design of ROS-mediated therapeutics and offers a promising perspective for precise cancer treatment.
研究领域:
纳米技术
·
癌症治疗
·
药学
·
生物医学工程
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
ADVANCED FUNCTIONAL MATERIALS
·
2025
·
IF 19
Mengjun Wang,Linyu Nian,Shuo Zhang,Yan Zeng,Wei Man,Xiaoyang Sun,Suilou Wang,Chongjiang Cao
Despite significant advancements in probiotics therapy for ulcerative colitis, its unsatisfactory efficacy and safety concerns impede further clinical applications. Herein, inspired by the natural secretion of outer membrane vesicles (OMVs) and colon colonization behavior of probiotics, a biomimetic probiotics platform (OSM) using bicontinuous single primitive metal–phenolic networks (SP-MPNs) loaded with OMVs derived from E. coli Nissle 1917 (EcN) is developed. Notably, the ordered mesopores, high specific surface area, and excellent antioxidant properties of SP-MPNs demonstrate a high loading capacity (≈30%, w / w ) and protective effects for OMVs. Impressively, OSM not only responds to transferrin (Tf) for the slow release of OMVs but also strongly interacts with mucin in the mucus layers, prolonging the retention time of OMVs in the colon (>48 h). Furthermore, OSM exhibits robust antioxidant, anti-inflammatory, and immunoregulatory activities. Significantly, in comparison with the probiotic EcN, OSM demonstrates superior adhesion properties, higher OMVs release amount, and eliminates the risk of inducing bacteremia. To protect OSM from gastric acid degradation, OSM is encapsulated into ascorbyl palmitate (AP) to form OMVs@SP-MPNs@AP (OSMA) hydrogel, which demonstrates preventive and therapeutic efficacy in colitis mouse models. In summary, the biomimetic platform provides a promising approach for the prevention and treatment of gastrointestinal disorders.
研究领域:
胃肠病学
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药理学
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生物医学工程
·
治疗学
✓ 已验证
产品关联
DOI
高影响因子
BIOSENSORS & BIOELECTRONICS
·
2014
·
IF 6.451
Wei Fang,Zhuyuan Wang,Shenfei Zong,Hui Chen,Dan Zhu,Yuan Zhong,Yiping Cui
A type of pH-controllable drug carrier is demonstrated based on mesoporous silica nanoparticles and chitosan/poly (methacrylic acid), which can simultaneously serve as the surface enhanced Raman scattering (SERS) traceable drug carriers for targeting cancer cells. The pH-sensitive releasing characteristics can be achieved by coating the nanoparticles with a layer of chitosan/poly (methacrylic acid) (CS-PMAA), while strong SERS signals can be obtained from the SERS reporter tagged Ag nanoparticles in the core. Our experimental results show that doxorubicin (DOX) was effectively encapsulated into the nanocarriers and can be released in response to the ambient pH value. Specifically, an increased amount of DOX release was observed at lower pH value. In addition, the composite nanoparticles were conjugated with transferrin (Tf) to target transferrin receptor (TfR)-overexpressed cancer cells. The targeting ability as well as the intracellular location of the drug carrier was investigated through SERS mapping while the distribution of DOX was monitored by fluorescence images. The results show that the demonstrated drug carrier can simultaneously fulfill the functionalities of pH-responsive drug release, SERS-traceable characteristics and cancer cells targeting, which has a unique potential for the pH-controllable drug delivery nanosystems .
研究领域:
纳米技术
·
药学
·
癌症研究
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2024
·
IF 9.4
Xiaoqin Zhang,Yijun Zhai,Bin Xie,Min Li,Haoran Lang,Yi Yang,Ji Chen,Yuxiang Chen,Qiaoji Zheng,Yu Huo,Ruyi Zhao,Kwok-Ho Lam,Dunmin Lin
Aqueous zinc-ion batteries (AZIBs) have attracted significant attention owing to their inherent security, low cost, abundant zinc (Zn) resources and high energy density. Nevertheless, the growth of zinc dendrites and side reactions on the surface of Zn anodes during repeatedly plating/stripping shorten the cycle life of AZIBs. Herein, a simple organic molecule with abundant polar functional groups, 2,2,2-trifluoroether formate (TF), has been proposed as a high-efficient additive in the ZnSO 4 electrolyte to suppress the growth of Zn dendrites and side reaction during cycling. It is found that TF molecules can infiltrate the solvated sheath layer of the hydrated Zn 2+ to reduce the number of highly chemically active H 2 O molecules owing to their strong binding energy with Zn 2+ . Simultaneously, TF molecules can preferentially adsorb onto the Zn surface, guiding the uniform deposition of Zn 2+ along the crystalline surface of Zn(0 0 2). This dual action significantly inhibits the formation of Zn dendrites and side reactions, thus greatly extending the cycling life of the batteries. Accordingly, the Zn//Cu asymmetric cell with 2 % TF exhibits stable cycling for more than 3,800 cycles, achieving an excellent average Columbic efficiency (CE) of 99.81 % at 2 mA cm −2 /1 mAh cm −2 . Meanwhile, the Zn||Zn symmetric cell with 2 % TF demonstrates a superlong cycle life exceeding 3,800 h and 2,400 h at 2 mA cm −2 /1 mAh cm −2 and 5 mA cm −2 /2.5 mAh cm −2 , respectively. Simultaneously, the Zn//VO 2 full cell with 2 % TF possesses high initial capacity (276.8 mAh/g) and capacity retention (72.5 %) at 5 A/g after 500 cycles. This investigation provides new insights into stabilizing Zn metal anodes for AZIBs through the co-regulation of Zn 2+ solvated structure and surface crystallography.
研究领域:
材料科学
·
电化学
·
电池技术
✓ 已验证
DOI
高影响因子
Nature Communications
·
2022
·Vol. 13
·期 1
·1-8
·
IF 17.694
Liu Chun-Yu,Yuan Shang-Fu,Wang Song,Guan Zong-Jie,Jiang De-en,Wang Quan-Ming
Copper hydrides are important hydrogenation catalysts, but their poor stability hinders the practical applications. Ligand engineering is an effective strategy to tackle this issue. An amidinate ligand, N,N′-Di(5-trifluoromethyl-2-pyridyl)formamidinate (Tf-dpf) with four N-donors has been applied as a protecting agent in the synthesis of stable copper hydride clusters: Cu 11 H 3 (Tf-dpf) 6 (OAc) 2 ( Cu 11 ) with three interfacial μ 5 -H and [Cu 12 H 3 (Tf-dpf) 6 (OAc) 2 ]·OAc ( Cu 12 ) with three interstitial μ 6 -H. A solvent-triggered reversible interconversion between Cu 11 and Cu 12 has been observed thanks to the flexibility of Tf-dpf. Cu 11 shows high activity in the reduction of 4-nitrophenol to 4-aminophenol, while Cu 12 displays very low activity. Deuteration experiments prove that the type of hydride is the key in dictating the catalytic activity, for the interfacial μ 5 -H species in Cu 11 are involved in the catalytic cycle whereas the interstitial μ 6 -H species in Cu 12 are not. This work highlights the role of hydrides with regard to catalytic hydrogenation activity.
研究领域:
材料科学
·
化学工程
·
催化
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）