Journal of Materials Chemistry B
·
2018
·Vol. 6
·期 21
·3586-3599
·
IF 4.776
Xiaoqin Chen,Jing Sun,Huan Zhao,Ke Yang,Yuda Zhu,Hongrong Luo,Kui Yu,Hongsong Fan,Xingdong Zhang
For synchronous theranostic systems, there are two areas of focus. These are: excellent in vivo imaging and a multi-drug resistance (MDR) reversing ability for chemotherapy. Upconversion nanoparticles (UCNPs) exhibiting bright red emission in the “optical window in biological tissue (600–1100 nm)” could be a very useful candidate, although there have only been a few reports on UCNP-based conjugates with a MDR reversal ability explored for chemotherapy. Herein, we report an innovative theranostic system (D-UNT) via binding of an antitumor drug (DOX) and a MDR reversal agent (TPGS) to NaY(Mn)F4:Yb/Er UCNPs (UN) with synthetic optimized red emission and properties. The in vitro study demonstrated that the D-UNT was uptaken into drug-resistant MCF-7/ADR cells via caveolin dependent endocytosis and overcame P-gp mediated efflux. The cytotoxicity was significantly promoted to be much higher than that of free DOX. Accordingly, our D-UNT illustrates an enhanced reversal ability for chemotherapy. Our in vivo study further indicated that the D-UNT had excellent therapeutic efficacy against MDR tumors with minimal organ toxicity detected. In vivo deep-tissue imaging showed that the D-UNT accurately diagnosed MDR tumors at a 1.5 cm depth with high-contrast luminescent signals. Thus, the D-UNT is an effective theranostic system for the diagnosis and therapeutic treatment of MDR tumors. The present work opens new pathways to engineering powerful theranostic agents to simultaneously target, image and kill deep-tissue MDR tumor cells.
研究领域:
纳米技术
·
癌症研究
·
药学科学
·
生物医学工程
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DOI
PubMed
高影响因子
Sustainable Energy & Fuels
·
2021
·Vol. 5
·期 22
·5814-5824
·
IF 6.367
Ping Mu,Man Zhou,Kai Yang,Chensheng Zhou,Yuan Mi,Zhenzhen Yu,Kangqiang Lu,Zhengquan Li,Shaobo Ouyang,Weiya Huang,Changlin Yu
Using ion doping to engineer sulfur vacancies over metal sulfides is an effective method to improve photocatalytic properties, such vacancies form the center of the electron-captured state to promote the separation and transfer of photogenerated carriers. In this research, Yb/Er co-doped bulk Cd0.5Zn0.5S (CZS) was fabricated by a one-step simple hydrothermal process, and used for evaluating the catalytic activity for aquatic hydrogen production under visible light irradiation. The results showed that the Cd0.5Zn0.5S:Yb(15%), Er obtained exhibited a higher efficient photocatalytic activity of hydrogen evolution, in which the efficiency of Cd0.5Zn0.5S:Yb(15%), Er (422.0 μmol g−1 h−1) was 2.7 times higher than that of bare Cd0.5Zn0.5S (154.7 μmol g−1 h−1). This can be attributed to the augmented active surface area, the broadened spectral absorption of visible light and the facilitation of the separated efficiency of the photogenerated carriers. This finding provides a simple way to activate the metal-chalcogenides with S-vacancies for optimizing the photocatalytic performance.
研究领域:
材料科学
·
能源化学
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DOI
高影响因子
CRYSTAL GROWTH & DESIGN
·
2018
·
IF 3.972
Lihua He,Xiao Zou,Xiang He,Fengying Lei,Na Jiang,Qiaoji Zheng,Chenggang Xu,Yongfu Liu,Dunmin Lin
A variety of NaYF4:Yb/Er upconversion materials were successfully synthesized via a facile hydrothermal method by altering the volume ratios (0:1, 1:1, 2:1, 3:1, 4:1, 5:1) of ethanol to water and various alcohols (methanol, n-propyl alcohol, isopropyl alcohol, ethylene glycol, polyethylene glycol, and phemethylol), and the grain size and luminescence of the materials were effectively tailored. The addition of alcohol effectively reduces the grain size of the materials and simultaneously leads to the surprising enhancement of the UC emission. The increase in the volume ratio of EtOH/H2O causes the transformation of the crystal structure of the materials from hexagonal to cubic phase. The particle size of the material with the EtOH/H2O of 2:1 is almost 1000 times smaller than that of the material without EtOH, and the strongest luminescence is observed at the EtOH/H2O of 2:1. The type of alcohol in the solvent exhibits a significant influence on the luminescent properties of the materials. The NaYF4:Yb/Er nanocrystals obtained using different alcohols as solvent possess much a smaller grain size and stronger upconversion luminescence than that using water as solvent, and the NaYF4:Yb/Er materials with n-propyl alcohol exhibit the strongest luminescence intensity. The mechanism of the reduction of grain size and enhancement in the luminescence of the NaYF4:Yb3+, Er3+ upconversion materials has been proposed. This study may suggest a simple method to significantly reduce the grain size and improve the upconversion luminescence properties of NaYF4-based fluorescence material.
研究领域:
材料科学
·
光学
·
纳米技术
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DOI
高影响因子
JOURNAL OF MODERN OPTICS
·
2024
·
IF 1.2
Hui Ying Zhang,Wan Ying Xie,Peng Zhang,Xiao Hui Li,Zian Cheak Tiu
In this work, NaGdF4: 20%Yb, 2%Er microcrystals with varying contents of Cr3+ doping were obtained by conventional hydrothermal process. The microcrystal phase structure, morphology, upconversion luminescence mechanism, as well as temperature sensing behaviour under different treatment methods were researched. Based on the thermally coupled 2H11/2 and 4S3/2 levels of Er3+ and the dependence of fluorescence intensity ratio (FIR) on temperature, the optical temperature sensing behaviour of micrometer crystals were experimentally demonstrated. The NaGdF4: 20%Yb, 2%Er, 7%Cr microcrystals treated with high-temperature annealing show the best temperature sensing behaviour within the temperature span of 298–498 K. NaGdF4: 20%Yb, 2%Er, 7%Cr microcrystals with high temperature annealing presented the feasibility and promising properties for optical temperature sensing. The endeavour of emerging materials could lay the groundwork for future sustainable photonics engineering industrial growth.
研究领域:
材料科学
·
光学工程
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DOI
高影响因子
JOURNAL OF FLUORINE CHEMISTRY
·
2023
·
IF 1.9
Shuang Wu,Yanhui Dong,Hao Cui,Daguang Li,Weiping Qin
The morphology and size of LiYF 4 :Yb,Er nanoparticles were controlled using an automatic nanomaterial synthesizer by changing the reaction time at high temperature. It was found that the nanoparticles underwent a growth and change process from small to large and then to small, and then remained at a basically stable size, reflecting the different growth stages of the nanoparticles, such as nucleation, growth, phase transition, and internal Ostwald ripening, etc. XRD analyses showed that LiF nanocrystals were first formed during the reaction process, and then all the products were converted into LiYF 4 nanocrystals. Under the excitation of a 980 nm laser, the LiYF 4 :Yb,Er nanoparticles showed regular downconversion and upconversion luminescence properties, which was basically consistent with the regularity of nanocrystal growth. The experimental results showed that the upconversion luminescence and downconversion luminescence intensities of nanocrystals increasd rapidly when the synthesis time was between 0 and 50 min, and they increased slowly after the synthesis time exceeded 50 min.
研究领域:
材料科学
·
光学
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DOI
高影响因子
JOURNAL OF SOL-GEL SCIENCE AND TECHNOLOGY
·
2021
·Vol. 101
·期 1
·215-226
·
IF 2.326
Li Ping,Zhao Liuyong,Wang Song,Zhang Xiaohui,Jiang Huaiyuan,Liu Ruizhen,Zhao Nengchuang,Cheng Jian,Xu Caili,Zhao He,Lyu Renliang
Known as one efficient upconversion luminescent material, Rare-earth ions doped natrium yttrium fluoride NaYF 4 :Yb/Re has broad application prospects. However, due to the limitation of the existing preparation methods, it is difficult to realize industrial production. In this paper, the upconversion luminescence microparticles, rare earth ions doped Natrium Yttrium Fluoride NaYF 4 :Yb/Er, were synthesized productively by impinging stream method. Synthesis conditions were optimized as EDTA: Ln to 0.5 and NaF: Ln to 6 (Ln represents the sum of moles of Y, Yb, and Er), reacting temperature and time to 50 °C and 3 h to obtain a high yield of 99.92% and particle with good monodispersity. To get strong upconversion luminescence, the effect of the calcination temperature and the amount of EDTA were investigated. The bright upconversion emissions by excited with laser radiation at 975 nm were found at 510–690 nm. The higher the calcination temperature, the stronger the luminescence and the strongest luminescence occurs when calcined at 600 °C. And the adding of EDTA will decrease the luminescence intensity. However, the sintering of particles at high temperatures and aggregation of particles without EDTA are unfavorable for the application of the products. Based on the above considerations, the optimal calcination temperature was determined at 450 °C, and the ratio of EDTA: Ln is preferred at 0.5. The impinging stream method to prepare upconversion material has the advantages of being simple in the process and equipment, high in output, low in investment, and convenient to be applied and popularized.
研究领域:
材料科学
·
化学工程
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DOI
高影响因子
ISRAEL JOURNAL OF CHEMISTRY
·
2015
·Vol. 56
·期 4
·242-248
·
IF 2.221
Junwei Zhao,Jian Wu,Junfei Xue,Qiannan Zhu,Weihai Ni
Graphical Colloidal superparticles (SPs) are nanoparticle (NP) assemblies in the form of colloidal particles. Assembling nanoscopic objects into mesoscopic or macroscopic composite architectures allows for the bottom-up fabrication of functional nanomaterials. In this study, a method for single-step self-assembly synthesis of Au/NaYF 4 : Yb,Er SPs was developed using oil-in-water (O/W) microemulsions to simultaneously encapsulate gold nanoparticles (AuNPs) and NaYF 4 : Yb,Er upconversion nanoparticles (UCNPs) via evaporation at room temperature. The synthesized Au/NaYF 4 : Yb,Er SPs possess good dispersibility and stability. When the number of AuNPs added is increased, the SPs exhibit decreased upconversion luminescence, which can be ascribed to the Förster resonance energy transfer (FRET) from the NaYF 4 : Yb,Er UCNPs to the AuNPs. Time-resolved measurements of the green emission further confirm the existence of a new decay route corresponding to the FRET process. Our research provides a facile and versatile strategy for the synthesis of novel multifunctional nanocomposites with tunable upconversion luminescence properties, which can be of great significance in biological applications.
研究领域:
材料科学
·
纳米技术
·
光学
·
生物医学工程
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产品关联
DOI
高影响因子
Nanomaterials
·
2018
·Vol. 8
·期 12
·1023
·
IF 3.504
Dandan Ju,Feng Song,Adnan Khan,Feifei Song,Aihua Zhou,Xiaoli Gao,Huimin Hu,Xu Sang,Victor Zadkov
The dual-mode emission and multicolor outputs in the time domain from core-shell microcrystals are presented. The core-shell microcrystals, with NaYF4:Yb/Er as the core and NaYF4:Ce/Tb/Eu as the shell, were successfully fabricated by employing the hydrothermal method, which confines the activator ions into a separate region and minimizes the effect of surface quenching. The material is capable of both upconversion and downshifting emission, and their multicolor outputs in response to 980 nm near-infrared (NIR) excitation laser and 252 nm, and 395 nm ultraviolet (UV) excitation light have been investigated. Furthermore, the tunable color emissions by controlling the Tb3+-Eu3+ratio in shells and the energy transfer of Ce3+→Tb3+→Eu3+were discussed in details. In addition, color tuning of core-shell-structured microrods from green to red region in the time domain could be obtained by setting suitable delay time. Due to downshifting multicolor outputs (time-resolved and pump-wavelength-induced downshifting) coupled with the upconversion mode, the core-shell microrods can be potentially applied to displays and high-level security.Keywords:NaYF4:Yb/Er@NaYF4:Ce/Tb/Eu microrods;dual-mode emission;time-resolved emission spectra;multicolor emission
研究领域:
材料科学
·
光学
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产品关联
DOI
PubMed
高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Jian Zhang,Cong Cao,Jinsong Wang,Shiwen Li,Yu Xie
Multicolor upconversion luminescence (UCL) plays an essential role in anti-fake and information encipher. Here, we report a strategy to expand the color-adjustable emission range by regulating the doping concentration of Yb3+ in core@shell (C@S) upconversion nanoparticles (UCNPs) under the excitation of near-infrared (NIR) light at 980 nm and promoting the energy-transfer process. Subsequently, multicolor UCNPs were combined with acrylamide hydrogel to construct a three-dimensional (3D) information code with an adjustable emission color. The encoded information is readable only under 980 nm excitation light and disappears as soon as the excitation light is removed. We adopted three strategies to improve the security: multiple permutations and combinations of different emission light hydrogel blocks, the combination of rich optical information and binary code, and the shape coding of hydrogel blocks. Constructing a complex and changeable coding library significantly guarantees that the data can be enciphered and deciphered by simple light irradiation, and the content can be edited by permutation and combination combined with information coding rules. Therefore, it is expected to provide ideas for developing intelligent anti-counterfeiting materials and devices.
研究领域:
材料科学
·
光学
·
纳米技术
·
化学
·
安全技术
✓ 已验证
产品关联
DOI
高影响因子
ACS Applied Nano Materials
·
2026
·
IF 5.8
Yan Xiangyang,Li Ningning,Li Maoyi,Fan Kaixuan,Xia Huiyun
This study addresses the efficient
and safe purification
of low-concentration
atmospheric NO. A Yb/Er-codoped nanostructured BiOBr was synthesized
via a solvothermal method, and a composite superhydrophobic coating
(FSBE) was fabricated by a layer-by-layer spraying strategy using
epoxy resin, nano-SiO 2 , and perfluoroalkyltrimethoxysilane,
achieving integrated high photocatalytic activity and excellent micronano-structured
superhydrophobicity. The Yb/Er codoping successfully modulates the
original layered BiOBr into spherical hollow microspheres assembled
from interconnected nanoplates with an optimal Yb/Er ratio of 10:1.
This modification enlarges the specific surface area by approximately
7 times, broadens the light response range, and effectively restrains
the recombination of photogenerated carriers. The constructed FSBE
coating possesses a micronano rough surface with water and ethylene
glycol contact angles above 150 ° , demonstrating superior self-cleaning
performance. Under visible light and full-spectrum irradiation, the
FSBE coating delivers NO degradation efficiencies of 62.0 and 78.4%,
which are 2.85-fold and 1.5-fold higher than those of pure BiOBr,
respectively, while efficiently suppressing NO 2 accumulation.
The coating maintains a photocatalytic efficiency of 65.8% after five
cycling tests and exhibits excellent mechanical abrasion resistance
and chemical stability. The synergistic effect between the superhydrophobic
self-cleaning structure and nanoscale rare-earth-doping-enhanced photocatalysis
accounts for its durable NO purification capability. This work provides
an insight into the design of high-performance and long-lived photocatalytic
nanocoatings for atmospheric environmental remediation.
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DOI
高影响因子
JOURNAL OF LUMINESCENCE
·
2025
·
IF 3.6
Yue Wang,Yaomin Lei,Wuqin Chen,Ruian Yang,Xinyang Gu,Gaofeng Pan,Xuesong Zhai,Jinshan Wang
Luminescence quenching effect of lanthanide-doped upconversion materials occurs with high probability even in larger-sized particles, but their main quenching pathway remains controversial. In this work, we investigate the influence of the surfactant and pH value on the luminescence properties of β-NaLuF 4 :Yb,Er microcrystals. A convincing evidence can be provided by the combination of X-ray diffraction (XRD), inductively coupled plasma (ICP) spectrometer, and Eu 3+ structural probe measurements that the major quenching pathway comes from the fast energy migration from the excited lanthanides to nearby OH − defects in the crystal lattice rather than surface quenching effect. Even at OH − -rich reactant condition, the upconversion luminescence intensity becomes more efficient by reduced internal quenching effects. Our findings provide a new and fundamental understanding of severe luminescence quenching effect at microscale, thus guiding the design and preparation of highly efficient upconversion materials.
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DOI
高影响因子
OPTICAL MATERIALS
·
2021
·
IF 3.08
Huilian Qin,Jing Li,Meijuan Yuan,Yaru Peng,Yuxin Huang,Li Chen
Monodisperse sub-10 nm Sc 2 O 3 : Yb, Er upconverting nanoparticles (UCNPs) were firstly synthesized via solvothermal method in three-neck round-bottom flask. The X-ray diffraction (XRD) shows that the prepared UCNPs possess cubic structure. The transmission electron microscopy (TEM) shows that sample has monodisperse spheroid morphology with high crystallinity . The average size of spheroid UCNPs could be controllable manipulated as small as 3 nm. Furthermore, the sample exhibits stronger red and green upconversion luminescence (UCL) than reported Sc 2 O 3 : Yb, Er nanostructure by biphasic solvothermal method. The Fourier-transform infrared (FTIR) spectra and decay curve reveal that ultra-small Sc 2 O 3 : Yb, Er UCNPs exhibit the reduced surface groups and long decay time of Er 3+ ions. The results indicate Sc 2 O 3 : Yb, Er UCNPs is a probable oxide material with small size and intense UCL for biological applications.
研究领域:
材料科学
·
光学
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）