JOURNAL OF MOLECULAR STRUCTURE
·
2024
·
IF 4
Yan Fan,Bo Hou,Dongcheng Hu
In this work, a novel Zn(II) coordination polymer (denoted as Zn-CP) was constructed by the mixed ligands of 6-(3′,4′-Dicarboxy phenoxy)isophthalic acid (H 4 L) and 4,4′-bis(imidazolyl)biphenyl (bib) under solvothermal method. And based on the Zn-CP, the surfactant agent sodium dodecyl sulfate (SDS) was further introduced into the structure, thus obtaining the Zn-CP(S) which possessed the same phase but a smaller size compared with the Zn-CP. Interestingly, the Zn-CP(S) presented a significantly ameliorated fluorescent intensity, about 4.36 times higher than that of the Zn-CP prepared in the absence of SDS. Taking advantage of the improved fluorescence trait of the Zn-CP(S), a fluorescence recognition towards hazardous matters was further carried out. The results showed that Zn-CP(S) could simultaneously recognized for Hg 2+ , Cr 2 O 7 2− and a broad range of hazard nitroaromatic explosives with the satisfactory limits of detection (LODs). In addition, Zn-CP could also be used as a recyclable adsorbent to remove methyl orange (MO) in aqueous medium. The maximum equilibrium adsorption capacity of Zn-CP for MO was 61.01 mg/g, and the adsorption mechanism could be attributed to the weak inter-molecular interaction involved π-π stacking and hydrogen bonding between Zn-CP and the MO molecule. Therefore, the bifunctional material has potential application prospects in fluorescence recognition and adsorption.
研究领域:
材料科学
·
环境科学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
NEW JOURNAL OF CHEMISTRY
·
2019
·Vol. 43
·期 41
·16138-16147
·
IF 3.069
Yu Guo,Qing-Ying Yu,Ji Zhang,Hui-Zhen Yang,Zheng Huang,Xiao-Qi Yu
The unique properties of 1,4,7,10-tetraazacyclododecane (cyclen) make it not only a suitable polyamine headgroup in cationic lipids for gene delivery, but also a good host molecule for metal coordination. In this study, a series of cyclen-based lipids and their Zn(II)-complexes were synthesized to study the effect of Zn-coordination on the gene transfection. Both the Zn-free and Zn-containing lipids could form nano-sized particles with suitable positive potential to condense and protect DNA from degradation by DNase. More importantly, Zn coordination could significantly reduce the cytotoxicity of the liposomes. Meanwhile, the gene transfection efficiency of the cyclen-based lipids could also be distinctly improved by the Zn-coordination. Mechanistic studies reveal that the Zn-free and Zn-containing liposomes showed similar cellular uptake properties. However, confocal microscopy shows that Zn-containing liposomes may induce more efficient endosomal escape than the Zn-free counterpart, which could be attributed to their much higher pH buffering capacity. This study presents an efficient strategy to enhance the gene transfection efficiency and biocompatibility of cyclen-based cationic lipids.
研究领域:
药学
·
分子生物学
·
纳米技术
·
生物医学工程
✓ 已验证
产品关联
DOI
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2022
·
IF 16.744
Yichuan Wang,Xiaojin Zhang,Yu Dai,Fan Xia
Organometallic nanozymes, organometallics of which mimic the cofactor of natural enzymes, have the advantages of tunable catalytic activity, high stability, and material variety. By assembling organometallics (catalytic site) on inorganic nanoparticles (support), organometallic nanozymes have been rationally designed, but modulating their assembly and activity remains a tough challenge. Here, we construct a photo-modulated organometallic nanozyme by anchoring azobenzene-modified triethylenetetramine (Azo-N4) to the surface of β-cyclodextrin-capped gold nanoparticles (AuNP@CDs) through host–guest interaction, followed by Zn(II) coordination to form organometallics. The catalytic site derives from the outer organometallic layer. The nanozyme catalyzes the hydrolysis of 4-nitrophenyl acetate to 4-nitrophenol and the catalytic signal is used to detect Zn(II). Due to the photoisomerization of azobenzene, the supramolecular assembly of host–guest interaction is modulated by light. The disassembly leads to cascade catalysis of AuNP@CDs-Azo-N4-Zn and the recovery of AuNP@CDs. Our study provides a new idea and reference for the rational design and activity modulation of organometallic nanozymes.
研究领域:
生物化学
·
纳米医学
·
分析化学
✓ 已验证
产品关联
DOI
高影响因子
DALTON TRANSACTIONS
·
2022
·Vol. 51
·期 14
·5624-5634
·
IF 4.569
Jia Wang,Xiange Huang,Hegen Li,Deyue Yan,Wei Huang
Here two Zn(II) coordination polymers [Zn20(DMCA)12]O12 (DMCA = demethylcantharic acid, DMCA-Zn1) and [Zn(DMCA)](H2O)2 (DMCA-Zn2) are synthesized from a broad-spectrum anticancer drug norcantharidin (NCTD) and Zn(NO3)2·6H2O under solvothermal conditions. By mechanical grinding with a biocompatible polymeric surfactant F127, ultrasonic treatment and filtration, DMCA-Zn1 and DMCA-Zn2 can be transformed into stable nanoparticles (DMCA-Zn1 NPs and DMCA-Zn2 NPs) suspended in water with average diameters of around 190 nm and 162 nm for drug delivery. The in vitro evaluation indicates that DMCA-Zn1 NPs and DMCA-Zn2 NPs can enter into HepG2 and Hep3B cancer cells via endocytosis and inhibit their proliferation. Meanwhile they exhibit relatively low toxicity to L927 normal cells. The in vivo evaluation confirms that DMCA-Zn1 NPs and DMCA-Zn2 NPs can more effectively inhibit the growth of Hep3B tumors with relatively few side effects compared with free NCTD. This approach can be extended to other anticancer drugs to construct nanodrug delivery systems for cancer treatment.
研究领域:
化学
·
材料科学
·
药理学
·
肿瘤学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Molecular Catalysis
·
2018
·
IF 0
Fuhai Li,Dairong Hu,Yahui Yuan,Binbin Luo,Yibing Song,Songtao Xiao,Guanghui Chen,Yiwen Fang,Fushen Lu
To mimic biological enzyme in catalysis, metal-imidazole-salen complexes were proposed (via DFT calculation) and synthesized in situ within the cavities of Y zeolite. Among the synthesized zeozymes, the Cu-salenIIY exhibited a prominent catalytic efficiency for the selective oxidation of benzyl alcohol. Specifically, the activity and selectivity of the encapsulated catalyst were comparable to those of the free Cu-salenII complex in solution. Furthermore, the high activity and selectivity were preserved during the repeated cycles. The similarity in the initial activity implies that the Cu-salenII complex just resides in the cavity of the zeolite Y, and its intrinsic properties responsible for the catalytic activity keep intact after encapsulation. The confinement of zeolite nanocavities effectively inhibited the dimerization or aggregation of the Cu-salenII complex and prevented the active species from escaping into reaction solution, thus resulting in a remarkably improved in the catalytic reusability and durability.
研究领域:
催化
·
材料科学
·
化学工程
·
无机化学
✓ 已验证
产品关联
DOI
CRYSTENGCOMM
·
2023
·Vol. 25
·期 46
·6424-6433
·
IF 3.1
Ya-Ping Li,Jian-Hua Zhang,Xiao-Xia Zhang,Sui-Jun Liu
A new Zn(II) metal–organic framework (MOF) with the formula [Zn(BBIP)(2,6-NDC)]n (JXUST-44, BBIP = 3,5-bis(1H-benzo[d]imidazol-1-yl)pyridine and 2,6-H2NDC = 2,6-naphthalic acid) was synthesized under solvothermal conditions. The adjacent Zn(II) ions are connected by BBIP ligands to form one-dimensional (1D) chains, which are further linked by carboxylate groups of 2,6-NDC2− ligands to obtain a two-dimensional layer structure, resulting in a 2D → 3D polycatenated MOF. JXUST-44 can be simplified as a 4-connected sql topology and shows good chemical stability in a wide pH range from 2 to 12 at room temperature. The fluorescence experiments indicate that JXUST-44 presents sensitive and selective detection of salicylaldehyde (SA), acetylacetone (acac) and H2PO4− with the detection limits of 0.074, 10.311 and 0.011 ppm, respectively. It is worth noting that JXUST-44 shows turn-on fluorescence toward acac and H2PO4−, as well as good recyclability and stability for acac, SA and H2PO4−. Therefore, JXUST-44 can be considered as a good fluorescent sensor for acac, SA and H2PO4−. The sensing mechanism has also been studied in detail.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
APPLIED SURFACE SCIENCE
·
2022
·
IF 7.392
Zhen-Peng Cui,Le-Xi Zhang,Heng Xu,Yan-Yan Yin,Bo Tang,Li-Jian Bie
Metal-organic frameworks (MOFs) have been proved to be outstanding candidates for humidity sensors, however, pure MOFs are still limited in hysteresis, integration, and intelligence. In this investigation, inspired by a single-site-ion strategy for catalysis, UiO-66-NH 2 is first grafted by 2, 6-DPA (2, 6-dipicolinic acid) molecules (named as U-DPA) and then combined by Zn (II) ions (noted as U-DPA-Zn). Taking advantage of electrolyte and MOF, U-DPA-Zn exhibits significantly enhanced humidity sensing performance than UiO-66-NH 2 and U-DPA. U-DPA-Zn possesses the highest sensitivity (S r = 8.07 × 10 3 ), the best linearity (R 2 = 0.994), the shortest response-recovery time (τ res = 2 s, τ rec = 105 s), the smallest hysteresis (ΔH = 1.81%), as well as good repeatability in a wide relative humidity (RH) range (11%-97%). Thanks to its excellent properties, U-DPA-Zn shows great potential in the field of monitoring human respiration (breath detection) and water evaporation on human skin (finger detection). Additionally, the humidity sensing mechanism is discussed based on complex impedance analysis, revealing the single Zn (II) make giant contribution to MOFs. This work provides an optional material for humidity sensors and further a new strategy to improve the humidity sensitivity of pure MOFs.
研究领域:
材料科学
·
传感技术
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
·
2021
·
IF 4.539
Kun Jiang,Kun Liu,Qian Peng,Muyang Zhou
Montmorillonite (MMT) and humus have a good adsorption effect on heavy metal ions . This study proposed a synthetic method for a novel composite of humus-like substances/MMT (HLS-MMT) by introducing humus precursors into the interlayer domain of MMT and then forming HLS through in situ catalytic polycondensation reaction. The structure and morphology of samples were characterized by XRD , FTIR, and SEM , which demonstrated the successful loading of HLS on the internal and external surfaces of MMT. The experimental results showed that the loading of HLS on MMT was very stable, and the adsorption capacity of the modified MMT for lead and zinc ions was greatly enhanced. The effects of single-factor experiments showed that the pH value was the key factor affecting the adsorption process . In addition, the adsorption process was found to be in good agreement with the Langmuir isotherm model and the pseudo-second-order kinetic model . The competitive adsorption experiment displayed that HLS-MMT had a higher affinity for Pb ions than Zn ions, and the cycling experiment presented that the adsorbent had good regeneration and cycling performance. This study shows that HLS-MMT is a novel adsorbent with a good capacity to separate and enrich Pb and Zn ions similar to ion-exchange resin.
研究领域:
环境科学
·
材料科学
·
化学工程
✓ 已验证
产品关联
DOI
高影响因子
ANALYTICA CHIMICA ACTA
·
2014
·
IF 4.517
Xiaoyu Mu,Li Qi,Juan Qiao,Xinzheng Yang,Huimin Ma
A chiral ligand exchange capillary electrophoresis (CLE-CE) method using Zn(II) as the central ion and l -4-hydroxyproline as the chiral ligand coordinating with γ-cyclodextrin (γ-CD) was developed for the enantioseparation of amino acids (AAs) and dipeptides. The effects of various separation parameters, including the pH of the running buffer, the ratio of Zn(II) to l -4-hydroxyproline, the concentration of complexes and cyclodextrins (CDs) were systematically investigated. After optimization, it has been found that eight pairs of labeled AAs and six pairs of labeled dipeptides could be baseline-separated with a running electrolyte of 100.0 mM boric acid, 5.0 mM ammonium acetate, 3.0 mM Zn(II), 6.0 mM l -hydroxyproline and 4.0 mM γ-CD at pH 8.2. The quantitation of AAs and dipeptides was conducted and good linearity ( r 2 ≥ 0.997) and favorable repeatability (RSD ≤ 3.6%) were obtained. Furthermore, the proposed method was applied in determining the enantiomeric purity of AAs and dipeptides. Meanwhile, the possible enantiorecognition mechanism based on the synergistic effect of chiral metal complexes and γ-CD was explored and discussed briefly.
研究领域:
分析化学
·
生物化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF CHROMATOGRAPHY A
·
2024
·
IF 3.8
Jian-hua Zu,Xiao-han Pan,Xing-dong Su,Feng Liu,Jie Zhan,Ye He,Jiu-geng Chen
The removal of zinc ions (Zn(II)) in water and the separation of zinc isotopes were fully investigated in this study. Imidodiacetic acid (IDA) type adsorbent (named PSGI) based on polystyrene spheres (PS) was synthesized by simultaneous irradiation grafting. By adsorption method, the removal of Zn(II) from water by the chelating adsorbent was studied in batch experiments. Under optimized condition, PSGI showed the removal efficiency of more than 98 % for Zn(II) and the adsorption capacity of 70.1 mg/g. Langmuir isothermal and pseudo-second-order kinetic model fitted the experimental results better, indicating that the adsorption is dominated by chemical adsorption. The spent adsorbent (PSGI-Zn) was used for further zinc isotope separation by displacement chromatography using EDTA-NH 4 solution as eluent. Due to the mass effect of isotopes, 70 Zn was found to preferentially fractionated into the front-end effluents with the highest front enrichment values of 70 Zn/ 64 Zn. By extending the migration distance to 20 m, we obtained the best isotope enrichment with the front maximum enrichment values as 1.0949, 1.0739 and separation coefficient values as 1.977 × 10 −3 , 8.33 × 10 −3 corresponding to the isotope pairs 66 Zn/ 64 Zn, 68 Zn/ 64 Zn.
研究领域:
环境科学
·
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF COORDINATION CHEMISTRY
·
2025
·
IF 2.1
Hou Cong Li,Ming Zhu Wang,Ye Fan Zheng,Ning An,Min Hou,Jing Hu,Wen Ge Li
Three chlorinated metal complexes [Ni2(HL)2(C2H5OH)2Cl2]·2C2H5OH (complex 1), [Co(HL)(L)] (complex 2), and [Zn2(HL)2(CH3COO)2] (complex 3) derived from 5-chlorosalicylaldehyde and 2-(2-aminophenyl)-1H-benzimidazole Schiff base ligand (H2L). The crystal structures of the three complexes were characterized by elemental analysis, infrared spectroscopy, thermogravimetric analysis, X-ray single-crystal diffraction, and UV-visible absorption spectrum. The in vitro cytotoxicity of chlorinated ligand and its metal complexes were evaluated on four different tumor cell lines (A-549 lung cancer, SMMC-7721 liver cancer, MDA-MB-231 breast cancer, and CNE-2Z nasopharyngeal carcinoma), and normal ovarian epithelial cell (IOSE 80) was determined by MTT assay. The results indicated that chloro-benzimidazole Schiff base Co (III) complex (complex 2) displayed higher cytotoxicity against MDA-MB-231 cell line than cisplatin, while the cytotoxicity on IOSE 80 was lower than that of cisplatin. The results of further study of MDA-MB-231 cells by complex 2 showed that complex 2 could inhibit MDA-MB-231 cells in the G0/G1 phase, inhibit cell proliferation and migration, promote cell apoptosis, and increase intracellular ROS level. The Western blot analysis demonstrated that complex 2 could increase Bax protein expression and decrease Bcl-2 protein expression in MDA-MB-231 cells.
研究领域:
无机化学
·
药理学
·
肿瘤学
✓ 已验证
产品关联
DOI
高影响因子
CHINESE JOURNAL OF STRUCTURAL CHEMISTRY
·
2022
·
IF 0.847
Hui-Chao GUAN,Xiao-Tong SONG,Gui-Bao LIU,Shu-Mei YUE
Complexes [Zn(pbm)(5-hip)3] ( 1 ), [Zn(pbm)(5-nip) 3 ] ( 2 ), [Mn(pbm)(H 3 btc) 2 (H 2 O)] ( 3 ) and [Mn(pbm)(5-nip) 3 ] ( 4 ), where H 2 HIPA = 5-hydroxyisophthalic acid, H 2 nip = 5-nitroisophthalic acid, H 3 btc = trimesic acid and pbm (pyridine benzene chelate material) = 2-(2-pyridyl)benzimidazole, were identified via single-crystal XRD analyses. 1, 2 and 4 pertain to the monoclinic space group C 2/ c , while 3 belongs to the triclinic space group P ① . The interplay of CT-DNA with those complexes was delineated using ultraviolet, fluorescence, and circular dichroism (CD) spectroscopy and viscosity measurements. Complexes 1, 2, 3 and 4 interact with CT-DNA in an electrostatic or grooving mode. We wish to offer a theory-wise foundation for developing anti-tumor medicines.
研究领域:
无机化学
·
生物化学
·
药学
✓ 已验证
产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）