MATERIALS CHEMISTRY AND PHYSICS
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2026
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IF 4.7
Sheng Lin,Yuting Wang,Chunxiang Huang,Yu Niu,Yongming Liu,Wangchuan Xiao,Fenghua Chen,Rongrong Xue
Co-amorphous systems, including co-amorphous and co-amorphous salts, can enhance the solubility of poorly water-soluble small molecules. It is important to identify them because co-amorphous and co-amorphous salts have different physicochemical properties. Co-amorphous system of luteolin (LUT, a well-known poorly soluble flavonoid) and amino acids at a molar ratio of 1:1 was prepared using neat ball milling. Only amorphous luteolin-arginine (LUT-Arg) and luteolin-lysine (LUT-Lys) exhibit significant solubility enhancements in the media of water and PBS. The Δ p K a rule suggests that LUT-Arg (Δ p K a , 2.8) and LUT-Lys (Δ p K a , 2.9) are close to co-amorphous salts. Diffuse reflectance spectroscopy and Raman spectroscopy confirmed that LUT-Arg and LUT-Lys are co-amorphous salts, while IR spectroscopy, the most common used method, cannot distinguish them. Comprehensive multiple characterizations (>2) are essential to confirm the formation of co-amorphous or co-amorphous salts, such as applying the Δ p K a rule, diffuse reflectance spectroscopy, and Raman spectroscopy for LUT-Arg and LUT-Lys.
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高影响因子
Acta Biomaterialia
·
2023
·
IF 9.7
Mengsi Zhang,Hao Jin,Yi Liu,Lanlan Wan,Shuwei Liu,Hao Zhang
NO gas therapy is a supplementary approach for tumor treatment due to the advantages of minimal invasion, little drug resistance, low side effect and amplified efficacy. l -Arginine (L-Arg), a natural NO source with good biocompatibility, can release NO under the stimulation of H 2 O 2 in tumor microenvironment. However, the conventional l -Arg delivery systems via noncovalent loading usually lead to inevitable premature leakage of nano-cargos during blood circulation. In this work, an efficient l -Arg self-delivery supramolecular nanodrug (SDSND) for tumor treatment is demonstrated by combining Mannich reaction and π-π stacking. l -Arg links to (-)-epigallocatechin gallate (EGCG) with the assistance of formaldehyde through Mannich reaction, and then assembles into nanometer-sized particles via π-π stacking. The guanidine group of l -Arg and the phenolic hydroxyl groups of EGCG are preserved in the SDSNDs, which allows for accomplishing gas therapy by provoking tumor cell apoptosis and combining with EGCG to amplify apoptosis, respectively. In addition, the SDSNDs exhibit high biocompatibility and avoid the premature leakage of l -Arg in blood circulation, providing an alternative l -Arg delivery system for NO gas therapy. Statement of significance NO gas therapy has attracted emerging interest in tumor treatment. However, the controlled NO release and the avoidance of premature leakage of NO donors remain challenging. In this work, L-Arginine (L-Arg) self-delivery supramolecular nanodrug for efficient tumor therapy is demonstrated through the Mannich reaction of L-Arg, (-)-epigallocatechin gallate (EGCG) and formaldehyde. Stimulated by tumor microenvironment, the guanidine groups of L-Arg allow for accomplishing NO release and thus provoking tumor cell apoptosis. The nanodrug also avoids the premature leakage of L-Arg in blood circulation. Moreover, the preserved phenolic hydroxyl groups of EGCG combine with L-Arg to amplify apoptosis. The nanodrug exhibits high biocompatibility and good therapeutic effect, providing an alternative L-Arg delivery system for NO gas therapy.
研究领域:
药学
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纳米技术
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癌症治疗
·
药物递送系统
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PubMed
高影响因子
ENERGY & FUELS
·
2013
·
IF 2.853
Shufeng Shen,Xiaoxia Feng,Shaofeng Ren
Preliminary screening experiments of carbon dioxide (CO2) absorption into aqueous 35 wt % equivalent potassium carbonate (K2CO3) solution with different additives were performed in a wetted-wall column at 322 K. Arginine was found as an effective promoter to enhance the absorption rate in aqueous K2CO3 solution. The effect of arginine concentration and CO2 loading on the absorption rate into carbonate solutions is discussed. The vapor–liquid equilibrium of 35 wt % equivalent K2CO3 with 0–5 wt % arginine was obtained in the temperature range from 323 to 343 K using inert-gas stripping method. Desorption curves of the unpromoted and arginine-promoted carbonate solutions are also discussed.
研究领域:
化学工程
·
环境科学
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能源技术
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气体吸收
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热力学
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高影响因子
SENSORS AND ACTUATORS B-CHEMICAL
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2026
·
IF 8.3
Mingzhe Hu,Xin Zhang,Chang Zhang,Feng Qiu,Jiujie Ruan,Xiaoli Wang,Yu Zhang,Jie Zou,Qinghui Jin,Jiawen Jian
Metal halide perovskite nanocrystals (MHPNCs) have emerged as promising fluorescent sensing materials owing to their excellent optical properties. However, surface defects significantly influence their sensing performance, highlighting the importance of defect passivation for improving sensing capability. In this study, a fluorescent NH 3 sensor film was fabricated via electrospinning, in which arginine(ARG)-modified MAPbBr 3 (MA refers to methylammonium) quantum dots were encapsulated within poly(methyl methacrylate) (PMMA) nanofibers to investigate the effect of arginine passivation on NH 3 sensing performance. Under dynamic gas sensing conditions at 25°C and an ambient relative humidity, the sensor exhibited a concentration-dependent NH 3 response in the range of 1.25–200 ppm. The ARG-modified sensor exhibited an approximately 115% higher sensitivity than the sensor without ARG. The sensor showed a more pronounced response toward NH 3 than interfering gases at 200 ppm. Moreover, the maximum response variation was 3.33% during five consecutive NH 3 sensing cycles, and the fluorescence intensity of the sensor membrane remained above 80% of its initial value after 180 days of storage.
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JOURNAL OF NANOBIOTECHNOLOGY
·
2026
·
IF 15
Chen Rui,Xu Xingjian,Zhu Chuansai,Li Bangliang,Liang Weijia,He Miao,Pan Jinjin,Chen Shengjie,Bao Hongying,Wu Zhenhua,Li Xiang,Guo Qian,Zhou Qiang,He Zuhong,Lin Sen
High-intensity noise exposure induces cochlear injury through mechanical trauma, disruption of ionic homeostasis, and secondary oxidative stress, ultimately leading to noise-induced hearing loss (NIHL). Increasing evidence suggests that oxidative stress not only causes direct cellular damage but also drives pathological remodeling of the cochlear microenvironment by triggering persistent inflammatory activation and disrupting endogenous nitric oxide (NO) biocatalytic regulation. However, current therapeutic strategies based solely on antioxidants or anti-inflammatory agents are insufficient to simultaneously restore inflammatory homeostasis and endogenous catalytic regulation within the injured cochlea. Here, we developed a carrier-free arginine–dexamethasone nanoplatform (AD NPs) through a one-step ultrasound-assisted self-assembly strategy to achieve biocatalytic remodeling of the pathological cochlear microenvironment. By integrating the anti-inflammatory activity of dexamethasone with the physiological substrate function of L-arginine for endothelial nitric oxide synthase (eNOS), AD was designed to coordinately suppress inflammatory signaling while supporting endogenous NO biocatalysis. The resulting nanoparticles exhibited an average diameter of approximately 169.9 nm, a positive surface charge (+ 17.18 mV), sustained drug release with accelerated release under H₂O₂-containing conditions, excellent biocompatibility, and prolonged AD-associated fluorescence in the cochlear region following tympanic bulla administration. In H₂O₂-induced cellular models, AD markedly reduced intracellular reactive oxygen species (ROS) accumulation, inhibited NF-κB signaling activation, promoted macrophage polarization toward a pro-repair phenotype, modulated eNOS/iNOS-associated NO biocatalytic regulation, improved endothelial functional phenotypes, and protected HEI-OC1 cells against oxidative injury. Furthermore, L-NAME markedly attenuated the AD-induced recovery of NO-related fluorescence, supporting the involvement of endogenous NOS activity in this response. In a C57BL/6 mouse model of NIHL, prophylactic administration of AD before noise exposure significantly preserved high-frequency hearing, reduced cochlear hair cell loss, maintained ribbon synapse integrity, and corrected the pathological imbalance between eNOS and iNOS within the stria vascularis. At the mechanistic level, AD remodeled the pathological cochlear microenvironment through coordinated suppression of ROS/NF-κB-mediated inflammatory activation and support of endogenous NO biocatalytic regulation, thereby interrupting the reciprocal amplification between inflammatory dysregulation and vascular-associated dysfunction following acoustic injury. Collectively, this work establishes a carrier-free biocatalytic nanoplatform that harnesses endogenous enzymatic regulation to remodel the pathological cochlear microenvironment. This strategy provides a mechanistic framework for microenvironment-oriented biocatalytic nanomedicine and offers a promising protective approach for preventing or mitigating noise-induced cochlear injury. Graphical Design rationale and biocatalytic protective strategy of the Arg–Dex self-assembled nanoplatform for noise-induced hearing loss.
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PHYSICAL CHEMISTRY CHEMICAL PHYSICS
·
2024
·
IF 2.9
Fuge Niu,Xinyu Hu,Christos Ritzoulis,Weiwei Tu,Xurui Zhao,Yuanzhi Xia,Yinghua Lu,Junfeng Yin,Weichun Pan
The formation of aggregates was studied in amino acid aqueous solutions. Regarding to arginine (Arg), the main driving force to form aggregates is hydrogen-bonds between the Arg molecules. The measurement of energy loss during this process, coupled with morphology data indicate that this aggregate is in solid state. The aggregation has two steps, with a liquid intermediate stage. An investigation of the effect of pH and solute concentration upon aggregate formation for other amino acid aqueous solutions verifies that aggregate formation is amino-acid specific, while small size of clusters formed by weak interactions lead to large size aggregation. Homochirality is observed in the aggregates; its existence sheds light on the origin of protein homochirality.
研究领域:
生物化学
·
分子生物学
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DOI
PubMed
高影响因子
Heliyon
·
2024
·
IF 3.4
Aitong Yang,Junyan Zhang,Guangying Lv,Jiabao Chen,Long Guo,Yan Liu,Yuguang Zheng,Lei Wang
Angelica dahurica is a medicinal herb of the Umbelliferae family. The dried root of A. dahurica , also known as Angelicae dahuricae Radix, is widely used in clinical treatment. However, the aboveground part of A. dahurica which accounted for over 70% of the total plant was abandoned in the field. In order to develop the value of the aboveground part of A. dahurica , the chemical constituents and arginine kinase (AK) inhibitory activity of A. dahurica leaves were studied. 85 volatile components were identified from A. dahurica leaves by GC-MS; 39 non-volatile components including sugars, amino acids and organic acids were identified by pre-column derivatization GC-MS analysis; and 7 coumarins were qualitatively and quantitatively analyzed by HPLC. Then, an inhibitory enzyme-linked immunosorbent assay (iEIA) was applied for evaluation of AK inhibitory activity. The extracts of A. dahurica leaves exhibited well inhibitory effects on AK. Further, potential AK inhibitors were screened by grey relational analysis and their inhibitory activities were validated by iEIA. l -aspartic acid exhibited strongest inhibitory effect on AK with its IC 50 value was 0.558 mM, which was much lower than that of chlorpheniramine (6.644 mM). The obtained chemical profiles displayed chemical diversity of A. dahurica leaves and will provide data support for the future development and utilization of A. dahurica leaves. The screened potential AK inhibitors from A. dahurica leaves could be candidates for development of antiallergic substances or insecticides.
研究领域:
药理学
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植物化学
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PubMed
高影响因子
ACS Sustainable Chemistry & Engineering
·
2025
·
IF 7.3
Hanghang Zhang,Yingxi Zhang,Manli Yu,Lin Zhou,Pengyue Zhao,Chong Cao,Qiliang Huang,Lidong Cao
The development of novel pesticide formulations with the minimization of the adverse impact and simultaneous maximization of utilization efficiency is highly urgent. A new window for pesticide delivery has been created for green and sustainable agriculture using chitosan (CS) and chitooligosaccharide (COS) as carrier materials because of their economic, biocompatibility, and versatile functional properties. However, the difference of properties between CS and COS is not well clarified in pesticide delivery. In this study, pyraclostrobin (PYR)-loaded microcapsules based on arginine-modified CS (PYR@CS-Arg) or COS (PYR@COS-Arg) were successfully prepared through an electrostatic self-assembly strategy. Notably, in addition to possessing pH-responsive release characteristics, PYR@CS-Arg exhibited faster release kinetics in alkaline environments compared to PYR@COS-Arg, attributed to the formation of a larger space following CS-Arg dissociation from microcapsules. Comparative analysis with other formulations revealed that both PYR@CS-Arg and PYR@COS-Arg demonstrated superior performance in terms of target deposition, bioactivity, UV stability, biosafety, and nutritional function. These characteristics significantly enhance the pesticide utilization rate while reducing environmental risks, aligning with the principles of sustainable agricultural development. Owing to the multifunctional properties of COS, PYR@COS-Arg showed enhanced performance in maximum retention, fungicidal activity, UV protection, and plant growth promotion compared to PYR@CS-Arg. Conversely, PYR@CS-Arg exhibited lower nontarget organism acute toxicity, owing to its larger particle size facilitating gravitational sedimentation in aqueous environments. These findings provide valuable insights into carrier material selection based on application scenarios and target control requirements, offering a promising and practical strategy in sustainable agricultural practices.
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JOURNAL OF CONTROLLED RELEASE
·
2024
·
IF 10.5
Yi Chen,Xian Shu,Jia-Yi Guo,Yun Xiang,Shi-Yu Liang,Jin-Mei Lai,Jia-Yi Zhou,Li-Han Liu,Ping Wang
As a potential treatment strategy for low immunogenic triple negative breast cancer (TNBC), photodynamic therapy (PDT) induced antitumor immunotherapy is greatly limited by the immunosuppressive tumor microenvironment (ITM), especially the M2 phenotype tumor-associated macrophages (TAMs). The balance of arginine metabolism plays an important role in TAMs polarization. Herein, a multifunctional nanoplatform (defined as HN-HFPA) was employed to burst the anti-tumor immunity of TNBC post PDT by reeducating TAMs through interfering the TAMs-associated arginine metabolism. The L -arginine ( L -Arg) was loaded in the hollow cavity of HN-HFPA, which could not only generate nitric oxide (NO) for tumor therapy, but also serve as a substrate of arginine metabolism pathway. As an inhibitor of arginases-1 (Arg-1) of M2 TAMs, L -norvaline ( L -Nor) was modified to the hyaluronic acid (HA), and coated in the surface of HFPA. After degradation of HA by hyaluronidase in tumor tissue and GSH-mediated disintegration, HN-HFPA depleted intracellular GSH, produced remarkable reactive oxygen species (ROS) under light irradiation and released L -Arg to generate NO, which induced tumor immunogenic cell death (ICD). Real-time ultrasound imaging of tumor was realized taking advantage of the gas feature of NO. The L -Nor suppressed the Arg-1 overexpressed in M2, which skewed the balance of arginine metabolism and reversed the ITM with increased ratios of M1 and CD8 + T cells , finally resulted in amplified antitumor immune response and apparent tumor metastasis inhibition . This study remodeled ITM to strengthen immune response post PDT, which provided a promising treatment strategy for TNBC.
研究领域:
癌症生物学
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免疫学
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药学
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生物医学工程
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PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2019
·
IF 4.784
Jinxing Song,Huafeng Feng,Mengqi Wu,Linxiao Chen,Wei Xia,Wenqing Zhang
Chitosan and its derivatives are widely used in medical, cosmetic and food fields. In this study, chitosan-N-arginine (CSA) was synthesized and characterized by Fourier-transform infrared (FT-IR), 1 H NMR, gel permeation chromatography (GPC), thermogravimetric analysis (TGA) and scanning electron microscopy (SEM). A novel antibacterial composite film consisting of CSA, hydroxypropyl methylcellose (HPMC) and glycerol was then prepared. The transparent and homogeneous film presented good compatibility between CSA and HPMC, confirmed by SEM. The thickness of the film was about 44.8 μm and its moisture content was 23.0%. Antimicrobial evaluation of CSA/HPMC film showed 9.0 mm bacteriostatic diameter zone against E. coli and 10.5 mm one against S. aureus . The film exhibited cell biocompatibility and promoted proliferation with L929 cell cytotoxicity test . Both antibacterial and cytotoxic results showed that the CSA/HPMC film was a promising material for medication, cosmetics and food preservation applications.
研究领域:
生物材料学
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医学
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食品科学
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PubMed
高影响因子
FIBERS AND POLYMERS
·
2018
·Vol. 19
·期 5
·941-948
·
IF 1.353
Li Xiaojie,Chao Guiqun,Wang Liangan,Xu Xianlin,Cai Zhanjun,Shi Lei,Zhuang Xupin,Cheng Bowen
In this work, an affinity nanofiber membrane was successfully prepared by solution blowing of arginine-modified chitosan (CS-Arg) for bovine serum albumin (BSA) adsorption. CS-Arg was firstly synthesized by coupling L-arginine onto chitosan backbone. Then, CS-Arg nanofiber membranes (CANFs) were fabricated using solution blowing process with Polylactide (PLA) as assistant polymer. The results showed that CANFs effectively adsorbed BSA, and the adsorption capacities were influenced by the degrees of substitution (DS) of arginine in CS, pH value, contact time, and initial protein concentration. The highest adsorption capacity of 445.19 mg/g was achieved uvnder the following conditions: DS of 43.7 %, pH of 7.14, and initial concentration of 3.0 mg/ml. BSA adsorbed on the CANFs membrane conformed to Langmuir model, and the adsorption rate was consistent with the second-order kinetics model. This work implies that an arginine-modified chitosan nanofiber-based novel biomaterial has a potential application in adsorption of BSA.
研究领域:
材料科学
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生物技术
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化学工程
·
生物化学
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高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2022
·
IF 8.025
Liu Yang,Lixuan Ren,Yanzhen Zhao,Siqun Liu,Huifang Wang,Xianghua Gao,Baolong Niu,Wenfeng Li
In this study, arginineated chitosan (ACS) was used as a soft brain membrane and chelating agent to synthesize ACS-ZnO NPs, and then ACS and ACS-ZnO NPs were added to a polyvinyl alcohol (PVA) matrix as an antimicrobial agent to form films by casting. The formation and structural morphology of ACS and ACS-ZnO NPs were investigated by applying FTIR, 1 H NMR, XRD, EDS, SEM, and TEM techniques, and ACS has shown better water solubility. The cytotoxicity experiments of ACS and ACS-ZnO NPs on A549 cells showed that both had good cytocompatibility. The incorporation of ACS and ACS-ZnO NPs improves the composite film's mechanical properties, water barrier, and oxygen barrier and exhibits excellent antibacterial activities against S. aureus and E. coli . More importantly, in addition to extending the shelf life of cherry tomatoes, the composite film is also biodegradable to some degree. Therefore, polyvinyl alcohol films based on ACS and ACS-ZnO NPs added as antimicrobial agents have great potential for food packaging applications.
研究领域:
材料科学
·
纳米技术
·
生物医学工程
·
食品科学
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DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）