INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2025
·
IF 8.5
Long Li,Song Hu,Feng Shao,Xiuyu Liu,Yan Jiang
Lignocellulosic nanofibers (LCNF), blending nano-scale cellulose and lignin, were carboxylated and integrated with PVA and baicalin to create a molecularly imprinted membrane (CLCNF-MINM). This innovation, leveraging reactive deep eutectic solvent technology and electrospinning, boosts adsorption capacity by 12.3–21.5 % and resolution by 31.6 %, achieving a max capacity of 142.1 mg·g −1 . The high surface area, layered structure and tunable surface chemistry of carboxyl lignocellulose nanofibers (CLCNF), along with chemisorption and multimolecular adsorption mechanisms, significantly improve adsorption efficiency and selectivity. The membrane's mechanical strength is quadrupled and it retains 96.4 % of its absorption capacity after eight cycles of use. CLCNF-MINM significantly enhances the efficient utilization of biomass resources while exhibiting exceptional performance in the separation and purification of natural products. This study provides valuable insights into the development of advanced materials for improved natural product purification.
研究领域:
材料科学
·
天然产物化学
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DOI
PubMed
高影响因子
JOURNAL OF MICROENCAPSULATION
·
2024
·
IF 3
Wei Wang,Xuan Xin,Mengmeng Zhang,Xiaofeng Li,Guanglei Zhao,Wei Dong Bai
The instability of ester bonds, low water solubility, and increased cytotoxicity of flavonoid glycoside esters significantly limit their application in the food industry. Therefore, the present study attempted to resolve these issues through liposome encapsulation. The results showed that baicalin butyl ester (BEC4) and octyl ester (BEC8) have higher encapsulation and loading efficiencies and lower leakage rate from liposomes than baicalin. FTIR results revealed the location of BEC4 and BEC8 in the hydrophobic layer of liposomes, which was different from baicalin. Additionally, liposome encapsulation improved the water solubility and stability of BEC4 and BEC8 in the digestive system and PBS but significantly reduced their cytotoxicity. Furthermore, the release rate of BEC4 and BEC8 from liposomes was lower than that of baicalin during gastrointestinal digestion. These results indicate that liposome encapsulation alleviated the negative effects of fatty chain introduction into flavonoid glycosides.
研究领域:
药学
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食品科学
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化学
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DOI
PubMed
高影响因子
BioNanoScience
·
2025
·Vol. 15
·期 4
·1-10
·
IF 3.2
Ding Ziyang,Lei Shiqi,Zhou Chang,Wang Xinming,Quan Yanling,Jiang Zhongliang,Ni Qingqing,Ma Ke,Chen Wei
Hepatocellular carcinoma (HCC), as a highly lethal malignant tumor, ranks as the sixth most common cancer and the third leading cause of human death worldwide. Traditional treatment methods are limited by toxic side effects and drug resistance. This study focuses on the poorly water-soluble herb release characteristics of multi-layer coaxial nanofibers (NFs) tubes in hepatic artery embolization (TACE). A PVP/PCL core-shell structure was developed for the efficient loading and controlled release of baicalin (BG). The water-soluble PVP core ensured loading, while the compatible PCL shell enabled controlled release. Further sustained-release experiments simulated the treatment process. During in vitro release, the NFs shell showed a stable release rate after 20 h. Its cumulative release was 4.3% with a duration exceeding 1500 h. In contrast, the nanofiber core (NFC) layer exhibited rapid release and stabilized after 25 h. Accurate regulation of the release rate of the poorly water-soluble herb BG can be precisely controlled. This study provides innovative strategies for the treatment of HCC, which are expected to improve treatment efficacy and reduce side effects.
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高影响因子
Advanced Therapeutics
·
2025
·
IF 2.6
Qi Tan,Yuwei Hu,Bo Wang,Songwei Tan,Yang Guan,Li Zhou,Qing Tang
Ulcerative colitis (UC) is a chronic inflammatory bowel disease with a need for more effective and less invasive treatment options. This study aimed to develop a targeted drug delivery system using hyperbranched polyglycidylglycerol-poly(lactic acid)-hydroxyacetic acid (HPG-PLGA)nanoparticles (NPs) loaded with baicalin (BN), a flavonoid with potent anti-inflammatory properties, to enhance therapeutic efficacy in UC. HPG-PLGA NPs are synthesized, characterized, and loaded with BN. The particle size, polydispersity index (PDI), encapsulation efficiency, and in vitro release profile of the NPs are evaluated. The in vivo biodistribution and therapeutic efficacy of the NPs are assessed in a dextran sulfate sodium-induced UC mouse model. The synthesized HPG-PLGA NPs demonstrated good stability and a controlled release of BN. In vivo studies showed significant accumulation of NPs in the inflamed colon, with a subsequent reduction in disease activity and inflammation markers. The treatment group exhibited lower levels of tumor necrosis factor-alpha, interleukin-1 beta, and interleukin-6 compared to the model group, indicating effective alleviation of inflammation. Furthermore, the NPs showed no significant toxicity to major organs. This study provides a promising approach for the development of targeted UC treatments, offering a potential clinical application by enhancing the bioavailability and specificity of BN to inflammatory sites.
研究领域:
药剂学
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纳米技术
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胃肠病学
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炎症性肠病
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药物递送系统
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DOI
高影响因子
Materials Today Physics
·
2021
·
IF 9.298
Xiaodan Tang,Huiyong Wang,Hongmei Yu,Brian Bui,Wei Zhang,Shaoyan Wang,Mingli Chen,Liqin Yuan,Zhizhi Hu,Wei Chen
Baicalin, a flavonoid compound extracted from the rhizome of Scutellar iae Baicalensis, plays a vital role in improving liver function after injury, reducing liver disease and treating primary liver cancer, which is also the first SARS-CoV-2 3CLpro virus inhibitor according to the latest research data published in BioRxiv. Therefore, constructing a simple and highly sensitive analytical method for the determination of baicalin is of great significance for the clinical and pharmacy settings. Herein, for the first time, carbon dots are explored for baicalin detection. Using biomass waste grape peels as the organic carbon source, nitrogen-doped fluorescent carbon dots (PT-NCDs) were fabricated, which were synthesized perfectly by a simple, environmentally friendly and one-step solid-phase thermal method without adding any other organic or acid/base reagents. Based on the synergistic effect of photo-induced electron transfer and dynamic quenching, a quenched fluorescence sensor for the determination of baicalin with a good linear range of 0.1–20 μM and a satisfactory detection limit of 43.8 nM was constructed, which successfully quantified trace amount of baicalin in baicalin capsules, human serum and urine samples. The results indicate that PT-CDs are expected to become potential sensing materials for the real-time monitoring of baicalin in organisms, which is very important for our health.
研究领域:
药理学
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分析化学
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材料科学
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DOI
高影响因子
PREPARATIVE BIOCHEMISTRY & BIOTECHNOLOGY
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2020
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IF 1.415
Xiao-Di Ma,Xin-Guo Zhang,Si-Jia Guo,Guo-Yan Ma,Wen-Jie Liu,Nan Wang,Ming Feng,Yu Su
Endophytes may depend on degrading the plant cell wall with cellulases for their survival. Therefore, cellulase produced by endophytes may be useful in releasing the active ingredient of medicinal plants. Scutellaria baicalensis Georgi is a traditional Chinese medicinal plant widely used in China and baicalin is one of its main active ingredients. In this study, fresh S. baicalensis Georgi was used to isolate endophytes, Congo red staining was used to screen cellulase-producing strains, and HPLC was used to determine the content of baicalin in S. baicalensis Georgi. As a result, a highly active strain of endophyte capable of the extraction of high levels of baicalin was obtained. The strain was named HG-5 and identified as Bacillus sp. Scanning electron microscopy analysis confirmed that the enzyme better promotes the dissolution of plant active ingredients. After optimizing the enzyme production and extraction processes, we found that when compared with the traditional extraction method, the baicalin yield was increased 79.31% after extraction with the HG-5 enzyme. The current study provides a novel approach and method for the use of endophyte cellulase to improve the extraction of compounds from medicinal plants.
研究领域:
药用植物学
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生物技术
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药物化学
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DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2024
·
IF 13.3
Yiwei Zhang,Yong Chen,Ping Shao,Yingjie Luo,Xuesong Liu,Tengfei Xu
Diabetes is a chronic disease affects nearly 10% of the global population, the prolonged metabolic abnormalities and the complex microenvironment in diabetic wounds often leading to impaired healing. To address the typical characteristics of diabetic wounds, such as hyperglycemia, low pH, excessive reactive oxygen species (ROS) production, and chronic inflammation, this study designed a baicalin derivative dynamically cross-linked natural polysaccharide hydrogel (CFPB) and explored its potential to promote diabetic wound healing. The framework of CFPB utilized chitosan and modified with dextran to introduce aldehyde groups via mild grafting, and crosslinked with the modified active substance baicalin to effectively extend the drug delivery time. A series of characterizations demonstrated that CFPB hydrogel possesses excellent mechanical properties, self-healing ability, and responsive release capability. Subsequently, multi-level biological experiments validated the promoting effect of CFPB hydrogel on diabetic wound healing in vitro and in vivo . This study not only offers a potential candidate for the local therapy of diabetic wounds, but also provides new insights for the development of advanced wound dressings.
研究领域:
药剂学
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材料科学
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生物医学工程
·
伤口愈合
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DOI
高影响因子
ADVANCED POWDER TECHNOLOGY
·
2026
·Vol. 37
·期 11
·105471
·
IF 4.5
Fuhua Luo,Dan Liu,Pan Yu,Luyi Xu,Mingyan An,Songlin Chen,Shuming Wen
During the separation process of pyrite and chalcopyrite, baicalin has an inhibitory effect on pyrite. • The adsorption amount of baicalin on pyrite is greater than that on chalcopyrite. • It elucidates the adsorption mechanism of baicalin on the surface of pyrite. • Baicalin adsorbed on pyrite and blocked subsequent collector adsorption on the mineral surface. In this study, baicalin (BA), a flavonoid compound, was used as a depressant for the selective separation of chalcopyrite and pyrite. The performance and mechanism of the depressant were comprehensively investigated. BA exhibited selective inhibition of pyrite during flotation separation. Under conditions of pH = 6, a BA dosage of 20 mg/L, a potassium butyl xanthate (KBX) dosage of 15 mg/L, and a MIBC dosage of 20 mg/L, the copper recovery rate in the concentrate reached 74.51%, with a grade of 33.707%. Contact angle and ToF-SIMS measurements showed that BA exhibited selective adsorption on the pyrite surface, thereby enhancing surface hydrophilicity. In contrast, the adsorption of BA on the chalcopyrite surface was found to be negligible. XPS and FTIR analyses further confirmed that the carboxyl or hydroxyl groups in baicalin exhibit strong adsorption at Fe sites on the surface of pyrite, whereas adsorption on the surface of chalcopyrite is weaker. Therefore, BA has the potential to serve as a depressant for the selective separation of chalcopyrite and pyrite. As a flavonoid, BA contains carboxyl (–COO) and hydroxyl (–OH) groups, which readily interact with active metal sites on the mineral surface. XPS results further confirm that the carboxyl (–COO) or hydroxyl (–OH) groups of BA interact with Fe ion sites on the surface of pyrite, while FTIR results further confirm that BA exhibits strong adsorption through the interaction of its hydroxyl (–OH) groups with Fe ion sites on the surface of pyrite. BA adsorbed on the pyrite surface occupies space and exerts electrostatic repulsion, thereby hindering the adsorption of KBX on the pyrite surface, thus achieving the selective flotation separation of pyrite and chalcopyrite. Based on the experimental results and mechanistic analysis, the adsorption of BA and KBX on pyrite and chalcopyrite was qualitatively simulated; Fig. 16 shows a schematic diagram of the qualitative adsorption of BA and KBX on pyrite and chalcopyrite. Download: Download high-res image (206KB) Download: Download full-size image
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DOI
高影响因子
ACS Biomaterials Science & Engineering
·
2025
·
IF 5.5
Zhengqun Huang,Mingrun Tang,Huirong Tan,Yuanfeng Li,Yong Liu,Hongping Wan
The sharp-edged structure of inorganic nanomaterials has attracted considerable interest due to its potential to confer broad-spectrum antiviral properties. Herein, a series of hydroxyapatite-balance-based (HA-B) nanorods with well-defined aspect ratios were synthesized to investigate their antiviral activity. Among them, HA-B0.05wt% exhibited the highest aspect ratio (AR = 11.7 ± 4.7) and demonstrated potent, broad-spectrum antiviral activity against enveloped virus, including pseudorabies virus (PRV, DNA virus), transmissible gastroenteritis virus (TGEV, RNA virus), and porcine epidemic diarrhea virus (PEDV, RNA virus). For extracellular viruses, HA-B0.05wt% exerts its antiviral effect primarily through the physical disruption of viral envelopes, facilitated by its sharp-edged nanostructures. In the case of intracellular viruses, HA-B0.05wt% mitigates infection by attenuating virus-induced intracellular reactive oxygen species (ROS) accumulation and activating the host’s innate immune responses, thereby effectively suppressing viral replication and release. Furthermore, in vivo evaluation demonstrated that treatment with HA-B0.05wt% significantly reduced viral load and improved survival rates in PRV-infected mice. Collectively, these findings highlight HA-B0.05wt% as a promising candidate for broad-spectrum antiviral therapy with potential applications in biosecurity and infectious disease control.
研究领域:
纳米材料
·
病毒学
·
抗病毒治疗
·
生物医学工程
·
传染病防控
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产品关联
DOI
PubMed
高影响因子
ANALYST
·
2026
·
IF 3.3
Yijie Zhang,Yongxin Tao,Shan Li,Yong Qin,Jinmin Wang
Baicalin (Bn), a bioactive compound derived from natural plants, has significant pharmaceutical value and is used in the treatment of diseases such as influenza. However, excessive baicalin administration may lead to increased drug toxicity, immune system disturbances, reduced therapeutic efficacy, and allergic reactions. The synergistic combination of bimetallic MOF and carbon nanotubes (CNT) yields a pronounced enhancement in electrochemical signal toward the analyte. In this study, a simple and low-cost one-pot method was proposed to fabricate ZnNi-MOF@MWCNT nanocomposites, which were used to develop an electrochemical sensor for the detection of Bn. Under optimized conditions, the sensor demonstrated a wide linear detection range of 5 × 10⁻⁹ to 6 × 10⁻⁷ M for Bn, with a limit of detection (LOD) of 1.12 × 10⁻⁹ M and a sensitivity of 130 A•M⁻¹. The sensor exhibited excellent stability, reproducibility, and resistance to interference from various substances. Additionally, the sensor showed satisfactory stability and recovery rates when applied to real sample goat serum. The proposed sensor material can be synthesized at room temperature, offering a new approach for the green synthesis of MOF-derived materials in pharmaceutical analysis.
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PubMed
高影响因子
RSC Advances
·
2017
·Vol. 7
·期 14
·8178-8185
·
IF 3.108
Xueyang Fang,Xianlin Wu,Chang'e Li,Binwei Zhou,Xiaoyin Chen,Tianfeng Chen,Fang Yang
As a traditional Chinese medicine, baicalin exhibits high antitumor activity towards hepatitis B virus (HBV)-infected liver cancer, but low toxicity towards normal tissues. However, the properties of baicalin, including its low hydrophilicity and poor biocompatibility, have limited its clinical application. Herein, in this study, we have designed and synthesized multifunctional selenium nanoparticles (SeNPs) with baicalin (B) and folic acid (FA) surface-modifications for the targeted treatment of HBV infected liver cancer. B–SeNPs–FA showed appropriate particle size distribution, high stability, and higher cellular uptake by tumor cells than normal cells. The nanoparticles primarily targeted lysosomes in HepG2215 cells through utilization of the main pathways of caveolae-mediated endocytosis and energy-dependent endocytosis. B–SeNPs–FA induced HepG2215 cell apoptosis by down-regulating the generation of reactive oxygen species (ROS) and the expression of the HBxAg protein. In addition, B–SeNPs–FA exhibited an excellent ability to inhibit cancer cell migration and invasion. Taken together, these results suggest that baicalin-loaded selenium nanoparticles with a folic acid targeting moiety could be a promising strategy for the design and synthesis of cancer-targeted nanomaterials to treat HBV-infected liver cancer.
研究领域:
药理学
·
肿瘤学
·
纳米医学
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产品关联
DOI
高影响因子
Frontiers in Pharmacology
·
2021
·
IF 5.811
Wei Jingyao,Liu Ruijuan,Zhang Jiali,Liu Shuaibing,Yan Dan,Wen Xueqian,Tian Xin
Background: Sorafenib (SOR) is an oral, potent, selective, irreversible epidermal growth factor receptor tyrosine kinase inhibitor (EGFR-TKI) used as the first-line therapy for advanced hepatocellular carcinoma (HCC). Baicalin (BG) is used as adjuvant therapy for hepatitis, which accounts for the leading cause of the development of HCC, and is commonly coadministered with SOR in clinic. The purpose of the current study was to characterize the pharmacokinetic changes of SOR and the potential mechanism when SOR is administered concomitantly with BG in rats for single and multiple doses.Methods: Parallel randomized pharmacokinetic studies were performed in rats which received SOR (50 mg/kg, i.g.) alone or coadministered with BG (160 mg/kg, i.g.) for single and multiple doses (7 days). Plasma SOR levels were quantified by ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS). Rat liver microsomes (RLMs) which isolated from their livers were analyzed for CYP3A and SOR metabolism activities. The inhibitory effect of BG on the metabolism of SOR was also assessed in pooled human liver microsomes (HLMs). The effects of BG on the intestine absorption behaviors of SOR were assessed in the in situ single-pass rat intestinal perfusion model.Results: Coadministration with BG (160 mg/kg, i.g.) for single or multiple doses significantly increased the Cmax, AUC0–t, and AUC0–∞ of orally administered SOR by 1.68-, 1.73-, 1.70-fold and 2.02-, 1.65-, 1.66- fold in male rats and by 1.85-, 1.68-, 1.68-fold and 1.57-, 1.25-, 1.24- fold in female rats, respectively (p < 0.01 or p < 0.05). In vitro incubation assays demonstrated that there were no significant differences of Km, Vmax, and CLint of 1-OH MDZ and SOR N-oxide in RLMs between control and multiple doses of BG-treated groups. BG has no obvious inhibitory effects on the metabolism of SOR in HLMs. In comparison with SOR alone, combining with BG significantly increased the permeability coefficient (Peff) and absorption rate constant (Ka) of the SOR in situ single-pass rat intestinal perfusion model.Conclusion: Notably enhanced oral bioavailability of SOR by combination with BG in rats may mainly account for BG-induced SOR absorption. A greater understanding of potential DDIs between BG and SOR in rats makes major contributions to clinical rational multidrug therapy in HCC patients. Clinical trials in humans and HCC patients need to be further confirmed in the subsequent study.
研究领域:
药理学
·
肿瘤学
·
药学
·
临床研究
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DOI
PubMed
高影响因子
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