COLLOIDS AND SURFACES B-BIOINTERFACES
·
2026
·
IF 5.9
Xueli Hou,Fang Jian,Jinyao Xu,Fanfan Zhang,Shengyue Wu,Dexin Xia,Lin An
A multifunctional pH‑responsive calix[4]arene‑based carrier CMP with dual hydrophobic alkyl substituents and biotin‑PEG chains was constructed for co‑delivery of DOX and Ce6. • The blank calixarene matrix acts as a supramolecular chemotherapeutic agent with certain intrinsic antitumor activity, while co-loaded DOX and Ce6 elicit prominent in vitro chemo-photodynamic suppression. • The biotin‑targeted DOX@CMP@Ce6 nanosystem achieves potent in vivo tumor inhibition along with favorable biosafety. Conventional nanoplatforms often suffer from complicated fabrication, poor structural controllability, insufficient tumor targeting, and unsatisfied therapeutic efficacy. To address these issues, herein we rationally design and construct a novel calix[4]arene derivate CMP, whose upper rim is functionalized with pH-responsive biotin-PEG hydrophilic chains, and lower rim is dually modified with hydrophobic alkyl chains and antitumor pharmacophores. This “all-in-one” supramolecule can not only serve as an excellent supramolecular chemotherapeutic agent itself, but also act as a versatile carrier to co-deliver doxorubicin (DOX) and chlorin e6 (Ce6). The nanoplatform therefore integrates two types of chemotherapeutic modalities and biotin-targeted photodynamic therapy for multi-modal tumor treatment. Notably, in vivo experiments demonstrate that the resultant DOX@CMP@Ce6 nanosystem achieves a 90.5% tumor growth inhibition rate, while displaying biotin-mediated tumor tropism, excellent biocompatibility, and robust triple-modality combinatorial therapeutic effects. Collectively, this work provides key insights into the rational construction of multifunctional supramolecular platforms, reinforcing the broad prospects of calixarene derivatives for nanomedical applications.
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CURRENT ORGANIC CHEMISTRY
·
2012
·Vol. 16
·期 22
·2745-2751
·
IF 3.064
Khalid Khan,Hong Huang,Yan-Song Zheng
A new family of non-ionic amphiphilic dendro-calix[4]arene bearing hydrophilic branched substituents at the upper rim and lipophilic alkyl chains at the lower rim was designed and synthesized. Micelles of various sizes are obtained due to the amphiphilic nature of the calix[4]arene derivatives in aqueous medium. The amphiphilic calix[4]arene derivatives effectively load hydrophobic dye such as alizarin yellow via secondary interactions such as hydrogen bonding and π-π stacking. The length of alkyl chain and the intrinsic cyclic nature of calixarene scaffold have shown a significant impact on the transport potential of all amphiphiles.
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RSC Advances
·
2016
·Vol. 6
·期 43
·36256-36263
·
IF 3.289
Huiqi Wang,Shigang Wei,Huihui Zhang,Qiong Jia
A functionalized calix[4]arene (alkenyl@C[4]A) was introduced into the poly(butyl methacrylate-ethylene dimethacrylate) monolith inside a capillary to prepare a polymer monolith microextraction (PMME) material (poly(BMA-alkenyl@C[4]A-EDMA)). Various techniques, including scanning electron microscopy, Fourier transform infrared spectroscopy, X-ray photoelectron spectroscopy, and thermo-gravimetric analysis, were employed to characterize the synthesized poly(BMA-alkenyl@C[4]A-EDMA) monoliths. A new method was developed for the preconcentration and analysis of bisphenols using PMME coupled with high performance liquid chromatography (HPLC). Under the optimized conditions, the monolithic column afforded acceptable linearities, low limits of detection, and good intra-day/inter-day relative standard deviations. The method was applied to the determination of bisphenols in human serum samples with recoveries ranged from 77.6% to 109.7%.
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TALANTA
·
2021
·
IF 6.057
Wei Gao,Ye Wang,Feng Zhang,Sen Zhang,Hong-zhen Lian
Effective protein adsorption by solid matrices from complex biological samples has attracted attention for broad application in biomedical field. Immobilization of calixarenes to solid supports is an essential process for their application in protein separation and purification. Silica is the most widely used support material in calixarene immobilization. With high concentration of polymer microspheres as templates, the large pore mesoporous silica microspheres with controllable, uniform size and structure were successfully synthesized and the resulting large pore mesoporous silica microspheres were modified with water-soluble tetrasulfonate calix[4]arene of unique hollow cavity-shaped structure. The tetrasulfonate calix[4]arene modified large pore mesoporous silica microspheres (SCLX4@LPMS) were characterized by diverse analytical techniques and their protein adsorption performance were also investigated. The obtained SCLX4@LPMS gave rise to an adsorption efficiency of >90% for cytochrome c and lysozyme within a wide pH range of 3.0–10.0 and possessed remarkably high adsorption capacity of cytochrome c (363.64 mg g −1 ) and lysozyme (166.11 mg g −1 ). The retained cytochrome c and lysozyme can be readily eluted by using phosphate buffer solution containing NaCl as a stripping reagent with the recoveries of 81% and 86% after 5 times enrichment, respectively. The SCLX4@LPMS microspheres have been applied for the selective adsorption of proteins in real samples and had the application potential in protein adsorption, drug delivery, biosensors, and other biomedical fields.
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Environmental Chemistry
·
2019
·Vol. 16
·期 8
·577-586
·
IF 2.193
Fang-Zhu Xiao,Cheng Wang,Li-Mei Yu,Yi-Qiu Pu,Yu-Li Xu,Kang Zhang,Jia-Qi Luo,Qi-Qi Zhu,Fang Chen,Yong Liu,Chun-Hsing Ho,Guo-Wen Peng,Shu-Ya He
Environmental context Uranium-containing wastewaters have high potential to harm the environment and human health. We found that the combination of calix[4]arene with magnetic Fe3O4 particles produced good adsorption of uranium from wastewater. In addition, this material can be recycled and reused, so it has good prospects in practical applications for uranium remediation. A magnetic functionalised calix[4]arene composite consisting of Fe3O4 and calix[4]arene phosphonate derivative (CPD) was prepared through a facile self-assembly method. The composite was characterised by scanning electron microscopy (SEM), powder X-ray diffraction (PXRD) and Fourier transform infrared spectroscopy (FTIR). The as-synthesised Fe3O4/CPD composite was used to remove UVI from aqueous solutions under different conditions. Meanwhile, the adsorption isotherm, kinetics and thermodynamics were fitted and analysed. The results show that the Fe3O4/CPD composite may be a promising adsorption material for the separation and enrichment of UVI from aqueous solutions in the cleanup of environmental pollution.
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JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
·
2018
·Vol. 317
·期 3
·1235-1241
·
IF 1.181
Wang Cheng,Xiao Fang-zhu,Pu Yi-qiu,Xu Yu-li,Xu Dong-yang,Zhang Kang,Liu Yong,Peng Guo-wen
P -carboxyphenyl azo calix[4]arene phosphate derivative (P-CACPD) was successfully synthesized using calix[4]arene as raw material. The P-CACPD was characterized by FT-IR and 1 H-NMR. The effects of pH, extraction time and temperature on the extraction of U(VI) by P-CACPD were investigated. The results show that pH value, extraction time and temperature have an effect on the extraction of U(VI) by P-CACPD. When the initial pH is 5, temperature is 25 °C, extraction time is 2 h, the extraction rate of U(VI) by P-CACPD reaches the maximum. Both kinetics parameters and thermodynamic parameters of the extraction process were calculated. The calculated data indicate that the extraction process of uranium by P-CACPD is an exothermic spontaneous process, which well fits with the pseudo-second-order kinetic model.
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CHIRALITY
·
2025
·Vol. 37
·期 11
·e70060
·
IF 3
Shuling Dong,Jiayi Sun,Fan Ding,Ji Wu,Ronghua Fan,Li Zhou
In this work, a new strategy was proposed for the preparation of a chiral stationary phase based on β-cyclodextrin and calix[4]arene polymer. The chiral stationary phase was characterized by scanning electron microscopy, energy dispersive x-ray spectroscopy, Fourier transform infrared spectroscopy, and thermogravimetric analysis. The introduction of calix[4]arene polymer increased chirality recognition by increasing recognition sites and interactions, including hydrogen bonding, π–π interaction and synergistic inclusion effect. Compared with the home-made β-cyclodextrin–based chiral column, the prepared β-cyclodextrin–calix[4]arene polymer-based chiral column showed superior enantioseparation performance toward 1-phenylethanol, prothioconazole, promethazine, propranolol, and bisoprolol. These chiral compounds can be separated within 10 min under reversed-phase mode with resolutions ranging from 1.62 to 1.80. These findings will provide an important reference for developing novel supramolecule-based chiral stationary phases.
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Journal of Environmental Chemical Engineering
·
2019
·
IF 0
Alemtsehay Tesfay Reda,Dongxiang Zhang
Selective Removal of metal ions from simulated wastewater by sulfonated calix[4]arene intercalated with layered double hydroxide (SC4A-NO 3 -LDH) is reported in the present paper. The SC4A-NO 3 -LDH exhibited high adsorption performance towards metal ions with selectivity order of Fe(III) > Cu(II) > Pb(II) > Ag(I) for heavy metal ions, and Eu(III) > Nd(III) > La(III) for rare earth metal ions. Kinetics of Fe 3+ , Cu 2+ and Eu 3+ were found to follow pseudo-second-order reaction, suggesting chemisorption mechanism. Efficient sorption, with 100% removal rate and 3.80 × 10 7 mL/g distribution coefficient ( K d ) towards Fe(III) is typical potential of SC4A-NO 3 -LDH. For Cu 2+ and Eu 3+ ions sorption, K d values of 1.03 × 10 6 and 7.25 × 10 6 mL/g, and removal rates of 99.88 and 99.98%, respectively, were obtained. 0.005 g of SC4A-NO 3 -LDH was enough to lower 2.6 ppm of Fe 3+ –< 1 ppb. After the sorption, samples were characterized by analytical methods such as X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), and Fourier transform Infrared spectroscopy (FTIR) and proved that the target ions on their respective samples. XRD and FTIR were also used to check the stability of the samples after sorption.
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TALANTA
·
2026
·
IF 6.7
Xianglin Liao,Yanxia Ma,Bingni Huang,Dehui Yang,Yiying Liang,Xixiang Yang,Junhua Li,Li Wang,Xiaogang Hu
Enrichment and detection of trace antibiotics in complex matrices are challenged by severe matrix interference and low analyte abundance. Herein, a synergistic recognition interface was engineered on magnetic imprinted polymers by integrating acryloyl-calix[4]arene (AC[4]A) and aptamer (Apt). This dual-receptor interface exploits complementary binding modes to specifically recognize enrofloxacin (ENR). Specifically, AC[4]A captures the hydrophobic moiety of ENR via host-guest inclusion, while the aptamer targets its aromatic/carboxyl groups through hydrogen bonding and π-π stacking. Multimodal analyses ( 1 H NMR, CD, molecular docking, and MD simulations) reveal spatially distinct binding sites. Molecular docking indicates a synergistic enhancement of −2.9 kcal/mol in the ternary complex relative to binary sums, while MD simulations reveal that the cooperativity arises from entropy-driven conformational adaptation and interface complementarity. Moreover, the imprinted framework stabilizes the aptamer, retaining >80% extraction capacity after DNase I treatment. With an imprinting factor (IF) of 8.5 and a synergistic recognition factor (SRF) of 1.5, this dual-receptor interface demonstrates a clear “1 + 1>2” effect and the resulting method offers a wide linear range (2.5-300 μg/L) with a low detection limit (0.42 μg/L), well below regulatory limits. Applied to the enrichment and analysis of animal-derived samples, it significantly reduces matrix interference with recoveries of 83.3-98.2%. This dual-receptor strategy provides a reliable and sensitive platform for trace antibiotic enrichment and detection in complex matrices.
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JOURNAL OF COLLOID AND INTERFACE SCIENCE
·
2019
·
IF 6.361
Yufeng Yao,Jia Fan,Ming Shen,Weizheng Li,Bin Du,Xue Li,Jingtao Dai
In this study, hexylresorcinol calix[4]arene (HRCA) is introduced into the reaction system, and HRCA-capped ZnO–Ag nanocomposites are prepared via a simple one-step reflux method. HRCA is used not only as a reducing agent for deoxidizing Ag + to Ag, but also as a protectant for wrapping around the microstructure of the formed ZnO–Ag. The prepared samples are characterized by X-ray diffraction, scanning electron microscopy, transmission electron microscopy (TEM), high-resolution TEM, X-ray photoelectron spectroscopy, Fourier-transform infrared spectroscopy, and water contact angle. The Ag nanoparticles and ZnO adhere to each other and HRCA molecules encapsulate on the surface of ZnO–Ag nanocomposites. HRCA-capped ZnO–Ag nanocomposites with different Ag contents are investigated for use in photodegradation of organic pollutants (rhodamine B (RhB) and levofloxacin hydrochloride). The sample with 10.20 mol% Ag, denoted as ZA3, exhibits the highest catalytic activity for photodegradation of RhB and levofloxacin hydrochloride. Moreover, ZA3 exhibits high stability during photodegradation of organic pollutants even after multiple reuses. The possible photocatalytic mechanism is discussed. We believe that O 2 − and h + are the chief active species responsible for the photocatalytic activity of HRCA-capped ZnO–Ag nanocomposite system. HRCA-capped ZnO–Ag nanocomposite is expected to be an effective photocatalyst with potential application to sewage treatment under sunlight.
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SENSORS AND ACTUATORS B-CHEMICAL
·
2015
·
IF 4.097
Shaofei Zhang,Hui Yang,Ying Ma,Yu Fang
A bis-nitrobenzoxadiazole (NBD) derivative of calix[4]arene (L 1 ) and a control compound (L 2 ), mono-NBD derivative of the calixarene were designed and prepared via click chemistry. Fluorescence studies demonstrated that L 1 as created can function as a switch with the presence of Ag + in THF, of which the free state of L 1 emits at ∼527 nm, but the binding state at 576 nm. Based upon this discovery, L 1 was studied as a chemo-sensor of Ag + in a mixture solvent of THF and H 2 O with a detection limit (DL) of ∼6.2 × 10 −7 mol/L. Presence of other commonly found metal ions shows little effect upon the determination. Moreover, the L 1 in the Ag + -L 1 complex could be fully released with introduction of HCHO, a bases for the sensitive and selective detection of the toxic chemical. The DL of this test is 6.6 × 10 −7 mol/L. Interestingly, binding and releasing of the fluorescent ligand could be repeated for at least 5 times. Furthermore, both sensing could be performed in a visualized manner. It is believed that the fluorescent compound as created should have a potential to find real-life applications.
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MICROCHIMICA ACTA
·
2025
·Vol. 192
·期 3
·1-14
·
IF 5.3
Xiong Lihao,Tong Yuqi,Song Jiayi,Chen Sihan,Liu Yu,Liu Jinquan,Li Le,Zhen Deshuai
A novel fluorescence/colorimetric dual-mode detection strategy for uranium ions (UO 2 2+ ) is presented based on a cerium-sulfonyl calix[4]arene (SC4A) platform. The exo- and endo-rim sites of SC4A can coordinate with Ce 3+ and Ce 4+ ions, respectively, quenching Ce 3+ fluorescence and influencing the oxidase-like activity of Ce 4+ . In the absence of UO 2 2+ , the solution of 3,3,5,5-tetramethylbenzidine (TMB) remains blue, but upon UO 2 2+ binding, Ce 3+ dissociates from SC4A, restoring fluorescence, while UO 2 2+ interacts with oxTMB, turning the solution from blue to colorless. This dual-mode system provides a linear fluorescence detection range of 30–800 nM with a detection limit of 20.20 nM, and a colorimetric range of 30–800 nM with a detection limit of 27.78 nM. By combining high-sensitivity fluorescence with visual colorimetric analysis, the proposed method possesses high sensitivity, accuracy, and reliability. Notably, smartphone-based color capture facilitates rapid and convenient sample analysis, enabling straightforward quantification at varying UO 2 2+ concentrations. The method has been successfully applied to real water and urine samples, demonstrating its practical utility in environmental and biological monitoring of UO 2 2+ . Graphical abstract
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危险品化学品经营许可证（带存储）