APPLIED CLAY SCIENCE
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2022
·
IF 5.907
Tianqi Yuan,Miao Chen,Xiaotong Sun,Jianping Guan,Fawei Zhu,Kai Tang,Zhipeng Zhang,Qi Liu,Xiaoqing Chen
Designing chiral adsorption separation material with high enantioselectivity and stability is a promising route to realize the enantioselective recognition and separation of racemic molecules. Here, for the first time, camphor sulfonic acid derivatives (CSA) were synthesized as a chiral resolving agent, and it was modified on Mg/Al layered double hydroxide (Mg/Al-LDH) through electrostatic self-assembly to construct functionalized chiral adsorption separation material (CSA@LDH), which could be served as an adsorbent for enantioselective recognition and separation of propranolol enantiomers ( R,S -PRO). The CSA@LDH maintained the advantage of limited chiral space in layered structures to achieve the selective enrichment of R -PRO, and the e.e. % value of single separation could reach 19.5%. Meanwhile, density functional theory (DFT) calculations supported that chiral recognition and separation were ascribed to the discrepancy in affinities stemming from the difference of π-π interaction force and hydrogen bonding capacity of CSA with R,S -PRO. Hence, considering the superior ability of hydrogen bond coordination and stereocontrol of camphor sulfonic acid derivatives, it is expected to be more widely used as a chiral resolving agent for other enantiomeric recognition and separation.
研究领域:
化学
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材料科学
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药物化学
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DOI
高影响因子
PLoS One
·
2021
·Vol. 16
·期 9
·e0255504
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IF 3.24
Jing Zhang,Zhou-Tao Pei,Ya-Ni Zhao,Meng Zhang,Li-Ling Zhang,Wen-Qiang Wang,Jing-Ya Wu,Ran Yu,Li-Wei Sun
Benzophenone (BPs) and 4-Methylbenzylidene Camphor are used as ultraviolet (UV) filters to protect the skin and hair in personal care products. The discharging of the three chemicals may endanger the receiving water ecosystem. In the present study, the mutagenicity of BP-6, BP-8, and 4-Methylbenzylidene Camphor was tested using the Salmonella typhimurium reverse mutation test (Ames test) in the system with and without rat liver microsomal preparations (S9). Four S . typhimurium strains, TA97, TA98, TA100, and TA102 were employed in the Ames tests. The mutagenicity was detected from all three chemicals. The addition of S9 increased the mutation ratios of three chemicals to four strains, except BP-6 to TA100 strain and 4-MBC to TA97 and TA98 strain. In the mixed experiment, all positive effects were detected in the absence of S9. However, the results all became negative in the presence of S9. For the mixture of BP-6 and 4-MBC, positive results were detected on four tester strains except for the TA100 strain. For the mixture of BP-6, BP-8, and 4-MBC, positive results were detected on four strains. The mixture test results showed antagonism in mutagenicity for the mixture of BP-6 and 4-MBC to TA98 and TA100 strains and the mixture of BP-6, BP-8, and 4-MBC to TA100 and TA102 strains.
研究领域:
环境科学
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毒理学
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生物学
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DOI
高影响因子
ACS Sustainable Chemistry & Engineering
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2026
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IF 7.6
Xuemei Xiao,Wei Shao,Xiaoman Ye,Sheng Liu
The practical deployment of aqueous zinc-ion batteries is severely hindered by parasitic reactions and dendrite growth at the zinc metal anode, making advanced electrolyte engineering a critical pursuit. In this work, an efficient camphor-derived electrolyte additive, sodium camphorsulfonate, was developed to significantly improve the electrochemical performance of aqueous zinc-ion batteries by synergistically regulating the Zn2+ ion solvation microenvironment and directing the strong Zn(002) deposition texture. The efficacy of the trace sodium camphorsulfonate additive is demonstrated by an ultralong cycling lifespan of 7450 h and a cumulative plated capacity of 11.2 Ah cm–2 for Zn||Zn symmetric cells (3 mA cm–2, 1 mAh cm–2), and is further corroborated by the 72.5% capacity retention of Zn||V2O5·nH2O full cells after 2000 cycles at 2 A g–1. This study establishes a paradigm for harnessing natural compounds in electrolyte engineering, thereby guiding the development of sustainable, high-performance batteries.
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DOI
高影响因子
JOURNAL OF NATURAL PRODUCTS
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2026
·
IF 3.7
Yuling Zeng,Jing Nie,Haiyan Lan,Yichao Zhang,Yufang Dai,Xiaojie Cao,Liang Zhang,Jianjian Hu
Camphor is a key quality determinant of lavender oil. Bornyl dehydrogenase (BDH) catalyzes the final camphor biosynthesis step, yet its gene family and mechanism in lavender remain uncharacterized. We phylogenetically classified 154 short-chain dehydrogenase/reductase (SDR) genes into six clades and screened 17 BDH genes. Integrated transcriptomic and metabolomic analyses revealed that camphor biosynthesis primarily occurs via the plastidic 2-C-methyl-D-erythritol 4-phosphate (MEP) pathway, with coordinated expression of geranyl diphosphate synthase (GPPS), bornyl diphosphate synthases (BPPS), bornyl-diphosphate diphosphatase (BDD), and BDH genes. Most biosynthetic genes, especially BDH and BPPS, were significantly upregulated in L. × intermedia “Xinxun 4”, correlating with its highest camphor content. Subcellular localization showed BDH1 resides in the cytoplasm, suggesting plastid-cytoplasm collaboration. In vitro assays demonstrated that BDH1 and BDH2 both oxidize (+)- and (−)-borneol to camphor. Molecular dynamics simulations revealed that BDH1’s active site exhibits conformational flexibility, accommodating both enantiomers with similar binding affinities, which was confirmed by enzyme kinetics. Asn90 was identified as a key catalytic residue. These findings reveal BDH family expansion, coordinated gene expression driving camphor accumulation, and BDH1’s catalytic flexibility, offering key genetic resources and mechanistic insights for optimizing lavender camphor content via metabolic engineering and molecular breeding.
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DOI
PubMed
高影响因子
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
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2024
·
IF 5.7
Li Zhang,Yizhong Huang,Xinying Duan,Hongyan Si,Hai Luo,Shangxing Chen,Liheng Liu,Haohua He,Zongde Wang,Shengliang Liao
Rice sheath blight, caused by the fungus Rhizoctonia solani, poses a significant threat to rice cultivation globally. This study aimed to investigate the potential mechanisms of action of camphor derivatives against R. solani. Compound 4o exhibited superior fungicidal activities in vitro (EC50 = 6.16 mg/L), and in vivo curative effects (77.5%) at 500 mg/L were significantly (P < 0.01) higher than the positive control validamycin·bacillus (66.1%). Additionally, compound 4o exhibited low cytotoxicity and acute oral toxicity for adult worker honeybees of Apis mellifera L. Mechanistically, compound 4o disrupted mycelial morphology and microstructure, increased cell membrane permeability, and inhibited both PDH and SDH enzyme activities. Molecular docking and molecular dynamics analyses indicated a tight interaction of compound 4o with PDH and SDH active sites. In summary, compound 4o exhibited substantial antifungal efficacy against R. solani, serving as a promising lead compound for further optimization of antifungal agents.
研究领域:
植物病理学
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植物化学
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分子生物学
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DOI
PubMed
高影响因子
SEPARATION AND PURIFICATION TECHNOLOGY
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2025
·
IF 9
Miao-Miao Jia,Si-Yuan Yang,Ke-Ke Chen,Pan-Pan Zhang,Wei Shao,Zhen Chen,Zi-Meng Xu,Qing-Yun Wu,Yi Li,Ming Xue
Thin-film composite (TFC) reverse osmosis (RO) membranes, fabricated by interfacial polymerization, have achieved significant success in addressing the global water scarcity. Over the past three decades, the camphor sulfonic acid (CSA)/triethylamine (TEA) has been widely used in fabrication of TFC RO membranes. However, the mechanism of this unique formula remains elusive and contentious. In this work, for the first time, deciphering that introducing CSA/TEA into the aqueous phase has negligible impact on the selective polyamide (PA) layer but facilitate the aqueous solution impregnating of porous polysulfone (PSf) support. Specifically, the acidic CSA significantly hinders amine diffusion yet preserves the porosity of the PSf support during high-temperature curing. TEA is essential in modulating the pH changes and balancing the monomer diffusion rate that results from CSA. The COMSOL simulations have further elucidated that the presence of an aqueous solution within the porous support can mitigate the thermal expansion of the PSf, consequently inhibiting the shrinkage of surface pores. The TFC membrane demonstrated a substantial improvement in water permeance due to the preservation of its pore structure. The obtained TFC membrane demonstrated an exceptional NaCl rejection of 99.3 % and a high water flux of 76.8 L m –2 h −1 (2000 ppm NaCl, 15.5 bar), exceeding that of the state-of-the-art TFC RO membranes. Moreover, the RO membrane manifested with long-term stability and good fouling resistance. The mechanistic insights have important implications to more efficient membrane-based desalination and water reuse, thereby reducing energy consumption and minimizing environmental carbon footprint.
研究领域:
材料科学
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环境工程
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产品关联
DOI
高影响因子
Journal of Environmental Chemical Engineering
·
2026
·Vol. 14
·期 5
·123882
·
IF 7.5
Weilong Wu,Chao Li,Yi Wang,Xun Hu
Pyrolysis and activation are common methods for preparing biochar adsorbents, but these treatments often increase porosity while destroying oxygen-containing functional groups that are important for pollutant binding. In this work, a non-carbonized strategy was developed to regulate biomass surface chemistry using camphor wood. Instead of thermal treatment, lignin was removed and the material was modified with tannic acid (TA) and Fe 3 + to construct adsorption sites. The degreasing–oxidation process removed lignin and hemicellulose, exposing cellulose surfaces rich in -OH. TA and Fe 3+ further introduced polar and coordination-active sites. Structural characterization showed that lignin removal triggered hydrogen‑bond rearrangement accompanied by pore contraction, which critically governed the subsequent adsorption behavior. These interfacial changes strongly affected adsorption behavior. Raw camphor showed almost no adsorption toward methylene blue because of the inaccessible functional groups. Fe-modified samples displayed limited adsorption due to site occupation by coordination. Oxidized camphor exhibited improved adsorption because more −OH and −COOH groups were exposed. TA modification alone produced only slight enhancement because of pore restriction and hydrogen-bond competition. In contrast, TA/Fe-modified oxidized camphor achieved the highest adsorption capacity of 312.07 mg/g, higher than oxidized camphor (164.09 mg/g). The improvement mainly resulted from the synergistic effect of exposed -OH, -COOH, and partially coordinated Fe 3+ sites. The material also maintained more than 80% of its initial adsorption capacity after five cycles. Overall, this work shows that adsorption enhancement mainly comes from interfacial reconstruction rather than pore development, providing a simple route for preparing biomass-based functional adsorbents.
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产品关联
DOI
高影响因子
Journal of Energy Storage
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2026
·
IF 10.7
Ruilan Xu,Zehong Chen,Jingjing Kou,Chen Nie,Wenhua Zhang,Xintu Lin,Yong Peng
Heteroatom doping is an effective strategy to break through the energy storage limitations of the conventional carbon-based supercapacitors and enhance the pseudocapacitive behavior. In this work, nitrogen and sulfur (N/S) co-doped porous carbon materials with controllable graphitized structures and abundant surface-active sites were synthesized via an in-situ doping method, using cellulase-pretreated de-oiled camphor leaves as the biomass precursor, potassium bicarbonate (KHCO₃) as the activator, and thiourea as the N/S source. N/S co-doping not only introduced numerous Faradaic active sites but also effectively balanced the graphitization degree and defect density of the material, significantly improving the pseudocapacitive contribution and overall capacitive performance. When the mass ratio of precursor, KHCO₃, and thiourea was 1:3:0.6, the resulting porous carbon electrode (PCNS-0.6) achieved a specific capacitance of 261 F·g −1 at the current density of 1 A·g −1 . At a scan rate of 10 mV·s −1 , the pseudocapacitive contribution reached 30.23%. Moreover, a symmetric supercapacitor assembled with PCNS-0.6 exhibited a capacitance retention rate of 89.5% after 10,000 cycles at 5 A·g −1 , and achieved an energy density of 13.63 Wh·kg −1 at a power density of 500 W·kg −1 , demonstrating excellent cyclic stability and promising potential for energy storage applications. This work provides an efficient synergistic modification strategy for the structural regulation and performance optimization of the biomass-derived carbon materials.
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DOI
高影响因子
Molecular Catalysis
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2022
·
IF 5.089
Xiaoxiang Hu,Huaxiang Deng,Yajun Bai,Tai-Ping Fan,Xiaohui Zheng,Yujie Cai
Arabidopsis has attracted increasing attention to biotechnology as a model plant. Among, many of studies have focused on monoterpenoids metabolism. Borneol is a typical representative of monoterpenoids and widely applied in fragrances and pharmaceuticals. And (+)-camphor also is also attracting more and more interest in the field of pharmaceutical. However, the enzyme involved the conversion of borneol and camphor in Arabidopsis is still unknown. In this study, a borneol dehydrogenase (BDH) from Arabidopsis lyrate was overexpressed in Escherichia coli BL21 (DE3). The optimum pH for reduction and oxidation were 7.5 and 9.0, respectively, and the optimum temperature was 45 ℃. The specific activity of reduction reaction for (-)-camphor and (+)-camphor were 1.09 and 0.76 U·mg −1 which were the highest so far. The AlBDH coupled with glucose dehydrogenase (GDH) of coenzyme regeneration could efficiently convert rac -camphor, yielding 4.64 mM rac -borneol within 3.5 h with a conversion of 92.8%. A single point mutation L205F could successfully be used for enzymatic resolution of 2 mM rac -camphor, yielding 95.9% of (+)-camphor with an ee s of > 99%. It also could respectively reduce (+)-camphor and (-)-camphor to optically pure (+)-borneol and (+)-isoborneol. The study of the enzymatic properties of AlBDH lay an important foundation for further studies on the conversion of borneol and camphor in Arabidopsis and provide potential industrial application value for the optically pure enantiomers borneol sustainable synthesis in the future.
研究领域:
生物化学
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生物技术
·
酶学
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产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE AND POLLUTION RESEARCH
·
2023
·
IF 5.8
Ren Suyu,Jin Xiaojie,Bekele Tadiyose Girma,Lv Min,Ding Jing,Tan Feng,Chen Lingxin
4-Methylbenzylidene camphor (4-MBC), a typical organic UV filter (OUVF) in personal care products, is considered to be a potential endocrine disruptor due to its estrogenic activity and bioaccumulation. Although 4-MBC residues have been extensively identified in aquatic waters, little is known about their occurrence, levels, and potential risk in coastal waters. This study developed a reliable sampling approach, based on diffusive gradients in thin films (DGT) with XAD-2 as the binding agent, for monitoring 4-MBC in coastal waters. The diffusion coefficients of 4-MBC in freshwater and artificial seawater were 3.65 × 10 −6 cm 2 /s and 3.83 × 10 −6 cm 2 /s, respectively. XAD-2 binding gel showed rapid adsorption to 4-MBC. The accumulated masses of 4-MBC in XAD-2 DGT increased linearly with deployed time for 7 days in freshwater and seawater, which agreed well with theoretical predictions. The sampling performance was independent of ionic strength (0.0001–0.5 M), pH (4.0–8.5), and dissolved organic matter (0–20 mg/L). Field deployment in the river estuary and bathing beach showed that DGT-measured 4-MBC concentrations were consistent in comparison with grab sampling. Environmental risk assessment showed that 4-MBC may pose a medium risk to aquatic organisms based on computed risk quotient (RQ) values. Sewage discharge is the main source of 4-MBC risk, while the residue in recreation beaches contributes more significantly in summer. The established DGT sampling is suitable for seasonal monitoring, source identification, and risk assessment of 4-MBC in coastal waters. Graphical abstract
研究领域:
环境科学
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分析化学
·
水质
·
毒理学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF HAZARDOUS MATERIALS
·
2025
·
IF 11.3
Hanye Ju,Yankun Zhang,Yongqiang Qin,Jin Liu,Yihou Tang,Inna M. Sokolova,Xiaoping Diao
UV filters, such as 4-Methylbenzylidene camphor (4-MBC), are emerging environmental contaminants that threaten marine life and ecosystem integrity. This study investigated metabolic disruptions in the liver of clown anemonefish ( Amphiprion ocellaris ) after exposure to 4-MBC (0, 10, 50 µg/L) for 7 or 14 days. Exposure led to 4-MBC accumulation and significant liver metabolic disturbances and endocrine disruption in the fish. Random forest analysis identified vitellogenin and testosterone levels as key factors distinguishing treatment groups. Molecular docking showed high binding affinity of 4-MBC to 17β-hydroxysteroid dehydrogenase and vitellogenin in the liver. Additionally, 4-MBC exposure reduced thyroid hormone levels and disrupted glucose and lipid metabolism, with more severe effects at 7 days compared to 14 days. Transcriptome analysis revealed that 4-MBC interfered with hepatic insulin sensitivity by disrupting pathways involving Insulin Receptor (INSR), Phosphoinositide 3-Kinase (PI3K), Insulin Receptor Substrate (IRS), and others. It also impacted genes related to lipid accumulation, gluconeogenesis, and lipid utilization. Furthermore, 4-MBC disrupted the endoplasmic reticulum (ER)’s protein degradation system, causing ER stress and activating lipogenic pathways, which enhanced lipid accumulation. The reduction in thyroid hormones and metabolic dysfunctions may impair the reproductive health and population stability of clown anemonefish. These findings underscore the potential ecotoxicity of 4-MBC and its adverse effects on coral reef fish populations, raising concerns about its environmental impact.
研究领域:
生态毒理学
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海洋生物学
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内分泌学
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分子生物学
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环境科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）