CARBOHYDRATE POLYMERS
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2017
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IF 4.811
Mingjin Zhu,Liming Ge,Yongbo Lyu,Yaxin Zi,Xinying Li,Defu Li,Changdao Mu
The oxidized κ -carrageenans with different oxidation levels were prepared through the hydrogen peroxide and copper sulfate redox system. The oxidation level of oxidized κ -carrageenan was successfully controlled by adjusting the dosage of hydrogen peroxide. The results showed that the microtopography of oxidized κ -carrageenan changed from rough granules to smooth flakes, mainly resulting from the easily melting property of oxidized κ -carrageenan induced by introduced carboxyl and aldehyde groups. Especially, the antibacterial activity of oxidized κ -carrageenans against Gram-positive bacteria ( Staphylococcus aureus and Listeria monocytogenes ) and Gram-negative bacteria ( Escherichia coli and Pseudomonas aeruginosa ) was systematically investigated. The results showed that the oxidized κ -carrageenan could damage the bacterial cell wall and cytoplasmic membrane and suppress the growth of both Gram-positive and Gram-negative bacteria. The oxidized κ -carrageenan possessed broad-spectrum antibacterial activity, which may be used as a new antibacterial agent.
研究领域:
食品科学
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微生物学
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产品关联
DOI
PubMed
高影响因子
Bioactive Carbohydrates and Dietary Fibre
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2015
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IF 0
Wei Xu,Weiping Jin,Chunlan Zhang,Hongshan Liang,Bakht Ramin Shah,Bin Li
Self-aggregation behaviors of κ-carrageenan/lysozyme (CRG/Ly) complex inducing by intrinsic and extrinsic factors were investigated form macro and micro aspects, including the ratio, pH, temperature and salt. High Ly content promote aggregation behavior of CRG/Ly complex, while CRG played a suppressive role. Except for CRY5, the complex displayed nano-size distribution. Both CRG addition and the self-aggregation behavior could enhance the thermal stability of Ly. Low ζ-potential induced by pH made the CRG/Ly complex easy to self-aggregate into structure with large size due to the gradual association of complex to form lager interpolymeric complexes. The tunable process means to control the dissociation and association behavior between interpolymeric complexes and soluble complex by pH. All systems shared high NaCl tolerance and presented stable transmittance. Heat-induced self-aggregation exhibited a temperature and polymers ratios dependant manner. The mechanisms of environment induced self-aggregation into interpolymeric complexes reflected the re-balanced physical interaction when they suffered from any treatment. Controlling and regulating self-aggregation behavior of protein/polysaccharide system could enrich the soft structures from food respective and also provide practical theory for food process.
研究领域:
食品科学
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生物大分子相互作用
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软物质结构
✓ 已验证
DOI
COLLOID AND POLYMER SCIENCE
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2026
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IF 2.9
Sun Aijing,Yang Duoping
Polysaccharides can be regarded as sustainable materials during utilization and disposal. However, this is not the case in their extraction processes. For instance, substantial amounts of alkali (e.g., NaOH and KOH) and heating energy are consumed in the extraction of κ-carrageenan, and polluted water is generated concomitantly. In this study, a light-weight thermal insulation material was prepared from κ-carrageenan, and a recycling strategy was developed as an alternative to degradation to improve the utilization efficiency of κ-carrageenan. In the preparation of monolithic porous κ-carrageenan (MPC), glyceryl monostearate (GMS) was used as a micro-bubble stabilizer for the stirred κ-carrageenan solution, followed by gelation and ambient pressure drying (APD). When the weight ratio of GMS to κ-carrageenan reached 0.5, the MPC exhibited the lowest density of 0.038 g·cm⁻³ and a thermal conductivity of 0.0400 W·m⁻¹·K⁻¹. Subsequently, this sample was subjected to 3 regeneration cycles; Fourier‑transform infrared spectroscopy (FTIR) and thermal conductivity analyses revealed no significant changes in the characteristic chemical bands and thermal insulation properties of recycled samples. Another advantage of MPC is that water was used as the sole solvent during both its preparation and recycling, with no organic solvent waste generated. Consequently, the recycling strategy not only provides novel insights into advancing the sustainable application of bio-based materials, but also improves the economic potential of such materials.
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
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IF 8.5
Duoping Yang,Aijing Sun
Carrageenan has good film-forming characteristics, but it is difficult to simultaneously improve its multiple performances, such as water-resistance, light transmittance and thermal stability. In this study, multi-advantage composite films were prepared by iota-carrageenan and quaternary ammonium surfactants according to solvent induced method. The weight change, FTIR and thermogravimetric analyses of the films before and after solvent inducement indicated that the inorganic counterions of iota-carrageenan were replaced by quaternary ammonium ions. By increasing surfactant content, the charge interaction with iota-carrageenan was enhanced and a new sharp peak appeared in the X-ray diffraction plots. Physical properties such as film thickness, water-resistance, water vapor transmission rate, and mechanical strength in various states were all related to the content of surfactants. In actual application, composite film with the highest waterproof property was able to maintain original state in water at 95 °C for >1.5 h. Meanwhile, composite films can be a water-induced generator with excellent self-charging and stable power output properties. A comparative study of the film transparency in terms of components and surface morphology was carried out. High light transmission, coupled with lower degradation rate in soil, suggests that these films are suitable for use as agricultural greenhouses and mulch films.
研究领域:
材料科学
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食品科学
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农业科学
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产品关联
DOI
PubMed
高影响因子
FIRE AND MATERIALS
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2022
·Vol. 47
·期 3
·400-410
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IF 1.979
Chenyu Wang,Hu Shi,Xin Wang,Lei Song,Yuan Hu
An eco-friendly and bio-based ternary hybrid hydrogel consisting of carrageenan, vermiculite, and dimethyl methyl phosphate (DMMP) was prepared through a facile one-pot method. Rheological tests showed that this ternary hybrid hydrogel was a power-law fluid. The formulation of the ternary hybrid hydrogel was also screened, and the optimal formulation was found to be the ternary hybrid hydrogel containing 1 wt% carrageenan, 2 wt% DMMP, and 4 wt% vermiculite. Firefighting experiments showed that the ternary hybrid hydrogel could stop the chain reaction and rapidly reduce the temperature of combustion. Compared to water, the extinguishing time of the ternary hybrid hydrogel was shortened by 46.6%, and the volume consumed was reduced by 43.3%. The superior fire extinguishing efficiency of the ternary hybrid hydrogel could be attributed to the combined effect of each component: carrageenan provides viscosity, making the hydrogel firmly cover the burning surface; DMMP works as a free radical scavenger that can stop chain reactions; and vermiculite acts as a barrier layer, which helps to insulate air and heat and prevent resurgence. This work provides an environmentally-friendly, cost-effective, and bio-based hybrid hydrogel for firefighting.
研究领域:
材料科学
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消防工程
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环境科学
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产品关联
DOI
高影响因子
Food Science and Technology
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2022
·
IF 2.602
ZHANG Chunlan,NING Yuli,JIA Yin,KANG Mengyao,HE Yawen,XU Wei,SHAH Bakht Ramin
Phase transition of lysozyme/carrageenan (Ly/CRG) complex system with different ratios, pH, ionic strength and temperature conditions was explored through ultraviolet-visible spectrophotometer, fluorescence spectrophotometer, fluorescence microscope, Zeta potential. The results showed that the main force between Ly and CRG is electrostatic interaction, and the Ly/CRG composite system has undergone three phase transition states: co-solubilization, gelation and aggregation. At pH = 1-3, the oppositely charged CRG and Ly form complexes based on electrostatic interaction. Whereas at pH = 12, both CRG and Ly are negatively charged and they repel each other electrostatically. The electrostatic shielding effect of salt ions had a greater impact on the formation of Ly/CRG complex. Temperature had a certain degree of influence on the structure and turbidity of the composite system. The interaction between polysaccharides and proteins can have a significant impact on the structure and stability of complex systems and the study of polysaccharide and protein complexes which will help to expand their application in food and medicine.
研究领域:
食品科学
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生物化学
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2020
·
IF 5.162
Ye Mi,Yao Xian Chin,Wan Xiu Cao,Yao Guang Chang,Phaik Eem Lim,Chang Hu Xue,Qing Juan Tang
Inflammatory bowel disease (IBD), including Crohn's disease and ulcerative colitis, has gradually emerged as a public health challenge worldwide. Carrageenan is a popular food additive that has been in use for decades. However, controversy exists regarding to the safety of carrageenan due to its exacerbation of colitis in experimental models. In this study, we studied the effects of vehicle and host intestinal microflora on carrageenan inflammatory properties in C57BL/6 J mice. We found that in high-fat diet model, native carrageenan in drinking water increased the disease activity index (DAI), myeloperoxidase (MPO) activity and the mRNA expression of TLR4 in colon, whereas carrageenan-supplemented diet has no visible effects. However, no signs of colitis were observed under low-fat diet regardless of the mode of vehicle used. Moreover, we discovered that carrageenan-induced colitis in high-fat diet model was robustly correlated with changes in the composition of gut microbiota, specifically Alistipes finegoldii and Bacteroides acidifaciens . Hence, we propose that the inflammatory property of carrageenan is influenced greatly by its intake form via modification of host intestinal microecology.
研究领域:
胃肠病学
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微生物学
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营养学
✓ 已验证
DOI
PubMed
高影响因子
MATERIALS & DESIGN
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2026
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IF 8.2
Qi Wang,Jianfu Qiao,Xing Luo,Hong Gu,Ziru Dai
A bioactive hydrogel was developed from carrageenan and tangerine peel. • The hydrogel shows antibacterial, anti-inflammatory, and improved strength. • It promotes fibroblast growth and accelerates full-thickness wound healing. • A safe and sustainable strategy for wound repair materials is proposed. Full-thickness skin defects caused by severe burns or trauma remain a major clinical challenge due to impaired self-healing and high infection risk. In this study, a bioactive composite hydrogel based on carrageenan and tangerine peel was developed as a safe, cross-linker-free wound dressing. Carrageenan provided a stable three-dimensional network, while tangerine peel endowed the hydrogel with antibacterial properties. The composite hydrogel exhibited enhanced mechanical strength, a more uniform porous structure, and improved stability compared with carrageenan alone. In vitro assays demonstrated excellent biocompatibility and significantly promoted fibroblast proliferation and adhesion. Moreover, the hydrogel showed effective antibacterial activity against both Staphylococcus aureus and Escherichia coli . In vivo studies further confirmed that the hydrogel markedly accelerated wound closure, enhanced collagen deposition, and promoted epithelial regeneration in full-thickness skin defects. This study presents a simple and effective strategy for constructing multifunctional hydrogels, highlighting their promising potential in wound healing and skin tissue engineering. Scheme 1. Schematic diagram of green carrageenan-tangerine peel hydrogel used to repair full-thickness skin defects. Download: Download high-res image (139KB) Download: Download full-size image
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
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2025
·
IF 8.5
Weiting Huang,Jueying Yang,Chunlei Long,Jingjing Yuan,Lizhi Lin,Yang Lv,Lijie Li,Yu Chen
κ-Carrageenan (KC) hydrogels are processed from a natural polysaccharide with abundant sources, simple preparation, and superior biocompatibility, which are widely used in the food industry and biomedical applications. Due to fixed water content and loose structure, KC hydrogels crosslinked by hydrogen bonding exhibit inflexible and inferior mechanical properties that considerably restrict their application potential. This study presents a comprehensive investigation of the Hofmeister effect for dynamically modulating KC hydrogels, combining multi-scale mechanistic analysis with versatile applications. The mechanical strength of KC hydrogels was reversibly tuned from 0 to 444 kPa and the hydrogel volume swelling ratio was varied from 0.7 to 1.3 times the original volume. Through a series of characterizations and molecular dynamics simulations, we elucidate the underlying mechanisms via three complementary perspectives: aggregation behavior of molecular chains, microstructural anisotropy, and molecular-level hydrogen bonding interactions. The Hofmeister effect confers dynamic shape tunability properties, regulable volume properties, and adjustable mechanical properties on KC hydrogel, positioning it as a potential shape-regulation material and also rendering it a suitable solution sieve and a probe to measure softness and hardness. The exploration of the Hofmeister effect on KC hydrogels establishes a generalizable framework for understanding Hofmeister effects in natural polymer hydrogels while significantly expanding their potential in intelligent materials.
研究领域:
材料科学
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生物医学
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食品科学
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产品关联
DOI
PubMed
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Jiahui Wang,Kehan Zhu,Miaomiao Zhang,Qian Zhou,Wen Ji,Zhen Yao,Duxin Li
Carrageenan (CGN) is a typical sulfated polysaccharide widely applied in the food and pharmaceutical industries. Its in vivo behavior plays vital roles in understanding structural and biological functional relationships. The lack of UV chromophores in highly sulfated polysaccharides presents a challenge for their in vivo behavior studies. Therefore, this study aimed to develop a fast and effective quantitative fluorescence method for investigating the pharmacokinetics and tissue distribution of CGN. Fluorescence isothiocyanate labeling of CGN (FCGN) and microplate reader-based measurements were developed and validated to study its pharmacokinetics. These results showed that the FCGN concentration peaked at 3 h, the mean residence time was 36.6 h, and the clearance rate was 0.1 L/h/kg. Most of the FCGN was excreted in the feces, while 9.2 % was excreted in the urine, suggesting absorption and metabolism. The pharmacokinetic parameters indicated that the FCGN was absorbed quickly, eliminated slowly, and could remain in the body for a sustained profile. Moreover, ex vivo imaging and quantification of FCGN in tissues revealed that FCGN accumulated in the liver and kidney. Furthermore, oral administration of CGN or KOs for 14 days led to changes in liver and kidney indices. Histological analysis of significant organs revealed hepatocyte necrosis in the liver, renal tubular vacuolization in the kidney, and incomplete colonic epithelial cells. The KOs had a more significant effect on inflammatory cell infiltration than did CGNs. These in vivo findings laid the foundation for the study and application of CGN in food and pharmaceutical applications.
研究领域:
药理学
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毒理学
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食品科学
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药学
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产品关联
DOI
PubMed
高影响因子
Innovative Food Science & Emerging Technologies
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2026
·
IF 6.9
Huihui Li,Shunchang Wang,Chenglong Zhang,Zhendong Long,Xichao Yin,Hongjin Tang
Reliable intelligent food packaging films based on polysaccharide–protein composites are often limited by interfacial incompatibility and unstable colorimetric responses under complex environments. Herein, a nanoconfinement-assisted interfacial engineering strategy is proposed to construct reliable intelligent κ-carrageenan/Zein films by incorporating anthocyanin-loaded zeolitic imidazolate framework-8 (Cy@ZIF-8) as an active interfacial nanomodulator. In this composite system (Cy@ZIF-8/Kc/Zein), Cy@ZIF-8 simultaneously stabilizes anthocyanins through confinement effects. It also reorganizes the polysaccharide–protein network via hydrogen bonding, electrostatic interactions, and coordination interactions, effectively suppressing phase separation and promoting the formation of a homogeneous polymer matrix with a uniform thickness of approximately 0.052 mm. As a result, the Cy@ZIF-8/Kc/Zein film exhibited altered water and gas transport behaviors, showing a high swelling ratio of 4154%, a low moisture absorption of 8.19%, and a reduced water vapor transmission rate of 0.549 × 10 −8 kg·m·m −2 ·s −1 ·Pa −1 . These structural features further led to enhanced functional performances, including antioxidant activity with DPPH and ABTS scavenging efficiencies exceeding 80% at 7.5 mg/mL. Additionally, the film showed synergistic antibacterial properties against Escherichia coli and Staphylococcus aureus with survival rates decreasing to 15.29 ± 0.50% and 1.42 ± 0.31%, respectively. Application validation assays confirmed reliable chromatic evolution of the composite film under complex environmental conditions. Therefore, this study demonstrates that MOF-based nanostructures can function as effective interfacial regulators to tailor structure–property relationships and improve functional reliability in polysaccharide–protein intelligent packaging films.
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2020
·
IF 3.99
Hao Zhou,Zhengjun Zhang,Leming Ou,Qiongyin Mai
As a typical gangue mineral in many sulfide deposits, naturally hydrophobic talc needs to be depressed by adding depressants to achieve a good flotation separation. Conventional talc depressants lack selectivity , resulting in the depression of both talc and sulfide minerals . In this study, carrageenan was applied as a selective depressant for talc. The mechanism of carrageenan in the flotation separation of chalcopyrite from talc when using collector sodium butyl xanthate (SBX) was investigated. Micro-flotation results showed that carrageenan can efficiently and selectively depress talc and barely influenced the flotation of chalcopyrite. The artificial mixed minerals flotation results further confirmed that carrageenan was a selective depressant for talc. A concentrate with Cu grade of 32.42 % was obtained at 91.86 % recovery from their artificial mixtures of minerals. The flotation results indicated that carrageenan exhibited stronger depressing ability than the conventional talc depressants of CMC and guar gum , suggesting it could become a promising potential depressant in the selective flotation separation of chalcopyrite from talc. Adsorption mechanism of carrageenan on the surface of talc was investigated using zeta potential measurements, adsorption measurements, FTIR measurements, XPS measurements and Langmuir adsorption model. The zeta potential measurements and adsorption measurements indicated that carrageenan selectively adsorbed on talc surface and therefore changed the zeta potentials. The FTIR results and XPS tests illustrated that the adsorption of carrageenan on talc occurred through physical interactions rather than chemical complexation. Langmuir adsorption modeling confirmed the major role of hydrophobic interaction.
研究领域:
矿物加工
·
化学工程
·
材料科学
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产品关联
DOI
高影响因子
危险品化学品经营许可证（带存储）