ACS Applied Nano Materials
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2025
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IF 5.5
Hanwen Xin,Xinru Wang,Xing Wang,Xinke Li,Xujie Yang,Jinghui Zhou,Dayin Sun
Current antimicrobial agents face challenges in recyclability and solvent compatibility. To overcome these limitations, we engineered core–shell Fe3O4@SiO2@Lignin@Ag nanoparticles (FLA) and assembled them into magnetically responsive colloidosomes via emulsion templating. Structural analyses confirmed a controlled size evolution from the magnetic core to the composite colloidosomes. The colloidosomes achieved complete elimination of pathogenic bacteria (Escherichia coli and Staphylococcus aureus) within 24 h─exhibiting 5-fold higher efficiency than nonassembled nanoparticles─while maintaining structural integrity across polar and nonpolar solvents. Crucially, the system demonstrated high biocompatibility (>80% cell viability in mammalian cells), establishing a green platform for recyclable antimicrobial coatings in diverse industrial applications.
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高影响因子
LANGMUIR
·
2022
·
IF 4.331
Rong-Kun Liu,Yu-Hang Gu,Jia Jia,Meng Qiao,Yan Wei,Qian Sun,Hong Zhao,Jie-Xin Wang
Colloidosomes as Pickering emulsion microcapsules are expected to serve various applications, including encapsulation of drugs and loading of functional materials. Normally, when using colloidosomes for drug encapsulation, the latex particles as shell materials need to be mixed with drugs before the assembly process. However, this procedure may cause aggregation of latex particles, thereby resulting in disordered assembled shells or a low loading efficiency. Herein, we propose a three-fluid nozzle spray drying process to efficiently assemble latex particles of P(styrene (St)-co-butyl acrylate (BA)) into colloidosomes. The three-fluid nozzle spray drying equipment allows for the preparation for drug encapsulation without advance mixing of drug and shell materials. This strategy enables the construction of colloidosomes with uniform and controllable pores and the loading of functional materials. The effects of the compressed air flow rate, inlet temperature, feed rate, and solid content were explored, revealing the formation mechanism of colloidosomes during the spray drying process. Doxycycline hydrochloride (DH) was encapsulated in colloidosomes for controllable release, and the sustained release time is up to 100 h. The release rate can be adjusted by varying the glass transition temperature (Tg) and size of latex particles. Furthermore, Fe3O4 nanoparticle (NP)-loaded colloidosomes were constructed by this strategy. The magnetic response intensity of colloidosomes can be modulated by varying the amount of Fe3O4 NPs. The anticancer drug encapsulation and loading of other functional particles were also explored to expand applications.
研究领域:
药学
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材料科学
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化学工程
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纳米技术
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高影响因子
Materials Today Chemistry
·
2026
·
IF 7.4
Xuan Yue,Feibo Li,Xiying Fu,Yanming Wang,Nan Yan
Binary colloidosomes with periodic cubic symmetry are fabricated from anisotropic gold nanocubes and isotropic gold nanospheres. • The spatial arrangement of AuNPs within the colloidosomes is predominantly governed by entropic effects between the two components. • This study provides a general and efficient route to precisely engineer of binary colloidosomes from geometrically distinct nanocrystals. Binary colloidosomes constructed from polymer-grafted inorganic nanocrystals have recently garnered significant attention for their potential in constructing multifunctional materials. However, the fabrication of well-defined binary colloidosomes with tailored internal architectures using geometrically distinct nanoparticles remains challenging. In this study, we demonstrate the preparation of binary colloidosomes with periodic cubic symmetry via emulsion interfacial co-assembly of polystyrene-tethered anisotropic gold nanocubes (AuNCs@PS) and isotropic gold nanospheres (AuNPs@PS). The spatial distribution of AuNPs@PS within the resulting colloidosomes is predominantly governed by entropic effects between the two components, which are quantitatively characterized using the proposed effective size ratio parameter ( λ eff ). Furthermore, by tailoring the core size of AuNPs@PS and the molecular weight of the grafted polymer, the λ eff value and the resulting configuration of the colloidosomes can be precisely controlled. This strategy provides a versatile pathway for constructing binary colloidosomes with tailored internal structures, facilitating the rational design of advanced functional materials for applications in catalysis, optoelectronics, and photothermal therapy. Well-defined binary colloidosomes with periodic cubic symmetry self-assembled from anisotropic AuNCs@PS and isotropic AuNPs@PS building blocks are constructed through emulsion interface co-assembly strategy. The spatial distribution of AuNPs@PS within the resulting colloidosomes is predominantly governed by entropic effects between the two components. Download: Download high-res image (297KB) Download: Download full-size image
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高影响因子
ANALYTICAL CHEMISTRY
·
2019
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IF 6.35
Kun Yin,Xi Zeng,Weizhi Liu,Yakun Xue,Xingrui Li,Wei Wang,Yanling Song,Zhi Zhu,Chaoyong Yang
As the third-generation nucleic acid amplification technology, digital polymerase chain reaction (PCR) has been widely adopted in the analysis of nucleic acids. However, further application of this powerful technology is hindered due to the limitation of surfactants. Here, for the first time, we propose the use of colloidosomes self-assembled from fluorinated silica nanoparticle for digital PCR to address this limitation. A one-step fluorinated silica nanoparticle synthesis method is proposed, which is much more convenient and reproducible compared with the synthesis of conventional fluorine-based surfactants. Fluorinated silica nanoparticles facilitate the formation of colloidosomes with excellent stability capable of enduring the rapid temperature changes associated with the PCR and avoiding material exchange (cross-talk) between droplets for high-fidelity analysis. The colloidosome digital PCR method was developed using these colloidosomes as highly parallel reactors for single-copy nucleic acid amplification and rare mutant detection. The method is robust and accurate, and it offers possibilities for a great variety of applications, such as gene expression studies, single cell analysis, and circulating tumor DNA detection.
研究领域:
化学
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纳米技术
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生物技术
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分子生物学
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医学诊断
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高影响因子
ACS Applied Materials & Interfaces
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2022
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IF 10.383
Qi Zeng,Mengmeng Sun,Xin Xie,Yuli Zhang,Haoyue Hou,Xingyuan Fang,Ting Guo,Hao Yuan,Tao Meng
Pickering interfacial biocatalysis (PIB) paves the way for efficient enzymatic catalysis in the biphasic system. However, the Pickering interfacial biocatalysts located on the oil–water interface still face the inevitable deactivation when one of the phases contains the reactant that inactivates the enzyme. Herein, the positioning of lipase-entrapped colloidosomes (LECs) at the emulsion interface is rationally designed by physically tuning the wettability, which allows LECs to protrude into the selected phase to protect the lipase away from the damage of the reactant. As a proof of concept, LECs with different positioning at the interface are used as Pickering interfacial biocatalysts to produce biodiesel by esterification of lauric acid and methanol. Impressively, the LECs that protrude into the oil phase possess an optimal catalytic performance to protect more lipases away from the damage of the reactant of short-chain alcohol, which shows an 8.18-fold enhancement in specific activity relative to the free lipase, reach a biodiesel yield of 80.37% after 8 h, and retain the 96.44% of relative activity after 10 cycles. This study provides a novel and robust platform for Pickering emulsion-enhanced biocatalysis.
研究领域:
生物化学
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材料科学
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催化工程
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高影响因子
Journal of Materials Chemistry B
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2022
·Vol. 10
·期 7
·1103-1115
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IF 7.571
Tao Ding,Jing Zhu,Haidi Guan,Daqing Xia,Yuxin Xing,Jixi Huang,Zhenqiang Wang,Kaiyong Cai,Jixi Zhang
A cell membrane barrier which dominates the therapeutic efficacy and systemic side effects is a major bottleneck in the field of drug delivery. Herein, a therapeutic system capable of photothermally triggered on-demand and cytosolic delivery was achieved by polydopamine (PDA) nanoparticle-stabilized colloidosomes. An organic phase change material (PCM, saturated fatty acids) was employed as the lipid core for Pickering emulsification and drug encapsulation, and arginine was utilized as a linker to induce the directional interactions between nanoemulsion droplets and heterogeneously nucleated PDA nanoparticles. Moreover, the PDA particle stabilizers concomitantly mediated the grafting of hydrophilic polymer PEG to further improve dispersibility. The resultant colloidosomes after cooling possess lowered melting points and superior dispersion stability over 7 days. When irradiated with near-infrared light (808 nm), sequential processes of fatty acid melting and direct drug perfusion into the cytosol took place within 10 min. The employment of vorinostat (SAHA, histone deacetylase inhibitor) as a model membrane-impermeable drug resulted in remarkable enhancement of anti-cancer effects both in vitro (5.2 fold reduction in IC50) and in vivo (7.3 fold increase in tumor inhibition rate) with respect to the free drug. The remotely triggered transformable nanoplatform paves a new avenue of responsive and efficient cytosolic perfusion to overcome biological membrane barriers on the basis of colloidosomes.
研究领域:
药物递送系统
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纳米技术
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癌症治疗
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材料科学
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生物医学工程
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PubMed
高影响因子
Bioactive Materials
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2022
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IF 16.874
Bitao Lu,Enling Hu,Ruiqi Xie,Kun Yu,Fei Lu,Rong Bao,Chenhui Wang,Guangqian Lan,Fangyin Dai
Complex yet lethal wounds with uncontrollable bleeding hinder conventional hemostats from clotting blood at the source or deep sites of injury vasculature, thereby causing massive blood loss and significantly increased mortality. Inspired by the attack action of torpedoes, we synthesized microcluster (MC) colloidosomes equipped with magnetic-mediated navigation and “blast” systems to deliver hemostats into the cavity of vase-type wounds. CaCO 3 /Fe 2 O 3 (CF) microparticles functionalized with Arg-Gly-Asp (RGD) modified polyelectrolyte multilayers were co-assembled with oppositely charged zwitterionic carbon dots (CDs) to form MC colloidosomes, which were loaded with thrombin and protonated tranexamic acid (TXA-NH 3 + ). The composite microparticles moved against blood flow under magnetic mediation and simultaneously disassembled for the burst release of thrombin stimulated by TXA-NH 3 + . The CO 2 bubbles generated during disassembly produced a “blast” that propelled thrombin into the wound cavity. Severe bleeding in a vase-type hemorrhage model in the rabbit liver was rapidly controlled within ∼60 s. Furthermore, in vivo subcutaneous muscle and liver implantation models demonstrated excellent biodegradability of MC colloidosomes. This study is the first to propose a novel strategy based on the principle of torpedoes for transporting hemostats into vase-type wounds to achieve rapid hemostasis, creating a new paradigm for combating trauma treatment.
研究领域:
生物医学工程
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材料科学
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止血
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伤口愈合
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高影响因子
JOURNAL OF COLLOID AND INTERFACE SCIENCE
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2025
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IF 9.7
Chenzhi Wang,Liangdong Liu,Chunhua Wang,To Ngai,Wei Lin
Colloidosomes have garnered significant interest as carriers for the controlled delivery of active ingredients across diverse applications. Nevertheless, effectively encapsulating hydrophilic actives within colloidosomes while maintaining their stability in aqueous medium without leakage remains a significant challenge. This arises from the high permeability of colloidosomes and the hydrophilicity mismatch between the carriers and the aqueous medium. Herein, we report a facile approach to the synthesis of colloidosomes with excellent sealing performance and tunable hydrophilicity. Our approach is based on the silica-stabilized Pickering emulsion templating, interfacial sol-gel reaction of TEOS and subsequent APTES grafting for surface hydrophilic modification. The size of colloidosomes agrees with the Pickering emulsion droplet and can be adjusted by changing the amount of silica. Notably, unlike other reported colloidosomes, the hydrophilicity of the synthesized colloidosomes can be controlled through the addition amount of APTES and their transfer into an aqueous medium can be readily achieved without any other steps. The colloidosomes demonstrated efficient encapsulation of hydrophilic active ingredients and feature a robust shell, enabling the high retention of enzyme activity (lipase) in practical liquid detergent applications. In contrast with unencapsulated lipase, colloidosome-encapsulated lipase demonstrated superior cleaning efficacy. This colloidosomes proposed in this study offers distinct advantages for the encapsulation and protection of hydrophilic active ingredients and shows great potential in detergents industry.
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高影响因子
ACS Applied Nano Materials
·
2022
·
IF 6.14
Meng Li,Chenxi Liu,Liang Qi,Hongsheng Liu
Hollow-structured nanomaterials, featuring a porous crystalline structure and hollow interior, are conducive to achieving a compartmentalized architecture comprising diverse functional entities. In this study, we have constructed a novel fluorescent enzyme nanocomposite derived from the nanosized hollow ZIF-8 (H-ZIF-8) colloidosomes via a diffusion strategy. Insights into the underlying mechanisms revealed that the diffusion process was driven by mesopore properties and electrostatic interactions. It has also been demonstrated that the molecular sieving property of the colloidosome shell induced an exceptional compartmentalized structure, where nitrogen-doped graphene quantum dots (N-GQDs) were anchored onto the outer surface of the nanosized H-ZIF-8 colloidosomes, whereas glucose oxidase (GOx) was homogeneously encapsulated in the entire cavity. The resultant nanocomposite inherited the mesopore properties of the colloidosome exoskeleton, catalytic ability of GOx, and fluorescence properties of N-GQDs. In particular, the porous properties of the nanosized H-ZIF-8 colloidosomes favored enrichment to target analytes, whereas the compartmentalized GOx and N-GQDs served as a “promoter” (initiate the biochemical reaction) and “signal unit” (intuitive observation) in the glucose probing system, respectively. Furthermore, anchoring N-GQDs onto the outer surface of the nanosized H-ZIF-8 resulted in tailoring of the fluorescence property of the nanocomposite. In the part of glucose sensing, the proposed fluorescence nanosensor could well quantify glucose within a range of 10 to 100 μM with a lower limit of detection of 5.4 μM. This proposed strategy presents opportunities to engineer novel metal–organic framework-based multifunctional nanocomposites and create new applications by combining their unique functions.
研究领域:
材料科学
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纳米技术
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分析化学
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生物传感器
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高影响因子
JOURNAL OF MATERIALS SCIENCE
·
2016
·Vol. 51
·期 20
·9455-9471
·
IF 2.302
Tan Jianbo,Fu Lili,Zhang Xuechao,Bai Yuhao,Zhang Li
Herein, we report a photoinitiated RAFT dispersion polymerization for the preparation of highly monodisperse poly(glycidyl methacrylate) (PGMA) microspheres at room temperature. Fast polymerization rates were achieved, with near quantitative yields within 2 h of UV irradiation. The effect of reaction conditions (e.g., stabilizer concentration, monomer concentration and solvent composition) on particle morphologies was studied in detail. Amine-functionalized PGMA microspheres were prepared by treating PGMA microspheres with ethylene diamine (EDA) at 70 °C, and the obtained product was characterized by FT-IR and XPS. Such amine-functionalized PGMA microspheres were able to stabilize oil-in-water Pickering emulsions. Covalently cross-linked colloidosomes were formed by cross-linking primary amino groups on the particle surface using (tolylene 2,4-diisocyanate-terminated poly(propylene glycol) (PPG-TDI) as a cross-linker. Amine-functionalized PGMA microspheres were also employed as templates for the synthesis of PGMA/gold (Au) hybrid microspheres and large gold nanoplates.
研究领域:
材料科学
·
化学工程
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高影响因子
Journal of Physical Chemistry C
·
2020
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IF 4.189
Xuan Yue,Xuejie Liu,Nan Yan,Wei Jiang
Self-assembly of gold nanorods (AuNRs) into hierarchically ordered superstructures is a prerequisite for the fabrication of functional materials and devices. Although 1D linear and 2D sheetlike ordered arrays of AuNRs have been successfully constructed, organizing AuNRs into ordered arrays on 3D spherical surfaces is still quite challenging because of the difficulty in controlling the orientation of anisotropic AuNRs on curved surfaces. Here, a facile yet robust emulsion interface self-assembly strategy is reported to obtain well-defined colloidosomes with highly ordered and oriented AuNRs through the self-assembly of polymer-tethered AuNRs at the emulsion interface, which is constructed with an external aqueous solution and an internal nonsolvent (hexadecane) as a liquid-core template. Moreover, the alignment and orientation of AuNRs can be controlled by varying the curvature of the colloidosome, the length of the AuNRs, and the molecular weight of the polymer ligands. This strategy provides a promising route to the design of hierarchical superstructures with a controlled AuNR arrangement and orientation.
研究领域:
材料科学
·
纳米技术
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高影响因子
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