ACS Omega
·
2019
·
IF 2.584
Xing He,Ziyan Zhou,Zhuo Han,Yang Zeng,Xiaojie Chen,Jiacan Su
The physical and chemical interactions with vancomycin (VAN) were accessed between graphene oxide (GO) and crumpled graphene oxide (CGO) to present the possible loading and release mechanisms. The improved hydrophilicity and surface charge were found on CGO through water contact angle and ζ-potential measurements. Fourier transform infrared and X-ray photoelectron spectroscopies confirmed the attachment of VAN onto CGO or GO through π–π stacking and hydrogen bonding. Both CGO–VAN and GO–VAN drug complexes showed pH-controlled release property. The high VAN loading and delayed release in CGO–VAN system were mainly due to the crumpled morphology.
研究领域:
材料科学
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药物传递系统
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生物医学工程
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产品关联
DOI
PubMed
高影响因子
RSC Advances
·
2022
·Vol. 12
·期 36
·23387-23395
·
IF 4.036
Jun Cen,Linhuai Li,Lingling Huang,Guangqi Jiang
This study aimed to achieve the controlled-release of bioactive ingredients in microcapsule pesticide delivery systems. A photothermal controlled-release microcapsule pesticide delivery system was constructed using chitosan and polydopamine (PDA) as the wall materials to encapsulate avermectin. All the prepared microcapsules were characterized by the methods of optical microscopy, scanning electron microscopy, transmission electron microscopy, and Fourier-transform infrared spectroscopy. The slow-release, UV-shielding, photothermal performance, and the nematicidal activity of the prepared microcapsules were also systematically investigated. The results indicated that the prepared microcapsules had excellent slow-release and UV-shielding performance when further encapsulated with the PDA layer relative to those of the non-PDA-encapsulated products. The photothermal sensitivity of the AVM@CS/CMA/PDA composite microcapsule under the irradiation of near-infrared light (NIR) was dramatically enhanced with the photothermal conversion efficiency (η) of 14.93%. Furthermore, the nematicidal activity of the AVM@CS/CMA/PDA composite microcapsule system was effectively improved on exposure to the irradiation of a light-emitting diode (LED) full-spectrum light. The strategies used in this study for developing the photothermal controlled-release pesticide delivery system might play an important role on improving utilization of pesticides.
研究领域:
材料科学
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农业科学
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生物技术
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DOI
PubMed
高影响因子
CARBOHYDRATE POLYMERS
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2016
·
IF 4.219
Cundian Gao,Junli Ren,Cui Zhao,Weiqing Kong,Qingqing Dai,Qifeng Chen,Chuanfu Liu,Runcang Sun
Xylan-based temperature/pH sensitive hydrogels were prepared by the crosslinking copolymerization of xylan with N -isopropylacrylamide (NIPAm) and acrylic acid (AA) using N,Ń -methylenebis-acrylamide (MBA) as a cross-linker and 2,2-dimethoxy-2-phenylacetophenone as a photoinitiator via ultraviolet irradiation. The influence of the NIPAm, AA and MBA amount on properties of xylan-based hydrogels was discussed. The morphology and interactions of hydrogels were characterized by SEM and FTIR. The lower critical solution temperature (LCST) of hydrogels was investigated by DSC. The results indicated that the LCST of hydrogels emerged at around 34 °C and increased with increasing the AA content. The drug encapsulation efficiency of as-prepared hydrogels reached to 97.60% and the cumulative release rate of acetylsalicylic acid was 90.12% and 26.35% in the intestinal and gastric fluid, respectively. Xylan-based hydrogels were proved to be biocompatible with NIH3T3 cell by MTT assay and showed the promising application as drug carriers for the intestinal-targeted oral drug delivery.
研究领域:
材料科学
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生物医学工程
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药剂学
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产品关联
DOI
PubMed
高影响因子
BIOMACROMOLECULES
·
2018
·
IF 5.738
Shifeng Yan,Jie Ren,Yuhang Jian,Weidong Wang,Wentao Yun,Jingbo Yin
Injectable hydrogels have shown great potential in bone tissue engineering. Simvastatin (SIM), a common hypolipidemic drug, has been suggested as a potential agent to promote bone regeneration. However, due to its hydrophobic nature, the compatibility between SIM and hydrogels is rather poor, thereby greatly affecting the drug release behavior, the mechanical properties, and dimensional stability of the hydrogels. Herein, we presented a novel design to entrap SIM in an injectable maltodextrin-based micelle/hydrogel composite system. Maltodextrin-based micelles were prepared to solubilize and encapsulate SIM. The SIM-loaded aldehyde-modified micelles were anchored to the hydrogel network and served as a cross-linker to realize improved mechanical strength of hydrogel, controlled release, and osteogenic capability of SIM. In all, this study demonstrated a strategy to incorporate drug loaded carriers into hydrogels for drug delivery and tissue engineering applications.
研究领域:
生物材料
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药物递送
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骨组织工程
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产品关联
DOI
PubMed
高影响因子
JOURNAL OF APPLIED POLYMER SCIENCE
·
2016
·Vol. 133
·期 24
·
IF 1.866
Xiaoyan Zhou,Anhua Lin,Xinxin Yuan,Hui Li,Dong Ma,Wei Xue
For insulin delivery, many reported glucose-sensitive materials are designed to response to the glucose in the blood. However, few particular studies on their blood compatibility have been reported. In this article, for controlled insulin release in diabetes therapy, a glucose-sensitive nanogel was prepared through thermally initiated precipitation polymerization using the aminophenylboronic acid-containing monomer to copolymerize with methacrylic acid. The obtained nanogels showed the uniform and spheroidal morphology as observed by SEM, and their sizes in aqueous solution are dependent on the concentration of glucose. Through in vitro and in vivo insulin release tests, it was found that nanogels showed the glucose-dependent insulin release and prolonged effect of lowing blood glucose level. The blood compatibility of nanogels has also been explored through various assays including the hemolysis, activated partial thromboplastin time, prothrombin time as well as the thromboelastography. All results indicated that the obtained glucose-sensitive nanogels showed good blood safety. Moreover, their low cytotoxicity suggested a potential application in diabetes therapy. © 2016 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2016 , 133 , 43504.
研究领域:
生物材料学
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医学
·
药剂学
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产品关联
DOI
高影响因子
COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
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2022
·
IF 5.518
Qingye Song,Xinyu Zhou,Chenwei Xue,Zhi-Ang Zhang,Jinming Feng,Mengfan Ji,Limin Wang,Xu Liu,Jianwei Han
The development of structurally diversified surfactants with multifunctional performance is an important task. Herein, we report a series of quaternary ammonium salts (QAS) as surfactants with hydrazone linker between a long chain and a triggered release of various fragrances . The resulting QAS with build-in aldehydes as a carrier of fragrances exhibited excellent amphiphilicity in water, their surface activity is evaluated by testing surface tension of the micelles in water with γ-CMC values ranging from 16.19 to 38.02 mN/m. Releasing performance by hydrolysis of hydrazones, meanwhile the formation of hydrazine derivatives as dynamic mixtures in acidic aqueous solutions, is investigated by headspace solid-phase micro-extraction (SPME) in combination with gas chromatography (GC) analysis, the results showed significant retention capacity for volatile aldehydes in up to 25 times higher than the neat reference of the corresponding aldehydes. The antibacterial performance of QAS is expressed by the minimum inhibitory concentration (MIC) values, along with an excellent activity on Gram-positive bacteria in the lowest concentration of 2 μg/mL. These QAS could be regarded as suitable fragrance delivery system in potential applications.
研究领域:
化学
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材料科学
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香料技术
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产品关联
DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2023
·
IF 8.2
Zhenzhen Qi,Xiaosheng Tao,Guohongfang Tan,Bin Tian,Lehao Zhang,Subhas C. Kundu,Shenzhou Lu
To date, very limited work has been done on convenient and active control of insulin release . Herein, we report an electro-responsive insulin delivery system based on thiolated silk fibroin . The disulfide cross-linking points in TSF were reduced and broken to form sulfhydryl groups under electrification, which led to the increase of microneedle swelling degree and promoted insulin release. After power failure, the sulfhydryl group is oxidised to form disulfide bond crosslinking point again, resulting in the reduction of microneedle swelling degree and thus the reduction of release rate. The insulin loaded in the electro-responsive insulin delivery system showed good reversible electroresponsive release performance. The addition of graphene reduced the microneedle resistance and increased the drug release rate under current conditions. In vivo studies on type 1 diabetic mice show that electro-responsive insulin delivery system effectively controls the blood glucose before and after feeding by switching on and off the power supply, and this blood glucose control can be maintained within the safe range (100–200 mg/dL) for a long time (11 h ). Such electrically responsive delivery microneedles show potential for integration with glucose signal monitoring and are expected to build closed-loop insulin delivery systems.
研究领域:
药学
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生物医学工程
·
材料科学
·
糖尿病研究
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产品关联
DOI
PubMed
高影响因子
Acta Pharmaceutica Sinica B
·
2019
·
IF 5.808
Zheng Luo,Chao Liu,Peng Quan,Degong Yang,Hanqing Zhao,Xiaocao Wan,Liang Fang
Background Hydrogen bonding interaction was considered to play a critical role in controlling drug release from transdermal patch. However, the quantitative evaluation of hydrogen bonding strength between drug and polar functional group was rarely reported, and the relationship between hydrogen bonding strength and controlled release capacity of pressure sensitive adhesive (PSA) was not well understood. The present study shed light on this relationship. Methods Acrylate PSAs with amide group were synthesized by a free radical-initiated solution polymerization. Six drugs, i.e. , etodolac, ketoprofen, gemfibrozil, zolmitriptan, propranolol and lidocaine, were selected as model drugs. In vitro drug release and skin permeation experiments and in vivo pharmacokinetic experiment were performed. Partial correlation analysis, fourier-transform infrared spectroscopy and molecular simulation were conducted to provide molecular details of drug-PSA interactions. Mechanical test, rheology study, and modulated differential scanning calorimetry study were performed to scrutinize the free volume and molecular mobility of PSAs. Results Release rate of all six drugs from amide PSAs decreased with the increase of amide group concentrations; however, only zolmitriptan and propranolol showed decreased skin permeation rate. It was found that drug release was controlled by amide group through hydrogen bonding, and controlled release extent was positively correlated with hydrogen bonding strength. Conclusion From these results, we concluded that drugs with strong hydrogen bond forming ability and high skin permeation were suitable to use amide PSAs to regulate their release rate from patch.
研究领域:
药学
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材料科学
·
药物递送系统
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DOI
高影响因子
PEST MANAGEMENT SCIENCE
·
2025
·
IF 3.8
Xia Wei,Feng Guo,Zhang Boshi,Shen Zhiyang,Tian Ya,Qian Kun,Xu Zhifeng
BACKGROUND Fluazinam is a broad-spectrum fungicide and acaricide, but its field performance is limited by temperature sensitivity and phytotoxicity. To overcome these challenges, a thermoresponsive nano-formulation (Flu@TRNP) was developed by encapsulating fluazinam in a poly( N -isopropylacrylamide–styrene) copolymer matrix via emulsion polymerization. RESULTS The microcapsules exhibited uniform spherical morphology (mean diameter: 3.4 μm), high encapsulation efficiency (75.3%), and temperature-dependent release governed by the polymer lower critical solution temperature (~32 °C). Below this temperature, release was almost complete, whereas above it, polymer shrinkage slowed diffusion and enabled sustained release. Flu@TRNP displayed significantly lower contact angles on leaf surfaces compared with commercial fluazinam, indicating improved wettability. Bioassays showed enhanced acaricidal activity against Tetranychus urticae , with median lethal concentration (LC 50 ) values reduced by up to 25% at 35 °C. Antifungal tests against Phytophthora infestans confirmed greater inhibition at 20 °C. Field trials demonstrated comparable or superior disease control efficacy at reduced or standard doses. Pot experiments under heat stress (40 °C) indicated lower phytotoxicity on cowpea and potato compared with the commercial formulation. CONCLUSION These results demonstrate that the thermoresponsive microcapsule formulation improves bioefficacy and crop safety while reducing the risk of phytotoxicity under fluctuating environmental conditions. © 2025 Society of Chemical Industry.
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产品关联
DOI
PubMed
高影响因子
Materials Science & Engineering C-Materials for Biological Applications
·
2016
·
IF 3.42
Wenchao Feng,Zhen Geng,Zhaoyang Li,Zhenduo Cui,Shengli Zhu,Yanqin Liang,Yunde Liu,Renfeng Wang,Xianjin Yang
Bacterial infections have been identified as the main cause of orthopaedic implant failure. Owing to their high antibiotic delivery efficiency, titania nanotubes loaded with antibiotics constitute one of the most promising strategies for suppressing bacterial infections. However, it is difficult to control the drug-release behaviour of such nanotubes. Although sealing the nanotubes with a polymer solution provides sustained release effects to a certain extent, it inevitably influences their initial antibacterial activity. This study reports on the controlled release of gentamicin sulphate (GS) from titania nanotube surfaces whereby their initial antibacterial activity remains unaffected. Titania nanotubes were fabricated via electrochemical anodization and loaded with GS through physical adsorption. Experimental results showed that this loading method is feasible and efficient. The GS-loaded titania nanotubes were further covered by a thin film comprising a mixture of GS and chitosan (GSCH). The release kinetics confirmed that the drug release could be controlled by this thin film. Moreover, such a film was shown to not only inhibit initial bacterial adherence owing to its strong antibacterial properties but also enhance cell viability. Thus, GS-loaded titania nanotubes coated with GSCH have considerable potential as biomaterials for preventing initial release and peri-implant infection in the field of orthopaedics.
研究领域:
生物医学工程
·
材料科学
·
微生物学
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DOI
PubMed
高影响因子
Journal of Materials Chemistry B
·
2014
·Vol. 2
·期 12
·1667-1672
·
IF 0
Yan-Zhi Tian,Yan-Li Li,Zhi-Fei Wang,Yong Jiang
In this paper, a DNA–PEI microcapsule with novel nuclease-responsive controlled release properties was demonstrated. This microcapsule was constructed by the self-assembly of native DNA and PEI, and can work as a dual carrier for both DNA in the capsule shell and drugs inside the capsule. The controlled release behavior of the model drug BSA–FITC was studied using fluorescence microscopy and UV spectroscopy, and the results show that the synergetic controlled release can be triggered very well by a bio-stimulus, DNA nuclease recognition capsule decomposition, as well as the pH value and salt concentration. The therapeutic effects of the drug are enhanced due to the bio-stimuli responsive properties and the synergetic release of DNA and the drug together.
研究领域:
生物医学工程
·
药物递送系统
·
分子生物学
·
材料科学
·
转化医学
✓ 已验证
DOI
JOURNAL OF BIOMATERIALS SCIENCE-POLYMER EDITION
·
2021
·
IF 3.517
Yifan Huang,Lei Wang,Yi Liu,Tingxiao Li,Binjie Xin
The bilayer nanofibrous membrane fabricated via electrospinning technique can be considered as an ideal structure for the treatment of chronic skin diseases and exudative wound dressings. Wound exudate would affect healing and increases the likelihood of infection at the same time. Therefore, it is essential to produce a kind of wound dressing with relatively high hygroscopicity which could absorb wound exudate and provide a relatively dry healing environment. Bilayer nanofibrous membranes of poly(L-lactide-co-ε-caprolactone)/tetracycline hydrochloride- polyethylene oxide/sodium alginate-zinc oxide (PLCL/TCH-PEO/SA-ZnO) with drug delivery potential were prepared by electrospinning for wound healing. Then, a cross-linking which involved soaking the samples in an aqueous solution containing strontium ions for 4 h was conducted. SEM images showed that membranes still maintained the peculiar nanofibrous structure. The spinning aid (PEO) used was removed in the cross-linked alginate without affecting the PLCL/TCH outer layer gave the membrane good mechanical properties and manageability. The hydrophilicity of the mats was tested to evaluate the ability of the bilayer membrane to absorb exudate from the wound. In vitro drug release suggested that antibacterial agents TCH could release continuously more than 10 days. The cross-linked fibrous membrane has improved mechanical properties and fluid repellency, thus representing a barrier to the external environment and effective wound protection. Consequently, the bilayer fibrous scaffold with good hygroscopicity and drug release properties would have wide applications prospects for the treatment of chronic skin diseases and exudative wound dressings.
研究领域:
生物材料学
·
药剂学
·
医学工程
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DOI
高影响因子
危险品化学品经营许可证（带存储）