ACS Applied Nano Materials
·
2026
·
IF 5.8
Wuqiong Wang,Linlin Gong,Zheng Zhang,Kangjun Wang
Abstract In the study, a novel mesoporous curcumin (CUR)−gallic acid (GA) self-assembled nanoparticles (CUR-GA NPs) were prepared via hydrogen bonding, π−π stacking, and hydrophobic interaction. The CUR-GA NPs and IR-820-loaded composites (CUR-GA@IR-820 NPs) have strong near-infrared (NIR) light absorption. The photothermal conversion efficiency of CUR-GA NPs and CUR-GA@IR-820 NPs can reach 24.9% and 38.6%, respectively. CUR-GA NPs can not only achieve drug release in an acidic environment but also can be a nanocarrier to load and release the DOX. The CUR-GA NPs demonstrated excellent pH-responsive drug release performance. The cumulative release of CUR-GA NPs and CUR-GA@DOX NPs can reach 70.02% (CUR), 67.22% (GA) and 67.16% (DOX), respectively. The novel CUR-GA NPs provided a reliable nanocarrier for chemotherapy and photothermal therapy.
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DOI
高影响因子
Natural Product Communications
·
2020
·
IF 0.468
Yuxiang Ma,Benguo Liu
Phenolic acid-polysaccharide conjugates, produced in plant food and medicine processing, are thought to account for the α-glucosidase inhibitory activity of the final products. However, this speculation lacks experimental support because of the complexity of the plant system and the polysaccharide structure. In this study, with dextran (average molecular weight, 1000) as the skeleton, a gallic acid-dextran conjugate was synthesized and confirmed by ultraviolet, infrared, and nuclear magnetic resonance spectroscopic analysis for the first time. Furthermore, this gallic acid-dextran conjugate showed inhibition of α-glucosidase due to galloyl groups in a mixed competitive and noncompetitive inhibition mode, whose performance was superior to that of acarbose.
研究领域:
食品科学
·
生物化学
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DOI
高影响因子
MICROBIAL PATHOGENESIS
·
2022
·
IF 3.848
QiMing Tian,SiMin Wei,HongRui Su,ShuMei Zheng,ShuYa Xu,MingJiang Liu,RuoNan Bo,JinGui Li
The continuous emergence of multidrug-resistant (MDR) bacteria has posed an increasingly serious public health threat which urges people to develop some alternatives. Gallic acid (GA) is a natural ingredient in many traditional Chinese medicines , which has many biological activities, such as antibacterial, and antiseptic. Here, clinical isolates of MDR Escherichia coli ( E. coli ) were used to evaluate the antibacterial effect of GA and the underlying mechanism. The results revealed that GA exerted bactericidal activity and inhibited the formation of bacterial biofilm. GA enhanced the activities of ceftiofur sodium or tetracycline against E. coli , and facilitated antibiotic accumulation in bacteria. Further analysis of morphological alterations and efflux pump gene expressions confirmed that GA damaged outer and inner membranes, and suppressed the mRNA expressions of acrA, acrB, tolC, acrD and acrF involved in membrane permeability . In addition, GA showed protective effects against bacterial infection and improved the survival rates of Galleria mellonella and BALB/c mice. These data highlight a better understanding of GA against bacteria and provide an alternative strategy for MDR bacterial infection.
研究领域:
微生物学
·
药理学
·
传染病学
·
分子生物学
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DOI
PubMed
高影响因子
CURRENT MEDICINAL CHEMISTRY
·
2025
·Vol. 32
·期 37
·8400-8416
·
IF 3.5
Junyi Luo,Zhaoxia Zhang,Liming Jin,Zhaoying Wang,Qiuyue Sun,Dawei He
ObjectiveThis study aims to investigate the effect of Gallic Acid (GA) on the alleviation of chemotherapy-induced bone marrow suppression, with a comparison to Diyu sheng bai tablets (DYSB) and RhG-CSF.MethodsA mouse model of bone marrow suppression was established in BALB/c mice using intraperitoneal injections of cyclophosphamide (CTX). All procedures were performed after obtaining ethical clearance from the institutional animal ethics committee. Mice were treated with low (100 mg/kg/d), medium (200 mg/kg/d), and high (400 mg/kg/d) doses of Gallic Acid (GA) to mitigate CTX-induced bone marrow suppression. In parallel, mice in the positive control group were also treated with DYSB and RhG-CSF at their respective standard doses (DYSB: 100 mg/kg/day, RhG-CSF: 125 mg/kg/day). The efficacy of GA in alleviating chemotherapy-induced bone marrow suppression was evaluated through blood cell counts, immune organ (thymus and spleen) indices, bone marrow nucleated cell (BMNC) counts, cell cycle analysis, apoptosis, histopathology of bone marrow and spleen, and analysis of splenic hematopoietic factors.ResultsCTX induced a decrease in peripheral blood cells and BMNC counts, reduced spleen and thymus indices, and diminished abnormal pathology of bone marrow and spleen, as well as decreasing disturbances in hematopoietic factors. GA was able to alleviate these abnormalities in the bone marrow. It modulated cell proliferation and apoptosis, adjusted the proportion of cells in the G0/G1 phase, and reduced apoptosis in femoral bone marrow.ConclusionGallic Acid (GA) alleviates chemotherapy-induced bone marrow suppression by improving immune organ function, promoting bone marrow cell recovery, and inhibiting apoptosis. These findings support GA as a potential adjunct therapy for chemotherapy, with promising clinical applications.
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PubMed
高影响因子
MICROCHEMICAL JOURNAL
·
2021
·
IF 4.821
Qin Tan,Xuanxuan An,Shuang Pan,Shujun Zhen,Yongmei Hu,Xiaoli Hu
Gallic acid (GA), which is widely found in some tea leaves, fruits and medicinal materials, has a variety of biological activities, including anti-oxidation, anti-cancer, anti-bacterial. Thus, monitoring the amount of GA is of great significance. We developed a GA ratiometric fluorescent sensor by carbon dots (CDs), CoOOH nanoflakes and o-phenylenediamine (OPD). In the absence of GA, OPD can be oxidized to 2,3-diaminophenazine (DAP) by CoOOH nanoflakes. DAP not only quenches the fluorescence of CDs at 450 nm through the inner filter effect (IFE), but also produces a new fluorescence emission peak at 570 nm. However, the presence of GA is able to cause collapse of CoOOH nanoflakes which are reduced to Co 2+ , thus impeding the formation of DAP. Based on this principle, ratiometric detection of GA is achieved. The novel ratiometric fluorescent sensor shows high sensitivity toward GA and the linear response is observed in the 2.0–60.0 μmol L −1 with a detection limit of 1.2 μmol L −1 . Furthermore, the CDs/CoOOH nanoflakes/OPD sensor is applied to the detection of GA in green tea.
研究领域:
分析化学
·
生物化学
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DOI
高影响因子
JOURNAL OF ELECTRONIC MATERIALS
·
2022
·Vol. 51
·期 4
·1752-1758
·
IF 2.047
Tian Wenjing,Ding Xu,Jiang Feifei,Du Xinrui,Shi Jipeng,Zhang Ji
Research into metal nanoparticles has increased, and they have been increasingly used in non-enzymatic sensor applications. However, there have been few reports on the use of natural products to prepare non-precious metal nanoparticles in an eco-friendly (green) manner. Studies were conducted on Cu nanoparticles (Cu NPs) prepared by the use of natural gallic acid (GA). This method is environmentally friendly and can be applied to H 2 O 2 detection. As-obtained Cu NPs were characterized by x-ray photoelectron spectroscopy (XPS), powder x-ray diffraction (XRD), and transmission electron microscopy (TEM). When applied to H 2 O 2 detection, Cu NPs had good sensitivity, stability, and anti-interference properties. Its electrochemical performance is no less than that of precious metal nanomaterials. Cu NPs mainly exhibit good sensitivity, reaching 5.74 μA mM -1 cm -2 ; the concentration range thereof is 1–20 mM. The process of constructing nanoparticles in this work used natural products, making it environmentally friendly and proving the practicality of constructing non-precious metal nanoparticles and the feasibility of their application to H 2 O 2 detection. Graphic Abstract
研究领域:
材料科学
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环境科学
·
分析化学
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DOI
高影响因子
Food Analytical Methods
·
2024
·Vol. 17
·期 5
·689-700
·
IF 2.6
He Hongmei,Wang Luwei,Huang Hui,Li Yongxin
In this study, a novel gallic acid-based anthocyanin electrospun sensor was developed to monitor the freshness of the shrimp. “The sensor contains blueberry anthocyanin as indicator dye, polyacrylonitrile as polymer, and gallic acid as copigment. The sensor was studied by SEM, FT-IR, color stability, and its response to dimethylamine and trimethylamine. The results showed that the anthocyanin electrospun sensor was copigmented with gallic acid, which improved the color stability during storage (Δ E <5) and sensitivity to dimethylamine and trimethylamine. The color changes were obvious by the naked eye, which proved that the anthocyanin-gallic of the anthocyanin-gallic acid electrospun sensor during shrimp storage over 5 days at 4 °C was positively correlated with the contents of TVB-N ( R 2 = 0.9905) and pH ( R 2 = 0.9906). The color of the sensors ranged from pink to purple to yellow, and they represented the freshness, medium freshness, and spoilage of shrimp. The color changes are obvious to the naked eye. The indicated membrane had good application value in the nondestructive testing of shrimp, as the anthocyanin-gallic acid sensor could evaluate the freshness of the shrimp. This membrane demonstrates significant potential for nondestructive testing of shrimp freshness. The combination of electrospun technology and copigmentation provided a new idea for detecting the freshness of food.
研究领域:
食品科学
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传感器技术
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高分子科学
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分析化学
·
食品安全
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DOI
高影响因子
FOOD CHEMISTRY
·
2025
·
IF 9.8
Haoqiang Wang,Shunjing Luo,Xiuting Hu,Chengmei Liu
This study explored the potential of gallic acid to enhance fiber formation in soy protein isolate (SPI)-based meat analogues produced from high-moisture extrusion. Specifically, the effect of gallic acid on the structure and characteristics of meat analogues was investigated. It was found that gallic acid enhanced the anisotropy index of meat analogues, with the strongest effect observed at a concentration of 0.06 mol/kg SPI. The hardness, chewiness and water binding ability of SPI-based meat analogues were also increased. Moreover, gallic acid increased the energy input to SPI during extrusion and the flow velocity difference of the SPI melt during cooling. SDS-PAGE analysis and the decrease in contents of free sulfhydryl and amino groups indicated that gallic acid induced covalent cross-linking of SPI molecules during extrusion. Also, 0.06 mol gallic acid/kg SPI had the most profound effect. Thus, it was inferred that these alterations induced promotion of fiber formation.
研究领域:
食品科学
·
生物化学
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DOI
PubMed
高影响因子
SENSORS AND ACTUATORS A-PHYSICAL
·
2025
·
IF 4.9
Xinjian Zheng,Qiao Zhang,Xianghua Yu,Huabo Huang,Jiayou Ji,Liang Li
Conducting hydrogels have gained great interest in the applications of flexible sensors, soft electronics, and health monitoring. However, the poor processability, limited reusability, and easy aggregation of conducting components significantly constrain the widespread implementation of traditional conducting hydrogels. Herein, the homogeneous conducting hydrogels based on polyvinyl alcohol (PVA) and polyaniline (PANI) are tailored with cheap and natural gallic acid (GA) for flexible sensors. The optimized hydrogel exhibits good mechanical properties, with a tensile strength of 1.61 MPa at a maximum elongation of 344 %, Young's modulus of 0.24 MPa, and toughness of 2.36 MJ m −3 , as well as long-term stability and reusability. The flexible sensor assembled with the as-prepared hydrogels demonstrated the desirable properties with a competitive gauge factor, sensing stability, and fast responsiveness. Therefore, the satisfactory performances enable it to monitor and distinguish different multi-scale human motions. This work fosters a PVA/PANI hydrogel platform tailored with GA, paving the way for the development of high-performance conducting hydrogels and applications in flexible electronics.
研究领域:
材料科学
·
生物医学工程
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DOI
高影响因子
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
·
2024
·
IF 7.7
Yongyan Yang,Ying Ma,Meiliang Wu,Xueping Wang,Yuan Zhao,Shuangling Zhong,Yan Gao,Xuejun Cui
Self-healing hydrogel is a promising soft material for applications in wound dressings, drug delivery, tissue engineering, biomimetic electronic skin, and wearable electronic devices. However, it is a challenge to fabricate the self-healing hydrogels without external stimuli. Inspired by mussel, the metal-catechol complexes were introduced into the hydrogel systems to prepare the mussel-inspired hydrogels by regulating the gelation kinetics of Fe 3+ crosslinkers with gallic acid (GA) in this research. The amine-functionalized carboxymethyl cellulose (CMC) was grafted with GA and then chelated with Fe 3+ to form a multi-response system. The crosslinking of carboxymethyl cellulose-ethylenediamine-gallic acid (CEG) hydrogel was controlled by adjusting the pH to affect the iron coordination chemistry, which could enhance the self-healing properties and mechanical strength of hydrogels. In addition, the CEG hydrogel exhibited great antibacterial and antioxidant properties. And the CEG hydrogel could strongly adhere to the skin tissue. The adhesion strength of CEG hydrogel on pigskin was 11.44 kPa, which is higher than that of commercial wound dressings (∼5 kPa). Moreover, the thixotropy of the CEG hydrogel was confirmed with rheological test. In summary, it has great potential in the application field of wound dressing.
研究领域:
材料科学
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生物医学工程
·
化学
·
生物材料
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DOI
PubMed
高影响因子
Experimental and Therapeutic Medicine
·
2021
·Vol. 21
·期 6
·1-11
·
IF 2.447
Xiaoming Lin,Guangfei Wang,Ping Liu,Lei Han,Tong Wang,Kaili Chen,Yonglin Gao
The aim of the present study was to investigate the effects of gallic acid (GA) on the proliferation and apoptosis of colon cancer cells and to further clarify the mechanism of GA function associated with SRC and EGFR phosphorylation. HCT116 and HT29 cells were treated with different concentrations of GA for 24 h. Cell proliferation and apoptosis were analyzed using plate clone formation and flow cytometry assays, respectively. In addition, the expression of apoptosis‑related proteins was examined by western blotting. Furthermore, the level of STAT3, AKT, SRC and EGFR phosphorylation was analyzed by western blotting and immunofluorescence. Subsequently, the SRC inhibitor PP2 and the EGFR inhibitor gefitinib were used to analyze the GA‑associated mechanisms. In addition, a xenograft tumor model was established to confirm the effects of GA in vivo. The results indicated that GA inhibited cell proliferation and promoted cell apoptosis by upregulating the ratio of cleaved caspase‑3/pro‑caspase‑3 and cleaved caspase‑9/pro‑caspase‑9. Concurrently, GA decreased the level of phosphorylated (p)‑SRC, p‑EGFR, p‑AKT and p‑STAT3. Following treatment with PP2 and gefitinib in both cancer cell lines and animal model, GA was demonstrated to inhibit EGFR and SRC phosphorylation to downregulate STAT3 and AKT phosphorylation. In vivo, GA prevented tumor growth, promoted tumor apoptosis and decreased the level of p‑SRC, p‑EGFR, p‑STAT3 and p‑AKT. In conclusion, GA was indicated to suppress colon cancer proliferation by inhibiting SRC and EGFR phosphorylation.
研究领域:
肿瘤学
·
分子生物学
·
细胞生物学
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DOI
PubMed
高影响因子
POLYMER
·
2020
·
IF 4.231
Longfang Ren,Xiangdong Ma,Jian Zhang,Taotao Qiang
WPU was prepared by a simple and bio-based method using poly(1,3-propylene glycol-adipic acid) (PPA) and isophorone diisocyanate (IPDI) as raw materials. Intriguingly, PPA can be synthesized using 1,3-propanediol which was extracted from plant stalk. Then a non-toxic, environmental-friendly gallic acid modified bio-based waterborne polyurethane (GWPU) was successfully prepared utilizing the prepolymer method with gallic acid (GA) was as a modifier. The structures, morphologies and thermostability of GWPU were confirmed by FTIR, TEM, TG , DSC and AFM . Furthermore. Its mechanical properties and water resistance were evaluated as well. The results demonstrated that self-prepared PPA has no influence on the properties of polyurethane. However, when the content of GA was increased from 0% to 3.3%, the tensile strength of GWPU film increased by 155.3% compared with that of unmodified PU film, the elongation at break decreased by 86%, and the decomposition temperature of the film increased by 23.8 °C, the surface roughness decreased by 41.0%. In addition, through the crosslinking of GA, the water resistance of GWPU is improved.
研究领域:
材料科学
·
高分子化学
·
环境科学
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DOI
高影响因子
危险品化学品经营许可证（带存储）