EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS
·
2015
·
IF 3.85
Xiaoming Luo,Maohua Chen,Yun Zhang,Zhoujiang Chen,Xiaohong Li
The premature drug release and structural dissociation before reaching pathological sites have posed major challenges for self-assembled micelles . To address these challenges, star-shaped amphiphilic copolymers derived from 4-armed poly(ethylene glycol) (PEG) were proposed for chemical conjugation of chemotherapeutic drugs and assembly into drug-conjugated micelles (DCM) with reductive sensitivity. The current study aimed to elucidate the in vitro and in vivo performance of DCM and a comparison with conventional drug-encapsulated micelles (DEM) was initially launched. DEM carriers were constructed with a similar structure to DCM from 4-armed PEG, and disulfide linkages were located between the hydrophilic and hydrophobic segments. Both DCM and DEM had an average size of around 130 nm, camptothecin (CPT) loadings of around 7.7% and critical micelle concentrations of around 0.95 μg/ml. Compared with DEM, DCM showed a lower initial drug release, a lower sensitivity of drug release to glutathione , and a higher structural stability after incubation with human serum albumin (HSA). The CPT derivatives (CPT-SH) released from DCM indicated cytotoxicities similar to CPT and remained a higher lactone stability than CPT in the presence of HSA. DCM showed slightly higher cytotoxicities to 4T1 cells and significantly lower cytotoxicities to normal cells than DEM. Pharmacokinetic analyses after intravenous administration of DCM indicated around 2.65 folds higher AUC 0–∞ , 2.66 folds lower clearance, and 1.87 folds higher tumor accumulation than those of DEM. In addition to a less disturbance to hematological and biochemical parameters and a lower acute toxicity to small intestines , DCM showed more significant tumor suppression efficacy and less tumor metastasis to lungs than DEM. It is suggested that DCM could overcome the limitation of conventional micelles by alleviating the premature drug release during blood circulation, relieving the systemic toxicity and promoting the therapeutic efficacy.
研究领域:
药学
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纳米技术
·
肿瘤学
·
药物递送系统
✓ 已验证
产品关联
DOI
PubMed
高影响因子
JOURNAL OF MOLECULAR LIQUIDS
·
2022
·
IF 6.633
Mingwei Gao,Peng Liu,Qiang Xue,Mingwei Zhao,Xu Guo,Qing You,Caili Dai
Supramolecular assembly determines the formation and transformation of soft materials. So far, the construction and transformation of conventional (
研究领域:
化学
·
材料科学
·
超分子化学
✓ 已验证
产品关联
DOI
高影响因子
COLLOID AND POLYMER SCIENCE
·
2020
·Vol. 298
·期 8
·1119-1128
·
IF 1.536
Wang Qiang,Gao Feng,Zhou Xianyong
Compared with conventional drug nanocarriers, multifunctional drug delivery systems exhibited characteristic advantages. In this study, we developed a multifunctional drug delivery system possessing stimuli-responsive drug release and cellular imaging. Amphiphilic polymers, methoxypolyethylene glycol-cystamine-tetraphenylethene (mPEG 1k -SS-TPE), were synthesized by combining methoxypolyethylene glycol (mPEG 1k ) and tetraphenylethene (TPE) using reduction-sensitive disulfide bonds that can be disconnected by high level of inherent glutathione (GSH). Size distribution and morphology of mPEG 1k -SS-TPE micelles were evaluated. Meanwhile, the reduction-sensitivity of mPEG 1k -SS-TPE micelles was surveyed compared with that of mPEG 1k -TPE micelles. Nile Red was encapsulated into mPEG 1k -SS-TPE micelles to visually observe intracellular drug delivery against SW480 cells. Paclitaxel (PTX) was chosen to be loaded into micelles to evaluate the cytotoxicity against HCT116, HT-29, and SW480.
Graphical Abstract
研究领域:
生物材料
·
药物化学
·
肿瘤学
✓ 已验证
DOI
高影响因子
Advanced Optical Materials
·
2025
·
IF 7.2
Junheng Gao,Fu Tang,Yuting Li,Likang Zhang,An Hu,Shuo Li,Lidong Li
Fluorescent hydrogels have immense potential and are widely studied for on demand displays. Response rate of fluorophores upon stimuli within the hydrogel matrix is a key role to improve the timely responsiveness, but rare reports are elaborated on it. In this work, the photoisomeric spiropyran methacrylate (SPMA) is introduced into the poly (2-hydroxyethyl methacrylate) hydrogel to fabricate a stimuli-responsive fluorescent hydrogel. Interestingly, the photoresponse rate of SPMA in the hydrogel is greatly accelerated at the presence of F127 micelles than without it. Both of the absorbance and fluorescence intensity of the hydrogels at the photostationary state are improved obviously with micelles. Besides, the normalized absorbance and the fluorescence kinetic studies indicated a more than 2 times quicker isomerization process. The absolute fluorescence quantum yields of SPMA in the hydrogel is also increased. These can be attributed to the hydrophobic microenvironment provided by the F127 micelles that facilitated the conformation transition of SPMA. Thus, the synergetic effect of the increased amount of activable SPMA and the promoted speed of isomerization contributed to the accelerated photoresponse of the prepared hydrogel. Taking advantage of these virtues, a timely and multi-responsive on-demand information encryption system is realized.
研究领域:
材料科学
·
化学
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2019
·
IF 3.683
Jinjin Li,Jianfeng Li,Liang Jiang,Xinchun Chen,Jianbin Luo
It is easy to achieve extremely low friction of graphene or graphite in dry conditions via the formation of an incommensurate interface but is difficult to achieve with water lubrication. Herein, we propose a new strategy to achieve extremely low friction on a graphitic surface in water by self-assembling cationic surfactant micelles in the contact zone. When uniform surfactant micelles are formed on silica and freshly cleaved graphene layers via self-assembly under low contact pressure, the friction coefficient between them can reduce to 0.0004. When the self-assembled micelles are ruptured in the contact zone by high pressure, the friction coefficient between them would increase to 0.005 (still in the superlubricity regime). The mechanism of the different friction behaviors was studied at the nanoscale, which was attributed to the formation of different shear planes that shifts from the interface of the micelle/micelle to surfactant molecules/graphene layers after micellar rupture. The results provide direct evidence that the cationic surfactant micelles can efficiently lubricate graphitic surface regardless of micellar rupture.
研究领域:
材料科学
·
表面科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
Nanoscale
·
2014
·Vol. 6
·期 24
·14772-14783
·
IF 6.739
Danling Yang,Rongfeng Zou,Yu Zhu,Ben Liu,Defan Yao,Juanjuan Jiang,Junchen Wu,He Tian
Polydiacetylene (PDA) micelles have been widely used to deliver anticancer drugs in the treatment of a variety of tumours and for imaging living cells. In this study, we developed an effective strategy to directly conjugate magainin II (MGN-II) to the surface of PDA micelles using a fluorescent dye. These stable and well-defined PDA micelles had high cytotoxicity in cancer cell lines, and were able to reduce the tumour size in mice. The modified PDA micelles improved the anticancer effects of MGN-II in the A549 cell line only at a concentration of 16.0 μg mL−1 (IC50). In addition, following irradiation with UV light at 254 nm, the PDA micelles gave rise to an energy transfer from the fluorescent dye to the backbone of PDA micelles to enhance the imaging of living cells. Our results demonstrate that modified PDA micelles can not only be used in the treatment of tumors in vitro and in vivo in a simple and directed way, but also offer a new platform for designing functional liposomes to act as anticancer agents.
研究领域:
癌症研究
·
生物医学工程
·
药物递送系统
·
分子生物学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHEMICAL ENGINEERING JOURNAL
·
2021
·
IF 13.273
Yangyuan Ji,Junfeng Niu,Yuhang Fang,Alliyan Tan Nou,David M Warsinger
Nonylphenol ethoxylates (NEPOs) are widely used as nonionic surfactant in the industry, which pose a threat to environment and human health. In this study, we conducted kinetic experiments and chemical analysis to investigate the effects of NEPOs micelles on degradation kinetics and electro-oxidation degradation mechanism. The electro-oxidation degradation of NEPOs followed pseudo-first order kinetics and more than 92% of NEPOs was degraded. Furthermore, the hydroxyl radicals generated by the Ti 4 O 7 anode contributed to 41% of degradation performance. During the entire degradation process, the micelles of NEPOs undergo growth, and the steric hindrance phenomenon of micelles prevents NEPOs from being attack by hydroxyl radicals. As the results of the oxygen substituents destruction on the benzene ring and the generation of various lengths of ethoxylated chains, the C aryl -O ether bond of NEPOs was inferred as the oxidation preferential site. This study may broaden the understanding of how surfactant micelles affect advanced oxidation processes and improve the application prospects of electro-oxidation in the treatment of wastewater containing NEPOs.
研究领域:
环境科学
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化学工程
·
水处理
✓ 已验证
DOI
高影响因子
JOURNAL OF MATERIALS RESEARCH
·
2016
·Vol. 31
·期 14
·2046-2057
·
IF 1.579
Yiting Xu,Ying Cao,Jianjie Xie,Qi Li,Xianming Chen,Shiao-Wei Kuo,Lizong Dai
Novel mixed micelle was successfully fabricated by the synergistic self-assembly of poly(methacrylate isobutyl polyhedral oligomeric silsesquioxane (POSS)-co-N-isopropylacrylamide-co-oligo(ethylene glycol)methyl ether methacrylate-co-acrylic acid) (P(methacrylate isobutyl (MAPOSS)-co-NIPAM-co-OEGMA-co-AA)) and poly(methacrylate isobutyl POSS-co-N-isopropylacrylamide-co-oligo(ethylene glycol) methyl ether methacrylate-co-2-vinylpyridine) (P(MAPOSS-co-NIPAM-co-OEGMA-co-2VP)). Dynamic light scattering (DLS) and transmission electron microscopy characterizations demonstrate that the formation of mixed micelles is driven by electrostatic interaction. The formation of the mixed micelles was further implied by a simple fluorescence resonance energy transfer based technique. The mixed micelle possesses the biggest size at pH = 7.0, which is attributed to the strongest electrostatic interaction between the two kinds of micelles. The zeta potential under different pH was detected to further investigate the surface charges corroborating the discussions. DLS and UV-vis indicate that the lower critical solution temperature (LCST) is pH dependent. The mixed micelles reach the highest LCST at pH 7.0. The LCST of the mixed micelle can be tuned by adjusting the volume ratio of the two kinds of micelles as well. Moreover, the thermo-responsive behavior of the mixed micelle is absolutely reversible.
研究领域:
材料科学
·
高分子化学
·
纳米技术
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2022
·
IF 4.331
Yimin Hu,Yu Chen,Zixian Cai,Xiaolan Jin,Lei Fan,Jie Han,Rong Guo
The effect of the hydrocarbon chain length of ionic liquid surfactants 1-hexadecyl-3-alkyl imidazolium bromide [C16imCn]Br (n = 1–16) on their aggregation behavior with polyoxyethylene lauryl ether (Brij 30) in aqueous solution was inspected. The rheological behavior, thermal properties, and microstructures of the different samples were studied using freeze-fractured electron microscopy. The interactions between [C16imCn]Br and Brij 30 were studied using nuclear magnetic resonance spectroscopy and theoretical simulation. With the addition of Brij 30, the rodlike micelles of [C16imCn]Br (n = 1, 2, 4, and 6) transition into wormlike micelles. The effects of the molar ratio of Brij 30 and [C16imCn]Br and the hydrocarbon chain length of [C16imCn]Br on the Brij 30/[C16imCn]Br (n = 1, 2, 4, and 6) wormlike micelles were studied. When Brij 30 was mixed with the rodlike micelles of [C16imC8]Br, the Brij 30/[C16imC8]Br mixtures form wormlike micelles at low Brij 30 concentration and gels at high Brij 30 concentration. The [C16imCn]Br (n = 10, 12, 14, and 16) rodlike micelles were induced by Brij 30 to turn into the Brij 30/[C16imCn]Br gels. The effect of the [C16imCn]Br hydrocarbon chain length on their rodlike micelles with the addition of Brij 30 is also theoretically discussed.
研究领域:
化学
·
材料科学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
CHINESE JOURNAL OF POLYMER SCIENCE
·
2024
·
IF 4.1
Chen Jia-Wen,Xiao Yan,Lang Mei-Dong
Insulin is an essential and versatile protein taking part in the control of blood glucose levels and protein anabolism. However, under prolonged storage or high temperature stress, insulin tends to unfold and aggregate into toxic amyloid fibrils, leading to loss of physiological function. Inspired by natural chaperones, a series of temperature-sensitive polycaprolactone-based micelles were designed to prevent insulin from deactivation. The micelles were fabricated through the self-assembly of amphiphilic copolymers of methoxy poly(ethylene glycol)-poly(4-diethylformamide caprolactone- co -caprolactone) (mPEG 17 -P(DECL- co -CL)), which had a regular spherical morphology with particle sizes of about 100 nm. In addition, the lower critical solution temperature (LCST) of the micelles could be tuned to 9 and 29 °C by changing the ratio of DECL to CL. Benefiting from the temperature-sensitivity of DECL segment, the binding ability of micelles to insulin could be modulated by changing the temperature. Above LCST, micelles effectively inhibited insulin aggregation and protected it from thermal inactivation due to the strong binding ability between the hydrophobic segment DECL and insulin. Below LCST, DECL segment returned to hydrophilic and bound weakly with insulin, leading to the release of insulin and assisting in its recovery of secondary structure. Thus, these temperature-sensitive micelles provided an effective strategy for insulin protection.
研究领域:
生物化学
·
材料科学
·
药物递送
✓ 已验证
产品关联
DOI
高影响因子
LANGMUIR
·
2017
·
IF 3.833
Yong Liu,Ying Chen,Yongchao Yao,Kui Luo,Shiyong Zhang,Zhongwei Gu
With the special nature of confined water pools, reverse micelles (RMs) have shown potential for a wide range of applications. However, the inherent water insolubility of RMs hinders their further application prospect especially for applications related to biology. We present herein the first successful transformation of water-insoluble RMs into water-soluble nanoparticles without changing the confined aqueous interiors by hydrolysis/aminolysis of arm-cleavable interfacial cross-linked reverse micelles formed from diester surfactant 1. The unique properties exhibited by the aqueous interiors of the resulting pool-buried water-soluble nanoparticles (PWNPs) were demonstrated both by the template synthesis of gold nanoparticles in the absence of external reductants and by the fluorescence enhancement of encapsulated thioflavin T (ThT). Importantly, the unique potential for PWNPs in biological applications was exemplified by the use of ThT@PWNPs and “cell targeted” ThT@PWNPs as effective optical imaging agents of living cells. This work conceptually overcomes the application bottleneck of RMs and opens an entry to a new class of functional materials.
研究领域:
化学
·
生物学
·
材料科学
✓ 已验证
DOI
高影响因子
Nanomaterials
·
2019
·Vol. 9
·期 1
·91
·
IF 4.034
Chuan Zhang,Yuzhuo Wang,Yue Zhao,Hou Liu,Yueqi Zhao,Xiangwei Li,Quan Lin
The chemotherapy of stimuli-responsive drug delivery systems (SDDSs) is a promising method to enhance cancer treatment effects. However, the low efficiency of chemotherapy drugs and poor degradation partly limit the application of SDDSs. Herein, we report doxorubicin (DOX)-loading mixed micelles for biotin-targeting drug delivery and enhanced photothermal/photodynamic therapy (PTT/PDT). Glutathione (GSH)-responsive mixed micelles were prepared by a dialysis method, proportionally mixing polycaprolactone-disulfide bond-biodegradable photoluminescent polymer (PCL-SS-BPLP) and biotin-polyethylene glycol-cypate (biotin-PEG-cypate). Chemically linking cypate into the mixed micelles greatly improved cypate solubility and PTT/PDT effect. The micelles also exhibited good monodispersity and stability in cell medium (~119.7 nm), low critical micelles concentration, good biodegradation, and photodecomposition. The high concentration of GSH in cancer cells and near-infrared light (NIR)-mediated cypate decomposition were able to achieve DOX centralized release. Meanwhile, the DOX-based chemotherapy combined with cypate-based NIR-triggered hyperthermia and reactive oxygen species could synergistically induce HepG2 cell death and apoptosis. The in vivo experiments confirmed that the micelles generated hyperthermia and achieved a desirable therapeutic effect. Therefore, the designed biodegradable micelles are promising safe nanovehicles for antitumor drug delivery and chemo/PTT/PDT combination therapy.Keywords:photothermal therapy;photodynamic therapy;biodegradable;stimuli-responsive drug delivery systems;cypate
研究领域:
癌症治疗
·
药物递送系统
·
生物医学工程
·
高分子化学
✓ 已验证
DOI
PubMed
高影响因子
危险品化学品经营许可证（带存储）