Pharmaceuticals
·
2024
·Vol. 17
·期 9
·1161
·
IF 4.3
Luge Chen,Yingwei Liu,Dawei Xu,Na Zhang,Yong Chen,Jin Yang,Lijuan Sun
With the increasing prevalence of insomnia-related diseases, the effective treatment of insomnia has become an important health research topic. Lavender (Lavandula angustifoliaMill.) essential oil (LEO) is a commonly used medicine for the treatment of insomnia and neurological disorders. However, neither the active components nor its sedative–hypnotic mechanism have been fully discovered. This study aimed to screen the main active terpenes and discover the possible mechanism of LEO through network pharmacology in the treatment of insomnia-related diseases, as well as to verify our hypothesis in insomnia mice. The results showed that, in LEO’s 15 potential active ingredients, beta-myrcene had strong sedative–hypnotic effects through the serotonergic synaptic pathway according to the network pharmacological prediction. Further, PCPA(DL-4-chlorophenylalanine)-induced insomnia mice were treated with beta-myrcene for one day or seven days. The quiet state of insomnia mice was increased effectively, and the hypnotic effect was enhanced by anaobarbital sodium by prolonging sleep duration, decreasing sleep latency, and increasing the rate of falling asleep. Beta-myrcene reduced the damage to hypothalamic neuron cells induced by PCPA and increased neurotransmitter levels of GABA, 5-HT, and Glu in the serum and hypothalamus of insomnia mice. Meanwhile, beta-myrcene exerted an improvement in insomnia by upregulating relevant genes and protein expression in the serotonergic synaptic pathway. These results support the merit of the sedative–hypnotic activity of LEO. Beta-myrcene, a terpene in LEO, may be the main source of its sedative–hypnotic properties. It may serve as a good potential compound in future clinical studies on coping with insomnia.
研究领域:
药理学
·
神经科学
·
医学
✓ 已验证
DOI
PubMed
高影响因子
INDUSTRIAL & ENGINEERING CHEMISTRY RESEARCH
·
2023
·
IF 4.2
Shuainan Zhao,Haijun Ji,Jie Yu,Rui Wang,Liqun Zhang,Runguo Wang
A series of green poly(isoprene-co-myrcene) (PIMy) elastomers were designed and prepared by coordination polymerization to solve the fossil shortage and achieve an excellent low-temperature resistance property. The properties of PIMy could be tailored upon varying the comonomer feed ratios. The structure and thermal stability were investigated by NMR, differential scanning calorimetry (DSC), and thermogravimetric analysis (TGA) analyses. The cis-1,4 structure content of PIMy exceeded 95%, and the Tg of PIMy was below −60 °C without crystallization at low temperatures. With the increase of myrcene content, the tensile strength of PIMy/silica nanocomposites decreased, the wet skid resistance was improved, and PIMy with myrcene content of 5–20 mol % had better comprehensive properties. The introduction of PIMy in solution-polymerized styrene–butadiene rubber (SSBR) increased the tan δ value at −20 °C and improved the ice skid resistance performance. The Laboratory Abrasion Tester (LAT-100) test results showed that the addition of PIMy significantly improved the friction of SSBR on the ice surface with a maximum improvement of 161%. The PIMy prepared in this study is expected to be used in low-temperature-resistant rubber products such as seals and winter tires.
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
高影响因子
ENVIRONMENTAL SCIENCE & TECHNOLOGY
·
2026
·
IF 12.2
Ya Zhao,Chong Wang,Yingqi Zhao,Yufeng Shao,Hua Xie,Jiayue Yang,Weiqing Zhang,Guorong Wu,Gang Li,Ling Jiang,Xueming Yang
Elucidating the impacts of gaseous pollutants on secondary organic aerosol (SOA) formation mechanisms is critical for developing effective PM2.5 mitigation strategies. However, the combined effects of NOx (NOx = NO2 + NO) and SO2 on SOA compositions under complex photochemical conditions remain mechanistically unresolved. Here, we investigated the individual roles of NO2/NO and their combined effects with SO2 on β-myrcene photooxidation. Our results showed that NO2 enhanced the SOA yield and the O:C ratio through oxidant amplification, whereas NO suppressed nucleation and oxidation states of products but facilitated particle size growth via organic nitrate partitioning. SO2 exhibited significant synergistic effects with both NO2 and NO, facilitating particle formation and growth processes. The newly built vacuum ultraviolet free electron laser photoionization aerosol mass spectrometer enabled the observation of a series of new compounds (i.e., organic peroxides, organic nitrate, and organosulfates) and identified new mechanisms of SOA formation. Notably, a novel compound with a molecular weight of 287 was characterized to be a nitrogen- and sulfur-containing species. These findings highlight the critical roles of pollutants in particle formation in environmental processes and provide key scientific support for regional air quality management and climate change mitigation.
✓ 已验证
产品关联
DOI
PubMed
高影响因子
EUROPEAN JOURNAL OF PHARMACOLOGY
·
2026
·
IF 5.7
Nana Long,Youwei Zuo,Jian Li,Renxiu Yao,Xiao Zhang,Hongping Deng
Background Atopic dermatitis (AD) is characterized by epidermal barrier impairment and immune-driven inflammation. Strategies that restore barrier architecture while constraining inflammation are of therapeutic interest. Purpose To evaluate the barrier-reparative and anti-inflammatory effects of β-myrcene (MYR) in experimental atopic dermatitis and to investigate whether ECM–FAK/Src–YAP signaling is associated with these effects. Methods A 2,4-dinitrochlorobenzene (DNCB)-induced murine model of AD-like dermatitis was evaluated by transepidermal water loss (TEWL), histopathology, dermal collagen organization, filaggrin (FLG) immunofluorescence, and circulating inflammatory mediators. Integrated skin transcriptomic and proteomic analyses and public human AD transcriptomic datasets were used to identify MYR-associated pathways. In primary human keratinocytes stimulated with tumor necrosis factor-α (TNF-α) and interferon-γ (IFN-γ), YAP localization, FAK Tyr397 and Src Tyr416 phosphorylation, YAP/TAZ target genes, barrier markers, and inflammatory outputs were assessed. Peptide 17 was used to examine the contribution of YAP-dependent transcription. Results MYR reduced dermatitis severity and epidermal hyperplasia, lowered TEWL, partially restored FLG immunofluorescence, and preserved dermal collagen organization in DNCB-challenged mice. Multi-omics profiling identified MYR-associated changes in extracellular matrix (ECM)–receptor interaction, focal adhesion, cytoskeletal remodeling, epidermal differentiation, and immune-related programs. In inflamed keratinocytes, MYR was associated with increased FAK and Src phosphorylation, YAP nuclear accumulation, CCN1/CCN2 expression, and barrier-marker expression, together with reduced inflammatory mediator production. Peptide 17 attenuated MYR-associated YAP nuclear accumulation and several downstream transcriptional responses. These findings support the participation of YAP-dependent signaling but do not establish MYR as a direct regulator of FAK, Src, or YAP or demonstrate a strictly linear signaling sequence. Conclusion MYR produced barrier-restorative and anti-inflammatory effects in experimental atopic dermatitis. The results identify ECM–FAK/Src–YAP signaling as a candidate pathway associated with the MYR response, with pharmacological inhibition providing partial functional evidence for a YAP-dependent component. Download: Download high-res image (265KB) Download: Download full-size image
✓ 已验证
DOI
高影响因子
MOLECULES
·
2024
·Vol. 29
·期 10
·2363
·
IF 4.2
Tao Li,Mingzu Zhang,Jinlin He,Peihong Ni
Graft copolymers have unique application scenarios in the field of high-performance thermoplastic elastomers, resins and rubbers. β-myrcene (My) is a biomass monomer derived from renewable plant resources, and its homopolymer has a low glass transition temperature and high elasticity. In this work, a series of tapered copolymers P(My-co-AMS)k(k = 1, 2, 3) were first synthesized in cyclohexane by one-pot anionic polymerization of My and α-methyl styrene (AMS) using sec-BuLi as the initiator. PAMS chain would fracture when heated at high temperature and could endow the copolymer with thermal degradation property. The effect of the incorporation of AMS unit on the thermal stability and glass transition temperature of polymyrcene main chain was studied. Subsequently, the double bonds in the linear copolymers were partially epoxidized and hydroxylated into hydroxyl groups to obtain hydroxylated copolymer, which was finally used to initiate the ring-opening polymerization (ROP) of ε-caprolactone (ε-CL) to synthesize the graft copolymer with PCL as the side chain. All these copolymers before and after modifications were characterized by proton nuclear magnetic resonance (1H NMR), gel permeation chromatography (GPC), thermogravimetry analysis (TGA), and differential scanning calorimeter (DSC).
研究领域:
材料科学
·
高分子化学
✓ 已验证
产品关联
DOI
PubMed
高影响因子
POLYMER
·
2026
·
IF 5.1
Yao Long,Jiahao Zhou,Xupeng Han,Min Zhang,Yayan Wang,Jiaping Tan,Meilin Liu,Lijun Li,Kun Liu
To develop myrcene-based polymers with both functionalization characteristics and controllable structure, this paper employs 1-(vinylbenzyl) piperidine (VBMP) as a tertiary amine functional monomer and achieves the controlled copolymerization of VBMP with β -myrcene (MY) under mild conditions above room temperature in cyclohexane using living anionic polymerization. By leveraging the dual role of VBMP as both a comonomer and a polarity regulator, and optimizing the monomer feed ratio, poly(MY- co -VBMP) copolymers with controllable molecular weight and narrow molecular weight distribution (1.11 < PDI < 1.23) are successfully prepared. 1 H NMR and FTIR characterizations confirm that VBMP is uniformly inserted into the polymer backbone via in-situ copolymerization, achieving a quantitative functionalization. The reactivity ratios are determined using the Fineman-Ross and Kelen-Tüdős methods, yielding r MY = 4.62-4.80 and r VBMP = 0.43-0.54. Moreover, DSC analysis shows that with increasing VBMP content, the glass transition temperature ( T g ) of the copolymers gradually rises from −18 °C to 25 °C, accompanied by significantly enhanced chain segment regularity. In addition, the LAP chain-end active center coordination mechanism and the N-Li coordination synergy mechanism within the polymer chain are proposed to rationalize the experimental results. Overall, this polymerization system not only exploits the weak regulatory effect of the tertiary amine group of VBMP on anionic polymerization but also achieves quantitative functionalization of β -myrcene copolymers, providing an efficient route to functional materials possessing both elastic properties and reactive sites.
✓ 已验证
DOI
高影响因子
POLYMER DEGRADATION AND STABILITY
·
2017
·
IF 3.386
Mei Li,Jianling Xia,Haiyang Ding,Chengxiang Ding,Mei Wang,Shouhai Li
An adduct of myrcene and maleic anhydride (AMMA) was synthesized using a Diels-Alder reaction. The adduct was transformed into the corresponding sodium , calcium salt and zinc salts (Na-AMMA, Ca-AMMA, and Zn-AMMA) using a metathesis reaction . The chemical structures of AMMA, Na-AMMA, Ca-AMMA, and Zn-AMMA were confirmed with Fourier transform infrared spectroscopy (FTIR), Inductively coupled plasma-atomic emission spectrometry (ICP-AES), 1 H and 13 C nuclear magnetic resonance ( 1 H NMR and 13 C NMR), and X-Ray Diffraction (XRD). Mixed Ca/Na/Zn salts from AMMA provided thermal stabilization for poly (vinyl chloride) (PVC). The thermal and mechanical properties of the PVC samples were investigated using discoloration and Congo red tests, scanning electron microscopy analysis (SEM), thermal gravity analysis (TGA), TGA–FTIR analysis, thermal gravity-mass spectrometer analysis (TGA-MS), and dynamic mechanical analysis (DMA). Optimal design of the Ca/Na/Zn-AMMA formulation was studied. The application of Ca/Na/Zn-AMMA in an optimized formulation for a biobased, primary thermal stabilizer for PVC could significantly improve PVC thermal stability. The optimized Ca/Na/Zn-AMMA formulation had higher thermal stability, higher storage modulus , and lower glass transition temperatures than PVC blends without any thermal stabilizers and using commercial CaSt 2 /ZnSt 2 . The weights of the Ca/Na/Zn-AMMA samples were 33.3–75.0% that of CaSt 2 /ZnSt 2 , but provided higher thermal stability. Myrcene-derived Ca/Na/Zn-AMMA was shown to have strong potential as a primary PVC thermal stabilizer.
研究领域:
材料科学
·
有机化学
✓ 已验证
产品关联
DOI
高影响因子
POSTHARVEST BIOLOGY AND TECHNOLOGY
·
2020
·
IF 4.303
Jinxin Che,Yue Chen,Yalan Wu,Lu Li,Nengguo Tao
Tremendous economic losses in the citrus industry are caused by infestations of Penicillium digitatum . Previous research has shown that the terpene myrcene in citrus essential oils could stimulate the spore germination and mycelial growth of P. digitatum . However, the underlying mechanism is poorly known. Here, how myrcene induces the spore germination of P. digitatum was elucidated. The addition of myrcene significantly promoted the spore germination of P. digitatum and green mold in citrus fruit. As the incubation time increased, the intracellular and extracellular myrcene contents both significantly decreased in myrcene-treated samples, and no downstream products were detected through a Gas Chromatography-Mass Spectrometer. Metabolomics analysis revealed that the contents of metabolites involved in central carbon metabolism, such as glycolysis, pentose phosphate pathway, and citrate cycle, were significantly affected after the addition of myrcene. The adenosine triphosphate content and the intracellular energy charge were also drastically increased. Overall, our results suggest that the ability of myrcene to stimulate the spore germination of P. digitatum might be mediated by the upregulation of central carbon and energy metabolism.
研究领域:
微生物学
·
植物科学
·
代谢组学
✓ 已验证
产品关联
DOI
高影响因子
RSC Advances
·
2016
·Vol. 7
·期 1
·238-247
·
IF 3.289
Xuejuan Yang,Chunpeng Wang,Shouhai Li,Kun Huang,Mei Li,Wei Mao,Shan Cao,Jianling Xia
Two novel bio-based epoxy curing agents derived from myrcene (MMY) and castor oil (CMMY) were prepared, respectively. Their chemical structures were confirmed by Fourier transform infrared spectrometry (FTIR) and 1H nuclear magnetic resonance (1HNMR). The two curing agents were used to cure a commercial epoxy resin (E-51). The MMY-cured epoxy resin had very poor toughness while the CMMY-cured epoxy resin had low strength, so the two curing agents were mixed at different weight ratios to form new curing agents for the E-51 epoxy resin. The tensile strength, impact strength, dynamic mechanical properties, thermal stability, micro-morphology of fracture surfaces and gel content of the cured epoxies were all investigated. The curing behaviors of the cured epoxies were studied by differential scanning calorimetry (DSC). Results show that the elongation at break is increased and the tensile strength and glass transition temperature are decreased with increasing weight ratio of CMMY, while the impact strength is increased gradually. The initial degradation temperatures of all the cured epoxy resins were above 367 °C. The gel contents of the epoxy resins cured with the mixed curing agents were above 87%. The activation energies for the systems with MMY and CMMY were 75.90 and 67.69 kJ mol−1, respectively.
研究领域:
高分子化学
·
材料科学
·
绿色化学
·
复合材料
·
热固性树脂
·
生物基材料
·
聚合物改性
✓ 已验证
DOI
高影响因子
危险品化学品经营许可证（带存储）